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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 64 Documents
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Search results for , issue "Volume 10 Issue 07: (2018) July 2018" : 64 Documents clear
Immunohistochemical Detection of Cryptosporidium-Induced Intestinal Tissue Alterations in Dexamethasone Treated & Un-Treated Mice Hagar F. Abdelmksoud
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Cryptosporidium parvum (C. parvum) is coccidian protozoan that causes cryptosporidiosis, a parasitic disease of the mammalian intestinal tract.  C. parvum is considered one of the most important waterborne pathogen among the most relevant parasitic enteric agents in man and animals. It is resistant to all practical levels of chlorination and it is an obligate intracellular pathogen. It has been the cause of multiple diarrhea outbreaks in developed and developing countries. The present work was carried out to evaluate the pathological, immuno-histochemical and molecular changes in the ileocecal region induced by chronic irritation with different inoculum sizes of cryptosporidium (50,500 oocysts) in immunocompetent and immunosuppressed mice. The mice were euthanized at different dates starting from 14, 21, 36, 45, 57 till day 64 to study these transformations. Histopathological examination of the ileocecal region revealed neoplastic changes in the form of dysplasia, polypoid structures, architectural distortion, glandular crowding, marked cellular atypia, exophytic adenomatous polypi, intramuscular adenocarcinoma and marked nuclear anaplasia. Immunohistochemical results showed positive K-ras expression. The present study proved that Cryptosporidium species is one of the infectious agents that may induce intestinal neoplasia, which is highly affected by repeated exposure and elevated parasite loads.Keywords: Cryptosporidium Mice, Intestinal tissue alterations, Histopathology, Immunohistochemistry.
A Study of the Pollution of Heavy Metal of Discharged Water from the South Baghdad Thermal Power Station Saud Salman Mohammed
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The present study was conducted to demonstrate the effect of the Thermal power station on the concentration of heavy metals (Fe, Pb, Ni, Cu, Cr, Cd, As, Se) from January 2017 to August 2017. The concentrations of the heavy elements under study were estimated by atomic absorption spectroscopy. The mean concentrations of heavy metals (Fe, Pb, Ni, Cu, Cr, Cd, As, Se) respectively in the industrial water discharged to the Tigris River were measured in mg/l (2.35, 0.266, 0.318, 0.314, 0.093, 0.117, 0.024 and 0.359). The results of the study recorded contamination of the soil of the study area with heavy elements (Pb 89.25 mg / l), (Cd 8.41 mg / l) and (Ni 93.75 mg / l). The study concluded that the power station affected the pollution of ecosystems and deteriorated the quality of the Tigris River in the southern part of Baghdad.                              Keywords:  Heavy metals, Thermal power station, Atomic absorption spectroscopy.   
Retrospective Analysis of Quality of Pharmacotherapy for Children with Acute Respiratory Infections on Background of ABC /VEN/ Frequency Analysis Based on Data of Patientsꞌ Medical Histories Vera Ulanova
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Increase in frequency of acute respiratory viral infection (ARVI) and difficult economic situation in Ukraine require rational use of financial resources to treat this disease in children. Comprehensive analysis on background of additional pharmacoeconomic methods: ABC-, VEN- and frequency analysis based on study of results of 180 children with ARVI - allows to estimate  cost of drugs in hospital of Burin town, Sumy region, Ukraine. It has been found out that part of money turned out to have been used inefficiently for treatment of children with ARVI and pharmacotherapy not always to be in line with government regulations because 16.15 % - 38.69 % of all funds were spent on drugs not included in Clinical Protocols for ARVI and related diseases. That is why there is an opportunity to cut down expenditures spent on unnecessary drugs during treatment period.Keywords: Drugs for treatment of children with acute respiratory viral infections, Clinical and economic analysis.
Effects of ascorbic and cinnamic acids on the Albumin glycation level in breast cancer patients Israa Ghassan Zainal
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract: Glycation is the non-enzymatic interaction of carbohydrates with proteins. It is considered as a factor that leads to Alzheimer's disease, diabetes, aging, neuropathy, cancer, and atherosclerosis. In vitro and in vivo glycation was studied with human and bovine serum albumin as a model of the protein. A concentration of 0.1M glucose was used as a glycation agent. The level of the Amadori product was determined by thiobarbituric acid calorimetric assay after hydrolysis. Advanced glycation end products (AGEPs) was measured by UV-Visible spectrophotometry. Different concentrations of ascorbic acid (vitamin C) and cinnamic acid were found to be potent inhibitors of both the subsequent end products and the glycation reaction. The result showed that the level of glycation in breast cancer patient is significantly high and ascorbic and cinnamic acids as inhibitors, decreased the glycation reaction of albumin.
