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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
A Physiological Study of Albumin Level for Patients with Non-Hodgkin Lymphomas Samer N. Khalaf
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Cancers cause increases in mortality in different countries each year. The late diagnosis of cancers contributes to patient death significantly. Recently, the efforts of scientists began towards examining several markers that help in early detection. This paper aims to monitor the relationship between serum albumin level and NHL beside some variables such as weight, age, sex and several other diseases. The demographic data and samples were collected from people with and without NHL. Then, the albumin concentration was assessed using the biochemical tests. After that, the data were analyzed statically using Minitab-16 program, T-test and ANOVA. The results showed a significant difference (P≤ 0.05) in albumin level between control and the patients with NHL. The same pattern was for patients with NHL and other diseases. In contrast, there was no considerable difference between male and female with NHL. Furthermore, the findings illustrated a decrease in albumin concentration for old patients' less than young patients. On the other hand, the overweight patients revealed more albumin level that the patients with normal weight. Serum albumin is considered an important sign for the early detection of NHL. This early diagnosis will play a good role beside the chemotherapy and other kind of treatment. This will help to reduce the risk and mortality because of cancers worldwide.   Keywords: Non-Hodgkin lymphomas (NHL), Serum albumin level, Cancer, Overweight.
Study of Characterization and Concentration of Trace Element in Human Hair of Radiation Workers Zahraa Abbas Rasheed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Human hairs experience damage and restoration processes consistently because of various external and internal factors. To analyze degrees of hair damage, morphological studies based on scanning electron microscopy (SEM).The present study aims to analyze degrees of hair damage, morphological and structural changes in human hair shaft and effect concentration of trace element under SEM and ICP-OES respectively in a sample of male radiation workers who worked in Al-Tuwaitha nuclear site.  The descriptive statistics of grade of hair damage, hair diameter, cell length under SEM. A statistically significant difference was found between the radiation worker and control group with respect to the SEM scores with the extent of damage being more in the radiation workers as compared to the control groups. The present study showed high percentage of grading damage under SEM for both Radiation worker& control group in grade 1(56%) and grade 0(60%), respectively. To validate the analytical of levels of Sr and U in scalp hair of radiation workers and control groups. U levels in of radiation workers was  significantly higher in radiation workers compared to control groups, whereas, Sr was significantly lower in radiation workers as compared to the control group. In conclusion, the obtained results occupationally exposed to low levels of ionizing radiation may be associated with increased deposits on the hair shaft surface; these findings may be consistent with those obtained in other studies, confirming that the deficiency and efficiency of trace elements play a role in clinical disorders and the pathogenesis of many diseases. Furthermore, to prove that human hairs are useful in the studies pertaining to chronic body exposure and good biomarkers in clinical studies for radiation worker.Keywords: Human hair, SEM, ICP: OES, Uranium, Strontium.
Organ Index, Toxicological, and Bioaccumulation Study of Sub chronic Intraperitoneal Injected Silver Nanoparticles in Albino Mice Males Sarab Mohammed M. Razooki
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

To investigate the sub chronic toxicity effects of intraperitoneal injected silver nanoparticles (Ag NPs) (24.52 nm), Albino mice males repeatedly exposed to three different doses (12.5, 25, and 50 mg/kg) of Ag NPs for 4 weeks. The accumulations of injected doses in different organs were evaluated. The results showed a significant changes in organs indexes with a good relations to the histopathological effects were noted which ranges between infiltration of inflammatory cells to coagulative necrosis in liver, multiple hemorrhage and cast forming in kidney, and amyloid deposition in spleen, thickening of intestinal villi, and sever interstitial broncho pneumonia as adverse effects in studied organs with dose related manner. Significant changes in hematological and biochemical parameters were detected combined with a considerable increasing in antioxidant enzymes in a dose dependent manner.   The reduction in thyroid hormones levels T3, T4, and thyroid stimulating hormone (TSH). The  highest accumulated Ag means values were recorded in liver, spleen, lung, and kidney respectively followed by brain, heart, small intestine, and testes in the order  with dose depended manner which express the toxicological effects were recorded.Keywords: Ag NPs, Accumulation, Organ index, Biochemical parameters, Histopathology.
