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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 04." : 74 Documents clear
Various Technical Parameters Influencing to Production of Polyscias Fruticosa Tea Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Polysicas fruticosa is available throughout Vietnam. This plant species contains large quantity of saponin. We have identified some basic chemical components of the leaf Polyscias fruticosa as moisture, ash and saponin content. On that basis, we chose the initial drying of the raw material with a vacuum drying method, the drying temperature of 50oC, for 6 hours to achieve a humidity of < 13% as required for medicinal herbs; The method of hot extraction in solvents is 70% ethanol with a solid/liquid ratio of 1/8, at a temperature of 70oC and extraction for a period of 1 hour limit affecting product quality. Examining the heavy metals and microbiological indicators of dissolved powders from Polyscias fruticosa, the product has produced standards for food safety as prescribed by the Vietnamese Ministry of Health.Keywords: Polyscias fruticosa, saponin, Drying, Extraction, Ethanol, Powder.
Choledocholithias Ascending Cholangitis and Gallstones Pancreatitis Diyar Ali Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Gallstone ailment is certain over the most frequent yet near high-priced digestive illnesses to that amount require hospitalization within the United States together with an estimated anniversary advise worth of $5.8 billion. Gallstone sickness is newly diagnosed of greater than 1 million people yearly, or cholecystectomy is executed of 700,000 cases. The incidence of gallstones has ethnical variability, with occurrence prices about 10% in accordance with 15% within the United States yet Europe. The medical spectrum concerning cholelithiasis degrees from an asymptomatic state in accordance with fatal complications .Patients any bear asymptomatic gallstones lift an annual hazard about approximately 1% because of biliary colic, over 0.3% for exquisite cholecystitis, concerning 0.2% because of symptomatic choledocholithiasis, then of 0.04% in conformity with 1.5% because of gallstone pancreatitis (GSP). These small percentages, however, signify a considerable quantity about patients, attached the common incidence about gallstones.
Behavioral Factors Affecting Patient's Compliance in Consuming Anti-diabetic Oral Drugs Liza Pristianty
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Treatment compliance is a major problem in overcoming diabetes mellitus. This case inhibits the achievement of optimal levels of health for people with diabetes mellitus. However, various types of factors that enable patients to be disobedient to treatment have not been widely studied in terms of pharmacy. Objective: This study aimed to identify behavioral factors that influence diabetes mellitus patient compliance in taking oral antidiabetic drugs. Methods: This study was observational analysis using cross-sectional design. Sampling was obtained by accidental sampling method. The independent variables in this study were the knowledge and attitudes of patients; availability of health care facilities, and behavior of pharmaceutical officers. Whereas, the dependent variable was the compliance of the patients with diabetes mellitus taking antidiabetic drugs. Data were collected using valid questionnaires then analyzed using correlational analysis. Results: The results of this study indicated that the support of pharmacists had significant effect on patient compliance (p = 0.006). Whereas, knowledge, behavior, and availability of health service facilities had no significant effect on patient compliance in taking oral antidiabetic drugs (results in sequence: p = 0.642; p = 0.379; p = 0498). Conclusion: The role of pharmacist is very important in efforts to provide information and motivation for the treatment of diabetes mellitus, especially the consumption of oral antidiabetic drugs. This research is expected to improve pharmacy services related to the accuracy of providing information to patients. It will also have an impact on improving the quality of life of patients and providing quality services.Keywords: Behavioral factors, Diabetes mellitus, Patient compliance.
Studies on Anti-Inflammatory, Antioxidant and Free Radical Scavenging of Cu (Ii)-N-Acetyl-Para-Aminophenol (APAP) Based Complex Ouiza HAMRANI
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

N-acetyl-para-aminophenol (APAP) or paracetamol–copper based complex with [Cu(APAP)2(OH)2.H2O] formula and noted Cu-APAP has been synthesized and characterized on the basis of elemental analysis, conductivity, IR and thermal (TG/DTG), NMR and electronic spectral studies. The value of molar conductance of the complex indicates a non-electrolyte nature.The antimicrobial activity of the complex was evaluated against several pathogenic microorganisms to assess its potential. The copper complex was found to be more active against Gram-positive than Gram-negative bacteria. The pharmacological and toxicological ability of the complex were equally explored. The results are compared to those obtained with the unbound drug molecule.The metal complex has been tested for antioxidant and catalase-like activity in order to assess its catalytic properties. The results are encouraging.
ART in Indonesia: A Current Review of Ethics cinta ayu abutari
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Currently, Assisted Reproductive Technology (ART) programs such as intrauterine insemination (IUI) and in vitro fertilization (IVF) are developed in Indonesia. As a religious country, the implementation of ART programs raises a variety of ethical issues and religion reactions such as sperm or oocyte donor was haram, sperm from the deceased husband, a sinful masturbation, surrogate mother was Zina, gender selection by human, man assumption as God to decide which embryo be transferred and to create life. Some specific religious organizations provide statements regarding this matter based on scriptural studies and the opinions of their respective religious leaders. Confucianism allows sex selection, while other religions refuse. Hindu and Buddhist allow all ART program, while Catholic declare rejection to all ART program. Islam allows ART programs, without sperm and oocyte donor or surrogate mother. This difference in views is mediated by government regulations that support ART programs but are still limited by legal marital status. The state provides government rules on the implementation of the ART program in Indonesia, although every spouse is allowed to follow their beliefs. In conclusion, ART programs were allowed by most of the religions in Indonesia, as long as not involve the third party as the donor.
