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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 73 Documents
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Search results for , issue "Volume 10 Issue 06: (2018) June 2018" : 73 Documents clear
Effects of Aqueous and Alcoholic Extracts of Peganum harmala L. Seeds on Male Fertility of White Mice Treated with Olanzapin Drug Hind A. Hanon
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was designed to study the effects of aqueous and alcoholic extracts of Peganum harmala L. Seeds on male fertility of white mice treated with Olanzapin, males were 25 to 30 days old and had a mean weight of 35 g. The mice were divided into two groups, a total of 5 negative control males were injected with distilled water for 15 days, the positive control group (experimental group) injected with Olanzapin drug for 15 days, the was then divided into five subgroups, the first subgroup consists of 5 males were injected with the drug only, while the other four subgroups were dosed with aqueous and alcoholic extracts for 7 days. The first subgroup dosage was with low concentration of aqueous extract (12 mg / kg) and the second with a high concentration of the aqueous extract at a concentration of 24 mg / kg, the third subgroup was dosage with the low concentration of the alcoholic extract at 12 mg / kg and the fourth was dosage with a high concentration of the alcoholic extract at a concentration of 24 mg / kg. The results showed a significant increase (p <0.01) in the level of prolactin hormone in the positive control mice serum, compared to the control group as well as a significant decrease in the level of testosterone hormone as well as the characteristics of the epididymal sperms represented by sperm concentration and percentages of normal and moving sperm. The dosage with aqueous and alcoholic extracts of the Peganum harmala led to the occurrence of significantly higher concentration (p <0.01) of the testosterone hormone and significantly lower in the level of the prolactin hormone concentration when compared with the experimental group as well as a significant improvement of p <0.01) in the parameters of epididymal sperms, and the best concentration was for the aqueous plant extract which 12 mg / kg.Keywords: Olanzapin, Piganum harmala, Testosterone, Prolactin, Sperms.
Prolactin Supplementation in Sperm Preparation A Study of Sperm DNA Fragmentation Silvia W. Lestari
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

One of the infertility management is performing intra uterine insemination (IUI), yet several reports indicated that the success rate is remained low. Sperm preparation, as one of contributing factor to IUI succeeds, has a possibility in generating on sperm DNA fragmentation. Recently, prolactin (PRL) is proved in enhance the sperm motility and protect the DNA integrity of the sperm. This study aimed to evaluate the efficiency of sperm preparation, in selecting sperm prior being utilized for IUI by PRL supplementation, based on the sperm DNA fragmentation. Semen samples were gained from 10 normozoospermic male who underwent sperm preparation for IUI. Semen analysis was performed to measure the sperm motility and velocity, before and after sperm preparation based on the WHO guideline. Samples were incubated at 500 ng (PRL 1), 750 ng (PRL 2), and 1000 ng (PRL 3). The Sperm Chromatin Dispersion (SCD) test was performed to evaluate the sperm DNA Fragmentation index (DFI). The percentage of motile sperm was higher in prepared sperm than in whole semen. PRL supplementation could not increase the percentage of motile sperm in sperm preparation by DGC method, while in SU method PRL worked uniquely in different concentration, since the lowest concentration performed the best result. The level of DFI after the supplementation of PRL was decrease in prepared sperm compared to the whole semen. PRL was proved to select the better sperm quality with decreased sperm DNA fragmentation in sperm preparation, particularly in moderate and severe DFI category.Keywords: Density gradient centrifugation, Prolactin, Sperm DNA fragmentation, Sperm motility, swim up.
Spectrophotometric Determination of Trifluoperazine hydrochloride in Pharmaceutical Tablets by Oxidative Coupling Reaction with 2, 5-Dimethoxyaniline Karrar Majeed
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

A simple and sensitive spectrophotometric method was developed for the determination of Trifluoperazine hydrochloride (TRF) in pure form and in pharmaceutical tablets. The method was based on oxidative coupling reaction of TRF with 2, 5 dimethoxyaniline to form colored product with maximum absorbance at 722 nm. The reaction conditions were studied and optimized. The linear range for the determination of TRF was 0.1–7 mg mL-1, while the detection limit and quantification limit are 0.018 and 0.061 μg ml-1, the molar absorptivity of 9.240×104 L mol-1cm-1 with Shandell's sensitivity index 0.0051 μg cm-2.The precision and accuracy of the method are checked by calculating relative standard deviation (RSD) (< 0.506%) and average recovery (99. 696%).  The value of the stability constant has been calculated and found to be 3.31 ×104     L.mol-1. A statistical comparison of these results with those obtained by the British pharmacopoeia procedure using the Student t-test and variance ratio F-test shows a good agreement and indicates no significant difference in accuracy and precision at the 95% confide.Keywords: Trifluoperazine hydrochloride, 2, 5-dimethoxyaniline, Pharmaceutical tablets, spectrophotometric.
