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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 65 Documents
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Search results for , issue "Volume 10 Issue 08: (2018) August 2018" : 65 Documents clear
Use High Temperature as a Curing to Change Antibiotic Resistance of Salmonella Typhi Sura Mohammed Sachit
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Gradual growing levels of antibiotic resistance in the developing countries had incurably increased in the last few decades as a consequence of evolutionary microbial characters and random antibiotic use. Many important clinical pathogens showed multiple resistances to many different antibiotics, this means any dangerous infection that can easily transfer from any country to any other, representing global increasing problem. Typhoidal Salmonellae represents interesting concern for world public health, especially fever caused by Salmonella typhi which cause different blood stream infection .Seven clinical isolates of Salmonella typhi were isolated and identified biochemically from a hospital in Baghdad. They had multiple resistances to Cefepime, Imipenem, Amikacin, Norfloxacin, Floxacin and Ceftazidime. The isolates appeared different elimination of multiple antibiotic resistances character after incubation at high temperature (45ºC), meaning the isolates lose antibiotic resistance plasmids after physical treatment by high temperature. This simple, inexpensive and safe treatment represents a promising way to eliminate antibiotic resistance character from many dangerous pathogenic bacteria. Keywords: Salmonella typhi, Antibiotic resistance, High temperature.
Variable Number Tandem Repeats (VNTR) MAOA Gene Promoter Polymorphism Association with Adolescent Delinquency in Bali: A Preliminary Study Anak Ayu Sri Wahyuni
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Background: One of the genes that concern behavioral problems is the MAOA. Animal studies have shown that increased dopaminergic and noradrenergic function is associated with aggressive behavior. It is therefore obvious that any change in the catabolism function possessed by MAOA can lead to aggressive behavior. Individuals with decreased or increased MAOA function in most cases had a 30 bps of VNTR (Variable Number Tandem Repeat) polymorphism on the MAOA gene promoter. Children with 3R or 5R alleles are more likely to develop into violent behavior than those with alleles of 3.5R or 4R. Aim: The study aims to determine the proportion of VNTR polymorphism of MAOA gene promoter with juvenile delinquency in Bali and the relationship between VNTR polymorphism of MAOA gene promoter with juvenile delinquency in Bali. Method: The populations in this study were adolescents (12-18 years old) divided into case and control group matched by age and sex. Participants were asked to provide a blood sample for DNA extraction. The analysis on MAOA data cannot be conducted because the outgoing data is a constant. Result: All samples in the group had a high activity (100%) and only two samples (4.6%) had heterozygous genotyping, as well as the statistical analysis, could not be performed. Conclusion: This study has not been able to answer the hypothesis, because it was unable to be analyzed. The analysis cannot be fixed because all the measurements obtained are homogeneous.Keywords: Variable Number Tandem Repeats (VNTR), MAOA, Delinquency.
Investigation of Dried Herbal Tea Production from Gymnema Sylvestre Leaf Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Diabetes mellitus is a major public health problem in the developed and developing countries. The Gymnema sylvestre is one of the important anti-diabetic medicinal plant. Gymnema sylvestre is a slow growing, perennial medicinal woody climber found in North of Vietnam. Gymnema sylvestre is useful in controlling blood sugar to treat type-II diabetes. Gymnemic acid, the active ingredient of this plant, is extracted from leaves. There is a growing demand for G. sylvestre leaves in the pharmaceutical trade. There was not any research mentioned to the production of herbal tea from Gymnema sylvestre. Therefore, objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to Gymnemic acid (%), color (sensory score) of the dried Gymnema sylvestre tea. Results showed that Gymnema sylvestre should be blanched in hot water 95oC at 4 seconds in ascorbic acid 0.5% and then beeing dried by heat pump dryer at 40oC until 6.5% moisture. The final herbal tea could be preserved under vacuum in PET/AL/PE bag at 4oC to maintain antioxidant activity for 12 months. Gymnema sylvestre is most important for plant prospecting.Keywords: Gymnema sylvestre, Herbal tea, Blanching, Drying, Vacuum, Gymnemic acid.
