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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
Microwave-Assisted Extraction of Phytochemicals in Cogongrass (Imperata cylindrica) Rhizome N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Microwave irradiation has received a lot of attention. It is a feasible green solvent extraction method as it utilizes water or alcohols at elevated temperature and controlled pressure conditions. Microwave extraction emerges as a promising technique from an economical point of view, being inexpensive, simple and efficient. Cogongrass (Imperata cylindrica) rhizome is a good source of antioxidants such as phenolic, flavonoid and saponin. The rhizome-root part serves as traditional medicine for the treatment of a wide range of infections.  In our research, different parameters such as power of microwave (50, 75, 100, 125, 150 W), frequency of microwave (15, 20, 25, 30, 35 GHz), duration of the microwave irradiation (1.5, 2.0, 2.5, 3.0, 2.5 min), ratio of liquid to solid (water: material, 1.0:1.0, 1.5:1.0, 2.0:1.0, 2.5:1.0, 3.0:1.0), extraction temperature (70, 75, 80, 85, 90oC), number of extraction cycles (1, 2, 3, 4, 5) affecting to the microwave-assisted extraction of phytochemicals in cogongrass (Imperata cylindrica) rhizome were examined. Total total phenolic (mg GAE/ 100g), total flavonoid (mg GE/ 100g), saponin (%) were important indicators to identify the optimal variable. Our results showed that microwave power 100 W, frequency 30 GHz, duration 2.5 min, liquid to solid ratio 2.0:1.0, temperature 75oC, 3 cycles of extraction were appropriate for extraction of phytochemical components inside cogongrass (Imperata cylindrica) rhizome.Keywords: Cogongrass, Imperata cylindrica, Rhizome, Microwave, Extraction, Phenolic, Flavonoid, saponin.
New Composite Material of Thermoset Base Reinforced by Micro-hyper-woven Fiber Resistance for Petroleum Derivatives Nagham H. Abood
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A new composite of polyester reinforced by micro-hyper-woven glass and carbon fibers has been prepared to obtain unique mechanical and thermal properties and physicochemical activity such as high specific strength, stiffness and corrosive resistance to different hydrocarbon derivatives. In this experimental work, an attempt has been made to test the aging of new hyper composites in terms of their thermo mechanical properties by changing the weight percent, Cw/gw, of the additive woven mixed fiber in the range of (1, 2, 3). This new composite is fabricated by manually layering the base polyester matrix and reinforced hyper woven fibers 200/20 (gm/gm) from the base matrix, and a hardener is applied for each cast with 1 gm of micro-zirconium. Different aging results of the thermo mechanical properties (thermal conductivity, thermal expansion, impact strength, flexural strength, tensile strength, elongation, hardness, and compression resistance) are obtained according to the American Society for Testing and Materials (ASTM) standards. The results for these aging thermo mechanical properties after one month show that the specimens reinforced by hyper woven gw/Cw with three percentage mixing ratios (1, 2, 3 wt.%) have excellent aging thermo mechanical properties. Keywords: Hyper woven fiber, Polyester composite, Aging characteristic properties.
Knowledge of Health Care Workers Regarding Zika Virus Infection in Baghdad City / Iraq Atta Ah Mousa Al -Sarray
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Background: WHO declared that   Zika virus infection as a global public health emergency of international concern. Objectives: To determine the level of knowledge of Health care workers regarding Zika virus in Baghdad city. Subjects and Methods: A descriptive; cross sectional study conducted at 41 randomly selected (multistage sample) hospitals and primary health care centers  in Baghdad city, included 600 health care workers, The data collection continued for the period starting on 11th November-2018 ending on 3th March 3, 2019. Results: The results of demographic data was conducted on health care workers with their mean age (37.8±10.7)  years ranging from (20-66) years and the highest percentage (34.2%) were in the age group (30-39) years and the lowest percentage(3.3) were in the age group (age>60) years, most of studied sample were females (73%) and married (71%),regarding Educational qualification the highest percentage (57%) from College and higher educational level, the lowest percentage from secondary school, the majority of studied sample (60%)  were medical staff and not well informed regarding the association of Zika virus and Guillain-Barre syndrome, the diagnostic test, and management options, There knowledge was mainly gained from Internet, Radio and T.V. Conclusion: This study concluded that the health care workers had fair and acceptable knowledge regarding Zika virus in Baghdad city during the period of study . Recommendation: Co-ordinate educational programs are needed to increase the knowledge level of health care workers about Zika virus and other emerging diseases, these programs can be extended to include the medical students, travelers and pregnant women. Key words:  Zika virus, Knowledge, Health care workers, Baghdad city.
Effect of Cayratia trifolia Ethanol Extract on Bcl-2 expression and Apoptotic Cells in Dmba-induced Breast Cancer of Sprague Dawley Rats I Ketut Sudiana
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The study aimed to clarify the effect of the administration of ethanol extract of Cayratia trifolia plants to breast cancer. This study was an experimental study using female animal model of Sprague Dawley rats, consisting of three groups, K0, the normal experimental animals, K1, the experimental animals with breast cancer receiving CMC 0.5%, and KP, experimental animals with breast cancer receiving ethanol extract of Cayratia trifolia in a dose of 300 mg/kgBW at 0.5% CMC.  The material to induce breast carcinoma formation was DMBA of 20 mg/kg in corn oil. The extraction of Cayratia trifolia plants used ethanol. The variables were the number of cells expressing Bcl-2 observed with immunohistochemical methods, and the number of cells undergoing apoptosis, which was observed using tunnel assay method. Statistical analysis was performed using ANOVA test. The number of cells expressing Bcl-2 and those undergoing apoptosis in breast cancer tissue between groups of animals receiving and not receiving ethanol extract of Cayratia trifolia showed significant difference (P<0.05). Oral administration of Cayratia trifolia ethanol extract has an effect on the decrease in the number of cells expressing Bcl2 and an increase in the number of cancer cells undergoing apoptosis.Keywords: Breast carcinoma; Proto-oncogene; Tumor suppressor gene; Cayratia trifolia.
Diagnostic of Plasma Spectral and Development Ti6Al4V Alloy with Deposition Titanium Layer by R-F Sputtering Mustafa Abdulkareem
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Ti6Al4V became the most favourable Titanium alloy due to its attractive mechanical and physicochemical properties and is currently extensively used e.g. in biomedical industry this work studies surface modification of Ti6Al4V to use in the implant bone. RF- sputtering is used for coating Titanium on the material Ti6Al4V alloy. The aim of this work is the power parameter (different power), used the ration power (50 watt, 100 watt, 150 watt and 200watt) the experimental Diagnostic of the coated layers by spectroscopy, FESEM and the average particle size (8.3-13.11) .The result show different colour layers, the TiN layer was shown the relationship between the electron temperature with the different power and electron density of TiN layer on Ti6 Al4V alloy with the different power (50,100,150and 200) Watt And during see the same figure the average particle size is equal for all picture between (8.3- 13.11) in the range of 100nm. The cumulative mass loss of the deposited coating specimen was about 3.71649mg for optimization samples TiN layer. The average hardness of the coating is about (264 to 331), which is higher than that of the substrate. The increases of average hardness depend on the different power.Keywords: Sputtering, Titanium, Homogenies, Implant, FESEM, Distribution, Surface modification and power.
Iraqi Legal System of International Environmental Responsibility Reyam Naji Ajmi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The domestic legal systems have shown an interest that varies from one system to another in the environment in which man lives. In the pursuit of progress and advancement, man has achieved great success in various fields, but on the other hand, he has contributed intentionally and unintentionally to harm the environment in which he lives, and the reaction of States when recognizing the dangers posed to the environment in an initiative to work to support their domestic laws to The adoption of programs and plans for the protection and preservation of the environment within the limits of its regional competence and the development of some laws and regulations in the field of the environment, which led to the flourishing support for domestic law in many countries, especially the developed world in the field of the environment, which led to the emergence of a series of national legislation However, efforts to protect and preserve the environment at the domestic level cannot lead to achieving their goals unless they are coupled with efforts at the other level, namely international relations, because the field of the environment highlights the close link between domestic and international law. The environment for natural and geographical considerations is ultimately only one integrated and connected in a natural format.Keywords: Environmental Law, Pollution.
The Role of Multi detector CT in Patients Presented with Undiagnosed Acute Abdorminal Conditions Mundher M. Mudhafar
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Background Intense stomach area traditionally alludes to torment inside the belly that has introduced for less than 7 days from the season of introduction. The utilization of CT check in the assessment of intense stomach agony has been expanded to an enormous degree because of high precision of CT in the analysis of explicit infections like a ruptured appendix and diverticulitis, particularly with the utilization of multi detector CT scanners. It has been demonstrated that the utilization of intravenous differentiation media builds the indicative exactness of CT check examination. The exactness of CT output imaging in patients with intense stomach conditions does not influenced by the absence of entral differentiate material.Aims of StudyTo decide the reason for intense stomach conditions in those with dubious conclusion by physical examination, U/S or plain X-beam.To assess the demonstrative precision of difference improved CT check versus unenhanced CT filter examination in the determination of intense stomach conditions.Patients and TechniquesThis planned report had been directed at Al-Sader medicinal city from the first of January 2013 to the first of December 2013.This examination incorporated all patients introduced to the crisis division with non-awful intense stomach conditions with dubious basic reason where the specialist unfit to recognize the careful hidden pathology inspite of nitty gritty history, appropriate physical examinations, stomach U/S, and plain stomach XR as the discoveries of radiological examinations were negative or uncertain.This examination included (40) patients, (22 male &18 female). Non improved CT output was performed first for all patients which was adequate to achieve the determination in (11) patients (27.5%), differentiate material was not utilized in light of the fact that blood urea was raised in 3 patients (7.5%). In (4) a patient (10%), CT angiography convention was performed for patients with suspected mesenteric vessels pathology. In the rest of the (22) patients (55%), intravenous complexity was given physically by means of a wide bore cannula (measure 18) and post difference sweep done in the entrance stage (postpone time 45-50 second).ResultsIn this examination, which was performed on (40) patients with undiscovered intense stomach conditions, we found that intense pancreatitis (10 patients) (25%) was the most widely recognized reason for undiscovered intense stomach torment pursued by intestinal hindrance (6 patients) (15%), while intense cholecystitis (4patients) (10%), entry or mesenteric vein thrombosis (4 patients) (10%), punctured viscus, (3 patients) (7.5%), mesenteric blood vessel thrombosis (2 patients) (5%), left gastric supply route aneurysm (1patient) (2.5%), intense appendicitis(1tolerant) (2.5%)diverticulitis (1patient) (2.5%) and ectopic pregnancy (1patient) (2.5%). In (7 patients) (17.5%), no particular pathology could be recognized.Keywords: Multi detector CT; Patients’ undiagnosed acute abdominal conditions.