Synthesis, Spectral Studies and Biological Activity of Azo dye Complexes with Some MetalIons Amer J. Jarad
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

2-(2-amino-5-nitro-phenylazo),-phenol was ready by grouping the diazonium salt of 2-aminophenol with 4-nitroaniline.Thegeometry of azo ligand(HL)was resolved on the origin of (C.H.N) analysis,1H and 13CNMR spectra, infrared spectra and UV–vis electronic absorption spectra. Dealing with the azo ligand produced with Rh+3 and La+3ataqueous ethanol for a 1:3 metal: ligand rate, and in perfect ph. The formation for compounds have been described by utilizing flame atomic, absorption,(C.H.N),Analyses, conductivity, infrared spectra and UV–vis spectral procedures. Nature in the produced compounds, have been studied, obey the ratio of mole and continuous, variance, manners, Beer's law, yielded up a concentration, rate (1×10-4- 3×10-4M),. High molar, absorbent, have been observed from compound solutions. At the origin data an octahedral geometry were assigned for the produced complexes. Biological activity of the produced compounds was assayed. In appending, the dyeing carried out of these compounds was practical above cotton fabric. The dyes were light and detergent stability.Keywords: Transition metals, Azo dyes, Complexes, Dyeing, Biological activity.
Contamination of Tea and Coffee by Ochratoxin A in Hilla City, Iraq Mohammad J Al-Jassani
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Analysis of several ground coffee and black tea samples sold in Hilla city market for Ochratoxin A (OTA) contamination. Ten of the most common Black tea and 10 Coffee samples were collected from the local ‎market. OTA was extracted following a standard technique then subjected to TLC analysis. All tested tea samples were found contaminated with OTA (100%). Five (50%) of coffee samples were found contaminated with OTA. This might indicate of bad quality tea have been ‎imported and/or with bad processing and packaging.‎ Iraq as a big importer and consumer of black tea is appeared ‎subjected to a high danger of OTA contamination. A very urgent concern need to be ‎directed and OTA safety level determination using HPLC for both imported and consumed tea ‎and coffee before marketing.Keywords: Coffee, Tea, Ochratoxin A, TLC.
Detection of Isotope Stable Radioactive in Soil and Water Marshes of Southern Iraq Reyam Naji Ajmi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was conducted to indicate Isotopic Stable Radioactive element (ISRe) of the Iraqi marshes by using Geographic Information Systems (GIS) to implement the comparing these elements with World Health Organization elements (WHO), and the Food and Agriculture Organization (FAO), this study achieved in several phases: Work included access to geographical data in six main stations of the Missan governorate (Al- Auda Marsh, Al- Battat Marsh ) during October 2016 period and selection of environmental factors Water and Soil . Results of water in all stations under study showed low concentrations of ISRe Pb212, Pb214,Pb138  and the remaining elements varied and mostly similar limited factors with natural boundaries of water bodies, A little increase come from of some pollutants that are discharged from the water drainage or waste populated .The soil samples showed ISRe, Pb214, Pb212, Pb138 , this may be due to the disintegration of the former previous radioactive element in the same region after wars or explosions , the remaining elements were found in variable concentrations . This database considered as a very important for environmental risks and health in aquatic environmental of marsh which can be updated through a unified future other periodic data. It is one of the method efforts of research for the Iraqi marshes because it represents the concept of ecological zones are covering relatively large areas in southern Iraq, which have a distinctive character of the natural geography of different types so there is a relationship between organisms and their environment an important in an aquatic ecosystem of the food chain.Keywords: Iraqi marsh, Pollution, Bioindicator, Isotopic Stable Radioactive.
