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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 93 Documents
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Search results for , issue "Volume 11 Issue 05." : 93 Documents clear
Protective Role of Propolis against Iron Overload Induced Genotoxicity and Oxidant/Antioxidant Status Mjida A.J. Al-Qayim
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The current study designed to investigate the protecting role of propolis in DNA damage  and oxidaant / antioxidant imbalance caused by  iron overload. 24 adult male wister rats divided in to 3 equal groups and handled as following: 1st group(C) as control, 2nd group, IO) group IP iron dextran 100mg/ kg BW each 72 hr. 3rd (IOP) given IP iron dextran 100mg/ kg BW each72 hr. and orally Propolis crude extract (50 mg /kg body weight) daily for two months. Results revealed that administered rats with propolis showed enhancement in oxidant/anti-oxidant indicators, categorized by raise of GSH, and MDA reduction on the contrast with IO group. Propolis adiminstration to IO  rats  decreased the  DNA damage and fragmentation. Conclusion, the present results are established for the first time a new role for the Propolis, in counter and reduce the iron overload harmful effects on DNA mainly via modulation of oxidant status in IO.
The Association Between the Severity of Diabetic Peripheral Neuropathy and Diabetic Risk Factors in Diabetic Patients Type I and II. Sarah Ali Alkindy
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Back ground: The diabetic risk factors can effect on the severity of diabetic peripheral neuropathy (DPN). The most risk factors have an effect on the peripheral nervous system are duration of diabetic disease, glycocelated hemoglobin (HbA1C) and type of diabetes (DM type). Objectives: To determine the association between severity of DPN and duration of diabetes, HbA1C, the type of diabetes, age and sex of diabetic type I and II patients. Patients and Methods: Three hundred individuals were participated in cross sectional study. They divided to two groups labeled as A and B. Group A regarded as diabetic patients with abnormal neurological examination. Group B regarded as diabetic patients with normal neurological examination. About 68 male and 82 female were participated in this study for each group.  The age of participant are grouped as <18, 18-30 and 31-60 year. The full history was taking from participants including socio demographic data and duration of disease with type of diabetes. All participants with type I and II underwent clinical assessment and biochemical investigation. The clinical assessment used Toronto clinical scoring system (TCSS) for screening diabetic peripheral neuropathy (DPN). The biochemical investigation was done for determining the level of HbA1C. The study was carried out at Marjan teaching hospital and Al Sadeq teaching hospital in Babylon province during the period from Aug.2017 to Sep.2018.Results:TCSS used for scoring the DPN to mild, moderate and severe. The severity of DPN show significant association with duration of DM disease,  type of diabetes , the level of HbA1C and age of diabetic patients, the P value about o.oo1, 0.02 , 0.001 and 0.001respectively. The sex of  diabetic patients showed no significant association with severity of DPN, the P value 0.45.Conclusions: There is higly association between severity of DPN and DM duration, HbA1C , type of DM and age of diabetic patients. There is no association between sex of diabetic patients and severity of DPN.
Detection of Fima and Fimh Genes in Klebsiella pneumoniae Isolated from Necrotizing Enterocolitis Patients in Infants Luma Abdalhady Zwain
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Sixty-four clinical isolates were collected from the children's protection hospital by Medical city in Baghdad for children infected with Necrotizing Enterocolitis where included (41) samples belong to stool and (14) samples belong to blood and (9) samples belong to urine for the period of 29/1/2018 to 4/4/2018. All the samples were cultured on MacConkey agar and Blood agar for the purpose of diagnosis.  All isolates were identification depending on macroscopic, microscopic, biochemical tests and definite with Vitek-2 compact system, forty three isolates were obtained from all samples, (26) isolates as K. pneumoniae (60.46%) and 8 isolates as E. coli (18.60%) and 4 isolates as P.aeruginosa (9.30%) and 2 isolates were K.oxytoca (4.65%) and 2 isolates were E. cloacae (4.65%) and 1 isolates was P. hauseri (2.32%). The results showed that K. pneumoniae was the predominant in the samples which taken from infants infected to Necrotizing Enterocolitis. In these study, oame of virulence genes have been investigated for K.pneumoniae included both fimA and fimH gens which encodes for the fimbriae adhesion protein that belonging to type 1 fimbriae named Fim protein, and the results showed presence of fimA and fimH genes (100 %).Keywords: Klebsiella pneumoniae, Isolation, Identification, Necrotizing, Enterocoliti, fimA, fimH.
