cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 52 Documents
 1   2   3   4   5 
Search results for , issue "Volume 11 Issue 08 (2019) Aug. 2019" : 52 Documents clear
Asthma Exercise Enhanced IL-10 Secretion but Had No Effect on IFN-ɣ in Patients with Persistent Atopic Asthma Rahmaya Nova Handayani
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.767 KB)

Abstract

Background: Asthma is a chronic respiratory disease which is considered as a frequent non-communicable disease that could affect the quality of life. It is widely known that Th1 and Th2 imbalance is one of the underlying pathogenesis of asthma and many approaches had been devised to interfere this process. One of the well-known non-pharmacological approaches in asthma is asthma exercise. Therefore, this study aimed to investigate the role of asthma exercises on the balance of Th1 (IFN gamma) and T-regulator (IL-10). Methods: A pre-post-test group quantitative study was conducted using 39 subjects with persistent atopic asthma. All subjects participated on asthma exercise program that was conducted twice a day, 60 min per session. Atopic status was determined by skin prick test while IFN-Ɣ and IL-10 was determined by ELISA. Results: Median level of IL-10 was increased from 1.6 pg/ml before intervention to 2.2 pg/ml after intervention (p=0.000). However, the exercise program failed to produce any effect on IFN-Ɣ level which only showed a slight median increase from 9.374 pg/ml before intervention to 10.238 pg/ml in the post-test analysis (p=0.07). Conclusion: Asthma exercises significantly increased IL-10 level, but not significantly affect serum IFN-Ɣ in patients with persistent atopic asthma.Keywords: Asthma exercise, IL-10, IFN-Ɣ, T-h1/T-h2 balance.
Pulmonary Arterial Hypertension and Risks of Progression Evgeniya Malashenko
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.298 KB)

Abstract

Pulmonary arterial hypertension is an increase in blood pressure above 140 and/or 90 mmHg, caused by irreversible changes in arterioles, either by an unknown reason (essential), or as a secondary condition.  691 people under the age of 7 to 14 years (343 males and 348 females) were examined. They divided into two groups: 1st-with high blood pressure; 2nd-control group with normal blood pressure. The study results show that 19.5% of the total number of patients had high blood pressure, where 46.7%-7-10 years old children and 53.3%-11-14 years old. Almost equal ratio of boys and girls was noted in both age subgroups. Thus, there were 24.4% of boys and 22.2% of girls among children with high blood pressure aged 7-10 years and 24.4% of boys 28.9% of girls aged 11-14 years. The gender differences were found in blood pressure, heart rate and pulmonary arterial hypertension, accordingly. The systolic blood pressure (SBP) and heart rate (HR) of 7–10 years girls were significantly lower than that of male peers (96.8 and 93.2%, respectively). The most of physical development indicators of males with hypertension significantly exceeded peers with normal blood pressure. The average body weight of males with PAR significantly exceeded the control groups of the corresponding age by 16 and 25.2%, respectively, in the studied age periods. The thoracic region of the younger subgroup boys with PAH was significantly greater than that of boys with normal blood pressure by 6.5%; in the middle age subgroup - by 11.3%. The hypertension in childhood and adolescence is associated with an increase in height, weight, BMI, BFM, MM, and LBM. Hypertension occurred much more often because of overweight and obesity than with normal body weight and protein-energy malnutrition.Keywords: Pulmonary arterial hypertension (PAH), Absolute muscle mass (MM), Body mass index (BMI), lean body mass (LBM), Body fat mass (BFM).
Feasibility of Pickling from Common Bean (Phaseolus vulgaris) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.983 KB)

Abstract

Common bean (Phaseolus vulgaris) is often a main source of protein, dietary fiber and minerals in diet offering benefits for human health. With the purpose of accelerating the commercial value of this vegetable, objective of this study focused on the lactic acid fermentation of the common bean into pickle. Different technical parameters such as blanching time and temperature, calcium chloride concentration in soaking, salt sugar percentage submersion affecting to fermentation were examined. This research was conducted in 2019 in the Labone Scientific laboratory. Results showed that 95oC in 6 seconds were suitable for blanching of common bean. The optimal calcium chloride concentration for soaking was recorded at 0.2% for soaking of common bean. The optimal salt: sugar was noticed at 7.5%:2.5% adequately for pickling in 14 days.  As a result from pickling process, common bean will get a longer shelf life, translucent appearance, firm texture and pickle flavor. Pickled common bean was ideal for promoting the positive health image of probiotics. The findings of this investigation help diversifying the multiuse of common bean in food processing enterprises.Keywords: Common bean, Phaseolus vulgaris, Pickling, Blanching, Soaking, Calcium chloride.
Feasibility of Composite Edible Coating Derived from Chitosan and Carboxymethyl Cellulose on Star Apple Quality during Post-harvest Preservation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.539 KB)

