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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
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Search results for , issue "Volume 11 Issue 11 (2019) November 2019" : 3 Documents clear
Hepatoprotective Effect of Zingiber Officinale Roscoe against Anti-Tubercular Drug-Induced Liver Toxicity in Albino Rats Babul Kumar
Journal of Global Pharma Technology Volume 11 Issue 11 (2019) November 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The present study was aimed to investigate the hepatoprotective effect of ethanolic extract of Zingiber officinale Roscoe against hepatotoxicity induced by antitubercular drugs in Wistar albino rats. The ethanolic extract of rhizomes of Zingiber officinale was prepared using a Soxhlet apparatus. 24 Wistar albino rats were randomly divided into four groups (n=6). Except Group 1, all the other groups were treated with antitubercular drugs [isoniazid (I) (7.5mg/kg), rifampicin (R) (10mg/kg) and pyrazinamide (P) (35mg/kg)].  Group 2 and group 4 were treated with Silymarin (100mg/kg) and Zingiber officinale (500mg/kg) respectively, one-hour prior administration of antitubercular drugs for 30 days. At the end of the study, blood was collected and the two animals from each group were sacrificed and the liver was sent for histopathological examination. Data calculated by mean ± standard error of the mean and by unpaired t-test. Any p-value less than 0.05 have been considered as statistically significant. Antitubercular drugs significantly increased the Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), Alkaline Phosphate (ALP), Total bilirubin (TB), unconjugated bilirubin (UB) and Total protein (TP) levels as compared to the control group. Treatment with Z. officinale extract (500mg/kg) significantly (P<0.05-P<0.001) reduces the antitubercular drugs induced hepatic toxicity and biochemical elevations towards normal. Zingiber officinale extract was hepatoprotective against antitubercular drugs induced hepatotoxicity in albino rats.Keywords:  Zingiber officinale extract, Isoniazid, Rifampicin, Pyrazinamide, Liver enzymes.
The Difference of Intelligence Quotient (IQ) Score Before and After Temporal Lobe Epilepsy (TLE) Surgery: A Quasi-Experimental Study in Indonesia Muhamad Thohar Arifin
Journal of Global Pharma Technology Volume 11 Issue 11 (2019) November 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Epilepsy is a serious disorder of the brain, affects almost fifty million people in the world. About 40% of the patients finally became refractory to epileptic drugs, especially those with temporal lobe epilepsy (TLE). Surgical therapy has an important role in stopping further damage to brain cells caused by repeated seizures. The elimination of the seizure after surgery will hopefully result in better intelligence score. This study aims to find out the effect of surgical therapy in TLE patients on the Intelligence Quotient (IQ) score. Method: A quasi-experimental study with pre-test and post-test group design was conducted among 15 respondents. The respondents were taken with consecutive sampling method that underwent anterior temporal lobectomy and have passed at least one-year postoperative period, and also had done an intelligence quotient (IQ) test before surgery. IQ before and after surgery were measured with WAIS and WISC-R method. The statistical tests used were paired t-test by SPSS version 20 for Windows. Result: Most of the respondents were males (66.7%), average age 24.3±7.17 years-old, and 7.7±4.70 year’s duration of seizures. The verbal IQ score after surgery was 98.8±9.88 significantly higher (p=0.01) compared with preoperative verbal IQ (92.7±9.60) score. On the other hand, the performance IQ score after surgery was higher (98.2±8.64) compared with preoperative performance IQ (96.0±9.39), however not statistically significant (p=0.5). A total IQ score after surgery tends to be higher (97.8 ±7.69) compared with preoperative total IQ (93.9±9.28) but not statistically significant (p=0.08).  Conclusion: Our study suggests that postoperative verbal IQ improvement was found to be significantly different compared to the preoperative verbal IQ. However, there was no significant difference in the performance and total IQ score after TLE surgeryKeywords: IQ, Epilepsy, Temporal lobe epilepsy, Surgery.
Formulation, Evaluation and Release Mechanism of Ketoconazole Microsponge by Liquid-Liquid Suspension Polymerization Method S. Parimalakrishnan
Journal of Global Pharma Technology Volume 11 Issue 11 (2019) November 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of the present study is to formulate a microsponge based release system contains ketoconazole for controlled release of drugs for an effective fungal treatment. Compatibility study involving drug and polymer mixture done by FTIR and was initiate to be compatible. Ketoconazole loaded microsponges were prepared by liquid-liquid suspension polymerization method using ethyl cellulose and hydroxypropyl methylcellulose as polymers with different drug polymer ratios. Later, formulated microsponges were characterized. The particle size was measured by SEM, entrapment efficiency by assay and in vitro drug release profile by dissolution. The effect of preparation variables such as a drug to polymer ratio and stirring speed on the physical characteristics of microsponges is examined. The formulated microsponges were spherical and porous, with a mean particle size of 100μm at 400 magnifications. 87.6% of drug was entrapped in the system and 89.40% of drug was released at 12th hour from FII. From the above findings, we conclude that microsponges were prepared successfully and evaluated. The evaluation report shows that the sizes of the particle are within the range and controlled release of drug was achieved. This indicates that polymer choosen for the study is appropriate. The mathematical kinetic modeling shows that FII formulation undergoes zero order kinetic and follows Higuchi model, which follows diffusion mechanism in the release of drugs.Keywords: Ketoconazole, Microsponges, Ethyl cellulose, Hydroxypropyl methylcellulose, Liquid-Liquid suspension polymerization.

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