The Comparative Effect of Liquid and Tablet Preparation of Purple Sweet Potato (Ipomoea batatas L) Extract to Lipid Profile, MDA, and SOD Level in Male Wistar Rats After Given High-Cholesterol Diet I Wayan Putu Sutirta Yasa; I Made Jawi; Putu Astawa
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background: Recent developments in tablet preparation of extract have brought advantages to keep active ingredients from plants in stable forms physically and chemically. This study aims to compare the liquid and tablet preparation of purple sweet potato (Ipomoea batatas L.) extract to lipid profile, MDA, and SOD level in rats after given high-cholesterol diet. Methods: A randomized pre- and post-test control group experimental study was conducted during 4 weeks among 21 male Wistar rats. They were divided into 3 groups in this study namely: control (only high-cholesterol diet), Treatment 1 (T1) group (high-cholesterol diet and 200mg/day tablet of purple sweet potato extract), and Treatment 2 (T2) group (high-cholesterol diet and liquid form of purple sweet potato tubers extract about 2 mL/day). Lipid profile, MDA, and SOD level examination were performed twice from retro orbital sinus blood drawn and analyzed using ANOVA in SPSS version 17.Results: Mean value of lipid profile was significantly lower in T2 group (Cholesterol 84.48 ± 3.38; LDL 23.05 ± 2.32; HDL 63.39 ± 1.56; and triglycerides 96.03 ± 3.82; P < 0.05) after study period. The mean value of MDA was also significantly lower in T2 group (1.25 ± 0.09; P < 0.05) and SOD level was significantly higher in T2 group (73.72 ± 4.14; P < 0.05) in the end of study. Conclusion: Liquid preparation of purple sweet potato extract showed a better efficacy in reducing lipid profile and MDA level, as well as enhancing SOD level in rats given high-cholesterol diet.Keywords: Lipid Profile, Liquid, MDA and SOD Level, Purple Sweet Potato, Tablet.
Improvement the Photo Catalytic Properties of ZnS nanoparticle with Loaded Manganese and Chromium by Co-Precipitation Method Luma Majeed Ahmed
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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This work aims to study the photocatalytic decolorization of Reactive black 5 as the commercial azo reactive dye was studied  with  a presence prepared  ZnS nanopowder and metalized by manganese and chromium (1:1)%. These prepared catalysts were have been made by using a co-precipitation method. The characteristics of prepared samples were investigated by X-ray  diffraction(XRD), AFM and fluorescence spectrometry, XRD data were  helpful to calculate the mean crystal size by the using Scherrer equation , the mean crystal  size for prepared bare ZnS is more  value compared with that value for prepared Mn: ZnS: Cr  and equal to19.986 and 17.114 respectively.  The AFM images explained that the shapes for prepared samples are semispherical and the number of particle sizes of them that equal to 93.740, 51.020 for bare ZnS and metalized (Mn, Cr) ZnS respectively. The Crystallinty index was calculated by depending on particle sizes attained from AFM and mean crystallite sizes obtained from XRD and results indicated to the particle sizes for them contain (5-3) crystals. The results of measured Bg of prepared samples were obtained, that the Bg of prepared ZnS was a small value (3.558 eV) at λ max =348.5while the Bg of metalized ZnS was (3.568 eV) at λ max =347.5. Atomic absorption spectrometry was used to ensure if all the loaded amounts from Mn: Cr were completed that, so, the loaded process is successful. The effect of temperature was estimated the calculated activation energies for prepared ZnS and prepared Mn: ZnS: Cr ( 14 ∆Ea=20.760 kJmole"> & 14∆Ea=13.420 kJmole)">  respectively. The  Efficiency (E %) of decolourization for reactive black 5 dye with prepared samples under the UV- A light whose intensity is equal to   (1.46 x 1410-7"> ) Einstein. s-1  was calculated for all prepared sample and indicated tothe effect of the metal loaded to increase the  efficiency % for metalized ZnS 87.128% compared with prepared ZnS E% 73.394%.Keyword: Textile wastewater, Advanced oxidation processes, Reactive Black 5 dye.
