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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 73 Documents
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Search results for , issue "Volume 10 Issue 06: (2018) June 2018" : 73 Documents clear
Production of Gooseberry (Phyllanthus Acidus) Jam Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Gooseberry (Phyllanthus  acidus) tree has been widely cultivated in Mekong region (Vietnam). The fruits of the plant have been used as an astringent. This fruit is eaten fresh, fruit juice, candied in sugar or pickled in salt. The potential for gooseberry extract as a food ingredient is increasing substantially, owing to the growing global nutraceuticals and functional food market. In order to improve its value by keeping for a stable duration,  we examined different technical factors such as a mixture of components (sugar 45%, 50%, 55%; carrageen an 5%, 10%, 15% and fruit juice 10%, 12% 4%); the effect of temperature (60oC, 70oC, 80oC) and time (3, 5, 7 minutes) in concentration (boiling), preservatives (potassium sorbate 0.05%, 0.1% and sodium benzoate 0.05%, 0.1%) affecting to production and preservation of gooseberry jam. Our results showed that with an optimal mixture of sugar 50%, carrageenan 10%, and fruit juice 12% concentrated at 70oC in 5 minutes we got a pleasant taste, bright color and elastic texture. With an addition of sodium benzoate 0.1%, we realized the gooseberry jam could be maintained until 60 days.Keywords: Gooseberry, Jam, Carrageenan, Concentration, Preservative, Sodium benzoate.
DFT Study for Characterization the Biological Activity of New Derivatives of Titanium (IV) Budotitane Complex Ahmed Abdul Sattar Ali
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The official use of organometallic complexes in chemotherapy dating back to 1969 when cis-platin "cis-diamminedichloroplatinum(II)" showed to have properties against tumors such as“ human testicular, ovarian, bladder, head and neck carcinomas” Titanium (IV) compounds are one of the promising alternatives and candidates drugs to anti-cancer treatments that have a wide spectrum of activity against tumors. These compounds are more effective and have less side effects than platinum compounds. In this work, we characterization the building and designing geometrical shape and crystal structure of six titanium complexes "titanium budotitane complexes (IV)" depending on the DFT "density functional theory" method survey of the title complexes were performed using the Gaussian 03 (2003) program. The study also include discuss "crystal structure information, Mulliken charges allocation, complex biological effectiveness, frontier molecular orbital energies (HOMO, LUMO) of the complexes, ionization energy (IE), hardness (η), electron affinity (EA), stability, and polarity" of titanium complexes with comparition. The results show that best one of the building complexes as anticancer activity is complex 5 (C5), then complex 6 (C6)are gave lower activity than (C5) and higher when compared with other complexes, while the other complexes (C2, C1, C3, C4) respectively gave lower activity than (C5,C6) complexesKeywords: Tumors; Budotitane; Titanium (IV) metallodrug; Titanocene; Density functional theory (DFT);(HOMO, LUMO) energies.
Three Novel Transition Metal with Ethylenediamine Complex Template Polyborates [Pt(en)3]4 [B5O6 (OH)4] Cl15, [Rh(en)3][B5O6 (OH)4]3∙ 10H2O, and [Zn(en)3] [B6O7 (OH) 6]· 2H2O have been Synthesized and Characterized by Elemental Analysis, FT-IR, H, 13C, 11B - NMR, TGA-DSC, Powder X-ray Diffraction and Magnetic Properties Mohammed A. Altahan
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Three new polyborate compounds [Pt(en)3]4[B5O6(OH)4]Cl15(1), [Rh(en)3][B5O6(OH)4]3∙10H2O(2), and [Zn(en)3][B6O7(OH)6]·2H2O (3)have been prepared. The new compounds have been identified by elemental analysis, FT-IR, H, 13C, 11B - NMR, TGA-DSC, powder X-ray diffraction and magnetic properties. The three new compounds are consisting of transition metals (platinum (IV), rhodium (III), and zinc (II)) cations, polyborate ([B5O6 (OH)4]-and [B6O7(OH)6]2-) anions, and lattice water molecules.Keywords: polyborate, zinc (II), platinum (IV), rhodium (III).
