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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
Molecular Diversity of Bacterial Isolated from Cozy and Cold Spring Water in Mosul / Iraq Mohammed Abdul_Razak Ibraheem Al-Qatan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The study involved determining the phenotypic and genotypic characterizations of the bacterial isolates from cozy springing water. Three bacterial species were elite supported on morphological bacterial, physiological and biochemical tests. In addition to molecular diagnosis using 16srRNAsequences. The cells were Rod_cocci, non-motile and their colonies appeared pigment red, yellow-orange and white, the range of their growth was at ph 4-8, temperature range 10-40 and the range of growth in NaCl 2-15%. All isolates were aerobic, positive for  catalase, oxidase, nitrate redaction and negative methyl red, also produced acid from fermentation of (arabinose, fructose, maltose and trehalose), while our  isolates exhibited variable results formation of acid from sugares such as  glucose, galactose, mannose, sorbitole, lactose and sucrose). Also the isolates were resistant for the foiiowing antibiotics amoxicillin, carbencillin, erythromycin, streptomycin and tetracycline but with various resistance to gentamycin and novobiocin. The 16srRNA sequences were performed by the ABI 3130XL gene analysis in Biology Bolumu 21280_Diyarbakir/Turkey. The isolated strains were mainly Serratia nematodiphila, Staphylococcus saprophyticus and Bacillus vietnamensis. Bioinformatic analysis alignment was done by Clustal W program mega 5 and phylogenetic tree analysis was constructed and drawn by Nieghbour_ joining program.Keywords: Phylogenetic tree, Spring water, Bioinformatic.
Self-care Practices of Diabetic Patients toward the Prevention of Osteoporosis in Babylon Governorate, Iraq Wael Sulaiman Sabea
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Background: Diabetic patients with uncontrolled insulin are exposed to a potential risk of osteoporosis because disorder of osteoblast-osteoclast function and confusion in the metabolism of calcium, phosphorus and vitamin "D". Objectives: The aim of the study to determine self-care practices of diabetics about the prevention of osteoporosis. Patients and methods :A cross-sectional design study had conducted in in Babel Governorate/Iraq in Endocrinology and Diabetes Diseases Center from 3rd November 2018 to 10th March 2019.Samples were collected during systematic random technique using a questionnaire form had constructed and developed by a researcher after extensive review of related books and available literature. SPSS was used for statistical analysis in the present study. Results: 420 diabetic patients of type 1 and type 2 had been participated in the study with response rate (96. 99%). Their ages ranged from 15-75 years with a mean and standard deviation of 51.8 ± 13.5 years, 53.4% were female and 46.7% were male. More than half of diabetics were married and the majority (63.3%) were livening urban areas. 26.9% of diabetics were illiterate and type 2 diabetes was accounted for 81.2%; hypertension was calculated for 36.4% while obesity for 35.7% of them. The majority (66.4%) of diabetic patients had illustrated fair score (62-77) towards self-care practices about the prevention of osteoporosis. There was significant correlation (P. value ≤ 0.05) between good self-practices of diabetics toward the prevention of osteoporosis and relating to their adult age group, living in urban areas, employed group, high educational grade, type 1diabetes and insulin intake, family member with diabetes, diabetics with normal body mass index. Conclusions: The current study had concluded that diabetic patients generally had fair grade of self-care practices about the prevention of osteoporosis. Recommendations: The study has been suggested the enforcement of well-organized ceaseless educational courses supported with modern educational technologies for diabetic patients in diabetic centers and conducting studies on large samples of diabetic patients in other governorates in Iraq to determine self-care practices towards the prevention of osteoporosis and as well as to determine the prevalence of osteoporosis among diabetics.Keywords: Diabetic patients, Self-care practices, Prevention, Osteoporosis.
Immuno-Molecular Diagnosis of Toxoplasma gondii in Blood and Meat of Indigenous Chickens in Some Rural Regions of Iraq Amal Hassan Abd Al-Shabbani
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Herein the object was to detect the prevalence rate of the parasite Toxoplasma gondii (T. gondii) in blood and meat samples of indigenous chickens. Total of 92 chickens of both sexes of more than one year old were selected from some rural areas of Iraq during a period of February to August / 2017 and tested by using indirect-ELISA and PCR techniques. Overall results showed that 19.57% and 14.13% of sera and meat samples respectively were seropositive for anti-T. gondii-antibodies. In meat samples, the sero-prevalence was 7.61% and 14.13% in tissues of skeletal and cardiac muscles respectively. Regarding PCR technique, the total results showed that 5.44% and 1.09% of blood clots and meat extracts respectively were positive for DNA reaction of T. gondii. In addition, although the PCR results were found to be positive in cardiac muscles (1.09%) only, no significant differences had been detected regarding the results of skeletal muscles that lack positive cases. According to the diagnostic assays, significant differences in positive results were reported between indirect-ELISA and PCR technique among the tested samples of sera and meat as well as skeletal and cardiac muscles.Keywords: Toxoplasma gondii, Chickens, Blood, Meat, Serology, Molecular, Iraq.
