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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 93 Documents
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Search results for , issue "Volume 11 Issue 05." : 93 Documents clear
Some Biochemical Parameters in Congestive Heart Failure Patients in Baghdad City Suha A. Al-Jowari
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study was designed to study the changes on some biochemical parameters in males with congestive heart failure (CHF). Ninety males with age ranges from (27-73) years have been involved in this study, divided into two groups; the first group involved 65 males with CHF and the second group involved 25 males without CHF from Teaching Baghdad Hospital. The patient's groups were divided according to their age into three groups (less than 40, 40-50 and more than 50 years). Blood samples were collected from each patient and control and used for analysis of renal function parameters, potassium, calcium and liver function. The results of the current study showed a highly significant (p < 0.01) increase in the concentration of blood urea, serum creatinine in HF patients as compared with the control group. While there is non-significant difference in the level of potassium in HF patients compared with the control group. Further, there was a highly significant (p < 0.01) decrease in concentration of calcium in patients group compare with the control. This study also illustrates a highly significant (p<0.01) increase in the liver function parameters which include alanine aminotransferase (ALT) and aspartate aminotransferases (AST) of HF patients compared with the control group. While there is non-significant difference in alkaline phosphatases (ALP) of HF patients compared with control group. There was also significant (P< 0.05) increase in total serum bilirubin (TSB) concentration of HF patients compared with the control group.Keywords: Congestive heart failure, Urea, Creatinine, ALT, AST, ALP, TSB.
Serine and Alanine as Corrosion Inhibitors for 5083 AA in Aqueous Solutions Zainab W. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

By means of potentiodynamic polarization methods, inhibiting the influence of serine and alanine on 5083 AA corrosion in 0.1 mol.dm-3 sodium hydroxide and 140.6 mol. dm-3 NaCl">  over temperature range (298-313) K was investigated. Potentiodynamic polarization results specified that these amino acids functioned as a functional inhibitor in an alkaline environment. The inhibiting efficiency raises as the inhibitor concentration raises. However, it drops as temperature rises. The maximum efficiency value found with alanine was 73 under 298 k and 1410-2 mol. dm-3">  alanine concentration. The adsorption of the amino acids complies with Langmuir adsorption isotherm. Some thermodynamic parameter 14∆Gads">  and activation energy 14Ea">  have been computed to demonstrate the process of corrosion inhibition. The kinetic limitations have been evaluated by means of Arrhenius theorem. An appropriate mechanism has projected for 5083 AA corrosion in alkaline medium. The surface morphology of uninhibited and inhibited samples was investigated using an optical microscope.Keyword: Corrosion inhibition, 5083AA, Amino acids, Free energy of adsorption, Adsorption mechanism.
Thiamine, Riboflavin and Magnesium Level Correction in Improving the Quality of Life of Patients with Chronic Heart Failure Fatima Dzalaeva
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Data are presented on the effectiveness of treating patients with chronic heart failure (CHF) with vitamins B1, B2 and magnesium (Mg) added to the standard complex therapy. The group of patients with cardiovascular diseases (CVDs) consisted of 143 patients with CHF I-III functional class according to NYHA (New York Heart Association Functional Classification), as a complication of coronary heart disease (CHD). To determine the preferred doses of vitamins B1 and B2, we studied the dynamics of the concentration of thiamine (B1) and riboflavin (B2) in blood plasma and their daily excretion with a single intake of vitamins by healthy volunteers at doses of 10, 20 and 30 mg. To determine the preferred magnesium-containing drug, Mg concentration dynamics in the blood plasma of healthy volunteers were studied when taken orally in an equal dose in the form of Mg oxide and in the form of Mg orotate. The study involved 80 healthy volunteers. In order to improve the quality of life for patients with CHF and increase tolerance to physical exertion, it is advisable to add Mg in combination with vitamin B1 and B2 in the standard complex therapy. When Mg salts are added to the standard complex treatment of CHF, it is preferable to use Mg orotate. When using vitamin B1 (thiamine), it is not advised to increase the daily dose of more than 10 mg/day, since this leads to a progressive increase in the excretion of this vitamin B1 and vitamin B2.Keywords: Chronic heart failure, Therapy, Mg salts, Thiamine (B1), Riboflavin (B2).
