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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 93 Documents
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Search results for , issue "Volume 11 Issue 05." : 93 Documents clear
Photographical Assessment of Face Pleasantness using Facial Analysis for a Sample of Iraqi Adults Females (Retrospective Study) Shahbaa A. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Aims: The aim of this study was to assess facial attractiveness and to check if the numeric facial analysis can determine this attractiveness for a sample of Iraqi adults' females and characterize the studied sample according to subjective concepts of facial esthetics in esthetically pleasant, esthetically acceptable and esthetically unpleasant, considering frontal photographs.  Subjects and Methods: Forty frontal standardized photograph of females aged between 20 and 22 years old. The frontal photograph and lateral photograph were obtained by asking each female to look to the center of the lens and at a distant mirror respectively which is placed in front of her face. All the frontal photographs were evaluated by using our own esthetics criteria (orthodontist evaluation) as graduation in: pleasant, acceptable and not pleasant. The numeric facial analysis was then performed. Linear, proportional and angular measurements were compared among groups. Results: The sample was consisted of 25% of unpleasant, 55% of acceptable and 20% of pleasant according to subjective analysis.  In most measurements there were no differences among groups. Just in one linear measurement (sn-U1 FILS) significant statistical difference was observed. Group III has higher right and a left symmetry angel despite it has lower facial symmetry Conclusions: In the evaluation of facial measurements, it was observed that there were statistically non-significant except for the sn-U1 FILS, which is statistically significant. The photographic evaluations require more than one evaluator in different specialties to give more reliable judgment. The facial analysis influenced by, age, gender, cultural and racial factors.Keywords: Attractiveness, Facial esthetics, Facial analysis.
Hospitalized Adults with Acute Bacterial Meningitis: Etiology and Antimicrobial Susceptibility Profiles Zainab Khamees Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Eeffective management of acute bacterial meningitis depending on the diagnosis of bacteria that cause disease, as well as, identification of the effective antibiotic or antibiotics against most of these causative agents, the objective of this study was to detect the causative agents of acute bacterial meningitis isolated from C.S.F of inpatients adults. Since June 2017 and July 2018; 135 C.S.F. specimens were collected, 53 (39.26 %) were positive for C.S.F culture, and 71 specimens were negative. Of 53 acute meningitis patients, there were 66% male and 34% female, predominant causative agents was S. pneumoniae (20.8%), followed by N. meningitides (18.9%) and K. pneumoniae (15.1%). Antimicrobial susceptibility profiles differ depending on the causative agents, the results shows a high sensitivity to Amikacin, Vancomycin, Gentamicin, and  Ciprofloxacin, S. pneumoniae were high sensitive to Vancomycin, Gentamicin, Chloramphenicol, as well as, Ciprofloxacin, While H. influenzae  and N. meningitides exhibited considerable susceptibility to Chloramphenicol.Key words: Meningitis; C.S.F; Antibiotics.
Detection of Candida albicans in Females Urinary Tract Infection by using Microscopical and Cultural Methods of Urine Samples in Kirkuk City - Iraq Burhan A. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Candiduria is an infectious condition worldwide distribution as a primary infection of human urogenital tract caused by Candida albicans predominantly. Increasing of urinary tract infections with Candida species has led to antifungal resistant conditions as a common problem of women specifically among pregnant women. This study is an attempt to show the incidence of Candida albicans among women attending gynecology clinical in Kirkuk General Hospital in Kirkuk city, by microscopically technique and urine inoculation into Sabouraud Dextrose Agar. Methods & Materials: In this study, one hundred and seventy-four midstream urine samples from women patients of gynecology clinical in Kirkuk General Hospital were collected. All the subjects were clinically assessed for studying C .albicans infection, and then inoculated on Sabouraud Dextrose Agar. Results: The highest percentage of infection of C. albicans was 38(52.8%) of the positive patients and in relation to the patients pregnancy status, C. albicans infection revealed a prevalence of 36(53.7%) higher than 2(40%) for the non-pregnant patients with abnormal general urine examination in age group 27-36 years respectively. Conclusions: The study revealed that the prevalence of Candidal urinary tract infections (UTIs) among the younger reproductive age of the pregnant women was higher than that of non-pregnant women and the Candida albicans was the most common Candida species causative agent of the urinary tract Candidiasis.  Keywords: C. albicans, Microscopical, Culture Methods, UTI.            