The Relationship between of Some Pathogens and Gallstones Formation Maytham Abas Makki
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The study was conducted from October 2016 to February 2017 at Al Hussein Educational Hospital in Samawah city. Forty-five patients diagnosed with gallstones which removed by surgical operation the gallbladder,then the bacterial implantation of all the isolated grits from the residual gallbladder.Most of the factors related to diseases of the infected were also recorded. Forty-five percent of the men and women aged 2-43 , 20 - 54 yearsrecpectivly .Three types of gravel were identified depending on appearance, size and color. Cholesterol stone (15.55%), pigmentedstone  (33.33 %) and mixed stone (51.11%).The results showed that all of these species were positive for bacterial culture and recorded species:Enterococcus faecales (88.88%), Klebsiella pneumonia (22.22%), Enterobacteraerogenes (28.88 %), Pseudomonas aerugenosa (77.7%) Vibrio alginolyticus (20%),Vibrio valunificus (46.6%), Escherichia coli (55.55%),Vibrio parahemolyticus (15.55%),،( Proteus merabilis (66.6%) Listeria monocytogenes (60 %   ( Staphylococcus aureus (42.22%), Staphylococcus epidermidis (4.44 %), Staphylococcus saprophyticus (6.66%), Proteus vulgaris (2.22%) ,Citrobacterfreundii (51.55%),Salmonella typhi (37.77 %), Salmonella entritidis 13.33% , Coliform bacteria (15.55 %).Keywords: Pathogens;  Gallstones formation; Enterococcus faecales.
Metformin and Insulin Treatment Influence on Monoamine Oxidase Activity in Diabetes Mellitus Type 2 Ruaa Hassan K. Alani
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The influence of anti-hyperglycemic drugs (Metformin, insulin) on the activity of Monoamine oxidase in the sera of diabetes millets type2 .This study included 54 volunteers, 36 with diabetes millets type 2, treated with Metformin, and metformin + insulin, and18 healthy volunteers without endocrinal diseases represent the control group. Activity of Monoamine oxidase, body mass index, fating blood glucose, glycosylate haemoglobin, and lipid profile levels respectively were examined in this study. The results revealed significant decrease in the levels of BMI, FBG, and lipid profiles in the two groups as compared to control.  Monoamine oxidase showed different in the patients groups as compared to healthy group. As conclusion this study showed different effect of treatment on the biochemical parameters and enzyme activity and this effect may decrease the occurrence of diabetes complication including neuropathy (neurodegredation diseases (Parkinson, and Alzheimer diseases) and increases patients life.
Different Parameters Affecting to Production of Curcumin-Dry-Salted Frog (Hoplobatrachus Rugulosus) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Frog (Hoplobatrachus rugulosus) meat is an attractive food choice in international market. Frogs are mainly collected from nature and with the rising human activities. Consumption of frog meat has increased in the last few years. Frog production has been growing up and down many times due to the spontaneous development of farmers. Meanwhile frog processing is not developed in Vietnam thus the export volume of this product is limited. Most of frogs are supplied directly to the market for consumers. It’s necessary having post-harvest management including the processing of this species into the value-added foodstuff. From that, commercial frog value chain can be enhanced. Most traditional sun dried frogs do not meet the expected standard for human consumption due to the infestation of the products by the fly, insect larvae, contaminants and spoilage. The simplicity of the salting process, the low cost of production and the easy combination with curcumin could be considered as a preservative. Objective of this research focused on the processing of frog into the curcumin-dry-salted product by salting and drying method. Different technical experiments were investigated such as the effect of salt, curcumin ratio during soaking, temperature of drying, and packaging storage to chemical, microbial and sensory characteristics of the finished product. Results revealed that dry salting was better than wet salting. With addition of 0.75% of curcumin, drying at 50oC in 3 hours, the curcumin-dry-salted frog products had the good physicochemical, microbiological and sensory characteristics. By preserving under vacuum at 4oC, the curcumin-dry-salted frog could be maintained shelf-life for 12 months without any deterioration.Keywords: Frog, Hoplobatrachus rugulosus, Curcumin, Salting, drying, Vacuum, Shelf-life.
Hepatoprotective Effect of Vitamin C and E on Antitubercular Drugs Induced Hepatotoxicity in Albino Rats Babul Kumari
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Objective- The hepatoprotective effects of Vitamin C and E were investigated in anti tubercular drugs induced hepatotoxicity in albino rats. Methods- Liver necrosis was induced by a combination of three anti tubercular drugs [isoniazid (I) 7.5mg/kg, Rifampin (R) 10 mg/kg and Pyrazinamide (P) 35mg/kg] given orally as a suspension for 30 days in rats. The liver damage was evidenced by the histological architectures of the liver tissues and the elevated levels of the liver enzymes like SGOT, SGPT, ALP, Total bilirubin, and unconjugated bilirubin. Results- Treatment with Vitamin C (250 mg/kg) and E (250 mg/kg,) significantly (P<0.05-P<0.001)  reduces the anti tubercular drugs induced elevations of the liver enzymes like SGOT, SGPT, ALP, Total bilirubin, and unconjugated bilirubin. Histological architectures of the liver tissues become normal in vitamin -treated group a comparison to the hepatotoxic group. Conclusion-The results of this study suggest that Vitamin C and E have a hepatoprotective effect against anti tubercular drugs induced hepatotoxicity in albino rats.Keywords:  Vitamin C, Vitamin E, Isoniazid, Rifampicin, Pyrazinamide, liver enzymes.
