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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 70 Documents
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Search results for , issue "Volume 10 Issue 05: (2018) May2018" : 70 Documents clear
A Simple Data Mining Model for Heart Disease Prediction Santhosh Kumar Sundar
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

The large amounts of data require information retrieval techniques to extract useful information. Medical data is generally complex and in large volumes.  Data mining techniques are widely used in medical field for various purposes. One of the important applications in medical data analysis is the prediction of diseases. Non Communicable Diseases (NCD) is known as life style disease which requires the medical history of patient. Among other diseases in NCD, Heart disease is the leading cause of death in the world. Heart disease affects the normal functionality of heart. The health care industry gives the huge amount of the health care data and that need to be mined to ascertain hidden information. With the help of data mining and medical history, the early prediction of heart disease can be possible. This paper focuses about the early prediction of heart disease using data mining techniques. For that classification and clustering algorithms are used.Keywords: Non Communicable Disease, Heart Disease, Medical Data Mining, Clustering, Classification.
Protective Effect of Sodium Selenite and Vitamin E in Physiological and Histological Parameters on Male Rats Treated with Lithium Carbonate Afyaa Sabah Nasir
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The current study was designed to determine the antioxidant effects of sodium selenite and vitamin E against oxidative stress induced by lithium carbonate in physiological blood parameters and histological parameters include (liver and kidney) on the adult male rats. The study was conducted in the animal house of the Faculty of Science/University of Kufa on 30 animals of adult male rats aged 2.5-3 months and the weight of 200-250 gm. The adult male rats which were divided randomly into five groups each group contains six animals, the first group promised to negative control which were administrated normal saline only, the second group administrated lithium carbonate at dose 4 mg/kg of body weight per day and promised as positive control, the third group administrated lithium carbonate at dose 8 mg/kg of body weight per day  also promised as positive control, the fourth group administrated lithium carbonate at dose 4 mg/kg of body weight per day with the solution containing to sodium selenite at dose of 2.4 mg/ml and vitamin E at  dose of 60 mg/ml daily and  the fifth group administrated lithium carbonate at dose 8 mg/kg of body weight per day with the solution containing to sodium selenite at dose of 2.4 mg/ml and vitamin E at  dose of 60 mg/ml daily,  for a period of eight weeks. after eight weeks the rats were sacrificed for  taking blood samples and removing the liver, kidney.   After the end of experiment the results showed the presence of a significant decrease (p<0.05) in the red blood corpuscles counts, haemoglobin concentration and hematocrit while significant increase (p<0.05) in the white blood cells counts and  erythrocyte sedimentation rate in the animals treated with lithium carbonate compared to the control group for eight weeks While the results show (p<0.05) significant increase (p <0.05) in the red blood corpuscles counts, haemoglobin concentration, hematocrit, as well as a significant decrease (p<0.05) in the white blood cells rate and erythrocyte sedimentation rate in the animals treated with lithium carbonate with sodium selenite with vitamin E compared with the control group for eight weeks. The results indicated a significant increase (p<0.05) in the Aspartate aminotransferase, Alanine aminotransferase & Alkaline phosphatase in the animals treated with lithium carbonate only compared to the control group for eight weeks of administration at the same time occur a significant decrease (p <0.05) in the liver enzyme levels in the treated animals with lithium carbonate, sodium selenite and vitamin E for a period of eight weeks compared with control group. Finally, the results of histopathological changes showed sever degeneration, vascular congestion in the liver and noticed degenerative cells with haemorrhage in the kidney in the group of rats treated by lithium carbonate while appeared improvement in the liver, kidney in the groups’ administrated lithium carbonate with lithium carbonate with sodium selenite, vitamin E. The study conclude  sodium selenite and vitamin E have effective antioxidants against oxidative stress induced by oral administration of lithium carbonate led to improve the physiological parameters and histopathological changes compared with control group.Keywords: Oxidative stress, Sodium selenite, Vitamin E and lithium carbonate.
Detection of Microbial Contamination and Hormonal Residues of Crispy Chicken available in Local Markets Aliaa Saadoon Abdulrazaq Al-Faraji
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The study aimed to knowing the contamination range in some cover Crispy Chicken samples imported for Iraq by evolution the microbial contamination and levels of some hormones , packaged food samples included 14 different types of crispy chicken are : C1 ,C2,C3,C4,C5,C6,C7,C8,C9,C10,C11,C12,C13,C14, The results shown for microbial assays of the sample C6 that contain 6.3 ×10 8 wt m /gm meat total number of aerobic bacteria by using BacTRAC 4300 Device , either sample C11 was a violation of health conditions with contained of Salmonella bacteria . According to the levels some hormone the result were shown that progesterone hormone have high level of sample C11 which was 15 ng /ml , so the testosterone hormone has been high in samples C1,C7,C8,C9 with rate ˃ 16, ˃ 16, 15.5 , ˃ 16 ng /ml Respectively . It was shown from the results that must all kinds of imported crispy chicken be subjected to constant detection of microbial contamination and hormones because have direct effect of maintaining on general health and customers health especially.Key words:  Crispy chicken, Microbial contamination, Hormones, Bactrac device.