Physiological Study about Rosuvastatin and Lovastatin as Compared with Quercetin in Rats (Rattus norvegicus) Wissam Sajid Hashim
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study was accomplished to compare the role of the flavonoid quercetin with some antihyperlipidemic drugs rosuvastatin and lovastatin on lipid profile and other serum parameters of rats. In this study, five groups of eight male rats each were used. The groups were allocated as: control, cholesterol, rosuvastatin, lovastatin and quercetin groups. The animals of the control group were maintained on standard diet, while other groups were maintained on cholesterol diet 15mg/kg of diet and dosed orally and daily as follow: rosuvastatin 20 mg/kg body weight, lovastatin 15 mg, and quercetin 100 mg respectively. The results revealed that rosuvastatin and lovastatin could lower lipid profile but still significantly higher than control group while quercetin lowers them without significant difference with control. The liver enzymes were elevated by statins and they were normal and without significant difference in case of quercetin comparing with control group at (P≤0.05).Key words: Quercetin, Rosuvastatin, Lovastatin, Lipid, Rats.
Synthesis, Characterization and Spectral Studies of Azo Dyes Ligands Complexes with Some Metal Ions and Their Industrial and Bacterial Application Wedian Mansor Obaid
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

1-[4-(4-Acetyl-2-hydroxy-phenylazo)-phenyl]-ethanone (HL1) and1-[3-Hydroxy-4(4-nitro-phenylazo)-phenyl]-ethanone (HL2) were produced by combination the diazonium salts of amines with 3-hydroxyacetophenone. (C.H.N) analyses, FT-IR, UV-Vis, 1H and 13CNMR spectral are use to identified for the ligands. Complexes for Zn+2,Cd+2 and Hg+2 were prepared as well specified through using atomic absorption of flame, analysis of elements, spectral methods also conductivity quantification. The nature of production complexes were studied continued mole ratio as well continued variance ways, Beer's law followed over condensation scope (1×10-4- 3×10-4)M. High molar absorption for compound solutions have been noticed. Analytical datum showed that in every the complexes offered 1:2 metal-ligand ratios. Depending physicochemical data a tetrahedral geometry were described of the metal chelates. Biological efficacy from compounds has been tested. Other than, dyeing completed of the produced compounds has been workable on fabric of cotton.Keywords: Complexes, azo dyes, microbial activity, dyeing.
Investigation of Antibacterial Activity and Cytotoxicity of ZnO nanoparticles Synthesized by a Novel Biological Method Shurooq S. Mahmood
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

This research explains the biosynthesis, characterization, evaluation of the antibacterial activity and cytotoxicity of zinc oxide nanoparticles (ZnO NPs) prepared by a low-cost and simple procedure. Bio-inspired ZnO NPs were synthesized with the aid of a novel, non-toxic, ecofriendly biological material namely; Banana peels extract (BPE). Qualitative phytochemical screening of the aqueous fruit peels extract of Banana revealed the presence of many phytocomponents in it. The structural, morphological and optical properties of the synthesized nanoparticles have been characterized by using UV–Vis spectrophotometer, XRD, FE – SEM with EDX analysis, AFM, and FTIR. The synthesized ZnO NPs were characterized by a peak at 373 nm in the UV–Vis spectrum. The XRD of the sample revealed the hexagonal wurtzite structure with an average grain size 11.98 nm. Particle shapes and sizes were determined by FE-SEM. Surface morphology of the sample was studied by AFM. FT-IR confirmed the presence of functional groups of both leaf extract and ZnO NPs. The results showed the antibacterial activity of the ZnO NPs against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). The cytotoxicity of ZnO NPs was tested against vero101 normal cell line and skin A431 cancer cell line by Crystal violet (CV) assay. Banana peels mediated ZnO NPs showed no evidence of toxicity against normal cell line, the nanoparticles are biocompatible and are non-toxic and effective cytotoxic effect against cancer cell line. These results clearly support the benefits of using a biological method for synthesizing ZnO NPs with anticancer activities.Keywords: Zinc Oxide NPs; Biosynthesis; Banana peels extract (BPE); Phytochemical; Antibacterial; Cytotoxicity
Biological Control of Fungal Brown Spot Disease in Rice Plants by Streptomyces spp. Farqad Fathi Hasan
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

This study used thirty isolates of streptomycetes were isolated from different locations of soil. All these isolates were subjected for antagonistic test (as biological control agents) against Brown spot fungus Bipolaris oryzae. About 43% of  tested  streptomycetes  isolates  gave  antifungal  activity  against Brown spot fungus but 57% of  tested  organisms  did  not  reveal  any  antifungal  activity. The highest antifungal activity were obtained from two isolates (42 mm and 45 mm), both streptomycetes isolates were identified according to International Streptomyces Project (ISP) based on morphological (macroscopic and microscopic) and physiological characterization as Streptomyces orientalis and Streptomyces exfoliatus.Keywords: Biological control, Streptomyces orientalis, Streptomyces exfoliatus, Bipolaris oryzae, Brown spot disease.
