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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 65 Documents
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Search results for , issue "Volume 10 Issue 08: (2018) August 2018" : 65 Documents clear
Detection of Lgc1 Gene Low Glutelin Content in Rice Cultivars Iraq using Indel Markers Zeina Thamer Abdul Hussein Al-Rufaye
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Low glutelin content rice is a good diet for patients with renal failure. Delete about a 3.5kb of a Low glutelin content Lgc1 gene sequence located in the second chromosome on the short arm between highly similar glutelin genes GluB5 andGluB4. To increase the significant, we proposed to select the adequacy in Lgc1 rice breeding, 2 molecular markers we developed to reveal the gene Lgc1, which were specified as InDel-Lgc1-2 & InDel-Lgc1-1, respectively. Our results such as The PCR results showed that band 509bp in all varieties of rice, we conclude varieties of rice in Iraq have high glutelin content. Therefore, we cannot use it for the patients with kidney failure and diabetes.Keywords:  Oryza sativa L, Lgc1 Gene, Indel Markers.
Herbal Tea Production from Moringa Oleifera Leaf Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Moringa oleifera is an important medicinal plant in Vietnam. The leaf of Moringa oleifera has shown the presence of some bioactive components which possesses phytochemical activity. It is highly valued as its vast medicinal properties. Moringa oleifera is currently being promoted as a means to combat poverty and malnutrition. The phytochemical and nutritional properties of the dried leaf of Moringa oleifera used as nutraceuticals, dietary supplements, functional foods. The low moisture content of the dried leaf tea is an attribute to a very high shelf life. Long storage of the dried Moringa oleifera leaf tea would not lead to spoilage due to microbial attack and this supports the practice of storage in dry form. Objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to vitamin C (mg/100g), flavonoid (mg/g) and sensory score of the dried Moringa oleifera leaf tea. Results showed that Moringa oleifera leaves should be blanched in hot water 95oC at 4 seconds in the present of CaCl2 2% and then beeing dried by heat pump dryer at 40oC until 6.5% moisture. The final herbal tea could be preserved under vacuum in PET/AL/PE bag at 4oC to maintain flavonoid content for 12 months. Keywords: Moringa oleifera, Herbal tea, Blanching, Drying, Vaccum, Vitamin C, Flavonoid.
A Modern Strategy to Study the Life Cycle of Lesser House Fly and the Biological Control against the Bacterial Pathogens by Using the Larvae on the Bacterial Cultures Hussein JabarJasim
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The current research was performed that the lesser house flies were completed the life cycle on the bacteria cultures, also, This study was used the larvae lesser house fliesas a modern biologic control method against several types of pathogenic bacteria include (E. coli, S.aureus and K. pneumonia).The lesser house flies were attracted and laid the eggs on the bacteria cultures during the period that extended from April to May 2016-2018 (two seasons). The Lesser house fly eggs Samples were collected from different regions in south and central of Iraq, Al-Muthanna province and Baghdad province. On the other side, Different bacterial isolates were used such as E. coli, K. pneumonia and S. aureus. The present study was divided into seven groups. The first group was used an organic substance such as a sliced tomato as a control group inside petri dishes. The second and third groups were included E. coli cultured on Maconkey agar and Nutrient agar respectively. While, the fourth and fifth group were included K pneumonia cultured on Maconkey agar and Nutrient agar respectively. The sixth group was included   S. aureus cultured on Nutrient agar. Finally, the seventh group was contained only Nutrient agar and Mackonkey agar without bacteria. The second  , third , fourth , fifth  and sixth , seven group were distributed in   the mentioned regions   each area was included 10 petri dish from each group  which 60 dish in each region. While the eggs were transferred from the other groups to the control group. The seventh group was used to ensure the attraction of the lesser house flies to the bacteria cultures was not because the culture media itself, the dishes of all groups except the control group were opened   to allow the flies to attract to bacteria growth and enter the petridishes of groups. Morphological examination of larvae in the present study was carried out, after 7 days of hatching the eggs size of all the groups was approximately 2 millimeters.Keywords: A Modern Strategy, Life Cycle, Biological Control, Larvae Lesser House Fly, Bacterial Cultures.