Gender and Age Differences with Myocardial Infarction Symptom Presentation and In-Hospital Mortality Gulnara Bedelbayeva
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Myocardial infarction (MI) is the main cause of death and disability worldwide; it increases the risk of many chronical diseases. This study assessed the correlation between the sex and age of patients with chest pain symptoms and the in-hospital mortality rate. Observational study of 6513 registry patients (2741 women and 3772 men) from Cardio logical Centre of Myocardial Infarction of Almaty (Kazakhstan), 2010-2011. Differences between study groups were assessed by χ2 test for categorical variables, the t test for continuous variables, and the nonparametric Wilcoxon rank sum test for median comparisons.  The proportion of MI patients who presented without chest pain was significantly higher for women than men. There was a significant interaction between age and sex with chest pain at presentation, with a larger sex difference in younger than older patients, which became attenuated with advancing age. Multivariable adjusted age-specific odds ratios (ORs) for lack of chest pain for women (referent, men) were younger than 45 years, 1,30; 45 to 54 years, 1,26; 55 to 64 years, 1,24; 65 to 74 years, 1,13; and 75 years or older, 1,03. Two-way interaction (sex and age) on MI presentation without chest pain was significant (P<0,001). The in-hospital mortality rate was 14,6% for women and 10,3% for men. Younger women presenting without chest pain had greater hospital mortality than younger men without chest pain, and these sex differences decreased or even reversed with advancing age, with adjusted OR for age younger than 45 years, 1,18; 45 to 54 years, 1,13; 55 to 64 years, 1,02; 65 to 74 years, 0,91 and 75 years or older, 0,81. The 3-way interaction (sex, age, and chest pain) on mortality was significant (P <0,001). In this registry of patients hospitalized with MI, women were more likely than men to present without chest pain and had higher mortality than men within the same age group, but sex differences in clinical presentation without chest pain and in mortality were attenuated with increasing age.Keywords: Myocardial Infarction, Chest Pain, Mortality, Sex, Age.
Effects of Silica Nanoparticles on Some Indicators of Fertility and Histological Changes in Male Rats Alaa Mohammad Hasson Al-Husseini
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The current study has been designed to evaluate the effect of silica Oxide nanoparticles (SiO2NPs) exposure on the reproductive performance of male rats. Forty adult Wistar male rats ( aged 60-70 days with body weight130-140 g), were randomly divided into four equal groups , 10 rats per group : control  group were received physiological saline, and three treated groups were administered by gavage at dose (1 mg , 10 mg and 100 mg/kg Body weight) of SiO2NPs suspension  daily for 22 days,  Body weight , some characters of sperms (sperm count, percentage of motility , abnormality , sperms viability ) and histological changes in testis and epididymis were investigated. The results showed insignificant decrease (p ≥ 0.05) in body weight of three treated groups in comparison with control group. Experimental results obtained from SiO2NPs treated  male rats  showed significant decrease (p<0.05) in sperm count , percentage of motility and viability sperms , while a significant  increase (p<0.05) in  percentage of dead and abnormality sperms  compared to control group, histopathological results revealed changes in tissues of testes such as atrophy in some seminiferous tubules with expanded lining . Also noted tubules in both testis and epididymis are empty from sperms with hyperplasia and damage in stereocilia of tubules lining cells of epididymis.Keywords: SiO2NPs, Rats, Reproductive, Sperm, Testis, Epididymis.
Study the Optical and Spectral Properties of Organic Dye as an Effective Medium in Dye Lasers Afrah M. Al-Hussainey
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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In this study, the absorption and fluorine spectra of the Acriflavine solution dissolved in ethanol and different concentrations were studied. The optical properties (absorption coefficient, linear refraction) and spectral properties (Fluorescence lifetime and Quantum Yield fluorescence) were calculated. It is observed that increasing the concentration increases the absorbance values and decreases the permeability values, thus increasing the values of the absorption coefficient and the refractive index. Also, the values of the fluorine intensity increase. The top of the emission spectrum is transferred to the longer wavelengths.Keywords: Acriflavine dye, Absorbance, Fluorescence, Dye Laser.                     
