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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
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Search results for , issue "Volume 11 Issue 06 (2019) June 2019" : 3 Documents clear
Development of analytical method and validation for Nadolol in pure and pharmaceutical formulations using UV-spectrophotometry and spectrofluorimetry using Hydrochloric acid Anton Smith A; Akanksha .; Arun R
Journal of Global Pharma Technology Volume 11 Issue 06 (2019) June 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Development of analytical methods is in need for the estimation of drugs in pure and different pharmaceutical formulations. A simple, sensitive, rapid, accurate, precise and economic Spectrophotometric and Spectrofluorimetric method were developed and validated for Nadolol in pure and Pharmaceutical formulations. Methods: The wave length (λmax) used for the estimation of Nadolol is 267nm by Spectrophotometry, excitation (λEx)-267nm and emission (λEm)-300nm by Spectrofluorimetry. Results: Linear correlation was obtained between absorbance and concentration of Nadolol in the concentration ranges of 20-60µg/ml with R2 value 0.998 by Spectrophotometry and linear correlation was obtained between intensity of fluorescence and concentration of Nadolol in the concentration ranges of 1-5µg/ml with R2value 0.993 by Spectrofluorimetry in 0.1 N HCl.  The linearity of the calibration curve was validated by the high values of correlation coefficient of regression. LOD and LOQ values for Nadolol were found to be 3.95µg/ml and 11.99µg/ml by Spectrophotometry and 0.90µg/ml and2.74µg/ml by Spectrofluorimetry. Conclusion: Among the two developed methods Spectrofluorimetric method is highly sensitive than the spectrophotometric method. These methods are simple and suitable for the determination of Nadolol in pure and Pharmaceutical preparations.
In-vitro Antioxidant and Cytotoxic Activities of Silver Nanoparticles of Mangiferin Isolated from Mangifera indica Mahendran Sekar
Journal of Global Pharma Technology Volume 11 Issue 06 (2019) June 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The present study aimed to synthesize mangiferin AgNPs and evaluate its in vitro antioxidant and cytotoxic properties. Mangiferin AgNPs was prepared using silver nitrate solution and characterized by SEM and Zeta potential measurement. In-vitro antioxidant and cytotoxic studies of mangiferin and its AgNPs were conducted by using DPPH and MTT assay method, respectively. The synthesized mangiferin AgNPs with particle size ranges from 25.30 - 40.79 nm. The charge of mangiferin AgNPs were confirmed by Zeta potential and found to be −33.7 mV. Mangiferin AgNPs showed 90.43 ± 1.90 % of inhibition at 500 µg/ml and the activity was well comparable with mangiferin in DPPH method. Mangiferin AgNPs exhibited significant reduction in cancerous cell growth when compared to Mangiferin in all the tested concentrations ranges from 10-100 µg/ml. This results representing that the mangiferin AgNPs was a capable nanocarrrier for distributing mangiferin to cancer cells. In future, mangifrin AgNPs will be further tested with other cancer cell lines to confirm its safety and effectiveness.
Investigation of Drug-Excipients Compatibility for Colloidal Delivery of Therapeutic Chondroitinase Krishnamoorthy Kannan
Journal of Global Pharma Technology Volume 11 Issue 06 (2019) June 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Proteins and enzymes are marginally stable macromolecules along with certain additives for converting them into suitable drug formulation. The research in pharmaceuticals claims the suitability of wide and variety range of micelles, reverse micelles, unsaturated fatty acids and their esters with glycols act as a protective fence for such therapeutic macromolecules against denaturants in colloidal form. The present study, address preformulation and compatibility study of different additives with bioenzyme- chondroitinase for futuristic colloidal microemulsion formulation. Methods: Initially the solubility of chondroitinase with excipients was determined to obtain suitable aqueous, oil and surfactants phase. FTIR spectra of individual chondroitinase and along with each additive in binary blend form were compared to retain characteristic bands of native protein. It was followed with non-denaturing SDS-PAGE to ensure native conformation of enzyme on gel in presence of additives. Circular dichroism technique was used to investigate stability of primary and secondary structure of enzyme in these binary mixtures. The control and accelerated studies were performed by spectroscopy. Results: Chondroitinase solubility was observed as: phosphate buffer > propylene glycol > glycerol > Tween 80 > Oleic acid. FTIR spectra retained characteristic bands of chondroitinase in binary blends. SDS-PAGE ensured no signs of protein fragments, aggrega­tion or degradation on gel. CD spectra revealed no major loss of enzyme activity. Control and accelerated studies confirmed concentration and purity of enzyme in binary blends in accepted limit. Conclusion: These results demonstrated that the excipients employed in this study were safe as additives with chondroitinase for colloidal formulation. Keywords: Circular Dichroism, FTIR-ATR, SDS-PAGE, Preformulation, Enzyme-additive compatibility, Therapeutic chondroitinase.

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