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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Synthesis and Characterization of 5- Amino-1, 3, 4-Thiadiazole-2-thiol and its Amine Group Derivatives Mustafa M. Shihab
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

This work includes preparation of 5-Amino-1,3,4-thiadiazole-2-thiol from thiosemicarbazide with Carbon disulfide (CS2) and KOH as catalyst. Also reaction of 5-Amino-1,3,4-thiadiazole-2-thiol with different aromatic aldehydes by using glacial acetic acid as catalyst to synthesis of some new Schiff bases derivatives that coupled with thioglycolic acid to synthesis five- member ring heterocyclic compounds derivatives. All synthetic compounds were definited by their melting point, FT-IR spectra and 1H-NMR spectra for some of them.Keywords: 5- Amino-1, 3, 4-thiadiazole-2-thiol, Thiosemicarbazide, Schiff bases, heterocyclic compounds, thiadiazole.
Effect of Modified Form of Porcelanite Rocks to Remove Remazol Brilliant Blue Dye From Aqueous Solution and Adsorption Isotherm Model Studies Noor A. Al-Khazali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The adsorption of Remazol Brilliant Blue dye from aqueous solutions by using (Porcelanite- Melamine-Urea) (PMUC) as an adsorbent .The characterization of (PMUC) was done by using FTIR spectroscopy, X-ray diffraction (XRD), (SEM) scanning electron microscopy and (AFM) Atomic force microscopy. Different experimental data such as contact time, pH, adsorbent dosage and ionic strength were studied. The equilibrium experimental data were analyzed by Langmuir, Freundlich and Temkin isotherm models. Thermodynamic parameters such as change in free energy (ΔG°), enthalpy (ΔH°), and entropy (ΔS°) were also determined.Keywords: Adsorption, Porcelanite rocks, Remazol Brilliant Blue, Isotherms, Langmuir, Freundlich, Temkin.
Formulation and Characterisation of Nanosuspension of plant extract Cocculus Pendulus Sampath Kumar Ramala
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
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ABSTRACT:Nanotechnology is a promising technique to increase the bioavailability of herbal medicines. The present study was  formulated to evaluate nanoparticles using an ethanolic extract of Cocculus pendulus. The sonoprecipitation technique was employed for the preparation of nanosuspensions with poloxamer-407 and PVA with many trails and finally the optimized nanosuspension demonstrated a mean particle size, polydispersity index, and zeta potential of 536 nm, 0.256, and − 17.6 mV, respectively. The results of the characterization studies illustrated that the nanosuspension was in the nanometer size range and spherical in shape had good surface morphology. The present outcomes clearly demonstrated that to obtain an effective therapeutic potential, nanoformulation of medicinal plants is a better alternative than conventional dosage forms. Key words:Nanosuspension, sonoprecipitation, mean particle size, polydispersity index, and zeta potential
Synthesis and Characterization of New Schiff bases Derivatives of Acetohydrazide and its Cyclization Reaction Mustafa M. Shihab
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This work includes synthesis of hydrazide from 5-Amino-1, 3, 4-thiadiazole-2-thiol. Also reaction of hydrazide with different aromatic aldehydes by using glacial acetic acid as catalyst to synthesis of some new Schiff bases derivatives that coupled with thioglycolic acid to synthesis five- member ring heterocyclic compounds derivatives containing thiazolidinone ring. All synthetic compounds were definite by their melting point, FT-IR spectra and 1H-NMR spectra for some of them.Keywords: 5-Amino-1, 3, 4-thiadiazole-2-thiol, thiazolidinone, Schiff bases, Heterocyclic compounds, Thiadiazole.
Nanoemulsion Preparation, Identification and Evaluation Review Mustafa R. Abdulbaqi
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Nanoemulsions consist of two immiscible liquids combined with emulsifying agents (surfactants and co-surfactants) in a thermodynamically stable, colloidal dispersion system, in order to form the same phase. Nanoemulsions have been thoroughly investigated as drug delivery systems. This review is aimed at providing comprehensive information on various techniques of nanoemulsion preparation and identification. There are two different methods for formulating nanoemulsions, the method of persuasion and the method of brute force. Different identification techniques for nanoemulsions include determination of trap efficiency, particle size, polydispersity index, zeta potential as well as characterization by differential scanning calorimetry, Fourier-transform infrared spectroscopy and transmission electron microscopy. Nanoemulsions are further assessed by studying in vitro release of drugs, in vitro permeation, stability and thermodynamic stability, shelf life, dispersibility, viscosity, surface tension, refractive index, percentage of transmittance, pH and osmolarity.Key words: Nanoemulsions, Nanoemulsion preparation, Identification techniques
The Potential Role of Alkaloid Extract against Phospholipase Extracted from Aspergillus Flavus in Male Rats Hussein A. R. Abbood
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This article aims to evaluate the role of alkaloid extract against phospholipase toxicity. The study sample contained 20 adult albino male rats divided into four groups, where each group consists of 5 rats. The groups are categorized as follows:The group of control which received ad libidium.The infected group, which was injected with (0.05ml/per animal) phospholipase.A group injected with (0.05ml/per animal) phospholipase and treated with (0.05ug/per animal) alkaloid extract.A group injected with (0.05ml/per animal) phospholipase and treated with (0.05ug/per animal) alkaloid extract.The results show a highly significant increase (P < 0.05) in the levels of Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) in the infected group compared with the control group. Oxidative stress factor in the infected group demonstrates a significant increase (P < 0.05) in the MDA (malonedialdehyied) levels. Nevertheless, it reported a significant decrease (P < 0.05) in the glutathione (GSH) levels compared with the control group. After using alkaloid extract in the treatment, non-significant changes (P < 0.05) are found in liver functions. Furthermore, MDA and GSH report non-significant changes (P < 0.05) compared with the group of control. The study demonstrates that alkaloid extract has a potential role against phospholipase that is extracted from A. flavus in rats.Keywords: Alkaloid extract; A. flavus; liver function; MDA (malonedialdehyied); glutathione (GSH).
Biocontrol of Pseudomonas Aeruginosa Biofilm Using Bacteriophages Zahraa J. Jameel
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

