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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 52 Documents
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Search results for , issue "Volume 11 Issue 08 (2019) Aug. 2019" : 52 Documents clear
Histological Description of Hedgehog (Hemiechinus auritus) Abdomen Skin Al-Zubaidi KA
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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The present study was conducted on six healthy male’s hedgehog, to distinguish the normal histology of the abdomen skin. The hedgehogs were anesthetized by ketamine (15 mg/kg. body weight) injected intramuscular after scarfing of hedgehogs, the skinning of the ventral surface of the abdomen was carried out, then the skin specimens fixed in the formalin (10%). Routein histological processes were done. The histological structure of the hedgehog abdomen skin was revealed many invaginations of the skin folds projected from superficial surface; these folds had many bifurcation were divided by grooves, and the folds appeared as the ridges. The abdomen skins of hedgehog covered by keratinized squamous epithelium, the keratin layer consider as protective layer foe the superficial skin which represented the epidermis. Under lining the epithelium there was loose connective tissue that supported the superficial skin; and consisted of collagenous and elastic fibers as well as cellular elements such as fibroblasts, lymphocytes, myoid cells were distributed among collagen and elastic fibers which extended into the cores of the abdomen skin folds. Beneath the loose connective tissue, the dermal spines follicles were found and surrounded via a layer of smooth muscle fibers. Clusters of sweat glands were distributed deeply under the dermal spines follicles. Striated muscle fibers below the sweat glands. The striated muscle fibers were arranged; circular, longitudinal and oblique in the orientation, these muscle fibers which support the upper layer of the skin. The dermal papillae was absent in the hedgehog skin. Keywords: (hedgehog, Histology, Abdomen skin).  
Isolation and Antimicrobial Characterization of Aerobic Pathogenic Bacteria from Egg Shell and Egg Contents in Table Eggs in Erbil Ahmed I. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Contaminated eggs are the major reservoirs for many foodborne pathogens and their ability to produce toxins causing diseases or even death in human. One of the essential quality characteristics of eggs is hygienic quality, lack of good hygienic practices, which may lead to loss the quality and deterioration of eggs. This study was focused on fresh chicken eggs to determine the prevalence and level of contamination in process as well as risk of antibacterial resistance of isolated bacteria. The level of contamination of table eggs with pathogenic bacteria and the antimicrobial resistance (AMR) were examined. Total numbers of 72 fresh chicken eggs were collected from eight flocks including conveyer belt and storage eggs from two large scale poultry layer farms in Erbil. The total bacteria on its eggshell was counted, bacterial loads were ranged between 5.174-5.854 log cfu/ eggshell. Bacteria isolated colonies subculture on Macconkey agar and gram negative baccilli were inoculated on VITEK® 2 ID-GNB (identification-Gram-negative bacilli) and antimicrobial susceptibility testing (AST)-GN69 cards. The bacterial pathogenic contamination ratio was 22.2% Staphylococcus and 22.2% enterobacteriaceae mostly (E-coli 11%). Whereas no bacteria were found in polls egg contents. The highest resistance rate was detected against Cefazolin, Amoicillin, Trimethoprim/ Sulfamethoxzol, Nitrofurantoin, Ciprofloxacin, Levofloxacin. The high sensitivity rate was recorded against Piperacillin/Tazobactam, Imipenem, Ertapenem, Gentamycin, Tobramycin, Cefipime, Cefitraxone. The results of this study conclude that the bacterial load on egg shells and contents were at the accepted level while the isolation of pathogenic bacteria due to lack of hygiene practice should be considered, also we suggest that the farmer must fumigate the fresh eggs with a good hygienic practice before marketing.
Managing Consumer Loyalty in the Pharmaceutical Market of a Metropolis Olga Pashanova
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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The article presents the results of a study of a complex of factors that determine consumer behavior in a pharmacy for visitors of an older age group (elderly people over 65). The main problems in providing pharmaceutical care to elderly consumers in the local pharmaceutical market of a large metropolis (for example, Moscow) are identified. Positive and negative factors of consumer loyalty of elderly customers of Moscow pharmacies are indicated. The purpose of the study was to formulate a comprehensive socio-psychological portrait of an elderly consumer receiving pharmaceutical assistance in pharmacies in Moscow. In order to achieve this goal, a study of the behavior of visitors to pharmacies over 65 years of age, their sociological surveys, as well as a survey of pharmacy managers and employees to identify positive and negative factors that affect the consumer behavior of the studied focus group of customers, were conducted. A sociological survey of visitors to Moscow pharmacies and a survey of managers and employees of pharmacies revealed the positive and negative factors of consumer behavior of elderly consumers and identified the main problems encountered in pharmacies in the provision of pharmaceutical care for this category of patients. A comparative analysis of Russian and world experience in serving elderly visitors in pharmacies was carried out. The necessity of studying the behavior of consumers of older adult focus groups is proved in order to improve the quality of pharmaceutical and psychological care. Elderly clients (over 65) account for 40-65% of visitors to Moscow pharmacies. The consumer behavior of the studied category of patients is characterized by pronounced polypharmacy, the need for advisory services and psychological assistance, the need for communication, a significant lack of information about the assortment, the interaction of drugs, their correct use, and storage. The psychological and medical problems in most elderly patients complicate the process of providing them with timely and high-quality medical care; require the use of a special psychotherapeutic approach in the work of pharmacy employees, and the introduction of a specific “client-oriented pharmaceutical advising”.Keywords: Elderly patients; Elderly consumers; Older adults; Polypharmacy; Pharmaceutical assistance; Pharmacy organizations; Socio-psychological portrait; Client-oriented pharmaceutical advising.
