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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
Synthesis of New 2, 4, 5-Triphenyl Imidazole Derivatives Derived from Benzoin and Studying their Biological Activity Rana S. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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In this work a series of new 2, 4, 5-triphenyl imidazole derivatives were synthesized. In the beginning, compound [1] was formed from the reaction of benzoin and benzaldehyde in the presence of ammonia, which was reacted with sodium hydride in DMF to obtain imidazole salt. This salt was reacted with adipoyl chloride to give compound [2]. Acid hydrazide derivative [3] was obtained from the reaction of compound [2] with hydrazine hydrate. After that Shiff bases [4-9] have been synthesized from the reaction of compound [3] with different aromatic aldehydes. These new formed compounds were diagnosed by 13C-NMR, 1H-NMR for some of them (in Ahl-Albate University in Jordan) and FT-IR spectroscopy (In Baghdad University). All of the prepared products have been studied their biological activities toward two kinds of bacteria. These products showed good efficacy to moderate toward bacteria.Keywords: Imidazole, Shiffs bases, Biological activity.
The Effect of Thymus Vulgaris Extract on Smooth Muscle Relaxation of Guinea Pig Aortic Ring: Study In Vitro Muhammad Basheer Abdullah Alsubbi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Objective: Hypertension appears to have a complex association with endothelial dysfunction. One of herbs that potential to develop as anti hypertension is Thymus vulgaris which contains high concentrations of phenols, including thymol and carvacrol that offer protection from hypertension. This study aimed to prove the correlation between different concentration of Thymus vulgaris extract and response of aortic ring relaxation. Methods: Using a laboratory experiment (in vitro study), treatment with provision doses of Thymus vulgaris extract was conducted to guinea pig (aorta ring) after pre-contracted by phenylephrine (PE). Thymus vulgaris extract (TM) at the doses of 0.0625, 0.125, 0.25, 0.5 and 1% were administered to experimental groups including 5 doses of extract with intact aorta rings and 5 doses of extract with denuded aorta rings. Pearson correlation test and T-test were used to analyzed the data. Results: The results indicate that administration of Thymus vulgaris extract can decrease the contraction of aorta guinea pig. Different doses of Thymus vulgaris extract have different relaxation responses of smooth muscle cell in aortic rings of guinea pig. The lower concentrations doses of Thymus vulgaris extract (0.0625% and 0.125%) can cause an effective and better relaxation effect on contraction of smooth muscle in denuded aorta than in intact aorta. Conclusion: The higher concentrations doses of Thymus vulgaris extract (0.025%, 0.5% and 1%) can increase the contraction of smooth muscle for both intact and denuded aorta of guinea pig.Keywords: Thymus vulgaris, intact aorta rings, denuded aorta rings, phenylephrine 
Assessment of Endocan with Progression and Severity of Diabetic Nephropathy in Babylon City Ahmed M. Mosleh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Background: Diabetic nephropathy (DN) is one of risk complication in type2 diabetes mellitus (T2DM) that required for new biomarker for early detection and to decrease the progression in deterioration in kidney function. Excessive angiogenesis is a main factor in the development of diabetic nephropathy. Aim: Our aim was to examine the association between serum endocan levels and urine protein creatinine ratio (PCR) as biomarker for assessment DN This study focused on evalution of endocan as biomarker for establishing diagnosis of DN and evaluate its effect on progression and developing DN Methods: In this study we evaluated endocan and levels in DN and diabetes patients without nephropathy and compared them with healthy subjects. Poor glycemic control by assess HbA1c and duration of DM are proofed to be a risk factor for DN. Endocan estimation by ELISA technique. Blood urea and creatinine and protein in urine were estimated by spectrophotometric method. Results: Endocan levels in DN was 327.9‎±106.9 and in diabetic patient without nephropathy and healthy control were (206.3‎±91.5, 122.7‎±45.7), respectively which is statistically significant at p-value<0.05. Endocan is significantly correlated with protein to creatinine ratio (PCR) and estimated glomerulofilteration rate (eGFR) at p-value<0.05. Conclusion: Endocan could be used as reliable marker for assessment diabetic nephropathyKeywords: Diabetic nephropathy, Endocan, Type2 diabetes mellitus.
