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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Effect of Carbonic Anhydrase Inhibitor Combination on Fertility Male Rats Anmar Shukr Mahmood
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Carbonic anhydrase inhibitors are many drugs, the main usage in epilepsy and raised intracranial pressure and the most commonly used are acetazolamide and topiramate. Twenty healthy adult males Wistar rats After acclimatization three weeks and divided to two groups randomly (10 rats/group) and treatment for 60 days as follows: high dose (Hd) group administrated 30 mg/kg/B.W of Acetazolamide and 9mg/kg/B.W of Topiramate and low dose (Ld) group received 5mg/kg B.W of Topiramate and 30 mg/kg B.W of Acetazolamide orally/day. Serum Hormones concentration tested are testosterone (ng/ml) and follicular stimulation hormones (FSH), Serum luteal hormones (LH) mlU/ml. The histological section showed the pathological changes in the Hd group while in the Ld have semi normal changes, the results confirm that the rats received of low dose more safety than the high dose of these  drugs combination.
The Impact of FLG Mutation and TRBV Insertion/deletion Gene Polymorphism in Molluscum Contagiosum and Papillomavirus Iraqi Patients Saba Amer Mughir Al-Ammar
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: Filaggrin (FLG) has very important role in the skin terminal differentiation and formation, which encoded by FLG gene. TRBV4-3, TRBV3-2 are an insertion/deletion polymorphism in human T cell receptor beta locus (TRBV).The polymorphisms in these genes have been reported in several diseases. To evaluate the impact of FLG (R501X), TRBV (I/D) polymorphisms in Molluscum contagiosum(MCV) and Papillomavirus (HPV) Iraqi patients. Material and Method: thirty one blood samples from each MCV and HPV patients and  healthy control group was collected, then DNA was extracted and analyzed for FLG and TRBV genotypes and Alleles frequencies with (PCR) and by Gel electrophoreses using 1.5%, 2% Agarose concentration (respectively) was examined. Results : FLG mutations have been detected in 35% of MCV patients and in 26% of HPV patients while only 10% in the control group , in addition mutant allele (T allele) has been detected in 18% in MCV patients , 13% in HPV patients and only in 5% in the control group ,when we compared with the control group, we found that the genotype and allele frequency have significant association with MCV infection group P<0.05 , and have no significant relation with HPV infection group. For TRBV (TRBV4-3, TRBV3-2) gene polymorphism has no significant association with MCV and HPV infection groups when compared with the control group P>0.05.Conclusion: FLG mutations are associated with MCV infection while there is no significant associated with the HPV. Moreover the TRBV gene polymorphisms have no significant association with the MCV and HPV infection.Keywords Molluscum contagiosum, Human Papillomavirus, FLG (R501X), TRBV Polymorphism.
Shock and Flexural Strength of Composite Materials Reinforced by Kevlar Fiber Mustafa A. Rajab
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Composite materials in this regard represent nothing but a giant step in the ever-constant endeavor of optimization in materials.  The research aims to study the mechanical properties (shock strength and Flexural strength) of composite materials (epoxy resins with phenolic formaldehyde resin) supported by graphite or silica particles or both, and reinforced with Kevlar fibers.
Synthesis, Characterization, DFT Calculation, Photochromic, Antimicrobial and Antifungal Properties of Co(II), Ni(II), Zn(II), Ag(I) Complexes with Azo Dye of 2-Aminopyrimidine Yareeb Jwad Sahar
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A New azo dye 3-(2-pyrimidinylazo)-4-dimethylbenzaldehyde (PADB) consisting 2-aminopyrimidine was synthesized by coupling reaction of diazonium salt and 4-dimethylaminobenzaldehyde. The PADB was further utilized to synthesis of its complexes with Ni (II), Co (II), Zn (II) and Ag (I). All the synthesized complexes were characterized by different techniques (infrared, UV-VIS and mass spectroscopies and elemental analysis). The complexes of Co (II) and Ni (II) were found to be octahedral and nonelectrolytic with general formulas [M (PADB)2 Cl2]. The complexes of Zn (II) and Ag (I) were tetrahedral and electrolytic with general formulas [Zn (PADB) Cl2] and [Ag (PADB) (H2O)] NO3 which iselectrolytic. The PADB and its complexes exhibited potent antimicrobial activities against two types of bacterial strains, Staph-aureus (positive gram) and E-coli (negative gram) and two types of fungies: Aspergillus niger and Pinicillium-Sp. The PADB dye exhibited good phtochromic and solvachromic properties.Keywords: Pyrimidine, Photoisomerization, Pyrimidinylazo, Biological activity, Inorganic chemistry.
Bioactive Phenolic Compounds from Natural Zygophyllum fabago Plant: Isolation, Purification and Characterization Omar T. Ali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This study is to investigate the chemical constituents of the aerial parts of Zygophyllum fabago in Iraq. The compounds were isolated by silica gel and column chromatography from deferent extracts. Their structures were characterized by various spectroscopic data (HPLC, 1H and 13C-NMR) and compared with the literature. As a result, three phenolic compounds were isolated, and their structures were identified as Catechol, Coumarin and Resorcinol. Biological testing of the extracts against six different Gram-positive and Gram-negative bacteria showed significant results.   Keywords: Zygophyllum fabago, Bioactive, Purification.