Antioxidant Peel off Gel Mask with Stevia Rebaudiana Bert Extract Lia Kusmita
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Anti-oxidant activity is the activity to deter free radicals. Stevia rebaudiana Bert contains multiple compounds, such as flavonoid, that are capable of deterring free radicals.  The aim of this research was to produce peel off gel mask based on Stevia rebaudiana Bert extract with anti-oxidant abilities. Additionally, it was also used to determine the characteristics including pH, viscosity, dispersion, adhesion, and drying time of the preparation. This research was initiated by creation of the extract, continued by creation of peel off gel mask formula, and finalized by testing the anti-oxidant properties. The research showed a result with the value of Stevia rebaudiana Bert extract (IC50 = 60 µg/ ml). From the evaluation result of anti-oxidant activity from the peel of mask using Stevia rebaudiana Bert extract, it was proven that the higher the extract’s concentration, the smaller the IC50 value, which indicated higher anti-oxidant activity. The characteristic evaluation result of all formula showed that the characteristic evaluation value still fulfilled the set criteria to produced good peel off gel mask. Keywords: Stevia rebaudiana Bert; anti-oxidant; peel off gel mask
Effectiveness of Intravenous Subanesthetic Dose of Ketamine on the Subarachnoid Block to Attenuate Inflammation Response in Transurethral Resection of the Prostate Surgeries Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: Perioperative anesthesia and surgery can induce a stress response in the body. Regional anesthesia with local anesthetic drugs in the transurethral Resection of the Prostate (TUR-P), has been proven to minimize inflammation. Patients and Methods: Forty-eight patients of ASA I-II, scheduled for TUR-P with spinal subarachnoid anesthesia were randomly divided into two groups, group A with ketamine and group B without ketamine. The blood level of interleukin (IL)-10, IL-8, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and IL-10/IL-8 ratio were measured in both groups at 1 hour before operation, also at 1 and 24 hours after operation. Results: Blood level of IL-10 (p<0.001) and IL-10/IL-8 Ratio (p<0.05) were significantly different with higher values on group A. Other parameters were not found to be different. Conclusion: Subanesthetic dose of ketamine on spinal subarachnoid anesthesia technique done for TUR-P operation was found able to control inflammation and prevent the deterioration of immune system perioperatively.Keywords: IL-10, IL-8, CRP, NLR, Benign prostatic hyperplasia.
Association between Obesity and Markers of Inflammation, Oxidative Stress and Neuronal Injury in Women with Non-alcoholic Fatty Liver Moushira Zaki
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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The present study aimed to investigate the association of Nuclear Factor (NF)-κB, oxidized –low density lipoprotein (o-LDL), total antioxidant capacity (TAC), neuron-specific enolase (NSE) and CD4 in obese women with non-alcoholic fatty liver (NAFLD). A total of 36 NAFLD obese women were enrolled in this study and 36 female control healthy women (aged 30-39) without cognitive impairment were examined. NAFLD patients were diagnosed by magnetic resonance elastography. Anthropometric parameters including body height, weight, waist circumference (WC) and body fat % were measured. Serum NF-Κb, TAC, CD4, o- LDL and NSE   were measured by ELISA.  Also, liver function tests, lipid profile were done. The present results showed marked elevation in serum NF-κB and o-LDL, while significant reduction in TAC and CD4 in obese NFALD than normal control subjects. In conclusion results provide evidence of association between obesity, high levels of oxidative stress, inflammatory markers and brain biomarker in women with NAFLD.
Factor Analysis of Patient with Hypertension on Self-Regulation Based on Self-Belief Riza Fikriana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: The purpose of this study was to analyze the factors that influence self-regulation based on the self-beliefs of hypertension patients. Methods: The design of the study used observational analytics with a cross-sectional study approach. The sample size consisted of 108 patients with hypertension in health centers in Malang Regency, East Java, Indonesia. The independent variables were physical activity, food consumption, medication adherence, control in health care and stress management. The dependent variable was self-regulation. Data were collected using a questionnaire tested for validity and reliability. Logistic regression was used to analyze the results. Results: Age (p = 0.014) and support of health workers (p = 0.004) had an effect on the self-regulation of food consumption. Age (p = 0.008), gender (p = 0.006), family history (p = 0.004), family support (p = 0.014) and health insurance (p = 0.028) had an effect on the self-regulation of medication adherence. Age (p = 0.022) affected the self-regulation of control to health services. Peer support (p = 0.008) was significantly associated with stress management. Conclusion: The consolidation of social support and health services is important to improve self-regulation based on self-beliefs in patients with hypertension.Keywords: Self-regulation, Confidence, Hypertension.