Genotypic and Phenotypic Detection of Mutant Thrombolytic Enzyme (staphylococcal fibrinolysin) Expressed by Mutant Staphylococcus aureus Vancomycin Sensitive S.aureus (VSSA) and Methicillin Sensitive S.aureus (MSSA) by Hydroxylamine Chemical Mutagen Nebras Rada Mohammed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The aim of this study in order to determine mutagenesis of virulence S.aureus MRSA, VRSA then make it non virulent VSSA, MSSA by Hydroxylamine (HA) chemical mutagen. The study design of cases are Cross-sectional study so as to  limit types of epidemiologic studies including descriptive study of 500 isolates collected  from different sources of human infections from Tonsils, Nose, Tumors, Urine, Blood and Skin(Acne), all identification by Vitek2-GP. The  antimicrobial sensitivity test done of all 500 isolates against 14 antibiotics, the resistance of antibiotics including Vancomycin 475(95%), Methicillin 500(100%), Imipenem 475(95%), Erythromycin 175(35%), Cloxacillin 225(45%), Azithromycin 275(55%), Ceftazidine 125(25%), Ceftriaxone 75(15%), Cephalexin 75(15%), Norfloxacin 50(10%), Cefoxitin 25(5%), Gentamycin 25(5%), Oxacillin 25 (5%) and Clindamycin25 (5%)  compared with CLSI(2013).The expression of fibrinolytic enzyme (Staphylokinase) done on plasma agar plate to locate hydrolysis around well of plasma on medium, the result showed 180 (69%) isolates of Vancomycin resistance S.aureus (VRSA) and Methicillin resistance S.aureus (MRSA) produces Staphylokinase. The chemical mutagenesis was done by exposure VRSA S.aureus  and MRSA S.aureus  to different doses of chemical mutagen including Hydroxylamine(HA).The study of antibiotics after chemical mutagenesis accomplished on Muller Hinton Agar plate and in vitro to human serum to Vancomycin , Methicillin that have high resistance before mutagenesis, the result showed after chemical mutagenesis by Hydroxylamine (HA) of S.aureus (VRSA) and S.aureus (MRSA) become  sensitive to Vancomycin called Vancomycin Sensitive S.aureus (VSSA) and  sensitive to Methicillin called Methicilline Sensitive S.aureus  (MSSA) with possess higher productivity of Staphylokinase (thrombolytic enzyme).The genetic analysis of sak gene of mutant VSSA, MSSA S.aureus done by genotypic PCR after DNA extraction with  amplification of mutant VSSA, MSSA S.aureus sak gene to determine each isolates possess sak gene of VSSA ,MSSA  S. aureus   with high expression  of staphylokinase, the results showed all isolates of mutant VSSA MSSA S.aureus possess sak gene with 420bp compared with DNA Ladder Marker.  Key words: Fibrinolytic enzyme, Mutagenesis, Mutagenic specificity.
Estimation of the Microscope Point Spread Function by Using an Adaptive Image Deblurring Method Hana H. Kareem
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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As one of the most widespread techniques in biological investigation and dynamic process, light compound microscopy has used to analyze the optical properties of biological images. The optical microscope is often used to study and analyze the structures of biological cells and tissues. Microscope images are characterized by a number of specific parameters. Blurring is a major cause of image degradation in optical microscopes. We present an adaptive deconvolution based on the Richardson–Lucy (RL) algorithm to restore micrographs corrupted by out-of-focus blur with parametric estimation of the point spread function (PSF) of the acquisition system by using the blind deconvolution algorithm. This technique improves the quality of digital micrographs with defocus blur effectively. The evaluation algorithm is implemented to improve image quality by removing out-of-focus blur. The algorithm proceeds by randomly generating the PSF at each generation by using non-reference image quality. The PSF is used to estimate the actual image by applying the adaptive RL algorithm. Experimental results show that the proposed blind deconvolution method can estimate the core of the PSF, make good-quality restorted images with a slight ringing effect even, when the image is hardly blurred, and select input images for the non-reference image quality method for deconvolution.Keywords: Image Processing, Image restoration, Point Spread Function, Deblurring, blind deconvolution.
Synthesis of New Derivatives of Cephalexin with Isatin and Glycine Schiff Bases Shayma l. Abdulhadi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Objectives: Two derivatives of cephalexin were synthesized by reaction with isatin-glycine Schiff base and bromoisatin-glycine Schiff base separately. Methods: Cephalexin was linked through the amine group to isatin glycine and bromoisatin glycine Schiff bases by amide bond formation. Results: These derivatives were characterized by FT-IR, H-NMR, elemental CHN analysis and then tested for their antimicrobial activity compared to cephalexin against gram-positive, gram-negative bacteria and Candida albicans fungi. Conclusion: The two compounds showed better activity against Staphylococcus aureus, compound 3b is more active against Escherichia coli, and compound 3a is more active against Klebsiella pneumonia.Keywords: Isatin, Bromoisatin, Cephalexin, Schiff base, Antimicrobial activity.