Efficiency of a High-dose Intravenous Immunoglobulin Therapy in Children with Autism Spectrum Disorders Associated with Genetic Deficiency of Folate Cycle Enzymes Dmitry V. Maltsev
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Previously, it has been repeatedly reported on the effectiveness of intravenous immunoglobulin therapy in some children with autism spectrum disorders without specifying selection criteria of potential responders to immunotherapy. Objective: to evaluate high-dose immunoglobulin therapy efficacy and safety in children with autism spectrum disorders and genetic deficiency of folate cycle. The studied group consisted of 78 children aged 2 to 10 years who have been on intravenous immunoglobulin at a dose of 2 g/kg per month for 6 months. The control group included children of similar age and gender distribution, which received only non-drug rehabilitation support. The dynamics of psychiatric symptoms were assessed using the Aberrant Behavior Checklist scale. Complete elimination of the phenotype of autism spectrum disorders has been obtained in 21 patients and an improvement was marked in 33 children of study group. In parallel, positive dynamic of other clinical manifestations of folate cycle deficiency phenotype was evaluated: PANDAS (19 out of 21), epilepsy (29 out of 36) and gastrointestinal (in 49 out of 68 children) syndromes.  Intravenous immunoglobulin has a complex positive impact on the manifestation of a genetic deficiency of folate cycle, including autism spectrum disorders, extrapyramidal disturbances, bowel syndrome, epileptiform brain activity, immune deficiency, and leukoencephalopathy.Keywords: Folate cycle, Intravenous immunoglobulin, Autism spectrum disorder.
Estimation of Some Immunological Parameters Levels in Giardiasis Patients in Al- Najaf Province Jameel Jerri Yousif
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The current study was conducted during the period from August 2017 to April 2018 in the Department of Biology - Faculty of Education for Girls - University of Kufa to measure the level of some cytokines and immunoglobulins in patients with Giardia lamblia parasite in Al- Najaf Province. A total of 923 stool samples from patients, with diarrhea ranging in age from 1 to 60 years were examined with a direct smear and sedimentation methods. The results of the immunological examination were shown using the enzyme linked immunosorbent assay (ELISA) and single radial immunodiffusion (SRID) Plate. IgA, IgE, IgG and IgM concentrations were increased in patients with Giardiasis as 276 ± 32.3 mg / dl, 260 ± 39.3 IU / ml, 576 ± 42.4 mg / dL and 73 ± 17.8 mg / dL , respectively, compared with the control group of 65 ± 22.7 mg / dl, 175 ± 23.3 IU / ml, 365 ± 27.3 mg / dl and 47 ± 14.4 mg / dl, respectively, with a statistically significant difference P <0.05.As well as an increase in concentrations of IFN-γ , IL-4 and TNF-α (284 ± 21.4, 395 ± 27.1 and 443 ± 29.2) pg / mL respectively compared to control group (131 ± 18.7, 345 ± 22.6 and 191 ± 26.6) pg / ml, respectively, with a statistically significant difference P <0.05.Keywords: Giardia lamblia; Cytokines; Immunoglobulins.
Nefazodone Atypical Antidepressant Associated Hepatotoxicity- Drug Induced Liver Injury (DILI) A Possible Genotoxic Effect(s) Mustafa Tariq Sakin
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The atypical antidepressant Nefazodone  used in different concentrations (2.5, 5, 10 µg/ml ) to study its genotoxic effects on HepG2 cell line by using single cell gel electrophoresis assay (Comet) and spectral karyotyping test (SKY).The results showed that Nefazodone causes a significant increment in the  three important parameters (tail length, percent of DNA in tail and tail moment) of comet assay for the three used concentrations in a dose-dependent manner when compared with negative control (p˂0.01). SKY analysis was performed at the concentration of (10 µg/ml). Both the treated and negative control cells showed abnormal chromosomal number (44-54 XY) per cell, common chromosomal rearrangements and other abnormalities in the majority of cells analyzed. As a result Nefazodone has no chromosomal aberration at 10µg/ml and the comet assay results conceder as false positive.Keywords: Nefazodone, Genotoxicity, HepG2 cell line.

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