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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
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Search results for , issue "Volume 04 Issue 02: (2012) February 2012" : 1 Documents clear
Fundamental Aspects of Superdisintegrants: A Concise Review Gannu Praveen Kumar
Journal of Global Pharma Technology Volume 04 Issue 02: (2012) February 2012
Publisher : Journal of Global Pharma Technology

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Abstract

Disintegrants are substances or mixture of substances added to the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. An oral solid dosage form should deally disperse into the primary particles from which it is prepared. The inclusion of the right disintegrant is a prerequisite to get optimal bioavailability in tablets and capsules which need rapid disintegration. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances the drug dissolution rate. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1-10 % by weight relative to the total weight of the dosage unit. Examples of Superdisintegrants are crosscarmelose, crospovidone, sodium starch glycolate which represent example of a crosslinked cellulose, crosslinked polymer and a crosslinked starch respectively. This review comprises various kinds of superdisintegrants, which are being used in the formulation to provide safe and effective drug delivery with patient's compliance. Keywords: Disintegrants, Tablets, Superdisintegrants.

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