Preliminary Phytochemical Investigation and Antibacterial Activity Identification of Stems of Calotropis procera Plant in Iraq by GC. MS Estabraq H. Naser
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Calotropis procera is a plant from Asclepiadaceae family. The preliminary phytochemical investigation of C. procera stems exhibit its high contents of flavonoids, alkaloids, saponins, while terpenoids, and reducing sugar are in lower percent. Its previously used in treatment of many diseases such as cough, bronchitis, ascites, asthma, eczema, leprosy, cutaneous diseases, and intestinal worms. GC. MS analysis of stems ethanolic extract showed that the highest percent in 100% ethanolic stems extract belongs to Octadecanoic acid 20.33%, Hexa-hydro-farnesol 6.16%, and Linolenic acid ethyl ester 39.59 while the highest percent in 70% ethanolic stems extract belongs to (-)-Vincadifformine 17.13%, Dodecanoic acid 13.97%, Methyl arachidonate 9.01%, and (+)-α-Tocopherol 6.66%. The others chemical compounds percent range from about 5%-0.3%. The antibacterial activity of stems of Calotropis procera plant compared with streptomycin as standard antibiotic against four different types of bacteria revealed that the ethanolic extracts have no effect on Escherichia coli, and Pseudomonas sp. While these extracts have ability to kill Staphylococcus aureus, and Basillus subtilis bacteria which are more sensitive.Keywords: Usher, GC. MS, Calotropis Procera, phytochemical, Sodom apple, Antibacterial.
Van A Gene for Intestinal Bacteria Enterococcus faecium (E. faecium) Resistant to Vancomycin Venus H. Al-Saffar
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Out of 100 enterococcal strains clinical samples, a total of 59 (59%) Enterococcus faecium (E. faecium), 32 (32%) E. faecalis, 3 (3%) each of  E. casseliflavus, and E. avium, and 1 (1%) each of E. gallinarum, E. flavescens, and E. raffinosus  isolates were recovered, from burn, wound, and urine samples in Al-Hilla teaching hospital were identified to species level with a VITEK-2 system. For detection vancomycin resistance, all of enterococcus spp. isolates were tested by using multiplex PCR for (VanA, VanB, and Van C) genes. Results showed that only 5 isolates were resistant to vancomycin; 2 (VanA) genes were from E. faecium, 2 (VanB) genes were from E. faecalis, 1 (VanC) gene was from E. gallinarum.Keywords: VITEK-2, PCR.
Serum Levels of Zinc, Selenium and Homocystine among Iraqi Patients with Type-2 Diabetes Mellitus Aqeel Abbas Noaman
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background  and Objectives: ( The disease of  Diabetes  Mellitus ) is  a  main  medical,  economic and social   big problem,  because  the  high  pervasion  and increment incidence (of this depilating disease with )subsequent cascading of (several disabling complications) and it needs for special medical care. High prevalence of this disease) occur in Middle East.Its prevalence in Iraq increased from 5% in 1978 to19.7%in 2012). The current study initially focuses on the investigation of serum micronutrients [zinc (Zn), selenium (Se)] and homocystin (Hcy)] levels as well as their relatedness with (type 2 Diabetes Mellitus) in Iraqi patients. Subjects and Methods: This study was designed as a case - control investigation and conducted at diabetic center in Baquba General Hospital in Diayla, Iraq. This study involves 50 patients with type 2 DM and 25 apperently healthy, age and sex matched subjects for that represent as control group. The patients were classified into two sub-groups including, type 2 DM with nephropathy (33 patients) and type 2 DM without nephropathy (17 patients). (Fasting blood sugar, creatinine as well as some selected serum levels including two important micronutrients (Se, Zn) with addition and all of them were measured in each group. Results: The prevalence of DM Type2 was at age of 60 to ≥ 70 years. (Diabetes was more prevalent) in males than in females (58 % ,  42 % consecutively)  .The mean level of blood glucose  and creatinine (were  typically higher in  both diabetic groups) as compared to the control group (p = .000). Selenium level was lower in diabetic patients with a significant difference when it compared with healthy control. Study groups according to zinc level (p-value= 0.149) did not indicate a significant difference. In this study homocysteine levels was)higher in DM patients with nephropathy than diabetes without nephropathy (17.09±1.942 vs 16.72±2.323)  with statistically significant differences comparing  with the control group (6.74±0.946) No significant correlation  was  found among Zn , Se and Hcy with plasma glucose and creatinine. Conclusion: (The findings of the current research show obvious decreased in the serum Se among Type2 DM patients with and without nephropathy comparing with control. Additionally, serum homocystine levels were elevated regarding to the occurrence of diabetic nephropathy so it could be an indicator for observed DM and progression of DM nephropathy.Keywords: Type 2 Diabetes, Zinc, Selenium, Homocysteine.