Removal of Alizarin Red Dye from Aqueous Solution with Bio Sorption Technique Using Snail Shell as Low Cost Adsorbent Muneer A Al-Da&#039;amy
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Study evaluated the feasibility of removing Alizarin Red dye from aqueous solutions, using snail shell. The effect of contact time, adsorbent does, pH, ionic strengthinitial dye concentration and temperature on adsorption was studied. The pH 2.0 was observed to show optimum removal for Alizarin Red. The equilibrium time was fixed at10min. Maximum adsorption of Alizarin Red was a achieved at the suggested optimum conditions initial dye concentration 30mg.l-1 weight of adsorbent 0.01g .The adsorption isotherms could be well-defined with the Temkin isotherm model instead of the Freundlich isotherm model. Change in entropy (ΔS°), Gibb’s free energy change (ΔG°), and enthalpy (ΔH°) were calculated for the adsorption of Alizarin Red dye.Keywords:  Adsorption, Alizarin Red, Snail shell, Langmuir, Freundlich, Temkin.
Investigation of Heat Pump Drying for Herbal Passion Flower (Passiflora Foetida) Tea Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Passion flower (Passiflora foetida) is indigenous to many parts of Vietnam. Passion flower is a highly valued calmative nerve, used for nervous relentlessness, as a gentle sedative for sleep difficulties, and to reduce anxiety, neurasthenia, and nervous disorders. Passion flower is generally considered to be a safe herb, well tolerated and side effects are rare. Biologically active constituents include flavonoids, maltol, and indole alkaloids alkaloids, among numerous other constituents.  In order to utilize this good source as a healthy herb, we attempted to produce dried passion flower herbal tea. Heat pump technology has been used for heating, ventilation, and air-conditioning in fruit and vegetable industry. The main objective of heat pump drying is to produce a dried passion flower tea of desired quality at minimum cost and maximum throughput and to optimise these factors consistently. We focused on investigation of blanching, drying and storage of dried passion flower tea. Results showed that blanching at 95 oC in 10 seconds, drying by heat pump at 20 oC, vacuuming and packing in PET/AL/PE bag could maintain the flavonoid content in the dried passion flower tea.Keywords: Passion flower, Passiflora foetida, Heat pump drying, Herbal tea, Vacuuming, Blanching.
The Impact of Small Games use in Reducing Psychological Pollution and the Development of Psychological Skills and the Most Important Physical Abilities and Learn the Effectiveness of Running 100 Meter Mohammed Abdulreda Salman
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The research problem is that there is a weakness in the technical performance of jogging efficiency 100 meters for students aged 11-12 years. The researchers found that the use of teachers for specific and non-varied methods in the education of students in addition to the lack of focus in developing the physical abilities of students, Pupils for this event. This has prompted researchers to study the problem to find appropriate solutions. Where the researchers saw the development of a program of motor education in the style of small games and include exercises to reduce the psychological pollution and develop psychological skills and the most physical capabilities as well as technical performance in the effectiveness of running 100 meters relay to ensure the level of performance of students to this event and the goal of the research to: Preparation exercises small games in reducing pollution and psychological development of psychological skills and the most important physical abilities of students aged (11-12 years). Find out the effect of small games in the style of artistic performance development ran 100 meters for students aged (11-12 years). The researchers used the experimental approach to design the equal groups to suit the nature of the study. The research community consisted of 6 primary pupils in Al-Farahidi Primary School for Boys in Babil Governorate (ages 11-12). The research society was the sixth primary pupils (28).Small games contributed to reducing the psychological pollution of the pupils by 11-12 years. The small games that have been used within the physical exercise capacity in the development of its effectiveness ran (100 m) and psychological skills for pupils Reconstruction (11-12 years).The approach taken by the teacher contributed to the reduction of pollution and psychological development of physical abilities and mental skills for pupils Reconstruction (11-12 years).Keywords: Small games, Psychological pollution and physical abilities.
Killing of Multi-Drug Resistant Staphylococcus Aurous Isolated from Women with Genital Tract Infection with Special Reference to Laser Photosensitization Shaimaa N. Mizil
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Multi-Resistant Staphylococcus aureus(MRSA)were obtained from Al-Yarmook Hospital in Baghdad from women with urinary tract infection (UTI)and genital tract infection(GTI)after susceptibility test for 17 antibiotics we selected the (MRSA)isolates and detect the methicillin resistance gene(mecA),we investigate the best dye for photosensitization among the four dyes (methylin blue MB, crystal violate CV, toluidin blue TB and coomassie brilliant blue-G (CCB) that has the maximum absorption of the wave length of the red laser(635 nm),the most resistant isolate used in  laser photosensitization death time experiment with the selected dye( toluidin blue TB)as the best dye for photosensitization in different power density (12,24,40,60,80 and 100)mW/cm2 with different exposure time ,we found from the results that the percentage of survival cells decreased with the increasing the exposure time to laser light and the time of killing MRSA decrease when the power density increasing. This considers an alternative method to kill MRSA.Keywords: Multi-resistant S. aureus, photosensitization, Laser.

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