Simultaneous Determination of Furosemide, Carbamazepine, Diazepam and Carvedilol in Quaternary Mixture via Derivative Spectrophotometry Nahla. A. Alassaf
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Quick and accurate quaternary mixture resolution of furosemide (FURO), carbamazepine (CARB), diazepam (DIAZ) and carvedilol (CARV) by using derivative spectrophotometric method was performed. FURO and CARV were determined by means of first (D1), second (D2), third (D3) and fourth (D4) derivative spectrophotometric methods,  CARB was determined by using D1, D2, D3 derivatives, while D1 and D2 were used for the determination of DIAZ. The recommended methods were verified using laboratory prepared mixtures and then successfully applied for the pharmaceutical formulations analysis of the cited drugs. The results obtained revealed the efficiency of the proposed methods as quantitative tool of analysis of the quaternary mixture with no requirements for sample neither pretreatment nor preliminary separation of analytes from the pharmaceutical preparations.Keywords: Derivative spectrophotometry; Furosemide; Carbamazepine; Diazepam; Carvedilol.
Influence of Li Doping in NiO Thin Films Prepared by Simple Chemical Method Ahmed N. Abd
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This study deals with the study of the structural and visual properties of NiO and Li Doped NiO films in different percentages (0.02, 0.04, 0.06, 0.08% mol).Thin films of NiO were deposited on glass substrates at 300 ° C and 150 nm using droplet casting technique. X-ray diffraction (XRD) showed that multi-crystalline films had a cube structure with a preferred orientation along the length of (111). The tonic stimulator did not change between 0.02, 0.04, 0.06 and 0.08% Grammy% of the preferred trend. The average grain sizes of crystals classified from XRD data were found in the range of 15.62 - 37.52 nm. Atomic Force Microscope (AFM) data shows that the film surface is extremely smooth. The photovoltaic permeability of pure NiO membranes is 72% in the visual and x-ray regions (NIR), which is important for their applications as window layers in solar cells.Keywords: Nickel oxide, XRD, AFM, grain sizes, thin film.
Biological Activity Study of Schiff Base ligands and their Complexes: A Review Lekaa K. Abdul Karem
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Schiff  Bases (SB)  stand for  multipurpose  ligands  created  from  prime  amines  condensing  with carbonyl groups. These represent imperative compounds in pharmaceutical and medical domains as a consequence of their widespread spectra of organic performances. The majority of them exhibit antibacterial, antifungal and antitumor activities. Transition metal compounds based on biological SB ligands were extensively investigated. This study reviews the synthesizing and organic activities of SB and its complexes. Keywords: Metal complexes, Schiff Bases, Antitumor activity, Antimicrobial activity, Nonlinear optical properties.
Cycloyvoltammetry, ATR-IR of AlCl3/Amide and Thioamide DES and the Morphology of Deposited Aluminum at Variable Potential and Temperature Hadi M. A. Abood
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Aluminium was successfully electrodeposited from mixtures of aluminium chloride with two amides and two thioamides. Structure identification by ATR-IR spectroscopy suggested the interaction of   (AlCl2+) species with oxygen, sulfur and nitrogen respectively which influence the cyclovoltammetry behavior of the mixtures. Morphology of electrodeposited aluminium from the protected mixtures by decan layer examined by SEM and EDX showed variable shapes and microsize due to the effect of  variable temperatures (30°C to 60°C) and potentials (-0.6V to -1.6V), this in part is related to mass transport limitation and coordinating ligands.   Keywords: DES, Electro-deposition, Aluminium, AlCl3-amide, AlCl3-thioamide.