Extracellular Biosynthesis of TiO2 Nanoparticles Using Supernatant Culture of Lactobacillus crispatus Kawther H. Ibrahem
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this study, titanium dioxide nanoparticles were synthesized biologically using isolated L.crispatus from vagina of healthy women. The formation of TiO2 nanoparticles was characterized by atomic force microscope (AFM) using supernatant culture of L.crispatus .Extracellular biosynthesized TiO2 nanoparticles occurred with the average size (87.88) nm. For further characterization, the x-ray diffraction (XRD), energy dispersive x –ray spectroscopy (EDX), and scanning electron microscope (SEM) were used. XRD Confirmed the formation of crystallographic plane of anatase of TiO2 nanoparticles indicating that nanoparticles corresponded to anatase crystalline, while the EDX analysis of TiO2 nanoparticles indicated that the synthesized nanoparticles were anatase form and not frutile or brookite form. The SEM images of the synthesized TiO2 nanoparticles were showed spherical or oval in shape. The effect of independent variables, including different incubation times and storage condition on the biosynthesis of TiO2 nanoparticles was investigated. The average size (70.98)nm of TiO2 nanoparticle was observed after 72 h .The stability of the synthesized TiO2 nanoparticles for (1,2,3)months under cooling condition was studied and the result revealed that the synthesized TiO2 nanoparticle remained stable without change in color even after storage for three months under cooling conditions.Keywords: TiO2 nanoparticles; Biosynthesis; Lactobacillus Crispatus; Incubation time; Storage time.
A Survey of the Aquatic Insects in Shatt Al-Arab River, Iraq Sadek J.T.
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The study on survey of aquatic insects was done covering the zone of Basra city to Shatt A-Arab River, south of Iraq. The aquatic insects were collected using a plankton net method from three stations. There were varieties of aquatic insects belonging to 2 orders in the study sites. The orders of insect were Hemiptera and Coleoptera. During the study period, there is range from total of 26 to 58 individuals of aquatic insect trapped and collected in to Shatt A-Arab River from May to July 2018. Some species of aquatic insects (Berosus spinosus and Paracymus relaxus) were found significant (P<0.05) different compared with Plea leachi, Hydaticus histrio and Ochthebius kermanicus. This shows the richness and various species of aquatic insects in the study area. The quality of non-harmful habitats is most suitable for aquatic insects to reproduce under a natural ecosystem with abundant diet source.Keywords: Shatt Al-Arab River; Aquatic insects; Hemiptera; Coleoptera
Impact of Systemic Insecticides Neonicotinoids on Environment Zaid Raad Abbas
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Subsequently their detection in the overdue 1980s, nicotine repellers have developed the greatest extensively utilized, category of repellers universal, through significant requests fluctuating beginning plant defense (yields, greens, berries), veterinarian, harvests, and pesticides to weakly annoyance regulator in gudgeon cultivation. Nicotine presently counting for roughly single tertiary of the universe small arthropod animal repellent merchandise the yearly universe manufacture of the model nicotine, imidacloprid, was assessed selected fulness 20,000 tones vigorous material in 2010. Around stayed numerous explanations aimed at the primary achievement of nicotine: (1) there was no recognized repeller impedance in goal pests, chiefly because of their current growth, (2) their physicochemical possessions contained wthishin several recompenses concluded prior age group of small arthropod animal repellent (i.e., organic compound, compound carbamic acid, pyrethrin, etc.), and (3) they joint an supposed compact employee, then purchaser hazard. As a result of their complete landscape, there remain engaged above via the herthisages or greeneries and move from one place to another to entirely portions about the vegetable, that, in swthisch, manufacture those efficiently poisonous to eat vegetable pests. Keywords: Nicotine, Direction, Mode of action, Cultivation. Kernel handling, Transportation small arthropod animal repellent, Substance formed.
Optical Conduct of Nanostructure Co3O4 rich Highly Doping Co3O4: Zn Alloys Sami Salman Chiad
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The spray pyrolysis technique (SPT) was used because it is simple, low cost and less equipment. Structural, morphological and optical properties of pure Co3O4 and doping 1% and 3% Zn: Co3O4 were anayzed by X- Ray diffraction (XRD), Atomic force Microscope (AFM) and UV-visible Spectroscopy. XRD indicate a polycrystalline structure  with AFM images shows that the films was discontinuous surface with spherically  grains increase from (70 to 84 nm) with increase doping from 1% to 3%. The energy gap Eg was decreased from 2.75 to 1.64 eV when doping increase. Keywords: Co3O4, Zn: Co3O4 thin films, XRD, AFM and optical characterizations.
Evaluate the Effect of Biosynthesized Silver Nanoparticles on Wound Healing in Experimental Mice Neihaya H. Zaki
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Biosynthesized silver nanoparticles showed a change in solution color from light yellow to dark brown after 24hr incubation. Results of Ag-NPs characterized by Scanning electron microscopy showed oval, rectangle particles and the average size is 35.1 nm. X-ray diffraction shows one high peak at 2ø (32.5°) as standard XRD data of nano-silver crystals. Antibacterial activity of Ag-Nps against pathogenic isolates of E. coli, P. aeruginosa, Klebsiella pneumoniae and Staph. aureus was shown as inhibition zones (11, 12, 14 and 11) mm respectively. There are no toxicity of Ag-Nps in treated mice, and no significant changes nor clinically significant changes observed in the body. Ag-Nps (10mM) showed significant reduction in incision wound for 7 days. Actions of Ag-Nps on wound healing in mice provided a new therapeutic direction for wound treatment in clinical apply. Keywords: Biosynthesis of Ag-Nps, E.coli, Antibacterial activity, Wound Healing.

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