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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 81 Documents
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Search results for , issue "Volume 11 Issue 03" : 81 Documents clear
Influence of Staphylococcus Aureus on the Oral Candida Albicans Mouna Akeel Hamed Al-Oebady
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Candida albicans is that the most current isolated from the human body and it consider as a natural part of the commensal microorganisms. The mouth is colonized by many of bacterial species, and it also the relationship between these oral bacteria and C. albicans has been a subject of interest in understanding the event of candidiasis. Many studies have tried to explain the bacteria-fungal relationship within the oral environment; however, few have targeted on the single bacterial species inhibiting growth of C. albicans. Staphylococcus aureus and Candida albicans were isolated and purified from the samples of 50 patients with the fixed orthodontic appliances and PCR was performed to identify this isolated. The microscopic examination and qPCR were carried out to determine the inhibitory impact of S. aureus on C. albicans. This study demonstrated Staphylococcus aureus displayed the strongest inhibitory effect on the growth of Candida albicans. By qPCR assay, all isolated C. albicans were inhibited on the growth by S. aureus in the various periods. Mixed culture experiments also demonstrated inhibitory of C. albicans by S. aureus.Keywords: PCR, Staphyloccous, Candida, Oral cavity.
Spectrophotometric Determination of Ceftotaxime Following Azo Dye Formation with Resorcinol Muthana S. Mashkoor
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A sensitive, selective, rapid, simple and accurate of the spectrοphotometric determination of ceftotaxime in bulk and in dosage forms. This method depend on diazotization of primary amine group of cefotaxime with sodium nitrate and hydrochloric acid followed by coupling with ceftotaxime in aqueous mildly acidic medium to form azo dye a stable orange. Showed obeyed beers law between 0.5- 15 ppm, with molar absorptive 4.4*104L.mole-1.cm-1 at 456nm.Sandells sensitivity 0.008µg.cm-2, limit of detection (LΟD) 0.185ppm and limit of quantification (LΟQ) 0.619 ppm. This method has been successfully applied to determination of ceftotaxime in bulk and in pharmaceutical preparation, tablet with a good recoveries 99.43-100.32 %.Keyword: Cefotaxime, Resorcinol, Diazotization-coupling, Spectrophotometry.
Study Relation of the Fibrinogen and Homocysteine with Coronary Heart Disease Nasir Kareem Dhahir
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Because of wide spread chronic infections, especially in patients who have  the coronary heart diseases (CHD), and by measuring the inflammatory factors as a biomarker related to this disease including, fibrinogen, homocystein, and the relation of the disease with some risk factors such as the age, blood pressure, body mass index and blood sugar. The study was carried out in the Baqubah teaching hospital in a period from (September/ 2017) to (September/ 2018) in patients who are admitted to coronary care unit (CCU), including ( 35 patients with myocardial infarction, 24 males , 11 females), and( 35 patients with angina pectoris, 19 males, 16 females). The both groups are compared with other healthy group consisting of 20 persons (12 males, 8 females). The range of age was (40-70 years).  The principles of method used is by (7 ml) of blood from each patient to estimate the level of serum fibrinogen by using coagulation homeostasis analysis device, and the homocystein is measured by using ELISA technique, and the measuring of the other biochemistry factors by using Cobas Integra 400 plus device. The results of the study showed that, there is a significant value difference  p < 0.05 of fibrinogen, homocystein, body mass index, systolic blood pressure, fasting blood sugar of patients with myocardial infarction and angina pectoris compared to control (healthy), the levels of the fibrinogen and homocystein will elevated with extreme of the age and increase body mass index (BMI), also there is a positive correlation (r=0.04) and in significant value (p=0.70) for homocystein and systolic blood pressure, and the correlation (r=0.08) in significant value (p=0.46) for homocystein and diastolic blood pressure, while the levels of the fibrinogen to systolic blood pressure is(r= - 0.19) in significant value (p=0.07)but the diastolic blood pressure (r= - 0.09) in significant value (p=0.35). Also there is less positive correlation of fibrinogen to blood sugar (r=0.039) in significant value (p=0.71) while there is a negative correlation (r= - 0.04) in significant value (p=0.72) between homocystein and blood sugar. Aim of the study: to investigate the effect of levels of the inflammatory factors involving the fibrinogen and homocystein with relation to coronary heart diseases and study the correlation with other risk factors such as age, blood pressure, body mass index and blood sugar.Keywords: Fibrinogen, Homocystein, Coronary heart diseases (CHD), Body mass index (BMI), Myocardial infarction, Angina pectoris, Blood sugar,  Cardio vascular diseases(CVD).
Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu (II) and Ni (II) Complexes of Flavon Omar H. Al-Obaidi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A new series of Cu (II) and Ni (II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by  magnetic moments and molar conductance in DMSO solution .From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the Hyperchem-6 program for the Molecular mechanics and Semi-empirical calculations. Keywords: Flavone, Metal complexes, Synthesis, Spectral, Theoretical Evaluation.
A Quantitative PCR Approach for Recognizing the Functional Genes Involved in the Degradation of Naphthalene Dioxygenase and Polycyclic Aromatic Hydrocarbons in Contaminated Soils Hanan M. Ali
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Analysis of environmental pollutants is very important aspect; cheap and quick methods to clean-up the environment are required. Therefore, the polycyclic aromatic hydrocarbons (PAHs) and naphthalene dioxygenase (NAH-F/NAH-R) were separated from crude oil from north Al-Rumaila/ Iraq. These compounds were used in different concentrations as degraders that docking the functional genes of each of Aspergillus Niger strain AHBR3, Cladosporium ramotenellum and Penicillium brevicompactum isolate 66 small. The results were showed that the three microorganisms use these compounds as a source of food and energy to degrade the pollutants.Keywords: Pollutants, Polycyclic aromatic hydrocarbons, Aspergillus Niger, Cladosporium ramotenellum, Penicillium brevicompactum
Detection the Infections with Viral Hepatitis C in Suwayrah / Wasit Governorate/ Iraq Humam Kasem Hussein
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Hepatitis C virus (HCV) is worldwide distributed virus which may lead to the death, its responsible for 15-20% of acute hepatitis. Then, most of these cases will progress to chronic infection. IL-8 considered as a good indicator of liver disorder such as liver carcinoma, which is one of the main complication of infection with HCV. Objective: This study was carried out to detect infection of HCV and its association with serum level of IL-8 by ELISA kits.  Materials and methods: Blood specimens were collected from suspected persons who visited Suwayrah General Hospital during the period from March 2018 to September 2018. Blood specimens (5 ml) were taken from them under aseptic conditions and left for 10 minutes for spontaneous clotting at room temperature before being centrifuged (6000 rpm) to separate the serum. Serum samples were kept frozen at –20°C for determination of HCV Abs and IL-8 levels. Results: The results showed that, this virus was detected in 14 male (58.3%) and in 10 female (41.7%). Most age period susceptible to HCV was 21-40 years 14 (58.3%). Level of IL-8 in HCV patients was (210±2.422 pg/ml) which significantly high (p<0.05) than healthy persons was (48±3.241 pg/ml).  Conclusions: Absence of prophylactic procedures especially vaccination make HCV highly infectious and fatal disease. Both genders are under attack of HCV infection. Age period of the individuals associated with the resistance to gain this virus. IL-8 is a good indicator to liver disease such as HCV.Keywords: Hepatitis C virus; Hepatic inflammation; Liver cirrhosis; Hepatocellular cancer and IL-8.
Removal of Three Phenolic Compounds [Polychlorinated biphenyl (PCB 105, PCB 118 & PCB 150)] from Aqueous Solutions by Fiber Palm as a Biosorbent Athraa Hameed Mekky
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

 The aim of this work is to determine the potential of application of palm fiber as a biosorbent for removing of three phenolic compounds[polychlorinated biphenyl (PCB)] (2,3,3',4,4'-Pentachlorobiphenyl PCB 105, 2,3',4,4',5- Pentachlorobiphenyl; PCB 118, and 2,2',3,4',6,6'-Hexachlorobiphenyl; PCB-150 from aqueous solutions. The effect of pH, adsorbent dosage and contact time were investigated. Increase in the pH to neutrality resulted in the increase in the phenolic compounds adsorption capacity. The results showed that the increase in the fiber palm dosage to 0.5g/0.1L significantly increased the phenolic compounds adsorption rates. The adsorption process was fast, and it reached equilibrium in 30 min. contact time. The Freundlich and Langmuir adsorption models were used for mathematical description of the adsorption equilibrium and it was found that experimental data fitted very well to both Freundlich and Langmuir models. These results indicate clearly the efficiency of fiber as a low-cost solution for these compounds in aqueous solutions treatment and give some preliminary elements for the comprehension of the interactions between palm fiber as a bioadsorbent and the very polluting compounds from aqueous solutions.Keywords: Freundlich, Langmuir, Palm fiber and phenolic compounds.
Physiological Effects of Teucrium polium Extract Ameliorates Ovalbumin-Induced Allergy in Rabbits Aleem H.A. Nassar
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objective: This present study aims to evaluation the effectiveness of T.polium extract and compares with oral corticosteroid drug (prednisolone) for reducing signs and symptoms of ovalbumin-induced allergy in rabbits. Also, to detect and confirm the use of T.polium as anti-allergic agent and to weather extent may replace as an herbal therapy instead of oral corticosteroids. Methods : Ovalbumin was used to induce allergy and sensitization challenge was confirmed by the presence of the clinical symptoms of sneezing, wheezing and shortness of breath, chest tightness, changes in the levels of eosinophils, neutrophils, Immunoglobulin E, Interleukin-4. Eight days after allergy induction, Teucrium polium in a dose of (4, 8 and 12 mg/kg) was administrated orally for eight days.  Blood samples were collected at day 15, 30 of the experiment and complete blood count, IgE, IL-4 and levels were determined. Results: showed that ovalbumin could induce sensitivity and significantly increased eosinophils, Immunoglobulin E and Interleukin-4 levels (p≤ 0.05). Oral treatment with Teucrium polium showed a significant decrease in the number of eosinophils (p≤ 0.05) and serum levels of Immunoglobulin E and Interleukin-4 (p≤0.05).  The effects of this plant extract were comparable to those observed in the prednisolone-treated group.Conclusion: Teucrium polium extract have significant results in preventing allergic complications and diminish allergic symptoms especially in asthmatic condition, Also, produced a significant decrease in total WBCs Neutrophils, Eosinophils, IgE and IL 4 on contrast with oral corticosteroid causes dimargination of neutrophils and a significant increase in total white blood cells.Keywords: Teucrium polium; Asthma; Ovalbumin; Interleukin 4 and immunoglobulin E.
Histological and Anatomical Study of Cluster Pregnancy in Abortion Women at Al-Zahraa Teaching Hospital Zainab Sajid Mohammed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The contemporary revision was accompanied at Al-Zahraa-Teaching -Hospital for Obstetrics. This research comprised a histo-pathological study of women distress from cluster pregnancy in Najaf Governorate, who reviewed the obstetrics department at Al-Zahraa-Teaching-Hospital for the period from 1/9/2017 to 5/2/2018.About (10) of women with cluster pregnancies, (5) cases of complete cluster pregnancies and (5) cases of partial cluster pregnancy. The range age of women with cluster pregnancies ranged from (25-15) y. The consequences of the anatomical and histological revision of women with cluster pregnancy showed that there were two types of cluster pregnancies: full cluster pregnancy and partial cluster pregnancy. Also revealed that the placenta and the fetus looked as a block on the fluid-filled bags analogous to the grape cluster where the size of these bags about (8 * 8). It was also distinguished that the fetus and placenta were not distinctive in a clear and completely slanted. However the results indicated for women with partial cluster pregnancy that the fetus and a bulky partition of the placenta appeared in the form of a mass container on the bags filled with liquids, which were in the form of irregular clusters similar to the cluster of grapes, where the size of these bags about (5 * 5) .As noted that the fetus completely mutilated or non-existent but a minor portion of the placenta lingered intact and distinctive.Keywords: Molar pregnancy, Partial molar pregnancy, Abortion woman.
Synthesis, Characterization and Study the Biological Activities of new Schiff Base [5, 5,- (Ethane-1, 2- Diyl) Bis (4- ( 4-Bromobenzylideneamino)-4H- 1, 2, 4- Triazole- 3- Thiol)] and its Complexes with Cu (II), Cd (II), Hg (II) and Ag (I) ions Nada A. Rasheed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A series of coordination compounds of Cu(II), Cd(II) , Hg(II)  and Ag(I) ions with 5,5, -(ethane-1,2-diyl)bis(4-(4-bromobenzylideneamino)-4H-1,2,4-triazole-3-thio), as a ligand has been successfully prepared in alcoholic medium. The synthesized complexes were characterized quantitatively and qualitatively by using: elemental analysis CHNS, FT-IR spectroscopy, UV-visible spectroscopy, 1H and 13CNMR, atomic absorption measurements, magnetic susceptibility, thermal analysis) TG and DTG) and conductivity measurements. This ligand coordinates as a bidentate that to the metal ions through sulphur and nitrogen of (azomethine group) atoms. According to the spectral data, Cu(II)- complex has coordination of 6 with octahedral geometry while the Cd(II)-complex and Hg(II) have coordination of 4 with exhibited tetrahedral ,and the Ag(I)-complex has coordination of 3 with exhibited trigonal planer ,  The Schiff base and its metal complexes have been screened for antimicrobial activity against four  bacteria, namely :(Staphylococcus aureus, , Streptococcus sp. , Klebsilla Pneumonia  Escherichia coli )and the  fungi, namely ( Aspergillus flavus ) .Keywords:  Triazole complexes; Schiff base-triazole; Biological activity.

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