Synthesis, Characterization and Investigation Liquid Crystalline, Properties of 1, 2, 3-triazole Derivatives via Cycloaddition Reaction Nisreen H Karam
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The new of compounds synthesized by sequence reactions starting from a reaction of 3-phenylenediamine  or 4-phenylenediamine  with chloroacetyl chloride to produce the compounds [I]a,b, then the compounds[I]a,b reacted with sodium azide to yield compounds[II]a,b that reacted 1,3-dipolarcycloaddition reaction  with   acrylic acid to give compounds [III]a,b these compounds reacted with  methanol led to ester compounds[IV]a,b then reacted with  hydrazine to give acid hydrazide [V]a,b . Finally compounds [V]a,b reacted with   aromatic aldehydes to product shiff bases derivatives. The compounds characterized by mp. , IR, 1HNMR in addition to mass spectroscopy for some of them the liquid crystals properties were studied by using polarized optical microscope (pom) and deferential calorimetry (DSC).    Keywords: Liquid crystal, 1, 2, 3-triazole ring, Clicks reaction.
Estimation of Adenosine Deaminase in Adult Iraqi Patients with β-Thalassemia Hassanain K. Al-Bairmani
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Beta-thalassemia is a well-known hereditary hemoglobinopathy. Patients with major and intermedia thalassemia require periodic blood transfusions. The diagnosis of this disease involves the investigation of several biochemical and hematological markers. Adenosine deaminase (ADA) has received much attention due to its role in purine catabolism, and in this work the activity of ADA was estimated among two patient groups of thalassemia (major and intermedia) and control group. A significant increase was found in studied groups as compared with control group. The levels of Iron, ferritin, transferrin, ALT and AST were also estimated in the current study. It was found that the levels of these parameters were correlated with the activity of ADA.Keywords:  Beta-thalassemia; Adenosine deaminase; ALT; AST
Solid-phase Reactor with Immobilized Lead Dioxide for Flow Injection-Spectrophotometric Determination of Naringenin in Supplement Formulations Israa M. Jawad Al-mashhadani
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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This study includes a simple and economic method for sensitive determine of naringenin (NAR) in (pure and supplements). The determination method depends on the oxidative coupling reaction between N, N-dimethyl-p- phenylenediamine with NAR in the present of PbO2 immobilized on cellulose acetate matrix. The reaction was carried out in alkaline medium, to form blue color product has maximum  absorbance at wavelength of 596 nm. The experimental variables of solid phase reactor and flow injection parameters were investigated and optimized. Beer's law obeyed over NAR concentration range from 0.5 to 60 µg mL-1 with a sample throughput of 44 samples per hour.  The solid phase material showed good stability, the relative standard deviation was 2.786 for 38 injections. The proposed method was successful for NAR determinate in supplements capsules.Keywords: Naringenin, N, N-dimethyl-p-phenylenediamine, Immobilized lead dioxide, Solid phase rector, Flow injection determination.
Safety and Gastro protective Activity of Graviola Seeds Extract against Acidified Aspirin Induced Gastric Ulceration Mays Ali Fadhel
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Peptic ulcer disease attacks millions of people yearly around the globe, affecting both quality and quantity of life. There are many different causes responsible for the etiology of this disease; one of the most common causes is non-steroidal anti-inflammatory drugs (NSAIDs) through different mechanisms. Annona muricata have been found to have antioxidant effects, along with a good protective effect against inflammation in rats, making it a good candidate as a potential gastro protective agent. So, this study is designed to evaluate this possible pharmacological activity. Annona muricata seeds were extracted; chemical analysis of the extract has been done, acute toxicity study has been performed using different doses of ethanolic seed extract of Annona muricata (ESAM) 500, 2000, and 5000 mg/kg, the extract demonstrated relative safety at doses up to 2000mg/kg. The gastro protective effect of ethanol seeds extract of Annona muricata (ESAM) has been investigated using two doses of ESAM 250 and 500mg/kg of ESAM, using ranitidine 50mg/kg,  as a reference, ulcer was induced by acidified aspirin solution after 7 days. The extract caused reduction in the gastric content volume, ulcer index and TNF-α, and a significant elevation in the gastric PGE2 and SOD levels in dose dependent manner showing a good preventive index in compare to the acidified aspirin group. Gastro protective effect of ESAM was prevented by pretreatment with sulfhydryl alkylating group (NEM) and NOS inhibitor group (L-NNA) approving the involvement for sulfhydryl (SH) group and endogenous nitric oxide (NO) in the gastro protective effect of Annona Muricata seeds.  Immunohistochemical staining showed pretreatment with ESAM caused upregulation of HSP70. So, this study suggests that the seeds extract of Annona muricata is relatively safe. Its gastroprotective activity attributed to its antisecretory; cytoprotective; antioxidant and anti-inflammatory effects.Keywords: Acute toxicity, Annona muricata seed extract, Gastro protective, Non-steroidal anti-inflammatory drugs.

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