The Relationship between Chemotherapy and Level of IL-10 in Patients with Breast Cancer Hamid Naji Obied
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Background: Cancer is a group of diseases that cause cells in the body to change and grow out of control and most types of cancer cells eventually form a lump or mass called a tumor. Aim of this study; A descriptive study was conducting to determine the level of IL-10 and the lymphocytes as well as monocytes count in women with breast cancer, and to investigate the effect of chemotherapy on these two parameters. Methods: A non-probability (purposive sample) of (30) patients diagnosed previously with breast cancer were selected before (pre-chemotherapy) and after taking the first dose of chemotherapy, and 30 samples of healthy females as control group. Blood sampling were collecting and tested to estimate the level of IL-10(ELISA) and CBC to numerate the lymphocyte and monocyte.  The results of this study indicated that there was a significant increase in the level of IL-10in pre-chemotherapy patients group compared with control group, also there was elevated in lymphocytes count pre-chemotherapy group in comparisons with control group. Conclusion: In this study can conclude the amount of IL-10 and lymphocyte count in the women with breast cancer before chemotherapy were increased level than after chemotherapy.Keywords: Breast cancer, Chemotherapy, Lymphocyte, IL-10.
Alkaloids from Alphonsea Elliptica Barks and Their Biological Activities Saripah Salbiah Syed Abdul Azziz
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

This study was carried out to investigate the phytochemicals from the barks of Alphonsea elliptica. The barks  were harvested from Hutan Simpan Sembarong, Kluang, Johor; and extracted using dichloromethane (DCM), hexane and methanol successively. Isolation of dichloromethane crude extract was then performed using silica gel column chromatography and preparative thin layer chromatography (PTLC)techniques. Structural identification were carried out via 1D and 2D NMR, UV, IR, MS and comparison with reported data. Phytochemical study of the barks led tothe isolation of five alkaloid in which two were oxoaporphines; atherospermidine (1) and liriodenine (2),two were dioxoaporphines;cepharadione A (3) and N- methylouregidione (4), and an azafluorenone alkaloid;kinabaline (5). The hexane, DCM, and methanol crude extracts, together with five isolated alkaloids, were tested for theirradical scavenging activity,inhibition of xanthine oxidase activities and cytotoxicity. Atherospermidine and liriodenine possessed antioxidative activities with IC50 value of 20.17 and 10.73, respectively. Atherospermidine, liriodenine, N-methylouregidione and kinabaline showed xanthine oxidase inhibitiory activityof 46.29, 7.66, 42.10 and 50.72 μM,respectively. Meanwhile, atherospermidine, liriodenine, cepharadione A and kinabaline showed cytotoxicity  against breast cancer cell line with IC50 89, 86, 79.85 and 62 µg/mL respectively.  All the alkaloids tested in this study were isolated for the first time from this species while Cepharadione A is reported for the first time in a species belongs to Alphonsea genus.Keywords: Alphonsea ellipticaHk. f. et Th., Alkaloids, Radical scavenging activity, Xanthine oxidase, Cytotoxicity.
Zinc Oxide Nanoparticles by Biological Eco-Friendly Synthesis Matrixes for Antibacterial Applications Abdullah Hasan Jabbar
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

A zinc oxide nanoparticle (ZnONPs) is a prejudiced system because of utilizing into biomedical purposes such as mean conductivity, bacterial control, and lovely warmth resistance. The aims of this instruction are in imitation of synthesize nanoparticles on zinc oxide by biological techniques using a green method yet characterization over nanostructures. Many chemical or natural strategies have been utilized according to ZnO-NPs preparation, but organic techniques so inexperienced strategies among a range of substrates (eg enzymes, microorganisms, bacteria, or sow extracts) are probably to be dealt with as environmentally friendly alternatives in conformity with chemicals and/or applied sciences Physical properties. ZnO nanoparticles are nearly back in imitation of treat a difference about countless pores and skin illnesses and hold anticancer properties. ZnO nanoparticles hold featured so an appropriate meaning for offering medicine and senses. In it stricture article, we succinct the inexperienced synthesize of ZnO NPs or mentioned the antibacterial applications.Keywords: Nanotechnology, Zinc oxide nanoparticles, Green synthesis, biomedical applications.
Association of Insulin-Like Growth Factor 2 Apa 1 A820G (rs680) Polymorphism with Thyroid Dysfunction in a Sample Iraqi Patient Tamara A. Alubaidi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The research includes genetic study of insulin-like growth factor-II. The results showed a significant change comparing patients with of hypothyroidism with healthy group. The study included 60 people (males and females). Age ranged (20 - 45 years). Divided into 2 groups: The first group consisted of 30 patients (15 males and 15 females) with hypothyroidism .The second group consist of 30 people (15 males and 15 females) as control group. The results showed that individuals with non-homozygous allele AG had hypothyroidism. The aim of the study is to identify the common allele in a sample Iraqi society for hypothyroidism patients. The results showed a non-significant change when compared with the results of hypothyroidism with hyperthyroidism. While in the healthy group, the safety of individuals from any thyroid gland disease, but the genetic study showed that the number is not small also carrying the allele AG heterogeneous and that if anything indicates that these individuals with the allele AG will be vulnerable to thyroid disease during Next years. A pair of primers is designed to amplify exon 3of IGF-II gene and the polymerase chain reaction produced were sequenced to detect mutation.Keywords: Insulin- like growth factor-2, Hypothyroidism, Hyperthyroidism and thyroid dysfunction.
Interrelationships between Psychology and Medical Sciences Safaa Hussein Hameed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The area on psychological studies has extended in imitation of overpass the cutting-edge studies on Freudian, who has been especially worried including gangs, has flourished psychological diseases affect the organic side and organic diseases affect the psychological side. It is necessary because of professionals after drink outweighs over this twins aspects, focusing over the essential empirical development known namely the medical scanner, magnetic resonance imaging (MRI) imaging resonance the magnetic. A latter trend, referred to as the physical school, has been nee on the grounds that the sixties among France, who is concerned including both sides. The faculty emphasizes that the depressed or deteriorating psychological scenario is an essential factor among building the singular inclined in conformity with bodily illness, who is from time to time dangerous. It additionally holds so the sickness does now not usually have a bad cost as much that is, however, may carry a positive value, that is, the ailment affords the individual with entire the possibilities after reorganizing and resurface as postulate the ailment is a violation platform in imitation of restoring the individual after his equilibrium. Many clinicians have attached this theory, as has furnished them with useful field experiences, emphasizing the interplay about many psychological, bodily yet neighborly factors. The unaccompanied is a complicated embodied soul between who many elements overlap. With the creation then length about neurosciences about thirty years ago or its colorful results, a modern concept of bodily psychology referred to as neuropsychology, based totally over neuroscience between its research, has currently emerged, linking this principle in accordance with damage And adjustments in nerve centers, particularly the brain. In our intervention, we choice existing the almost vital field research including the findings, into kilter in accordance with hyperlink psychology, clinical sciences, and half other sciences.
Isolation and Identification of Fungal Propagation in Iraqi Meat and Detection of Aflatoxin B1 Using ELISA Technique Rawaa Emad Jaloud
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The study was conducted at the College of Education for Pure Sciences (Ibn Al-Haitham /University of Baghdad. The aim of this study was to isolate and diagnose fungi from meat samples and detection of aflatoxin B1. The samples included different types of sheep meat that collected from the local slaughter areas and government approved in Baghdad (Al-Karkh and Al-Rusafa); this study included the collection of 50 samples from fresh sheep meat (25 liver and 25 triceps muscles), 13 of minced meat and 12 of basterma samples. Two methods of isolation were used which are direct and indirect to detect Fungi in the samples; the results have been found the presence of various genus of fungi including Aspergillus spp., Penicillin spp.,Rhizopusspp.,Mucorspp.,Cladosporiumspp.,Fusariumspp.,Moniliaspp., Botrytis spp., Trichothecium spp., Ulocladium spp. And Yeast spp. According to the type of isolation method, Aspergillus spp. is the most common genus that isolated from the samples using direct method, while yeast was the most predominant in the samples using indirect method in all samples except in the muscles where Aspergillus spp. Were the predominant fungi in both isolation methods? Results of the detection of aflatoxin B1 showed that 71 of the samples were contaminated with toxin; the samples included minced meat, basterma, liver and muscles with different concentrations of aflatoxin ranging from 42-467 ppb, 25-442 ppb, 44-492 ppb and 242-459 ppb for respectively.
Green Synthesis Silver Nanparticles Using and Rographis Paniculata (nees) and its Antimicrobial Activity against Human Pathogens K Vijayakumar; G Thiruneelakandan
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

In the present examination, an undertaking was made to nanoparticle by using a remedially fundamental plant Andrographis panticulata. The applications plant materials which would help in the neutralizing activity of human pathogens. Silver nitrate (AgNO3) was used to coordinate the silver nanoparticle by using leaves focus of A. paniculata was used as a diminishing and offsetting administrator. The organized silver nanoparticles from 1mM AgNo3 game plan through the leaves expel were depicted using UV-VIS spectrophotometry, Scanning Electron Microscope (SEM) and Fourier Transform Infra-Red (FTIR). The nanoparticles should remarkable antimicrobial activity against multi-sedate safe human pathogenic sorts of the two tiny living beings and Fungi (Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Streptococcus fecalis, Aspergillus conicus, Aspergillus flavus, Aspergillus niger, Aspergillus terreus and Rhizopus. sp). The result reveals that the most outrageous antimicrobial activity was seen against the test life frame when stood out from the control.Keywords: Silver nanoparticles, Andrographis paniculata, SEM, UV-VIS spectroscopy, FT-IR, Antimicrobial activity.

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