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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
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Articles 70 Documents
Search results for , issue "Volume 10 Issue 05: (2018) May2018" : 70 Documents clear
The Relationship between Blood Groups and Dermatophytoses of Women in Karbala City Aseel Najah Sabour
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Objective: The current study aims to investigate the relationship between dermatophytoses and blood groups in women. Methods: Thirty women patients with dermatophytoses who visited the hospitals in the holy province of Karbala were diagnosed with the clinical manifestations of them by dermatologists specialists in these hospitals, and blood samples were obtained in the laboratory and the ABO examination for them to know their blood groups and Rh. Results:  Patients are women aged 3 to 90 years. The age group 33-47 years is the highest among the patients, reaching 30%. Most patients (96.67%) were Rh+, while 3.33% were Rh-. People with blood group A are the most likely to develop dermatophytoses with percentage 36.67% of patients, followed by women patients of blood group B with 26.67% , women patients of  blood group O were 20%, while AB blood group women patients were the lowest with 16.66%.The clinical manifestations tinea capitis of dermatophytoses were the most common among the others , and tinea capitis significantly correlated with blood group A, and the rest of the clinical manifestations showed no significant correlation with any of the blood groups. Conclusion: There is a relationship between infection of dermatophytoses and blood groups, specifically between tinea capitis with blood group A. Keywords: Dermatophytosis; Blood groups; Tinea capitis.
Measurement of Some Blood Parameters in Smokers of Men in the Province of Al-Muthanna Areej Shakeer Jassum
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The detached of this study is to consider the influence of smoking on some blood parameters and to calculate the negative special influences of cigarette on the biochemical properties of blood in males. This study was lead at Al- Hussein Educational Hospital in AL- Muthanna province."The study excluded (80) blood samples of men, (40) including smokers and (40) non-smokers and were considered a control group."The age of smokers and control group ranged between (20-50) years .The samples of blood were reserved and the hemoglobin concentration, full number of red blood cells, blood volume and full number of white blood cells were calculated. The results presented a significant enhance (p <0.05) in white blood cells, red blood cells, packed cell volume , grand cell and hemoglobin paralleled with control group. The study also displayed non- significant differences in the total of plates, lymph cell and mid cell paralleled with control group. In deduction, our findings displayed that continuous cigarette smoking has severe adverse influences on blood parameters (such as hemoglobin, total renal corpuscle). "These changes may be linked with a greater risk of developing at hero sclerosis, red fera, chronic uncooperative pulmonary disease or heart disease and blood vessels.
Relationship between Thyroid Hormones and TSH, FSH, LH, LH/FSH Ratio, Prolactin and Testosterone Hormones in Infertile Patient Women with Hyperthyroidism in Reproductive Age Dalal Abdul Hussain Kadium
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Our   work  involved  studies  for  levels of thyroid  hormones (Triiodothyonine T3,Thyroxin T4) and thyroid stimulating hormone   (TSH),follicular stimulating hormone(FSH), luitienzing hormone(LH), prolactin(PRL) and testosterone hormone LH/FSH ratio  in infertile patients women with hyperthyroidism and sanitary fertile women and to find the relationship between thyroid  hormones (T3 ,T4) and TSH, FSH, LH, PRL and testosterone hormones and LH/FSH ratio, and correlation of TSH with T3,T4, FSH, LH, PRL and testosterone hormones and LH/FSH ratio in sterile women with hyperthyroidism in reproductive age. (60) sterile women with hyperthyroidism with age (19-41) years old and body weight (65. 60 ±  0.20 kg ) who recalculated Endocrine unity of Teaching Al-Sadr hospital in Al-Najaf Al-Ashraf Governorate from  1/ 9 / 2015 to 1 / 10 / 2016  , patients women group was compared with (30) fertile non- patients women with age(19-41) years old and body weight (72.35 ±  0.42 kg) as control group. The results pointed to a significant increasing(P<0.05)in levels of T3,T4, LH, PRL , testosterone  and LH /FSH ratio, while a significant decreasing (P<0.05) was in TSH and FSH levels in sterile patient women with hyperthyroidism when compared with control group, and there was a positive significant (P<0.05)correlation between T3,T4 and LH,PRL , testosterone and LH/FSH ratio  , while the relationship was negative significant (P<0.05)between T3,T4 and TSH and FSH in sterile patient women    and the results showed a positive significant(P<0.05) relationship between TSH and FSH, while there was a negative significant(P<0.05) correlation  between TSH and  T3,T4, LH, PRL , testosterone and LH/FSH ratio in sterile women  patients with hyperthyroidism.Key words: Thyroid hormones, Infertility, Hyperthyroidism, TSH, FSH, Prolactin.