Technical Factors Influencing to Instant Powder from Strawberry (Fragaria) Juice N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Strawberry (Fragaria), a rich source of phytochemicals (ellagic acid, anthocyanins, quercetin, and catechin) and vitamins (ascorbic acid and folic acid), has been highly ranked among dietary sources of polyphenols and antioxidant capacity. Bioactive compounds in strawberry revealed high abundance of anthocyanins, flavonols, flavanols, and cinnamic acid.  To increase strawberrys popularity and expand their use in the food industry, it’s neccesary to explore the appropriate postharvest handling and storage.The aim of this work was to study the feasibility of spray drying of strawberry juice juice. Various characteristics of spray-dried fruit juice powders are well affected by spray-drying conditions including inlet air temperature, out let air temperature, feed flow rate, drying carrier agent. Results revealed that inlet/ outlet spray drying temperature (155oC: 85oC), speed flow rate (12 ml/ min), γ‐cyclodextrin: maltodextrin (4: 6 % w/v) were appropriated for spray drying of dried strawberry powder from its juice. The spray-dried product of γ‐cyclodextrin-maltoxetrin-strawberry juice was considered to be the good technique to dry strawberry juice on the result of phytochemical determination, physical and chemical properties and antioxidant activity. Value addition of strawberry juice has been created by changing in the physical form of the agricultural produce which leads to its greater acceptability, extended availability, enhanced market viability and increased cost to benefit ratio for the grower of the strawberry produce.Keywords: Strawberry juice, Spray drying, Dried powder, Inlet air, Out let air, Speed flow rate, γ‐cyclodextrin, maltodextrin.
Fabrication of PS/PMMA/MgO Nano Composites: Structural and Optical Properties as Coating Materials for Antibacterial Applications Ahmed A. Auda
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Optical properties of P.S.P.M.M.A. polymer composite with doped MgO nanoparticles have been studied. The composite study was prepared by the solution of casting. Various concentrations were used for polymer material P.S- P.M.M.A/ (75 %-25 %). The weight ratios for Nano material (MgO) were 0 %, 2 %, 4% and 6 % of the total weight for the 1g sample. The optical spectrometers were measured at a wavelength of 220 nm-890 nm using a FTIR device optical properties of PS such  as  absorbance,  transmittance, absorption  coefficient, refractive  index,  extinction  coefficient,  real   and  imaginary  parts  of dielectric constant have been investigated. The results of the test on the refractive index, the attenuation coefficient and the insulation constant in its real and imaginary parts give good results with increasing the concentration of nanoparticles. The composite materials of polymer and nanoparticles were applied as antibacterial to Pseudomonas bacteria and they give the concentration (0.02 and 0.04 MgO) a good effectiveness to those bacteria.Keywords: Optical properties, Polystyrene, PMMA, Pseudomonas Bacteria.
Proapoptotic Effect Annona muricata Leaf Extract on HT29 Colon Cancer Cell Abdullah Kshidan M
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The occurrence of colon cancer has rapidly increased across the globe and currently ranks among the third highest disease difficult to treat with drugs. Therefore, there is need for the use of natural compound in its treatment. Graviola (Annona muricata) leaf has several anti-apoptosis and proliferation active compoundswhich make the colon cancer induced by constitutive activation of NF-KB. This experiment therefore, utilized leaves of Annona muricataextracts obtained from Materia Medica in Batu. The leaves were found to inhibit cell proliferation by MTT assay and also induced apoptosis by Annexin V and Flowcytometry with the ability to inhibit NF-KB expression present in nucleus cells. The crude extract of Graviola leaves inhibits cell proliferation and increases apoptosis and through the inhibition of NF-KB pathway. It also increases the apoptosis of HT29 cell.
Expression relative of RANK, RANKL and OPG gene on Rat Femoral Fracture Healing Process in Delayed Union Model after Pulsed Electromagnetic Field exposure Luluk yunaini
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Pulsed electromagnetic field (PEMF) is application medical devices in healing bone fracture. Osteoblast and osteoclast cells have regulation in femoral fracture healing process. PEMF exposure has effect in cell nucleus activity. Genes that have critical role in bone remodelling are Receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG).This research aimed to analysis effect PEMF exposure in improve bone fracture healing process with delay union model, which its expression level in RANK, RANKL and OPG gene. Our research used experimental design. Sample for this research was callus from rat femoral fracture with delay union. qRT-PCR technique with Livak’s measurement were used to detection expression relative. Statistic analysis used two way ANOVA with a significant differences value p <0.05. The result showed that relative expression on RANK, RANKL and OPG have significance different in PEMF group and times (days) group. We found that the PEMF group can expedite the higher expression relative of RANK, RANKL and OPG than non PEMF group. The result has concluded using PEMF can improve the healing to normal union process on rat with delay union model.
The Effects of Methane Storage Capacity Using Telmisartan Organotin (IV) Complex Emad Yousif
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The fabrication of porous dibutylorganotin (IV) complex as methane storage was successful. Interesting physiochemical properties for diorganotin (IV) complex were observed using a combination of several techniques such as scanning electron microscopy, Brunauer–Emmett–Teller and nitrogen adsorption–desorption isotherm, Barrett–Joyner–Halenda and H-sorb 2600 analyzer. The mesoporous complex exhibit tunable porosity with Brunauer–Emmett–Teller surface area (SABET = 130.357 m2.g-1), pore volume (0.162 cm3.g–1) and narrow pore size distribution; the complex was found to has high physico-chemical stability. At 323 K and 50 bars, the complex has methane uptake (up to 1.116 cm3·g–1). The field emission scanning electron microscopy images, at different 100 and 50 µm magnification powers were confirmed, the morphological images of the polymeric film showed a rough surface.  Keywords: Gas storage; Methane capture; Diorganotin (IV) complex; Field emission scanning electronic microscope.

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