Abstract

Star apple (Chrysophyllum cainito) is well known as non climacteric fruit with high antioxidant capacity, high nutritional and health benefit. Its pulp is very sweet with glucose as the main sugar. This fruit has a short shelf life due to its perishable nature. Edible coatings have been extensively applied in the fruit preservation as an alternative method to preserve foodstuffs, improve shelf life and control loss of firmness and moisture in fresh fruits. Hence, purpose of this research penetrated on the efficiency of composited edible coating film prepared from chitosan and carboxymetyl cellulose (CMC) in different formulas to preserve star apple fruit. Weight loss (%), firmness (N), total soluble solid (oBrix), and vitamin C were the key indicators used to monitor during 15 days of preservation. After chitosan-CMC coating, the weight loss rate was restrained, and higher firmness, total soluble solid, and vitamin C were reserved. Our finding revealed that chitosan 2.0% combined with CMC 1.0% was appropriate for extending self-life of this valuable fruit. There has been a great demand of emerging fruit packaging from chitosan-CMC composited coating as antibacterial and barrier film. Composited chitosan-CMC coating would have wide prospect in the preservation of other post-harvest fruits and vegetables.Keywords: Chrysophyllum cainito, Chitosan, CMC, Coating, Weight loss, Firmness, Soluble solid, Vitamin C.
The Ratio of Runx-2 and Osterix in Tension Area of Orthodontic Tooth Movements on Days 7 and 14 after Giving Mangostin I Ketut Sudiana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.441 KB)

Abstract

Background: Orthodontic relapse is the return of the tooth to the first position after being treated with an orthodontic appliance. Bone density in tension area of orthodontic in new bone formation (apposition) is critical in orthodontic treatment to prevent relapse so that orthodontic treatment can be achieved optimally through runt-related transcription factor 2 (Runx-2) and Osterix evaluation. This study aims to determine the role of Runx-2 and Osterix ratio in the tension area of orthodontic tooth movement after Mangostin administration. Material and Methods: An experimental laboratory study was conducted among 30 male Wistar rats were divided into several groups. The K1 was a negative control group (K-) without treatment, K2 was a positive control group (K +) given orthodontic mechanical strength and observed for 7 days, and K3 was a positive control group, given orthodontic mechanical strength and was observed for 14 days. In addition, K4 was a treatment group (P) given orthodontic mechanical strength and were observed for 7 days, and K5 was the treatment group (P) given orthodontic mechanical strength and were observed for 14 days. Data were tabulated and analyzed using SPSS version 17 for Windows. Results: Mangostin administration is significantly increasing the expression of Runx-2 (8.3±0.4 ng/mL), Osterix (4.7 ± 1.8 ng/mL), and bone formation (1:3.23 vs. 1:1.23) in the tension area of the treatment group (P<0.05) after 14 days. The Osterix levels were also suggest a significantly higher among groups from K1 (0.2 ± 0.2 ng/mL), K2 (1.1 ± 0.2 ng/mL), K3 (1.4 ± 0.3 ng/mL), K4 (1.3 ± 0.6 ng/mL), and K5 (4.7 ± 1.8 ng/mL) (P<0.05). The ratio of Osterix (1:3.23) seemed to be higher in treatment groups, whereas Runk2 ratio was slightly lower compared with control groups (1:1.23).Conclusion: The administration of Mangostin can increase the expression of Runx-2 and Osterix in the area tension of orthodontic tooth movement on day 14.Keywords: Mangostin, Runx-2, Osterix, Tension area, Tooth movement.
Osteoporosis and Risk Factors among Postmenopausal Women in Integrated Health Post for Elderly Diana Lyrawati
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.133 KB)