Diorganotin (IV) Complexes Aid Switch to Protect the Photodecomposition of PVC in Outdoor Buildings Emad Yousif
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Three organotin (IV) complexes with different R-groups were used as additives for PVC. The photo-degradation rate constant of poly (vinyl chloride) upon irradiation with an ultraviolet light were investigated in the presence of Organotin(IV) complexes as photo stabilizers. Poly (vinyl chloride) photo-degradation rate constant was lower for the films containing Organotin (IV) complexes (5.6-1.5 × 10-3 sec-1) compared to the blank film (9.0 × 10-3 sec-1).Keywords: Organotin(IV), Photo stabilizers, UV irradiation, Poly(vinyl chloride), Photo degradation rate constant (kd).
Synthesis, Characterization and Antibacterial Study of New 4-Thiazolidinone and Tetrazole Compounds Derived from Thiosemicarbazone and Hydrazones Israa A. Mosa
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

A new 4-thiazolidinone, substitutedbenzylidene-thiazolidinone and tetrazole were synthesized from thiosemicarbazone and hydrazone. The thiosemicarbazone was prepared by the reaction of thiosemicarbazide with aldehyde derivative from L-ascorbic acid in absolute ethanol using glacial acetic acid as a catalyst. 1, 3-thiazolidin-4-ones were synthesized from the condensation of thiosemicarbazones with chloroacetic acid in presence of anhydrous sodium acetate. A 1, 3- thiazolidine-4-one was reaction with several 4-substitutedaldehydes to produce new derivatives with a double bond at the position-5 of the 4-thiazolidinone ring. While the tetrazole compounds were synthesized by 1, 3-cycloaddition reaction of sodium azide and hydrazone compounds in dimethylformamide. The hydrazone compounds were prepared by the reaction of phenylhydrazine or substituted phenylhydrazine with aldehyde derivative from L-ascorbic acid in absolute ethanol using glacial acetic acid as a catalyst. The structures of newly synthesized compounds were established on the basis of spectroscopy data.Keywords: L-Ascorbic acid, 4-Thiazolidinone, Alken, Thiosemicarbazone, Tetrazole, Hydrazone. 
Study Expression of Fibronectin in the Samples of Oral Squamous Cell Carcinoma Zaidoon Jasim Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The current study included samples of 30 sample oral squamous cell carcinoma with a ranged age 33-67 years in mean age 47±9 in different sex.  Regarding the size of oral squamous carcinomacase, 10 cases of each size T1, T2 and T3 appeared in the same percentage (33.3%). Concerning grade of oral squamous cell carcinoma case, majority of them (15) cases (50%) had grade I, while (10) cases (33.3%) had grade II (oral squamous carcinoma well differentiated), (3) cases (10.0%) had grade III and (2) cases (7.1%) had grade IV (differentiated poorly oral squamous carcinoma).The results of analysis showed Positive fibrnectin expression using Immuno staining teqnique was found in all oral squamous cell carcinoma cases as brown extracellular matrix, cellular localization expression and cytoplasmic expression, fibrnectin expression using immunohistochemichal staining of the oral squamous carcinoma cases  which reveals that (5) cases (17.3%) showed  protein expression weak positive, (15) cases (50%) showed protein expression moderate positive and (10) cases (33.3%)showed  protein expression strong positive.Keywords: Fibronectin, Squamous carcinoma in oral, Immunohistochemichal teqnique.
Biodegradable Chitosan Dyes for Clean Environment and Their Application as Alternative Green Dyes Shaimaa H Abdullah
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

This research aimed at preparing derivatives of natural polymer Chitosan (CS) carrying chromophoric chromatic groups, such as amine benzaldehyde groups (I, II, III) and aromatic azo dyes (I1-I5), (II1-II5), (III1-III4), which are characterized by their stability till the preparation of environment-friendly biodegradable polymers. The study identified polymers resulting from polymer (CS) interaction with three phenolic benzaldehydes and then the interaction of amine derivatives of these polymers with diazonium salts prepared simultaneously by some aniline in the infrared spectrum FT-IR, proton nuclear magnetic resonance, the X-ray spectrum (X-RD) and the change of physical properties.Keywords: Chitosan, Schiff Base, Azo Dyes, X-Ray, Chitin.