Determinants of Stigma Attitude Among People Living with HIV Nursalam .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: Human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is still a stigma in the community and becomes a barriers in dealing with HIV. This study aimed to identify the determinants of stigma attitude among people living with HIV/AIDS (PLWHA).Methods: This study used a cross-sectional design. Sample collection was carried out by simple random sampling involving 135 Housewife suffered by HIV in Surabaya. The independent variables were policy support, patient characteristics (including age, sex, education level, marital status, occupation, HIV status, first being diagnosed with HIV), family factors (including family burden and family resilience). The dependent variables were stigma. Data were collected using a questionnaire. The analysis used binary logistic regression with a significance level of p ≤0.05. Results: The results showed there are five factors related to stigma in PLWHA, namely policy support (p = 0.019), marital status (p = 0.039), first being diagnosed with HIV (p = 0.006), family burden (p = 0.000) and family resilience (p = 0.041). Out of five variables, only four had a significant effect on stigma, namely marital status (OR = 0.009; 95% CI 0.000 – 0.697), first being diagnosed with HIV (OR = 7,464; 95% CI 1,820 - 30,617), family burden (OR = 0.075; 95% CI 0,017 - 0.329), and family resilience (OR = 0.010; 95% CI 0.000 - 0.381).Conclusion: The determinants of stigma attitude among PLWHA include policy support, marital status, first being diagnosed with HIV, family burdens and family endurance. Tackling stigma on HIV which involves various sectors including society, family, private and government.Keywords: HIV/AIDS; PLWHA, Stigma attitude.
Microencapsulation of Lactobacillus plantarum in Lactic Acid Fermentation of Winter Melon (Benincasa hispida) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Winter melon (Benincasa hispida) is a popular vegetable that were grown primarily for its use as a vegetable and usually recognized for its nutritional and medicinal properties. Consumers tend to prefer the food and beverages that are fresh, highly nutritional, health promoting and ready to consume. Objective of this study focused on different technical parameters such as the initial soluble solid content (6.0, 6.5, 7.0, 7.5, 8.0 oBrix), loading ratio of Lactobacillus plantarum encapsulated in calcium alginate bead (2.0, 4.0, 6.0, 8.0 10.0 g/100mL), fructo-oligosacharide (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) as prebiotic affecting to the lactic acid fermentation of winter melon juice. Results showed that the best quality of the fermented winter melon juice would be achieved by the initial soluble solid content of juice 7.5 oBrix, Lactobacillus plantarum bead loading 8.0 g/100mL, fructo-oligosacharide 2.0%. Through fermentation, winter melon juice was preserved and maintained, while improving the nutritive and sensory properties. Lactobacillus plantarum was stable under acidic condition by the microencapsulation. The probiotic winter melon juice is very beneficial for health as health it plays an important role in immune system improvement.Keywords: Benincasa hispida, Lactobacillus plantarum, Microencapsulation, Fermentation, Fructo-oligosacharide, Juice.
Knowledge and Determinants of Use of Health Supplements among Undergraduates in Ipoh, Perak Malaysia Sook Ching Chan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background Objectives: Research on health supplement usage among Malaysian undergraduate students is still limited although an average of USD17.30 was reported spent for nutritional supplements monthly.This study aimed to determine the usage of health supplements among the undergraduate students in Ipoh, Perak, Malaysia and the relationship between consumption and knowledge of health supplement among these students. Methods: This cross-sectional study was conducted in March to April 2018. Health sciences students and non-health sciences students from four different universities/colleges were selected through cluster sampling and random sampling method. A questionnaire that included socio-demographic data, lifestyle practices, usage of health supplement and assessment of knowledge of health supplements was given to selected students. Data analysis was done using SPSS 22.0 (Trial Version).Results: There were 374 respondents of which 79 students (21%) consumed health supplements. The majority of those who consumed health supplements (82%) were from Health Sciences, female (61%), overweight (44%) and with family income of more than RM5000 (39%). The top three most common reasons for using health supplements were “to maintain good health” (82.3%), “to ensure adequate nutrition” (54.4%) and “to improve immune function” (40.5%). The most common types of health supplements used were vitamins (44%) and minerals (23%).  Fifty seven percent of the consumers had good knowledge compared to 30.5% of non - consumers. Conclusion: The majority of the consumers were from Health Sciences, female, overweight, had family income more than RM5000 and had better knowledge regarding the health supplements as compared to the non-consumers.Keywords: Health supplements, Undergraduates, Knowledge, Use.

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