Abstract

Abstract Objectives: The availability of prevalence data for osteoporosis in Indonesia is limited due to the constrained access to BMD measurements, especially in rural areas. Integrated Health Post for the Elderly (Posyandu Lansia) is one of the Indonesian government's programs to monitor and provide health care for the elderly, including postmenopausal women. This study aimed to determine the prevalence of osteoporosis and related risk factors in postmenopausal women. Methods: Respondents were 249 postmenopausal women from 440 people who attended the Posyandu Lansia from 9 villages in Sidoarjo. Quantitative ultrasound was used for calcaneal BMD measurement; other data were collected via questionnaires and enumerated by trained villagers. Results: Our study revealed that the prevalence of osteoporosis postmenopausal women was 73.5%. The osteoporosis risk factors of age, BMI, weight, and menopause duration were associated with T-scores both individually (p<0.05) or simultaneously (p< 0.001), while menopause age and exercise did not. Conclusions: Groups possessing high-risk factors associated with a high prevalence of osteoporosis are postmenopausal women age ≥ 65 years, BMI < 20 kg/m2, weight < 58 kg and duration of menopause > 6 years. Regardless of the groupings, the prevalence of osteoporosis was very high in postmenopausal women. Dietary and exercise adjustments as well as pharmacotherapy may be required to improve their bone health. 
Brown, White and Blue Bagging in Special Pharmacy: An Emerging Trend to Minimize Medication Error Sharad Chand
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Advancement in the sector of specialized pharmacy evolved a new concept of bagging system beyond the scope of traditional pharmacy service. Managed care organizations (MCOs) bring up the healthcare system in the network where the services are made available for the betterment of treatment and secure documentation system for reimbursement. Certain models namely brown bagging, white bagging, and blue bagging system are promising models for this system. These models generally cover expensive and high-risk medication to minimize the wastage and related drug related problems. In these models, all the prescribed medications reach to the health professionals, which meticulously review all the medications before its administration. This potential system has several advantages over the conventional pharmacy practices, despite several advantages many associated risk and disadvantages are equally challenging. But it can be concluded that benefits are outweighing the risk associated with these models, which may have more impact on patient wellbeing. Hence, this system of special pharmacy service can be recommended in the scope of hospital pharmacy and pharmacy practice.
The Impact of Extraintistinal amobiosis on TP53 Gene in Patients with Hepatocellular Carcinoma Basheer. Abd. Nasralla
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this study, 20 serum samples and 8 liver abscess biopsy specimens were taken from 20 hepatocellular carcinoma and E. histolytica infected patients. Laboratory findings of patients with liver abscess showed increased total white blood cell count (WBC), increased C-reactive protein, (AST), (ALT), alkaline phosphatase (ALP), gamma-glutamyl  transpeptidase (GGT) and bilirubin. The result of PCR performed on liver abscess patients was positive for the DNA of E.histolytica infected patients and 8 biopsy liver abscess patients. To detect TP 53 gene in hepatocellular with liver abscess of all 8(100%), mutation occurred in sequences of TP53, and there were changes in several locations on the exons. Nucleotides changes were shown in TP53 gene Exon 147,152,160.203 and 235amplified from tumor liver cancer samples. The mutation occurred on nucleotides TCC, GGT, ACT, CGC and ATC of TP53 gene.Keywords: Extra intestinal amebiasis. TP53 gene, Hepatocellular carcinoma.
Saccharomyces cerevisiae Immobilisation in Sodium Alginate for Red Dragon Fruit Winemaking N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Red dragon fruit is rich in sugar, organic acids and minerals and other nutrients. It has good processing properties; it is used in the production of fruit juice, jam, and preserved fruit. Its economic value in local market is quite low. Making wine is not only converting the fruit into wine, but also improves its economic value of dragon fruit. Objective of this study focused on the effect of encapsulation of Saccharomyces cerevisiae in sodium alginate complexed with calcium chloride in red dragon fruit wine fermentation. Different technical parameters such as sodium alginate concentration (2.0%, 4.0%, 6.0%, 8.0%, 10%), bead size (2mm, 4mm, 6mm, 8mm, 10mm), bead loading (5 g/100ml, 10 g/ 100ml, 15 g/100ml, 20 g/ 100ml, 25 g/ 100ml), initial total soluble solid (10, 12, 14, 16, 18oBrix), clarifying agent (gelatin, bentonite, wheat gluten, egg white, kieselsol and kaolin) in wine making. Results showed that the best wine quality based on ethanol content (19.38%v/v) and sensory score were recorded by encapsulation of Saccharomyces cerevisiae in 6% sodium alginate, bead size 6mm, bead loading 20 g/ 100ml, initial soluble solid 16%, gelatin as clarifying agent.Keywords: Dragon fruit, Sodium alginate, Calcium chloride, Saccharomyces cerevisiae, Encapsulation, gelatin, Wine.
The Effectivity of Clonidine Addition to Levobupivacaine 0.25% for Scalp Block in Patients Underwent Craniotomy Surgery Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The scalp nerve block technique is a relatively simple and safe technique. Clonidine is well-known as an agent that extends the analgesia effect of local anesthetic drugs. The goal of this study was to evaluate the effectiveness of clonidine addition as adjuvants in levobupivacaine 0.25% in scalp nerve block in craniotomy procedures. Patients and Methods: This was a clinical trial with a double-blind, randomized study using consecutive sampling technique. Inclusion criteria include patients underwent craniotomy surgery due to brain tumor using general anesthesia with endotracheal tube in 18-60 years of age. As an addition to general anesthesia, group a received levobupivacaine 0.25% and clonidine 2 µg/kg as a regiment for scalp block. Group B received levobupivacaine only for the same purpose. All other treatments were similar for both groups. Results: The intraoperative fentanyl requirement (100 (50-150) vs. 150 (75-200) mcg, p <0.001), the period to the postoperative first PCA dose (822.5±129.7 vs. 387.8±69.6 minutes, p <0.001), and the total need of postoperative morphine by PCA (2.0 (1.0-3.0) vs. 3.0 (2.0-7.0) mg, p <0.001) were lower in the clonidine-added levobupivacaine groups compared to levobupivacaine alone. 3 Conclusions: The addition of clonidine to levobupivacaine 0.25% on scalp block is effective in reducing the need for intraoperative and postoperative opioids, reducing postoperative pain, extending the duration of scalp nerve block, and delaying the first PCA dose.Keywords: Clonidine, Levobupivacaine, Fentanyl, Morphine, Pain, Requirements.

Page 2 of 6 | Total Record : 52

 1   2   3   4   5 

Filter by Year

2019 2019


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue