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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 53 Documents
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Search results for , issue "Volume 11 Issue 01." : 53 Documents clear
Production of Dried Roasted Watermelon (Citrullus Lanatus) Seed Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Watermelon seeds are a source of protein, B vitamins, and minerals. The watermelon seeds are often discarded while the fruit is eaten. Watermelon seeds are considered as a good source of food for human nutrition and health. Drying and roasting are the most important processes giving necessary alterations to the product.  Roasting can enhance flavour through caramelization on the surface of the food. There was no any research mentioned to varify the change of antioxidant (tocopherol) during infrared drying as well as storage. So the objective of the present study was to identify the effect of temperature in infrared drying, roasting condition, packaging and storage to tocopherol, total phenolic and antioxidant activity in the dried roasted watermelon (Citrullus lanatus) seed. Results demonstrated that drying temperature (45 oC), roasting (165 oC in 3 min), vaccum packing in polyethylene (PA) bag and keeping in 4 oC were recommended to maintain the tocopherol, total phenolic and antioxidant activity in the final products for 16 weeks. The effect of drying, roasting temperature and time were clearly demonstrated to produced dried roasted watermelon seed.Keywords: Watermelon seed, Drying, Roasting, Antioxidant, tocopherol, Phenolics, vaccum.
The Effectiveness of Socialization-media in Improving the Knowledge of Children and Teenager toward Cigarette in Denpasar, Bali Ida Ayu Jasminarti Dwi Kusumawardani
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background: Prevalence of children and teenagers smoker in Indonesia was more than 45%. This shows the gap between results and efforts of the Indonesian government to reduce tobacco cigarette consumption rate through various programs. Method: Aim of this study was to determine the level of children and teenager knowledge about cigarettes and to measure the effectiveness of socialization media improving their knowledge. This research was held in SMP Negeri 10 Denpasar and SD No. 12 Padangsambian. Design of study was cross-sectional experimental with cluster sampling. The sample size was 203 subjects divided into six groups. The study consists of a pre-test, intervention, and post-test. Level of knowledge about cigarette was determined by questionnaire and divided into 3 levels (good, average, and poor). Interactive communication was given to three groups of students, and the other got advertisement video as an intervention.  Result: The overall level of knowledge among children and teenager was good (50.2%), average (37.4%), and poor (12.3%). Level of knowledge among SD No. 12 Padangsambian students was good (42.1%), average (42.8%), and poor (15.2%). While in SMPN 10 Denpasar 70.7% of them was good, average (24.1%), and poor (5.2%). There was no significant difference between pre-test and post-test in the advertisement video intervention group (P>0.05). An increasing number of students with good knowledge was found in interactive communication intervention such as: group I (58%; p <0.05), group II (21.2%; p <0.05), group III (23.2%; p <0.05). Conclusion: Interactive communication could be used as media socialization to increase the knowledge of children and teenager about cigarettes and its negative impact on human health.Keywords: Cigarette, Knowledge, Socialization, Media, Children, Teenager.
Seroprevalance of Torch Infection in Pregnant Women in Basra City Southern of Iraq Ali. F. Hussein
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background torch infection (toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus) the causative agent for congenital infections in infants and abortion in pregnant women. Objectives the goal of the study was to determine the rates of infection of the toxoplasmosis and viruses that cause abortion in pregnant women. Methods kit (torch) igm, elisa technique. Result: a total of 50 serological samples were collected from adult pregnant women from 2018 -10 to 2018-oct-12. The number of qurna samples was 25 positive infection counts 15 and the estimated infection was 15/25 which accounted for 60%.while the infection rate in abi al-khasib district of the total 25 samples of the number of infection 8 and estimated the proportion of infection 8/25, which constitutes 32% of the toxoplasmosis. the results of the current epidemiological study confirmed that the viruses that cause abortion in the qurnah& abe al-khasib district of rubella were 4of the 50 blood samples (serum) showing that the percentage of infection is4/50, which is 8% and the rate of infection of cytomegalovirus 8/50 which is 16% the results showed that herpes virus was more infected than the virus above 24/50 and that the percentage was estimated to be 48%. these results indicate that the most common percentage among pregnant women toxoplasmosis& herpes virus cytomegalovirus, rubella).)60%, 48%, 16%, and 8%, respectively. The results have been confirmed by using a technique elisa. Conclusion: we concluded from the study the two most common cause's abortion in pregnant women in basra city southern of Iraq t gondi 60%, herpes virus 48%  Keywords: TORCHT- Toxoplasmosis, R –Rubella C- Cytomegalovirus. H- Herpes simplex virus.
Preparation and Evaluation of Hydrogels Containing Methanolic Extract of Brassica Oleracea ver. Italic Tahir Ansari
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: Herbal medicine usage is increasing nowadays because their usage is acceptable by most people to be safe and produce fewer side effects than synthetic drugs. This present study has been undertaken with the aim to formulate and evaluate herbal gel containing Brassica oleracea ver. italica methanolic extract.  Method: The gel formulation was designed by using methanolic extract of Brassica oleracea var. italica, Carbopol 940, propylene glycol, methyl paraben, propyl paraben and required amount of distilled water. PH of skin was maintained by adding tri-ethanolamine drop wise. The prepared herbal gel formulation was subjected to preliminary evaluation such as pH, total phenolic content and total flavonoid content, viscosity, drug diffusion study and anti-inflammatory study.  Result: The result of anti-inflammatory study showed that the gels with extract concentration of 1000 µg/ml have comparable anti-inflammatory activity with the Diclofenac sodium (100 µg/ml).Conclusion: Formulation of gel containing B. oleracea var. italica extract is a good attempt as herbal formulation has high demand in the market.Keywords: Brassica oleracea var. italica, Carbopol 940, Hydrogel.
Evaluation the Fractions from Extract Ethanol Psidium Guajava Leaves on Total Phenolic Content, Antioxidant Activity and Its Antibacterial Activity of Staphylococcus Aureus. Mustofa Ahda
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: The aims of this research to find the potential extract and fraction from ethanol extract of Psidium Guajava L for natural antioxidant and antibacterial. The extract and fraction of Psidium Guajava L was analyzed the phenol total content, antioxidant activity and its antibacterial. Methods: The ethanol extract of Psidium Guajava L was extraxted using n hexane, ethyl acetate and water. The all fraction and ethanol extract of Psidium Guajava L was determined the scavenging activity, penolic compound. The scavenging activity was determined by DPPH method. The phenolic compound was determined with Folin-Ciocalteu method. Results: The result of this research showed that the fraction of ethyl acetate has highest antioxidant activity with the value is 9.07 µg/mL. It is also supported by the result of screening phytochemical that ethyl acetate fraction contains mostly complete of chemical substances. However, The highest total phenol content was found in water fraction with phenolic content of 26%. The anbacterial activity of ethanol 96% extract of Psidium guajava leaves and ethyl acetate fraction have a highly activity to inhibit the Staphylococcus Aureus. Conclusion: The fraction of ethyl acetate has a highest of antioxidant activity, although it doesn’t have highest of total phenolic content. The highest of total fenolic content from water fraction is 26%. The scheme of antibacterial activities potential of Guajava extracts are ethanol 96% extract = ethyl acetate fraction > n-hexane fraction = water fraction
Several Parameters of Blanching and Drying Influencing to Quality of Dried Pumpkin Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Is one such plant that is frequently being used as food as well as traditional medicine for long days. It is a large climbing herb, annual or perennial, for use as vegetable as well as medicine. It contains several phytochemicals including alkaloids, flavanoids, phenols, carbohydrates, tannins, saponins, terpenoids and proteins.  The presence of these phytochemicals has been found to possess various medicinal functional functions which are essential in the management of various diverse ailments.  Pumpkin has gained a considerable attention in recent years for its nutritional and health promoting values. Drying is a relatively simple process in which water activity in food is reduced, minimizing or inhibiting the chemical and enzymatic reactions and microbial growth that are responsible for its deterioration. Therefore, objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to β-caroten (mg/100), vitamin C (mg/100g), rehydration capacity (kg moisture/kg d.s.), sensory score of the dried pumpkin (Cucurbita spp.). Results showed that pumpkin (Cucurbita spp.) should be blanched in hot water 95oC at 10 seconds in the present of citric acid 4g/l and then beeing dried by heat pump dryer at 50oC until 12% moisture. Blanching is carried out to improve food quality by inactivating enzymes, reducing microorganisms and preserve the natural color when pumpkin after blanching is subjected to drying. The final dried pumpkin was shelf-stable for a period of 12 weeks at ambient temperature without any appreciable adverse changes in physico-chemical as well as sensory quality characteristics of the dried products.Keywords: Pumpkin, Blanching, Drying, β-caroten, Vitamin C, Rehydration capacity.
