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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
 1 
Search results for , issue "Volume 11 Issue 12 (2019) December 2019" : 3 Documents clear
Bioethanol Production from Starch- A Short Review G. Veeramani
Journal of Global Pharma Technology Volume 11 Issue 12 (2019) December 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Bioethanol is an alcohol made by fermentation, mostly from carbohydrates produced in sugar or starch crops such as corn or sugarcane. Cellulosic biomass, derived from non-food sources, such as trees and grasses, is also being developed as a feedstock for ethanol production. Concentrated acid hydrolysis, dilute acid hydrolysis, wet milling process, dry milling process, sugar fermentation and fractional distillation process were used for production of bioethanol. Bioethanol is colourless and clear liquid. Brazil and United States of America are the largest ethanol producers, widely used alternative automotive fuel consists lower toxicity level. India produced 111 crore liters of ethanol in year 2015-2016, while the production was 38 crore liters in 2013-2014. Bioethanol fuel is mainly produced by the sugar or cellulosic fermentation process and it is transport fuel to replace gasoline and power generation by thermal combustion, fuel for fuel cells by thermochemical reaction, fuel in cogeneration systems and feedstock in the chemical industries because it is much more environmental friendly.Keywords: Bioethanol, Starch, Fuel, Hydrolysis, Hexoses, Fermentation.
A Validated Stability Indicating RP-HPLC Method Development for Platelet Aggregation Inhibitor Ticagrelor in Bulk and Tablet Formulation Kirtimaya Mishra
Journal of Global Pharma Technology Volume 11 Issue 12 (2019) December 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A stability-indicating Reverse Phase-HPLC technique for the quantification of Ticagrelor (TCG) in pharmaceuticals was developed and validated. Chromatography was done on Phenomenex Luna C18 5μm (250 mm×4.6 mm) analytical column with acetonitrile: methanol: water in 40:30:30% v/v/v ratio as mobile phase and 0.9 ml/min as a flow rate. TCG was detected at 280 nm UV-wavelength maximum. In this present research work developed technique was validated over 20-150μg/ml linear concentration range for TCG. This method was accepted with linearity coefficient value of 0.99 and the percentage recovery was found to be 99.3%. This method was shown with LOD and LOQ findings of 0.53μg/ml and 1.61μg/ml respectively. The drug was degraded in acid and alkaline medium and the percentage degradation values were 3.10 % and 4.54 % respectively. There was no degradation of drug when wide open to neutral, UV, thermal, sun-light and oxidative conditions. Drug was undergoing degradation when exposed to acid and alkaline conditions.Keywords: Ticagrelor, Reproducible, Degradation, Oxidative conditions.
Formulation Development and Characterisation of Perfluorocarbon Nanobubbles for Sorafenib Delivery Subramanian Selvamuthukumar
Journal of Global Pharma Technology Volume 11 Issue 12 (2019) December 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Nanobubbles (NBs) are novel drug delivery systems with combination of ultrasound contrast agents and drug carrier that could potentially act at specific target sites. Sorafenib is an anticancer drug for the treatment of hepatocellular carcinoma. In this study, sorafenib loaded nanobubbles were prepared by the thin film hydration method. Morphology was examined by Scanning electron microscopy and Atomic force microscope. Particle size and Zeta potential were determined by laser- scattering method. Ultrasound imaging was performed on a digital ultrasonic imaging system. The drug content in the sorafenib loaded NBs was determined by using HPLC method.  The in vitro release profile of sorafenib loaded NBs was determined using a Franz diffusion cell method with absence and presence of Ultrasound exposure. The sorafenib NBs expected a spherical shape with a uniform particle size (170 nm), negative zeta potential (-52.47 mV) and polydispersity index (0.289). Ultrasound imaging confirmed the acoustical activity of perfluoropropane nanobubbles. Drug content was found to be 96 %. A slow and prolonged spontaneous drug release was observed in vitro, which was enhanced upon ultrasound stimulation. This result suggests that sorafenib loaded NBs can be considered a novel chemotherapeutic approach for treating liver cancer in combination with an ultrasound contrast agents.Keyword: Nanobubbles, Sorafenib, Perfluorocarbon, Ultrasound, Hepatocellular carcinoma

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