Role of Chloride on Corrosion of Carbon Steel Reinforcing Bar in Simulate Concrete Electrolyte Abdulkareem M.A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

It is well known that chloride ion plays an important role in the destruction of various kinds of concrete structures such as bridges of buildings and reservoirs because of the corrosion of carbon steel reinforcement bar, causing huge human and material damages. In this study, the effect of saline conditions on carbon steel reinforcement was investigated artificial concrete solution in a range of sodium chloride concentrations from 0.5 to 4.5% and at temperatures of 20°C to 50°C. Three electrodes potentiostat was used to measure the corrosion rate and the probability of pitting corrosion through Tafel and cyclic polarization plots respectively. The measurements were supported using other techniques; atomic force microscopy and optical light microscopy. The results showed an increase in corrosion rates of the carbon steel reinforcing bar at all chloride ion concentrations, and increased with increasing the concentration and the temperature, all chloride concentrations showed susceptibility to pitting corrosion and highly depend on NaCl continents.Keyword: Reinforcing bar, Pitting, Artificial concrete solution.
Polymorphisms of IL-4 Gene in Iraqi Behçet’s Disease Pat Israa Harjan Mohsen
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present research was carried out to reveal the correlation of IL-4 gene polymorphisms with Iraqi Behçet’s Disease patients. The technique that used in the present study is PCR-SSCP technique. DNA was extracted from blood. The results show that there was strong association between IL-4 gene and Behçet’s Disease there were two patterns (A and B), polymorphisms show significant differences(p>0.05) between patients and control where pattern (A) was occurred with percentage (2%) and (39%) while in the control and patients respectively .The pattern (B) was occurred with percentage (98% ) and (61%)  in the control and patients respectively .The results concluded that IL-4 gene polymorphisms were involved in  pathogenesis of Behçet’s Disease , our finding require more exploration to use this result as early hint of Behçet’s Disease  prevalence.Keywords: IL-4 .PCR-SSCP technique, Haplotypes, Polymorphisms, Behçet’s Disease 
Nanocrystal Technology as a Tool for Improving Dissolution of Poorly Soluble Drugs Manar Adnan Tamer
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Many approaches have been developed over time to counter the bioavailability limitations of poorly soluble drugs. With advances in nanotechnology in recent decades, this issue has been approached through the formulation of drugs as nanocrystals. Nanocrystals consist of pure drug(s) and a minimum of surface active agent(s) required for stabilization. They are carrier-free submicron colloidal drug delivery systems with a mean particle size typically in the range of 200 - 500 nm. By reducing particle size to nanoscale, the surface area available for dissolution is increased, and thus bioavailability is enhanced. Drug nanocrystals constitute a versatile formulation approach to enhance the pharmacokinetic and pharmacodynamic properties of poorly soluble drugs. This enhancement is achieved by increasing the dissolution velocity, saturation solubility and mucoadhesion. However, stabilization of nanocrystals remains a major challenge in the development of nanocrystals. Main stability issues include increase in particle size, agglomeration, crystal transformation, and chemical instabilities. as such, combination of steric and ionic stabilizers are required for optimal stabilization. Nanocrystals can be administered by various routes including oral, parenteral, ocular, pulmonary and dermal routes with enhanced pharmacodynamic activity and safety. Functionalization of nanocrystals with radionuclide, imaging moieties and ligands further increases the versatility of nanocrystals. Nanocrystals has been proven successful, as demonstrated by the number of marketed drug products utilizing this technology. The present work provides an overview of the more recent achievements in improving the bioavailability of poorly soluble drugs according to their administration route, and describes the methods developed to overcome physicochemical and stability related problems.Keywords: Nanocrystals, Poorly soluble drug, Nanotechnology.

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