Technical Factors Affecting to Production of Dried Roasted Pumpkin (Cucurbita) Seed Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Pumpkin seeds are covered by a white husk. Pumpkin seeds are subtly sweet and nutty with a malleable, chewy texture. The seeds of pumpkin are rich in oil and nutrients. Pumpkin seed has been considered as beneficial to health because it contains various biologically active components. It lowers cholesterol level in blood. Drying and roasting are the most important processes giving neccessary alterations to the product.  Roasting can enhance flavour through caramelization on the surface of the food. There was no any research mentioned to varify the change of antioxidant (tocopherol) during infrared drying as well as storage. So the objective of the present study was to identify the effect of temperature in infrared drying, roasting condition, packaging and storage to antioxidant (tocopherol) in the dried Pumpkin (Cucurbita) seed. Results demonstrated that drying temperature (42 oC), roasting (155 oC in 4 min), vaccum packing in polyethylen (PA) bag and keeping in 4 oC were recommended to maintain the tocopherol, total phenolic and antioxidant activity in the final products for 12 weeks. The effect of drying, roasting temperature and time were clearly demonstrated to produced dried roasted pumpkin seed.Keywords: Pumpkin, Drying, Roasting, ANTIOXIDANT, tocopherol, Vaccum.
A Review of Probiotics Role in Enhancing Sperm Quality Andrian Fahmi Bahar
Journal of Global Pharma Technology Volume 11 Issue 01.
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Introduction: Probiotics have been used widely in medical world, but its use in infertility, especially in male infertility, is yet still unbeknown. The aim of this paper is to review the usefulness of probiotics in enhancing sperm quality in order to treat male infertility. Methods: Narrative review on literature surfing in the Pub med database, as well as  key words, that is probiotic, Lactobacillus, sperm quality, male infertility, sperm motility, sperm concentration, sperm morphology, sperm DNA fragmentation. Results: The results on literature surfing are mainly yielding to the positive effect of probiotics in enhancing sperm quality in animals, and in human, although there are some literature that shows conversely. The production of Gamma-Amino Butyric Acid and antioxidants by the probiotics are thought to be the main mechanism for the improvement of the sperm quality, especially in the enhancement of the sperm concentration, motility and the decrease of the DNA fragmentation. Contrarily, negative results left another mystery for researchers to solve. Conclusions: Although the probable mechanisms of probiotics role in enhancing sperm quality have been unveiled, still more researches should be performed to find more evidence in this issue.Keywords: Probiotic, Sperm quality, Sperm motility, Sperm concentration.
Variable Parameters Affecting to Nile Tilapia (Oreochromis Niloticus) Fish-Paste Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Tilapia has emerged as one of the most cultivated and marketed species in Vietnam. There is not much research mentioned to processing of fish-paste of this valuable fish. In order to improving the added value of this fish, we investigated a production of fish-paste from Nile tilapia (Oreochromis niloticus). By investigation different parameters probably affecting to gelation, the results was noticed that the best physicochemical properties and sensory characteristics of fish-paste would be obtained by the addition of modified starch 1.5%: guar gum 1.5%. These results demonstrated that the addition of modified starch and guar gum in the formulation of Nile tilapia fish-paste increased the nutritional value of the product without reducing its sensory preference.Keywords: Nile tilapia (Oreochromis niloticus), fish-paste, Modified starch, Guar gum, Physicochemical properties.
Investigation of Star Gooseberry (Phyllanthus Acidus) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

The star gooseberry fruit is pendulous, bear in small clusters from the branches, round or slightly flattened at the poles. Gooseberry fruit is rich in antioxidants including ascorbic acid and phenolic compounds. It is an important herbal medicine due to its effective antiviral activities. Effect of primary fermentation temperature (26oC, 28oC, 30oC, 32oC), sugar to pulp ratio (4, 8, 12, 16% w/w), Saccharomyces cerevisiae inoculation (1.0 x 108,1.5 x 108, 2.0 x 108, 2.5 x 108 cfu/g) on ascorbic acid (mg/ 100 mL), total phenolic content (mg GAE/ 100 mL) and total flavonoid (mg CE/ 100 mL) content of Phyllanthus acidus wine were thoroughly investigated. The aging (1, 2, 3, 4 weeks) was also examined to improve the turbidity (mJ/cm2) and sensory score of wine. The optimal conditions for fermentation of Phyllanthus acidus juice should be conducted at 12 days of primary fermentation with 12% of sugar supplementation inoculated with 2.0 x 108 cfu/ml of Saccharomyces cerevisiae and 4 weeks of aging to get pleasant physico-chemical characteristics of Phyllanthus acidus wine. Phyllanthus acidus wine was red-pink, clear and transparent. This present study revealed that horticulture farmers would get more added values from Phyllanthus acidus fruits not only by local commerce but also processing. It could be processed by fermentation and conversion into high valued wine.Keywords: Phyllanthus acidus, Wine, Fermentation, Sacchromyces cerevisiae, Ascorbic acid, Phenolic, flavonoid.

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