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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
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Search results for , issue "Volume 10 Issue 02: (2018) Feb 2018" : 3 Documents clear
Isolation, Purification and Structural elucidation of bioactive constituents from root bark of Crataeva magna Lour (DC) RADHA krishnan meera
Journal of Global Pharma Technology Volume 10 Issue 02: (2018) Feb 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The study was to isolate and characterize the bioactive phytoconstituents from Crataeva magna Lour (DC).Materials and methods: For isolation of the compounds, ethanolic extract of Crataeva magna Lour (DC) isolated first with petroleum ether, increasing amounts of EtOAc in petroleum ether and finally with methanol yielded a number of fractions. The proportion of solvent systems used to obtain CM-01 and CM-02 were hexane-EtOAc (80: 20) and EtOAc –methanol (98:2) from fractions 5 and 8.Results: The subsequent structures of isolated compounds were elucidated by various spectrophotometric analysis. Mass spectrum of CM-01 and CM-02 showed a parent molecular ion (M+) peak at 382 gm/mol and 614 gm/mol respectively. In the 1H- NMR spectrum of CM-01  has 0.728 (methyl H), 2.439 (OH ), 2.764 (long chain CH2), 3.953(H in CH2 adjacent to OH ) where as in the 1H- NMR spectrum of CM-02, 3.9-4.2 (CH3 protons), 5.7 (OH group), 6.2-7.2 (Aromatic protons)Conclusion: From the physical, chemical and spectral characteristic CM-01 and CM-02 were concluded as phytosterols (Ceryl alcohol (Hexacosan -1-ol)) and macropolyphenol (Tannic acid).Keywords: Crataeva magna Lour (DC), phytosterols, macropolyphenol.  
Preliminary phytochemical screening and Thin layer chromatography of plant Halodule uninervis R. Karthikeyan
Journal of Global Pharma Technology Volume 10 Issue 02: (2018) Feb 2018
Publisher : Journal of Global Pharma Technology

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Abstract

To study the Physico and phyto chemical characters of the plant Halodule uninervis (family Cymodoceaceae) and also to carry out the thin layer chromatographic fingerprint. Phytochemical investigations and fluorescence analysis were carried out as per the standard techniques. Various quantitative parameters like ash values, extractive values and flavonoid content can be used as quality control parameters for the plant Halodule uninervis were determined. The crude extract with methanol and fingerprinting pattern was developed by using Thin Layer Chromatography (TLC) technique equipped with pre coated Silica plate of 12cm height using automatic TLC scanner and detected in  Visual, UV light and fluorescent light. Preliminary phytochemical studies confirmed the presence of alkaloid, carbohydrate, glycoside, protein, tannin, flavonoid, triterpenoid and phenol. TLC analysis of methanolic extract of Halodule uninervis shown that there was many phytoconstituents with different composition of mobile phase. TLC fingerprint analysis of the plant Halodule uninervis can be used as a diagnostic tool for the correct identification of the plant and it is useful as a phytochemical marker and also a good estimator of genetic variability in plant populations.Key words: Plant extract of Halodule uninervis, Phytochemical screening, Physico chemical character, TLC fingerprinting.
A review on the role of phytoconstituents in cancer cells Sasikala Mariyappan; Vignesh Pichaiyan; Sivakumar Ramalingam; Renuka Saravanan
Journal of Global Pharma Technology Volume 10 Issue 02: (2018) Feb 2018
Publisher : Journal of Global Pharma Technology

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Abstract

For centuries, herbs and plants have been used for medicinal purpose and as food as well. This review deals with the phytoconstituents that could be useful in the destruction of cancer cells and in researches dealing with the development of drug molecules for the management of cancer. This review has centered on the action of plants such as Abelmochusmochatus, Adiantummvenusutum, Agelemarmelos, Biorhythms sensitivum, Yemeni plants, Hibiscus cannabinus, Leeaindica, Ginseng root, Cinnamon bark, Aloe vera, Cassia tora, Gmelinaasiatica, Curcumin, Magnolia officinalis, Syzygiumaromaticum, Silybummaianum, Pfaffiapaniculata which serves as anti-cancer agents. A variety of herbal molecules such as Brassinosteroids, Etoposides, Flavonoids, Limonoids, Rosmarinicacid, Polyphenols, Thymoquinone, Paclitaxel, Teniposide, Vinblastine, Vincristine, Paclitaxel, Vinca alkaloid have been identified in different types of herbs and investigation has been carried out successfully against cancer cells. In future, it would be helpful to explore the medicinal value of these plants for the discovery of new drugs by the researchers and scientists across the globe.Keywords: Cancer, Medicinal plants, Phytoconstituents and Chemotherapeutic drugs

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