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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 4 Documents
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Search results for , issue "Volume 11 Issue 01 (2019) Jan. 2019" : 4 Documents clear
Analytical Method Validation for the Determination of Tetrabutylammonium Bromide Content in Daclatasvir Dihydrochloride by LC-Ms/Ms Suresh Reddy. Yellampalli
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: A rapid, sensitive and selective analytical method was developed and validated for the determination of Tetrabutylammonium bromide content in Daclatasvir dihydrochloride. Method: Chromatographic separation was achieved on a Kinetex biphenyl 150X 4.6 mm, 5µm column using isocratic elution with the mobile phase consisting of acetonitrile and ammonium formate buffer with flow rate was 0.7 mL/min. Results: The retention time of Tetrabutylammonium bromide was found 4.65 min. The method was validated according to ICH [1] guidelines. The calibration curve was linear over the concentration range of 0.0310–0.1530 % (r = 0.9999). The intra- and inter-day precision (RSD %) was 3.8 % and the accuracy (%) was LOQ (91.8 %) to 150 % (101.6 %). Conclusion: The proposed method was simple, precise and accurate. The method can be used for the testing of content of Tetrabutylammonium bromide in Daclatasvir dihydrochloride API during routine quality control and stability testing.Keywords: LCMS/MS, Tetrabutylammonium bromide, Method validation, ICH guidelines and Daclatasvir dihydrochloride.
Prevalence of Medication Errors in a Tertiary Care Teaching Hospital Manoj Kumar Sethi
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The purpose of current research is to identify the incidence of all possible prescription errors and to categorise them in a tertiary teaching care hospital of south India. Methodology: This is a prospective observational study conducted for nine months of various departments of (SVS) Medical College and Hospital, Mahabub nagar, Telangana. Suitable data collection forms were designed to meet up the criteria. Patients those agreed to give informed consent were included and those not willing to give consent and of (ICU) were excluded from this study. Patients were monitored on a regular basis from the time of admission to the date of discharge for any type of prescription error and recorded accordingly. Results: Throughout the study duration total 2000 prescriptions were analysed and observed that 400 prescriptions contains some kind of medication errors. More incidences of errors observed in surgery department (34 percent) and least was found in gynaecology department (3.75%). Major types of errors were omission error. Parenteral formulations constitute maximum no. of errors than oral and other external routes.  Conclusion: Most of the errors were omission of dose followed by illegibility, omission of prescriber signature, error in units, omission of route of administration (ROA), over writing, omission of frequency, under prescribing, omission of medication, omission of superscription, irrational prescribing, over prescribing, abbreviations, error in writing ROA, error in dose. Thus the present study threw some light on the need of proper education and training of all health care professional to minimize medication errors by which proper therapeutic goal can be achieved.Keywords: Prescription errors, Omission error, Commission errors, Medication errors.
Rationality and Prescribing Pattern of Antimicrobials on Female Lower Genital Tract Infection in a Tertiary Care Hospital of Odisha Ginia Agasti; Rasmita Jena; Dipti rani Rath; Trupti Rekha Swain; Goutam Ghosh; Durga Madhab Kar
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions for the treatment of female lower genital tract infection and its validation of rational use in a tertiary care hospital of Odisha. Methods: The current prospective investigation was carried out in outpatient department of Obstetrics and Gynaecology department at a tertiary care hospital over a period of six months.   A suitable data collection was carried out from female lower genital tract infection patients who were of 11-55 years of age group. Results: The study result found that most commonly prescribed antimicrobials were antifungal (azoles derivatives) and its combination with other antimicrobials. The other antimicrobials include, topical (8.4%)/single antimicrobial oral (2.8%)/ combination (intravaginal as well as oral- 50%) followed by other antimicrobials like linozolid (4.8%). Our study reveals that, antifungal agents are the most common antimicrobial drugs prescribed on the basis of laboratory diagnosis report, which revealed that, staphylococcal infection in majority of the patients (42%). Conclusion: Hence, present study shall definitely provide a small initiative towards control of emergence of antibacterial resistance, its side effects and cost of therapy worldwide.Keywords: Prescribing pattern, Antimicrobials, Lower genital tract infection, Tertiary care hospital.
Antibacterial Evaluation of Gradient Extracts of Stenochlaena palustris (Burm.f) Bedd. Towards Bacteria Involved in Skin Diseases Toji Thomas
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The work attempted to analyse the antibacterial character of gradient distillate of Stenochlaena palustris, a healing fern used to treat burn. The plant was evaluated for its antibacterial capability towards bacteria occupied in skin infections. Methods: Whole plant of S. palustris was examined for its antibacterial potential and phytochemical constituents in different solvents extracts of incrementing polarity. The typical disc diffusion method was done to inspect antibacterial activity. Basic phytochemcal assessment was accomplished by various standard spraying reagents and used to detect the same. Minimum inhibitory concentration and minimum bactericidal concentration were established towards Pseudomonas aeruginosa. Results: The plant could basically demonstrate antibacterial activity in acetone extract. P. aeruginosa was the most sensitive organism observed out of the tested bacteria. Water extracts did not provide antibacterial activity to the analysed bacteria. Phenols, flavonoids, polyphenols and sterols were track down in various extracts. Flavonoids, phenols, polyphenols and sterols found in acetone extract of the plant could be responsible for its antibacterial activity. Acetone extract of the plant yielded minimum inhibitory concentration as 12.5 mg/ml and minimum bactericidal concentration as 25.0 mg/ml towards P. aeruginosa. Conclusion: S. palustris manifested antibacterial activity in acetone extract notably towards   P. aeruginosa, a bacterium frequently associated with nosocomial infection. Keywords: Stenochlaena palustris, Antibacterial activity, Pteridophytes, Disc diffusion, Phytochemicals.

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