Determination of Clonazepam in Pharmaceutical Formulations by Normal and Reverse Flow Injection Analysis Coupled with Solid-Phase Reactor Containing MnO2 Immobilized Malik H. Alaloosh Alamri
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Clonazepam (CLO) is an anticonvulsant agent which has hypnotic properties and widely used in the treatment epilepsy. Rapid and sensitive flow injection (FI) spectrophotometric methods are proposed for determination of CLO in pure and pharmaceutical formulations. Method (A)  is normal flow injection which depend on oxidation coupling of reduced CLO with 4-methoxyphenol (MP) in presence of sodium periodate to give a colored product measured at 550 nm. While the method (B) was developed using reverse flow injection coupled with on line solid phase reactor containing MnO2 immobilized on cellulose acetate (CA) the method based on the coupling of reduced CLO with MP to give colored product which easily measured at 612 nm. The experimental conditions were optimized for both methods (A and B) and the linear range of CLO concentration was 5 – 300 and 1-250 μg.mL-1 with limits of detection of 4.312 and 0.822 μg.mL-1for methods A and B respectively. Both proposed spectrophotometric methods have been applied successfully for the determination of CLO in pure and pharmaceutical formulations.Keywords: Clonazepam, flow injection, solid phase reactor, immobilized MnO2.
Estimation of Some Trace Elements and Antioxidant Status in Breast Cancer Patients Undergoing Radiotherapy Abdul Rahman R. Mahmood
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Breast cancer (BC) is the most prevalent tract cancer in the world, including Iraq. The classified breast tumors to benign, malignant, and radiotherapy. Cancer treatment depends on certain stages such as mastectomy then chemotherapy alone or with radiation therapy or endocrine therapy according to the prognostic features obtained from the pathology report. The present study included 100 females. The women were split into two groups, control group that consisted of 50 apparently healthy females and 50 patients with BC group who undergo the radiotherapy. The current study highlighted on some of the anthropometric measurements, including the oxidative stress index malondialdehyde (MDA), the concentrations of total antioxidant capacity (TAC), serum albumin (Alb), serum uric acid (UA), and finally the concentrations of copper (Cu) and zinc (Zn) as trace elements were measured as well. The results were compared to control. There was a significant variation in MDA and albumin when comparing patient group with control, while uric acid was statistically insignificant when comparing control group with patients group. Cu concentration was statistically high when compared with control group. On the other side, a significant decrease of Zn concentration of patients was observed compared to control group .In this study, the evaluation of these parameters maybe used as a helpful tool in treatment of breast cancer.Keywords: Breast Cancer, Malondialdehyde, Total antioxidant capacity, Copper, Zinc
Employing the Physicochemical, Spectroscopy, Antimicrobial and Antifungal Efficacy Studies of P-Hydroxy Acetophenone Based Azo Schiff Base Complexes Wurood Ali Jaafar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The azo Schiff base [Reaction of 4-aminoanypyrine and P-hydroxy acetophenone] and O-Phenylene diamine have been prepared. One azo  Schiff  base  chelate  of Co(Il), Ni(II), Cu(II) and Zn(II)ion was also  prepared. The chemical frameworks of the azo Schiff base and   like elemental analyses (CHN), determinations of molar conductance, 1 H &13C NMR, IR mass and electronic spectroscopy .The elemental analyses exhibited the combination of [L: M] 1:1 ratio. Established on the values IR spectral, it is showed that the azo Schiff base compound acts as neutral hexadentate ligand bonded with the metal ion from two hydroxyl, two azomethine  and  two azo groups  of the  azo  Schiff  base  compound  in  chelation  was confirmed  by  IR  , 1Hand 13CNMR  spectral outcomes. The UV-Vis spectral values appeared the existence of π→π* (phenyl ring), n→π* (N=N, -OH and HC=N) and an octahedral structure was suggested for the coordinate. The mass spectral outcomes assured the purity of the ligand. Furthermore, the antimicrobial and antifungal efficacy results revealed that the metal complexes were found to be more active than the free ligand.  In general the activity order of the synthesized compounds can be represented as Fe (II) > Cu (II) > Ni (II) > Zn (II) > Co (II) > L.   Keywords: Azo Schiff base, P-hydroxy acetophenone, antifungal efficacy, Spectroscopy.
Preparation, Characterization and Biological Activity of New Derivatives of 3-Cyclic Oxazepine, 3-Cyclic Lactam and 3-Aminomethyl Imidazo (1, 2-a) Benzthiazol Rana Abid Ali
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

In this work a series of fourteen new compounds were synthesized. Compound [1] was formed from the reaction of 2-aminobenzothiazole and p-bromophenacyl bromide. Aldehyde group [2] was obtained from the reaction of compound [1] with pocl3 in presence of DMF and CHCl3 .After that   shiff bases have been synthesized from the reaction of compound [2] with different aromatic amine to give new shiff bases [3-5]. These new shiff bases have been reduced to their corresponding amine [6-8] by means of sodium borohydride. Then reaction of shiff bases [3-5] with phenyl isocyanate gives 3-cyclic lactam derivatives [9-11].  3-cyclic Oxazepine derivatives [12-14] were obtained by reaction of shiff bases [3-5] with succinic anhydride. These new formed compounds were diagnosed by12 C-NMR, 1H-NMR for some of them and FT-IR spectroscopy. Some of the prepared products have been studied their biological activities toward two kinds of bacteria. These products showed good efficacy to moderate toward bacteria.Keywords: Benzothiazole, Shiff bases, Lactam, Oxazepine, Biological activity.