Study the Bacterial Infection of Chronic Supportive Otitis Media from Iraqi Patients Hiba M. Nasir
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

One hundred example had been secluded from CSOM were screened for the bacterial by utilizing distinctive morphological, microscopically, biochemically and API framework. The antibiotic susptibilty tests were done to demonstrate the ideal one for each bacterial segregate. Probiotic impact of saccharomyces cerevisiae were analyzed against bacterial disengages. The outcomes demonstrated that CSOM was most predominant in female than male with percent (54, 46%) respectively. Also, Pseudomonas aeruginosa was the most prevailing bacterial detached frame test of CSOM with percent (41%) after with Staphylococcus aureus, proteus mirabilis and Escherichia coli with percent (27%,19%,12%) individually. The antibiotic susptibilty test uncovered that diverse anti-microbial powerful against various bacterial disengage such Ciprofloxacin, Amikacin and others with various percent for each bacterial. While the consequence of probiotic from saccharomyces cerevisiae against bacterial secludes result demonstrate distinctive impact with various focuses.              Keywords: Chronic suppurative otitis media, Bacterial isolates, Probiotic.                  
Effects of Refined Sugar on Some Endocrine Glands Functions in Mice Rana Jaber Tarish Al-Baghdadi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Endocrine and nervous systems regulate blood glucose level in our bodies, but the reciprocal action yet to be addressed. To address this question, we employed the current study that included 24 mice of both sexes that were divided into control group that consumed standard mouse diet, a group that consumed high refined sugar diet (HS), a group that consumed high refined sugar and Vaccinium corymbosum L fruit powder diet (HSP). The study lasted for 3 months. The measured parameters included body weight gain, pancreas weight, glucose tolerance test and the leptin and thyroid hormone receptor gene expression. The results showed that the HS mice showed the highest body weight gain, pancreas weight, glucose blood level, and leptin gene expression. Most of those parameters went back to normal in the HSP group. In conclusion, the study reveals the deleterious effect of consuming refined sugar diet on the health and more specifically on the endocrine system response. The study shows that consuming refined sugar diet might be a precursor to initiate type 2 diabetes as a result of chronic high glucose level and insulin resistance. It also works as predisposing factor to develop obesity as the result shows high body weight gain and high leptin level indicating that the body develops leptin resistance as well. Keywords: leptin, Thyroid hormone, Refined sugar, Vaccinium corymbosum, Glucose.
Study the Association of CYP3A5 Polymorphism on the Risk of Breast Cancer in Some of the Iraqi Women Israa Hussein Hamzah
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Cytochrome P450 enzymesare involved in activation of numerouspro carcinogenic compounds such as polycyclic aromatic hydrocarbon as well as plenty of endogenous compounds including testosterone and estrogen. The CYP3A isoenzymes represent the predominant cytochrome P450 enzymes in the human liver and gastrointestinal tract.  CYP3A  subfamily have four members  (CYP3A43, CYP3A7, CYP3A5 and CYP3A4). The aim of the present work is to investigate whether the CYP3A5 polymorphism modifies the risk of breast cancer in the Iraqi population. A total of eighty women were recruited in the present study divided into fifty breast cancer patients aged 25-65 years who visit the Oncology Teaching Hospital, Baghdad, Iraq, as well as 30 healthy sex and age matched controls. The sequence analysis of CYP3A5 fragment with molecular weight 349bp resulted in two distinct genotypesin the breast cancer group, with 96% (n=48) had the CYP3A5*3/*3 homozygote genotype and 4% (n=2) had the CYP3A5*1/*3 heterozygote genotype. In the control group, 100 %( n=30) had the CYP3A5*3/*3 homozygote genotype. No significant differences between breast cancer patients and control were observed with respect to genotype distribution (P>0.05). Our results revealed that there is no association between risk of the breast cancer and CYP3A5 polymorphism in Iraqi women.Keywords: Cytochrome, CYP3A5, Iraq, Breast cancer, Polymorphism

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