Optimization Parameters for Enzymatic Clarification of Dragon Fruit Juice N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Fresh dragon fruit juice has high viscosity and turbidity. Fruit juice clarification by ultrafiltration only does not remove active haze precursors, allowing haze formation during storage. Pectinase treatment can resolve this matter. Pectinase can break down complex polysaccharides of plant tissues into simpler molecules like galacturonic acids. Pitaya or dragon fruit can be utilized to produce fruit juice as functional beverage. In our research, pectinase was used in different parameters of enzyme concentration (0.02, 0.04, 0.06, 0.08, 0.10%), temperature (30, 35, 40, 45, 50oC), time (45, 60, 75, 90, 105 min) and pH (4.2, 4.4, 4.6, 4.8, 5.0). Total soluble solid (oBrix), total phenolic (g/L), turbidity (NTU) and viscosity (cP) were important indicators to identify the optimal treatment. Our results showed dragon fruit juice would have the best total soluble solid, total phenolic, clarity as well as viscosity by treatment of pectinase concentration 0.08%, temperature 40oC in 90 min at pH 4.6. Our finding concluded that pectinase treatment would be a potential efficient approach of cloud removal in dragon fruit juice productionKeywords: Pectinase, Dragon fruit, Total soluble solid, Phenolic, Turbidity, Viscosity.
Phytochemical Properties and Antioxidant activity of Pollen of Typha domingensis pers. Grow in Marshes of Maysan Governorate Southern of Iraq Ali Nazar Yaseen
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The aim of this study was to evaluate the antioxidant activity of the Typha domingensis Pers, naturally growing pollen in the marshes of Maysan province in southern Iraq, and to link them effectively with the total flavonoids. (75 Ethanol+75 Water) for pollen these grains contain many effective plant compounds such as tannin, glucoside, alkali, saponin, polyphenols, and flavonoids. Flavonoids were extracted from pollen and detected using thin film chromatograph technique. The amount of flavons in the extract was estimated by chromatic method with aluminum chloride and was found to be approximately 71.3 milligrams per 50 grams of pollen powder. In determining antioxidant activity, the DPPH assay was used to show that the pollen extract had a good ability to inhibit DPPH free activity by 36.21% at 250 μg / ml of flavonoids compared to standard ascorbic acid (98.01% inhibition). The research concluded that the pollen extract contains the compounds of tannins, glycosides, alkalis, sapphones, flavonoids and phenolic compounds. Total flavonoids from pollen extract showed significant antioxidant activity.Keywords: Bardy, Typha domingensis Pers., Phytochemical, Phenolics, Flavonoids.
Study the Effect of Oxides Emitted from the Smoke of Bakeries on the Density of Bone Reham K.H. Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Objectives: Osteoporosis is bone disorders that excess a person’s dangers of fracture due to low bone mineral density, impaired bone microarchitecture/mineralization, & diminution bone strength. This asymptomatic condition often remains undiagnosed until it manifests as a low-trauma fracture of the hip, spine, proximal   humerus, pelvis, & wrist, which frequently leads to hospitalization. Methods: The present study of 41 bakeries worker’s various places in Baghdad. Serum levels of vitamin D3, PTH hormone, Calcium, magnesium   and phosphorus were measured and analyzed of the bakeries smoke resulting from the combustion of kerosene substance by a device (aeroqual).Results: a significant increase in serum level of parathyroid hormone in bakery workers' group when the compared to a healthy control group (P=0.003). a slightly decrease of vitamin D3 in bakery worker groups as compared with a healthy control group, but it was not significant differences (p=0.068). Calcium, magnesium & phosphorus were determined in sera of healthy control group & bakery workers' group as It is clear that, there is no significant variation in the   calcium   & magnesium concentrations between control group and bakery workers' group (p=0.612), (p=0.748), respectively, while a significant decrease in the phosphorus concentrations, in bakery workers' group as compared to a healthy control group. This result showed that there was an appositive correlation between magnesium and years of work. Conclusion: It is possible to predict the risk of osteoporosis in bakeries bone by measuring levels of vitamin D3, PTH and bone minerals (Ca, Mg, and phosphorus) in their sera, and measuring the toxic oxides concentrations (NO2 and CO) emitted from the smoke of bakeries resulting from combustion of kerosene used as fuel.Keywords: Osteoporosis; Vitamin 25 (OH) D3, PTH hormone, Magnesium.

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