Efficacy of Extraction and Microencapsulation of Betacyanin extracted and Freeze-Dried from Red Dragon Fruit (Hylocereus polyrhizus) Peel N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Microencapsulation is utilized to prevent chemically sensitive bioactive components from degradation due to harsh environmental conditions and is also applicable to handle the emission of the encapsulate. One of the key factors to be considered in the microencapsulation process is the coating material.  Dragon fruit peel derived from processing companies contains an abundant of betacyanin, a valuable pigment. In our research, different parameters of solvent extraction (kind of solvent, pH, ratio of solvent: material); microencapsulation (kind and concentration of coating agent, synergistic effect of combined coating agents) were thoroughly investigated. Our results showed that betacyanin can achieve the highest yield by extraction with water at pH 5.0 with dissolving ratio 5.5: 1.0 (water: material) within 8 hours at ambient temperature. The filtrates were then mixed with 20% maltodextrin+10% β-cyclodextrin as microencapsulating agent during the freeze-drying to get dried powder (6.5% moisture content). By this approach, the highest betacyanin could be maintained at utmost level.Keywords: Dragon fruit peel, Betacyanin, Extraction, Microencapsulation, Maltodextrin, β-cyclodextrin.
Spectrophotometric Determination of Loratadine in Syrup and Study Viscosity Conductivity and Thermodynamic of Binary Mixed Systems of Surfactants with Loratadine" Eman Thiab Al Samarraee
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A simple, rapid and highly accurate UV spectrophotometric and one viscosity and conductivity methods for estimation of Loratadine in bulk and its pharmaceutical preparation. The method based on using direct ultraviolet detection on the wavelength range 190-400 nm. An absorption maximum was found to be at 286 nm. The percentage recovery of Loratadine ranged from 100.113 to 99.564 % in pharmaceutical syrup form. The developed method was validated with respect to linearity, accuracy (recovery), precision, limit of detection (LOD), limit of quantitation (LOQ), Sandell's sensitivity, molar absorbtivity, molar extinction coefficient and specificity. Beer's law was obeyed in the concentration range of 5-35 μg/mL having line equation y = 0.0248x+ 0.0621 with correlation coefficient of 0.9988.Then studied the factors affecting the formation of wormlike micelles through focusing of different concentrations of Lor. 100-1000 µg.ml-1 in different temperatures (298.15, 303.15, 308.15 and 313.15 K) and at ratios of (20/80, 30/70 and 40/60).Thermodynamic functions (∆Go, ∆Ho, ∆So) were calculated for the process of micelles formation in the presence of Lor., the results indicated that the cationic (CTAB) and anionic (SDS) surfactants revealed a big tendency towards formation of wormlike micelles in Lor. Because intermolecular interactions. The other aspect included The prepared mixtures of surfactants have been study electrochemically using conductometric measurements in the aim of obtaining a relationship between conductivity (L(μS.cm-1)) and viscosity (η (pa.s)) of these solutions, but there is no linear relationship  has been achieved.Keywords: Loratadine, Surfactant, Viscosity and conductivity.
Characteristics of Modes in Photonic Crystal Fibers Altfat Radi Jlod
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

In this article, both the vector effect index method (VEIM) and finite element method (FEM) are exploited to calculate the effective index of FSM for the solid-and porous core PCF. For the solid-core, the EIM applies one time to estimate the equivalent cladding index. Then, the conventional characteristics’ equation will apply to construct the 14neff"> . For porous-core PCF, the EIM applies two times one for the core and other for cladding. Next, also the conventional characteristic equation will apply to explain the 14neff">  at the porous-core PCF.Keywords: Finite element method, Porous core PCF, Vector effect method.

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