Studying the Effect of Purified Lectin Producing from E. coli on Multidrug Resistance Pantoea Agglomerans Istabreq Muhammed Ali Salman
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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In this study, an isolate of E coli E2 isolated from diarrhea gave the upmost production level of lectin by microscopic glass slide and microtiter plate methods. The results revealed that human erythrocytes O+ gave hem agglutination activities with all E coli isolates and sheep erythrocyte gave hem agglutination activities with all isolates but with lower activity and the isolate coli E2 appeared higher hem agglutination level with O+ blood group by both methods. Purification of the lectin was achieved by45% saturation ammonium sulfate followed by affinity ion-exchange chromatography on DEAE -cellulose column with a yield of 10%, specific activity 754,477 and a purification fold of 6.059.  Thirteen isolates  of  P. agglomerans  were isolated  from blood specimens from infants patients with blood stream infections and surface swab in neonatal intensive care unit (NICU)  in  Child’s Central Teaching Hospital in Baghdad ,that showed resistance to cefazolin, cefepime,cefotaxime,gentamicin and ampicillin-sulbactum in different ratio while Purified lectin with concentration 200 µg/ml had antibacterial activity against clinical and environmental bacteria  more than other concentration and crud lectin .  Keywords: Pantoea  agglomerans, Lectin,  Antibacterial activity.
Physiological and Biochemical Changes Analysis to Labors Blood Samples in Plastics Recycling Factory in Mosul-Iraq Muwafaq Ayesh Rabeea
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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In this study, the healthy impacts of environmental and emitted pollutants from the recycling plastics factories in the Right Bank district of Mosul City were investigated. Urine and blood samples were collected from workers who exposed to these pollutants. Some of physiological and biochemical tests have been achieved which including Blood Pressure, Hb (Hemoglobin), PCV, ESR, blood urea, serum total protein, serum total cholesterol, serum triglycerides, ALT (GPT) and AST (GOT). Also, General Urine Examination has been performed. All results were compared with 20 unaffected persons as a control group. The results of the current study showed significant differences in some testes compared with the control group. Hemoglobin increased to ‏17.00 g/dl in the workers which had >20 years-work compared with the control (14.00 g/dl). Furthermore, PCV have a significant increase ranging from 55.53% to 90.53% in workers who have <10, 11-20 and >20 years-work. Blood Urea recorded highest value ‏50 g/dl for workers >20 years-work, while declined to the lowest value 37 g/dl in case <10 years-work. Also, liver enzymes (Aspartate Transaminase and Alanine Transaminase) were recorded slight increase reached to 13.3 and 6.6 IU/dl respectively. In addition, General Urine Examination exhibited various kinds of cells besides highest percentages of Calcium Oxalate, pus cells, amorphous and RBC (Red Blood Cells) reached to 40.85%, 13.85%, 8.71% and 3.85% respectively.Keyword: Emitted pollutants; Plastics wastes; Biological & chemical effects; Damage enzymes.
Alternative Current Electrical Conductivity of Octaphynyl Tetrapyrrazino Porphrazine Cobalt (II) Hasan Sabeeh Jabur
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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The alternative current (Ac) conductivity of octaphynyl tetrapyrrazino porphrazine cobalt (op Tp Pz Co) was measured at rate of frequency of 5 X I03to 5 X103 Hz of and temperature rate (303 to 423) k. The dc conductivity was carry out in the same temperature rate, which consists of frequency independent (Dc conductivity) and frequency dependent part. This type of conductivity results from hopping of cargo carriers between localized sites around Fermi levels. The jump position is indication of the degree of imperfection in the crystal. Crystallization degree the number of the jump position was calculated using Web band William equation which is estimated to be l x l020ev-1cm3.Keywords: Octaphenyl Tetrapyrazino Porphrazine cobalt, Temperature rate (303 to 423) k Frequency dependent, Conductivity Ac, Conductivity.

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