Estimation of C-Peptide, HSP60 and Anti-GAD Antibody Levels in Type 1 Diabetes Mellitus Duha T. Khalaf
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Type 1 diabetes, previously known as insulin-dependent diabetes or juvenile diabetes, is caused by the destruction of beta cells responsible for insulin secretion in the pancreas through a process in which T-cells play a central role. The study was conducted on 56 patients with type 1 diabetes, whose mean ages (12.68 ± 3.33) years, and 20 healthy people, as control group for comparison purposes at the National Center for Diabetes and Endocrine Research (Al-Mustansiriyah University) from February 2017 until July 2017. Venous blood samples were collected from patients and healthy individuals to evaluate the levels of Fasting Serum Glucose FSG, C-peptide, Heat Shock Protein 60 (HSP60) and Anti-Glutamic Acid Decarboxylase (anti-GAD) antibodies. The results of the study showed a highly significant increase in the level of FSG, HPS60 and Anti-GAD antibodies in patients compared to the control group (P <0.001),while C-peptide showed a highly significant decrease in patients when compared with the control group (p <0.001).Keywords: T1D – C-Peptide – HSP60 – Anti-GAD.
Synthesis and Antibacterial Activities of New 2-Mercapto-Imidazoline-4-one Derivatives Sahar Abdullah Kadham
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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New 2-mercapto-imidazoline-4-one Derivatives comprising 1, 3-thiazoline, Schiff's bases, pyrazole, pyrimidine and γ - lactam moieties are reported. Compound1was synthesized by the reaction of thiourea with Chloro acetyl chloride, compounds 2a - dwere converted into thioester 3a - d Compounds contains pyrazole 5a - h and pyrimidine 6a - hweresynthesized by the reaction of hydrazine hydrate and thiourea with compounds 4a – h respectively Compounds 3a-d and 8a – d were converted into a variety of derivatives. All structural of compounds have been confirmed by FTIR, 1HNMR and mass spectra and tested for invitro antibacterial activity against Escherichia coli, Staphylococcus aurous and Proteus mirabbilisby.Keywords: imidazoline-4-one, 1, 3-thiazoline, Schiff's bases, Pyrazole, Pyrimidine  and γ – lactam.
A First Record and Developmental Stages of an Exotic Species Cochlicellabarbara (Linnaeus, 1758) (Gastropoda-Cochicellidae) in Iraq Baghdad Maysaloon Lafta Al-Doori
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The aim of this study is to highlight this species of gastropoda Cochlicellabarbara( Linnaeus, 1758), which is recorded for the first time in Iraq, which is an exotic animal in this country. It is a terrestrial Molluscan, the study for three months (February, March and April) 2017. In garden houses in Baghdad Al-Karkh, we studied the development stages from the egg to the adult, they lay a hundred of eggs in about (15-20) eggs in each gelatinous sac, the shell with 7 whorls and about 10 mm in length.Keywords: Mollusca, Gastropoda, First recorded, Cochlicellidae, Cochlicellabarbara.
The Impact of the Educational Program Using Teaching Aids in Teaching the Skills of Service Receiving and Court Defending for the Students the Volleyball Majid Hameed Merzah
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The coaches and experts interested in preparing the volleyball teams from the physical, skill, planning and psychological aspects of their teams, on a set of bases, the most important of which are the basic skills which vary in level of complexity and complexity from one game to another .Based on this sense of importance of these skills, which reduces efforts, shortens time and material possibilities, and makes early learning processes a little more erroneous because errors at these stages, if developed, are difficult to correct. And through the researcher's practice of this game found that these skills are still taught in traditional ways, and educational curricula in the general sphere of volleyball lacks the use of aids and devices that help to accelerate and stabilize the processes of education and consolidate the differences between these skills, the use of traditional methods of learning, which It is not possible to arrive at a precise description or measurement of learning, and non-objective evaluation is accompanied by many errors in accurate monitoring of the movement parts.The research objects:Find educational aids to teach students the skills of service receiving and paying volleyball students.Learning about the impact of the learning program using some educational aids in teaching the skills of service receiving and paying students with volleyball.The researchers used the experimental method in the style of equal groups to suit the problem. The research society determines the students of the second stage in the Faculty of Physical Education and Sports Sciences at the University of Karbala for the academic year 2016-2017 Division (A, B, C) and the number of (82) (24) students, divided into two groups of each group (12) students.The most important conclusions were:The proposed learning program using innovative teaching methods has a positive impact on teaching service receiving skills.The proposed learning program using innovative teaching aids has a positive impact on the teaching of court defending skill.Keywords: Educational program, Teaching aids, Receiver service and defending of pitch skills.

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