Analysis of 4-Hydroxy-N-Desmethyltamoxifen and Tamoxifen in Dried Blood Spot of Breast Cancer Patients By Liquid Chromatography – Tandem Mass Spectrometry Yahdiana Harahap
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Tamoxifen is the first line hormonal therapy for breast cancer patients as their adjuvant therapy. The antiestrogen effect of tamoxifen is highly determined by its active metabolite, endoxifen. A simultaneous quantification method of tamoxifen and endoxifen in dried blood spot (DBS) using LC-MS/MS had been fully validated in this study. Extraction the analyte and metabolite from DBS card were conducted using methanol-acetonitrile (50:50). The separation was performed on UPLC Class BEH C18 column using 0.2% formic acid - acetonitrile as the mobile phase in gradient elution mode at 0.2ml/min. The detection of the mass was performed on Waters Xevo TQD using positive electrospray ionization for tamoxifen, endoxifen, and clomiphene as the internal standard with m/z value: 372.22>72.22; 374.29>58.2; 406.28>100.17, respectively. This method was linear in the range concentration of 5-200 ng/ml for tamoxifen and 1-40 ng/ml for endoxifen with r value 0.99. The method was applied to 40 breast cancer patients, where the results lied between 40.28 and 194.10 ng/ml for tamoxifen, meanwhile for endoxifen was 1.25 and 18.02 ng/ml. It showed that there were 4 patients received less effective tamoxifen therapy based on the endoxifen threshold in DBS sample, which was 3.3 ng/ml. This method has prospect future to optimize tamoxifen therapy by measuring tamoxifen and endoxifen concentration. Keywords: Breast cancer; Dried blood spot; Endoxifen; Tamoxifen; Clomiphene; Analysis;  LC-MS/MS; Validation.
Isolation and Identification of Saprolegnia Parasitica and Other Fungi from Farms Fishes in the Province of Wasit / Iraq Isa S Touhali
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Background: Fungal infections are one of the main factors responsible for mortality and economic losses among the ornamental and food fish farming industries. The most commonly identified fungal pathogens of fish are water molds of Saprolegnia genus. Objective: The goal of this study was to determine the presence of Saprolegnia species in the fish farm by utilizing traditional and molecular strategies and contribute to the knowledge of fungal biodiversity in the province of Wasit. Methods: This study included a total of one hundred samples were collected during the six months from September -2016 to February -2017 from fish culture ponds. in the province of Wasit , Iraq. After isolation of fungi by culturing and examination under microscopic by used special stains was showed 42 (42%) samples were positive for fungal growth. Out of 42 fungal growths; 13 (31%) isolates were identified as Saprolegnia species were identified in this study. Also other fungi were isolated; 11(26.2%) isolates were identified as Aspergillus sp.; 8 (19%) isolates were identified as Penicillium sp.; 6 (14.3%) isolates were identified as Alternaria sp.; 4 (9.5%)  isolates were identified as Fusarium  sp. and used specific primers sequences (ITS1 and  ITS4) to detection Internal transcribed spacer (ITS) gene of Saprolegnia parasitica were used in conventional PCR. The results of the PCR amplification of (ITS) gene showed that, 8 samples out 13 samples Saprolegnia species were positive to Saprolegnia parasitica with a PCR product size of approximated 750 bp, while 5 samples out 13 samples Saprolegnia species showed negative results for the presence of this gene as indicated by the absence of the PCR products in their relevant lanes. In conclusion, the cultured fishes frequently suffer from fungal disease, especially during the months from early December to late February when water temperature falls below 10°C and  several species of Saprolegnia cause several damages in fishes and economic losses for the aquaculture industry. However, with early diagnosis by culturing and molecular technique and appropriate management, has a good prognosis.Keywords: Saprolegnia species, Saprolegnia parasitica, fish culture ponds, Internal transcribed spacer (ITS) gene.