The Role of Antibodies Lipids in Antiphospholipid Abortion Occurred in Women with Toxoplasmosis in Kirkuk City Bafreen Mohamad Raza
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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In the study the level of antiphospholipin (APL) antibodies with T. gondii in 160 abortion women who clinically diagnosed with recurrent miscarriage their aged between 15– 45 years, attending to Kirkuk hospital and 20 pregnant women with good health had not been subjected to previous abortion were included as control in the study which extended from April 2017 to October 2017. Blood samples and the required information regarded with maternal age and number of previous miscarriage were collected from both patients and healthy. Shown from the results that 21 (13.13 %) cases of abortion women with previous miscarriage were positive in APL- IgG and 10 (6.25 %) cases of abortion women with recurrent previous miscarriage give for APL+ and T.gondii IgG +IgM, all test results give negative in healthy women. An obvious significant ant differences at probability level (P < 0.05) found when make comparison between (APL IgG, IgM) with T.gondii+ APL IgM, IgG in both patient and healthy. The highest percentage of abortions was in the age (15-25) group. The lowest number of abortions was within the age group (25-35) years. The overall rate was 31%. It was the proportion of antiphospholipin IgG+ 21% and%10 of (IgG+ IgM) for antiphospholipin with antibodies T.gondii. There was no case of acute infection IgM+ antibody.Keywords: Recurrent Abortion, Toxoplasma gondii, Antiphospholipid.
Quantitative Analysis of Lutein from Iraqi Tagetes erecta Zainab Aziz Ali
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Tagetes erecta is a plant belongs to the genus Tagetes and family Asteraceae. Phytochemical studies show that tagetes erecta leafs and flowers are rich in alkaloids, flavonoids, tannins and essential oils. Lutein which is an oxycarotenoid and phenolic compounds was found to be the major secondary metabolite. [1]The name lutein comes from the Latin word, lutea, meaning yellow. At normal concentrations in food, it is a yellow pigment, but can appear orange or red at high concentration [2].The tetraterpene Lutein and zeaxanthin are found in high concentrations in the macula of the human eye, giving the macula its yellowish color. In fact, the macula also is called the "macula lutea" (from the Latin macula, meaning "spot," and lutea, meaning "yellow") have an important role in reducing the oxidation and reduce the incidence of cataracts. It is believed that lutein and zeaxanthin in the macula block blue light from reaching the underlying structures in the retina, thereby reducing the risk of light-induced oxidative damage that could lead to macular degeneration (AMD) [3]. In this study lutein was isolated from Tagetes erecta by column chromatography. The isolated lutein was identified by TLC, HPTLC. Structure elucidation was performed using UV, FTIR, 1H-NMR and 13C- NMR. The quantity of lutein was measured in the Iraqi plant.Keywords: Tagetes; Lutein; Isolation.
PCR Detection for Epstein-Bar Virus Associated with Leukemia Patients in Babylon Province of Iraq Mohammed T. Al-Tameemi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The first virus to be implicated in the causation of a human cancer was the Epstein–Barr virus (EBV), discovered in 1964 by Epstein, and Barr in a lymphoid cell line established from a biopsy of an African Burkitt lymphoma. The present study establish  for detection Epstein-Bar virus  in thirty serum samples  collected from Marjan hospital in Babylon Province of Iraq. Detection of this virus conducted by polymerase chain reaction for blood diagnosed firstly as having Epstein-Bar virus with leukemia by ELISA technique. Twenty three from thirty samples are positive for EBV association with leukemia patients according to PCR produced 161 bp band referred to EBV gene noticed at gel electrophoresis technique. Keywords: Epstein–Barr virus, Leukemia, PCR.
Synthesis, Structural Characterization, Thermal properties and Biological Activity of New Complexes Derived from Ligands with N, O Donor Atoms Nihad Kadhum Hasan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The study includes preparation and characterisation of  a new tridentate  Mannich -β-amino carbonyl ligand and its metal complexes are reported. The formation of  the ligand (R)-2-((4-(dimethylamino)phenyl) ((2-nitrophenyl)amino)methyl)-5,5-dimethylcyclohexane-1,3-dione (HL) was achieved from the reaction of 4-dimethylaminobenzaldehyde, 2-nitroaniline and dimedone in a 1:1:1 mole ratio, respectively.The reaction of the ligand with Co(II), Ni(II) and Cu(II) metal ions in a 2:1 (L:M) mole ratio resulted in the  isolation of monomeric complexes. The ligand and its metal complexes were characterised using a range of analytical and spectroscopic techniques including; elemental microanalysis, magnetic susceptibility, conductance, TGA, FT-IR, electronic spectra and 1H, 13C-NMR spectra. The  characterisation data indicated the isolation of six coordinate monomeric complexes with the general formula; [M(HL)2] (where M= Co(II), Ni(II) and Cu(II)). The ligand and its complexes were screened against several bacterial strains and fungi species. The obtained data indicated that the complexes are more active against several kind of organism, under survey, compared with the free ligand.Keywords:  Dimedone;  Mannich -β-amino carbonyl  ligand; Monomeric metal complexes; Thermal properties; Structural study.

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