Synthesis and Characterization of Substituted 1, 2, 4-triazole Pendant on Poly Ethylene via Microwave and Study Anticorrosion for its Bahaa Fadhil Hamzah
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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New derivatives of 5-substited 1, 2, 4- triazole pendant on poly ethylene were obtained through this research. Aromatic acid hydrazide derivatives were prepared from reaction of different esters (prepared from different aromatic carboxylic acid with absolute ethanol in presence of H2SO4 ) with hydrazine hydrate in presence of ethanol as a solvent then reacted with poly acrylonitrile and poly acryl amide via microwave to give (4a-e) and (5a-e) compounds respectively. All prepared compounds were characterized by physical properties as (softening point, color and conversion⁒), FT-IR, 1H-NMR for some of them and anticorrosion applications were measured.Keywords: 1, 2, 4-triazole, Microwave, Anticorrosion.
Preparation of Poly (Hydroxamic Acid) from Poly (Styrene-co-Methyl Metha Acrylate) and the Study of the use of Water Purification of Heavy Metal Elements Noor Fakhrie Mohammed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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In this study, the poly (styrene-co-Methyl metha acrylo hydroxamic acid) was prepared from the poly(styrene-co-methyl metha acrylate) which  prepared  by free radical polymerization using the benzoyl peroxide initiator to  co- polymerization between (methyl metha acrylate) and (styrene) at atemperrature 70 ⁰C a mixing ratio (1:1) a conversion rate 20% and then conversion the polymer output to poly (hydroxamic acid) by reacting with hydroxyl amine hydrochloride in a strong base medium using potassium hydroxide with thermal escalation for 48 hours. The resulting poly (hydroxamic acid) and poly (styrene-co-Methyl metha acrylate) were identified by the FT-IR spectra. An adsorption study of heavy metal ions such as Fe3+, Cu2+, Co2+and pb2+ by poly (hydroxamic acid) was done. The effects of time, temperature and an acid function on adsorption ions were also studied. Calculation of desorption temperature of the metallic ions at two thermal degrees 10, 20 ⁰C shows that adsorption is chemical type.Keywords: Hydroxamic acid, Poly Hydroxamic acid, heavy metals, Adsorption.
Effect of the UV-Irradiation on the Linear Optical Properties of Ni-Phthalocyanine Thin Film Addnan H. Al-Aarajiy
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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A thin film of Nickel-phthalocyanine has been deposited with a thickness of 250 nm on glass, prepared by thermal evaporation using the Edward E306A coating at room temperature Rt. The high vacuum pressure during evaporation was about 10-5 m bar. The distance between the boat and the substrate was fixed at 20 cm. at the evaporation method, where the study of spectral behavior and optical properties of thin films of Nickel phthalocyanine (NiPc) by irradiation with ultraviolet (UV) at different times 0,10,20,40 and 80 min respectively, where we noticed that an increase of irradiation time leads to an increase absorbance and decrease the energy band gap. The absorption spectra recorded in the range of 190-1100 nm wavelengths showed the existence of two absorption bands, Soret or B-band and Q-band. The UV-Vis spectra showed that thin films deposited on same substrate types have directly energy-gap. The energy gap values of the prepared thin films were calculated from Tauc equation.Keywords: Thin film, Metal, Nickel phthalocyanine, Energy gap, Thermal evaporation.
The Effect of Adding Probiotics on Microbial and Organoleptic Characteristics of Beef Burger Product Asraa Yacoob Yousif
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The study examined the use of single and mixed probiotic isolates for the possibility of prolonging the preservation duration of meatballs in refrigeration. Chemical tests were conducted (free fatty acids, TBA and pH), sensory tests (color, flavor, juicy, tenderness and general acceptance), noting that the control sample was excluded from the experiment on the tenth day of conservation because the pH value exceeded the limit and according to the standard specifications. Samples of treatments with single and mixed probiotic isolates reached the allowable limits on the 11thday. A significant decrease in TBA and free fatty acid was observed in the single and mixed probiotic isolates compared with the control treatment during the preservation period. It was observed during the preservation period that the control sample was excluded from the experiment on the seventh day of preservation because the numbers of total bacteria and psychrophilic bacteria exceeded the permissible limits according to the standard specifications. The results of sensory evaluation showed a significant superiority of the probiotic isolates treated meat samples compared to the control sample, which improved all the sensory characteristics (color, flavor, juicy, tenderness and general acceptance). The highest of the sensory evaluation were in the mixed probiotic isolates treatments.Keywords: Probiotics, Organoleptic, Beef burger.