Controlled Release of Cefixime using Sodium Carboxymethyl Cellulose Polymer Kawther Abd Alwahid
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Environmentally benign and efficient route of synthesis of   PAA-g-SCMC was prepared via irradiation (800W) using modified household microwave alone (without using initiator). PAA-g-SCMC polymer before and after loading with the drug was confirmed on FT-IR spectrophotometer and SEM.   SCMC polymer was also used to extend the release of antibiotic namely, Cefixime.  Buffer solutions of pH 7.2 and 1.2 were used as the medium for the release of drug to simulate the pH media of small intestine and stomach respectively. We used UV-visible spectrophotometer fo imbibing measuring solution of antibiotic for Cefixime respectively at 285 nm. The antibiotic release was done at different temperature (25 ⁰C, 37⁰C). Generally, the release was   increased at pH 7.2 and temperature at 37⁰C. The results obtained from the grafted polymers were better than the non grafted polymers concerning the controlled release of the drug.Keywords: Cefixime; SCMC polymer; Buffer solutions; Deionized water (D.W); Grafted polymer PAA-g-SCMC.
Dyslipidemia among Apparently Healthy Adults in Baghdad, Iraq Shaymaa A Naji
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Introduction Circulating lipids and lipoproteins are long being recognized as risk factors for developing cardiovascular diseases (CVD). Objective To evaluate the prevalence and profiles of dyslipidemia in apparently healthy (AH) and asymptomatic subjects.  Method In this cross sectional study we had randomly selected 217 AH individuals of the both the genders that were of 18- 69 years of age and disease free. Individuals having history of any medications for diabetes, hypertension and CVD were excluded from the study. The remaining healthy individuals underwent detained physical examinations and tests of lipid profiles.  Results In the overall population, the prevalence of high density lipoproteins HDL (64.5%) and very low density lipoproteins VLDL (13.8%) were most common lipid abnormalities found.  Conclusion Thus it is concluded that the AH subjects is highly susceptible to develop dyslipidemia and HDL-C abnormalities and this information could be used to design the preventive polices for future CVD events and seriously may affect the choice of AH subjects as control group in clinical researches .Keywords: Apparently healthy subjects, Lipid profile, Dyslipidemia.
Analysis of the Employment Profile Offered by Employers to Graduated Bachelors of “Public Health” In Medical Universities Raushan Z Magsumova
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The purpose of this article was to improve the educational program for Bachelors of "Public Health" to prevent problems with their further employment. We have carried out an anonymous survey; we have also studied the curricula and employment lists of graduates. The research on the first three widespread vacancies for Public Health graduates in three medical universities has revealed the following positions: Epidemiologist, Statistics Specialist and Quality Assurance Manager. This should be taken into account in appropriate educational programs.Keywords: Employment analysis, Employment, Public Health graduates, Employment profile.
The Effect of Inhalation Smoking by Narghile on Some Parameters Biochemistry Noor Essam Abdul Rezaq
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The present study included 50 sample collected  different of Iraq.25 sample narghile smoker men group  and 25 control men  group show the results increase significant in MDA, ALT, AST and LDH in narghile smoker men group  when compared with control men  group , while decrease significant in C.K and ACHE in narghile smoker men group  when compared with control men  group   Keywords: Nargile, Oxidative stress, MDA, LDH , CK , ACHE , ALP , ALT and AST.
Green Synthesis of Reduced Graphene Oxide Using L-Cysteine as Reductant Hassan A. Alshamsi
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Graphene-derived materials have been studied in many applications due to its excellent electrical, mechanical, and thermal properties .There remains a real need for the easy, eco-friendly and scalable preparation method of graphene due to various potential applications. Chemical reduction is the most versatile method for the large scale production of graphene. Here we report the operating conditions for a one-step, economical and green synthesis method for the reduction of graphene oxide using a bio molecule L-cysteine under mild reaction conditions. Characterizations of the resulting product have been done by thermo-gravimetric analysis, X-ray diffraction, FTIR, UV-visible spectroscopy, EDX spectrum and the morphology of the synthesized reduced graphene oxide (rGO) was examined by AFM, SEM and TEM.

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