Study of Some Optical Properties of Poly Methylmethacrylate Copper Nanocomposites Films Nahida B. Hasan
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The addition effect of nano Cu on some optical properties for poly methyl-methacrylate has been investigated. Poly methyl-methacrylate with different weight percentages of nano Cu content and different thickness have been prepared. The wavelength range for which absorption spectra have been recorded is (200-800) nm. For indirect allowed and forbidden transition the absorption coefficient, extinction coefficient and energy gap have been determined. Results show an increasing in absorption coefficient and extinction coefficient and decreasing in the energy gap with the Wt.% concentration of nano Copper. Scanning Electron Microscope (SEM) Measurements certificates the compatibility between various components of the polymers and nano materials through the detection of phase separations and interfaces. All figures show the very detailed three-dimensional images at very high magnifications for all films.Keywords: Polymethyl-methacrylate, Nanoparticles, Nano-composites.
Photocatalytic Oxidation of 2-Butanol over Co3O4-Al2O3 Spinel Catalyst Hussein I. Ismael
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The catalyst Co3O4-Al2O3 was prepared by co precipitation methods in different ratios (40: 60, 50: 50, 60: 40,70:30) for the mixed oxides respectively, these ratios were calcinated at 550 °C for 4hours and characterized by using powder X-Ray Diffraction, Fourier transform Infrared spectroscopy. These catalytic activity were investigated in photo oxidation of 2-butanol by using 0.2g.of Co3O4-Al2O3 in different times (0, 15,30,45,60 and 75 min). The result showed that the best ratio gives high activity was 40:60 at 25 °C.  The resultant 2-butanone was measured spectrophotometrically at λ maximum=285nm and estimate this concentration depending on the calibration curve of 2-butanone.Keywords: Cobalt Oxide, Photooxidation of 2-butanol.
Synthesis and Spectroscopic Study of 3-Hydroxy-2-(3-(4-Nitrobenzoyl) Thiouriedo) Propanoic Acid with their Metal Complexes Abbas M. Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

A new ligand 3-hydroxy-2-(3-(4-nitrobenzoyl) thiouriedo) propanoic acid (NTP) where synthesized by reaction of 4-nitro benzoyl isothiocyanate with serine amino acid. The ligand was characterized by FT-IR, NMR spectra and the elemental analysis. The transition metal complexes of this ligand where synthesize and characterized by UV-Visible spectra, FT-IR, magnetic suscpility, conductively measurement, The general formula [M (NTP) 2] where M+2= (Mn, Co, Ni, Cu, Zn, Cd, Hg,), the form of molecular for these complexes as tetrahedral except Cu has square planer.Keywords: Serine, 4-nitrobenzoyl isothiocyanate, Transition metals.
The Role of Levan Produced from Pseudomonas fluorescens as Antipathogenic Substances and Phagocytic Enhancer against Some of Bacterial Isolates Alaa Raheem Kazim
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Levan is a natural substance that produced from many organisms, levan recognized as a homopolysaccharide with multi-functional features and a wide range of potential industrial applications. Pseudomonas fluorescens had the capacity to produce levan in the total absence of air which exhibited broad antibacterial spectra against foodborne pathogenic bacteria.  The results showed that three isolates of bacterial isolates were classified as a member of Pseudomonas fluorescens with antibacterial activity when tested against various pathogenic bacteria; levan has antibacterial activity against Staphylococcus. aureus, E.coli and Listeria but it had no activity against Salmonella  typhi, the results showed that levan increased phagocytic activity, The phagocytic index against S.aureus increased in the presence of levan in compared with control (without levan). The phagocytic index was (65%) when used levan in concentration (200µg ∕ ml|) while the phagocytic index was (40%) in control (without levan).Keywords: Levan, Antimicrobial activity, FT-IR, Pathogenic bacteria, Phagocytic index.

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