Metal Complexes of Mixed Ligands (Quinolone Antibiotics and α-Aminonitrile Derivatives) Their Applications: An Update with Fe (III), Co (II) and Ni (II) Ions and Study the Biological Activity Aseel H. Abd Al-Ameer
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Quinolones (ciprofloxacin) have abroad- antibiotics spectrum with best oral absorbing. Consequent to the biological action located on nucleus of CH3COOH which works in the 3-location and in best state a piperazinyl base circle (or any type of N-heterocycle) at 7- positron and an oxygen carbonyl atom at 4-position). Quinolones (L1) and 2-phenyl-2-(1-Naphthylamitie) acetonitrile (L2) can bind to the ions for metal return making complexes which acting as binary ligand. The complexes and ligands which diagnosed by Micro element analysis chloride container, FTIR, UV-Vis spectra, conductivity in addition to measurement of magnetic susceptibility. Under this act founding the likely geometries shapes were proposed as octahedral complexes, several of them were classified as non-electrolyte the rest consider as weak electrolyte. The L1and L2 with [Fe(III),Co(II) and Ni(II)] respectively provided the formulae:   [ML1L2 Cl]Cl.2H2O and [FeL1L2Cl]2H2O       Were M:{ Co2+ and  Ni2+}Keywords: Quinolones (ciprofloxacin), 2-phenyl-2- (1-Naphthylamine) acetonitrile. 
Histological and Immunological Study of Daily Supplement of Aqueous extract of Thymus vulgaris Leaf in Mice Challenged with Vibrio alginolyticus Ali. M. Al-Dahbi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The aim of current study was evaluation the potential effects of daily supplement of aqueous extract of thymus vulgaris leaf on immunity system and some of total serum proteins performances in mice was challenged with V. alginolyticus, a total of 20 mice was divided into four group, group I:(Normal saline), group II: injected subcutenously V. alginolyticus, group III administrated orally for 14 day with 400µgkg of aqueous extract Thymus vulgaris leaf. Finally group IV injected subcutenously with V.alginolyticus and administrated orally for 14 day with 400 µg/kg of aqueous extract Thymus vulgaris leaf. The results of phagocytic activity reported there were significant differences (P≤0.05) between group IV (3.90±0.24) and (2.77±0.24); group II (2.65±0.24), while there was no highly significant difference (P≤0.05) between groups II, group III. In other hand lymphocytes proliferation results were revealed group III, group IV (0.380±0.020, 0.400±0.08) were recorded highly significant differences with Group II (2.65±0.24).In addition,  the  total serum proteins  were  showed the highest value was recorded in group III and group IV at day  10 and day 14 with highly significant differences (P≤0.05), Furthermore For  delayed type hypersensitivity (DHT), the  results were revealed  group IV had the highest value after 48, 72  hr, (3. 6±0.33) and recorded a highly significant difference (P≤0.05) with group III, group II after 48, 72 hr. Finally the histopathological examinations of small intestines were showed changes in group II like losing of mucous membranes, damaging in villa, moreover in group IV there were presence of inflammatory cells in damaged area also there were villi partially damaged. This study was revealed depending on the results, the daily supplement of aqueous extract thymus vulgaris leaf (400 µg /kg) had positive effects on the immune response, total serum protein, and showed positive effects in histological examinations through protection the small intestine from V. alginolyticus invasion.Keywords: Aqueous extract of Thymus vulgaris leaf, Histological changes, Immunological response, V.alginolyticus.
Effect of Salvia officinalis on Thyroid Gland Function in Male Rats Ihsan Raisan Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The objective of the current study is to evaluate the protective role of Saliva officinalis extract against carbimazole that induce hypothyroidism. Experimental albino rats were divided into four groups, first group considered as a control group. While other three groups administrated Saliva officinalis extract, carbimazole and Salvia officinalis extract and carbimazole respectively. Rats were scarified at the end of experimental and blood samples collected. T4, T3 and TSH levels were assayed and data underwent statistical analysis. Results showed that T4 and T3 levels   significantly increased in rat’s administrated Saliva officinalis extract compared to the control group. While carbimazole significantly reduced these hormones in comparison with other groups.  On the other hand, treatment rats with Salvia officinalis and carbimazole increase T3 and T4 significantly. TSH significantly elevated in rats treated with carbimazole compared to groups treated with Saliva officinalis, carbimazole and Saliva officinalis respectively. It’s concluded that Salvia officinalis reduced effects induced by carbimazole in thyroid function.Keywords: Salvia officinalis, Thyroid hormones, Carbimazole.

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