inanimate surfaces. Clinically, it is considered essential in the practical therapy. In current study, the inhibition effect of bacteriophages against biofilm of P. aeruginosa detected by ELISA method had been assessed. 50 samples had been collected from wounds infections in General Baqubah Hospital to isolate Pseudomonas aeruginosa and tested for 10 groups of antibiotics.  Befor the treatment, Pseudophage was isolated from sewage water of General Baqubah Hospital through pseudophage enrichment. The biocontrol of biofilm activity of pseudophage was applied by using the ELISA method. For the 50 samples were collected from wounds infections, and 10 isolates only were able to grow on Pseudomonas and Cetrimide agar. P. aeruginosa isolates showed high resistance associated with Cefepime (30 μg), Fusidic acid (10 μg) and Ampicillin (10 μg) 9(90%) while P. aeruginosa isolates showed high resistance associated with Erythromycin 80% then Imipenem and Tetracycline 70%. All 10 P. aeruginosa isolates have the production of biofilm. 4 P. aeruginosa bacteriophages (Pab 1, Pab 2, Pab 3, Pab 4) were isolated from sewage water, the Pab4 had a wide range. P. aeruginosa were sensitive to pseudophage by spotting assay were inhibited the biofilm formation. Active effect of pseudophage to inhibit Pseudomonas aeruginosa' biofilm in vitro.
The Tolerability and Degradation Rate of Amoxicillin Alone and with Clavulanic Acid in the Acidic and Alkaline Medium Abbas Razzaq Abed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This study deal with the effects of various pH values (1-14) on the stability of Amoxicillin alone and with Clavulanic acid. The degradation rate of Amoxicillin alone and with Clavulanic acid was determined by using Bacillus thuringiensis as indicator to act of drug used in this study. Amoxicillin alone and with Clavulanic acid was high stability at an acidic pH, while increasing the pH value led to decrease its stability at the statistical level (P value < 0.05). Maximum stability of Amoxicillin alone and with Clavulanic acid was experienced at pH values (4, 5,6,7,8 and 9), While their degeneration rate was significantly higher at acidic medium (pH=1) and alkaline pH medium (pH= 11, 12, 13 and 14) at p-value < 0.05. Therefore, the Amoxicillin alone and with Clavulanic acid is best given to humans and animals in pH value from 4-9.Keywords: Tolerability, Degradation, Amoxicillin, Clavulanic, acid, Alkaline, Medium.
Evaluation of Some Oxidative Stress Parameters in Iraqi Patients with Inflammatory Bowel Disease Hisham A. Shaker
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objectives: Inflammatory bowel disease (IBD) refers to chronic inflammations that affect any part of the gastrointestinal tract (GIT). This study aimed to evaluate of some oxidative stress parameters (TOC, TAC, OSI and MDA) in sera of Iraqi patients with IBD. Methods: Three main groups were included in this study; 30 patients (15male &15female) with Crohn’s disease (CD group), 30 patients (15male & 15female) with ulcerative colitis (UC group) and 30 (15female & 15female) apparently healthy controls (HC group) comparable for age and gender without a history of IBD were involved in the current study. Results: TOC in the sera of both patient groups (CD&UC) was a highly significant increase (p<0.001) when compared to the (HC group) while significant decrease (p<0.05) in the TAC of (CD group), as well as highly significant decrease (p<0.001) in the TAC of (UC group) was observed in comparison with their levels in corresponding (HC group). A highly significant increase (p<0.001) in serum (OSI) of two patient groups (CD & UC) in comparison to that of (HC group).Meanwhile, significant increase (p<0.05) in serum MDA concentration of both patient groups (CD & UC) when compared to that of the (HC group) was observed. Conclusion: We found a significant increase in TOC, OSI and MDA while a significant decrease in TAC of patient groups. Therefore, CD and UC subjected to an increased in oxidative stress situation.Keywords: Inflammatory bowel disease, Crohn’s disease, Ulcerative colitis, Oxidative stress.
Effect of Substrate Temperature on Optical Properties of Cu2ZnSnS4 Thin Films Preparing by Chemical Spray Pyrolysis Technique Alaa Ali Diwan
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The optical properties of thin films of Cu2ZnSnS4 have been studied by deposited on glass substrate by chemical  splash spray pyrolysis method (CSP) ,with constant concentration and different substrate temperatures of (350, 400 and 450) °C. CZTS films were prepared by chemical spray pyrolysis by dissolving of copper (II) chloride (CuCl2), zinc (II) Zn (CH3COO).2H2O, tin (IV) chloride (SnCl4), and Thiourea (CS (NH2)2 ,were utilized as sources of Copper particles, Zinc particles, Tin particles and Sulfur particles individually. The UV-Vis study showed high optical absorption coefficient and wide direct band gap for solar region. Further the optical constants such as refractive index, extinction coefficient and dielectric constant have been calculated for all samples. The optical energy gap for permitted direct electronic progress was determined utilizing Tauc's equation.  It is discovered that the band gap diminishes as the substrate temperature increments and the optical permitted energy gap for the direct electronic transitions was in the range of (2-2.2) eV.  The optical absorption coefficient is found to be larger than (10 4 cm-1), which respectively these films have a direct transition.Keywords: CZTS thin Films, Spray pyrolysis Technique, Optical properties, Еnеrgy gap.

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