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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Study the Role of Anti-Mullerian Hormone in Polycystic Ovarian Syndrome and its Correlation with Thyroid Disorder Taghreed H. Al-Sadoon
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Many biochemical changes were associated with PCOS, the search for new parameters that affect by PCOS and vice versa is still an interesting field of research. In the present study, the level of serum antimüllerian hormone (AMH) level was studied and compared with many descriptive (age, body mass effect (BMI), waist/hip ratio (WHR). Thyroid stimulation hormones  anti -thyroid peroxidase auto antibodies ,anti-TPO and anti -thyroglobulin antibodies Tg is performed by means of immunoassay sandwich with a final fluorescent detection (ELIFA)    anti-thyroglobin.  One hundred and five     PCOS women patients were participated in the study. Their age was (31.35±6.61) year. The samples were collected from PCOS was diagnosed by specialist gynecologist doctors. Hormonal analysis was performed by using ready kit in accordance with the manufacturer's instruction (Biomerieux SA Etoile-France)AMH were measured by ELISA TSH and auto antibodies were performed by minividas full automated system  method with a final fluorescent detection (ELIFA).
Growth of Different Zinc Oxide Nanostructures for Hydrogen Gas Sensing Thamir A.A. Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work describes the synthesis of various Zinc Oxide (ZnO) nanostructures by a hydrothermal technique. The structures achieved included nanotubes, a lettuce leaf nanostructure and nanosticks, all starting from a ZnO nanostructure of 20 -30 nm and produced by thermal treatment in 6 M NaOH. The process did not use any catalyst or buffer layer and was carried out inside a purpose-built Teflon lined stainless steel autoclave, maintained at a temperature of 70 °C for 24, 48 and 72 hours. The reaction time had a significant influence on the morphology of the resulting products, whose crystallinity and structural properties were studied using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM). The FE-SEM images clearly show diffraction peaks associated with the Wurtzite hexagonal-shaped ZnO structure whilst AFM results show that the films produced have a high surface roughness, especially for the intermediate 48 h synthesis time. Nanostructures ultra-selective detection in gas phase lead to application of artificial sensing intelligence. In this paper, we show that fined the H2 gas concentrations on deliberately controlled sensor device toward specific prepare with ZnO nanostructure.  Keywords: ZnO, Nanostructure, Hydrothermal, IDE, Artificial intelligence.
Study of the Genetic Diversity in Three Species Belonging to Family: Daphniidae (Crustaceae, Cladocera) Collected from different Regions in Baghdad Province /Iraq Bdoor Satar Albhadly
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Molecular methods were used to study three species belonging to the family of water fleas Daphniidae (Crustaceae, Cladocera), one belongs to the genus Daphnia and two species belonging to the genus Simocephalus. Collected from different places in the Baghdad province / Iraq (Al-Adhamiya Cornish, Al-Shula neighborhood, Brahim Bin Ali area, Al-Zawra Park, Lake of games city). The results showed that there are two species: D. magna, S. vetulus, were registered in Iraq, while the species S.congener recorded in Iraq for the first time. The genes COI, 16s, that of mtDNA, and 18s of the nucleus studied for the purpose of obtaining genetic diversity among species and for detecting the differences in the studied genes. This included DNA extraction from a group of individuals resulting from an adult female reproduction that carries the same genetic features of the mother (Monoclonal) produced from Parthenogenesis to get Iso- female line. DNA sequencing analysis of the three species of the water flea family was carried out using the forward primers that used with the reverse primers in magnification of parts of the genes 18s, 16s and COI. It was observed that there were variations in the sequences of the nitrogen bases of both genes when comparing the study samples with Standard reference sequences from around the world, and recorded sequences of nitrogen bases for study samples at the NCBI site and there was a genetic diversity of the same species by different sampling sites in the form of substitutions in the sequences of the nitrogen bases of the studied samples of the COI and 18s genes, while for 16s gene, no differences were observed for the same species, The genetic relationships tree among the studied species was drawn and compared to standard samples from results of the same studies in other countries that registered in NCBI for each of the three genes and the study results showed that the maximum likelihood of changing in nucleotides among the three species was that there were genetic differences between Simocephalus and Daphnia ,while the two species of the Simocephalus were found to be common in the same branch, and there was a similarity between them, While there were no significant differences among the species.Keywords: Daphnia, Simocephalus, RFLP, mtDNA, COI.
Assessment of the Impact of Al-Dora Refinery and South-East Baghdad Electrical Power Generation Station on Air Quality at Al-Zafaraniya Region, Baghdad City Muhannad K Mohammad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

In recent years, air contamination has become a serious environmental problem especially in industrialized and populated cities. Some activities such as random solid waste burning, industrial processes, local electrical generators, motor vehicles, fossil fuel combustion and other human activities can cause air pollution. The aim of current study was to evaluate the potential environmental impact of Al-Dora Refinery and South-East Baghdad Electrical Power Generation Station on ambient air quality. Methods: In this study, dust deposition rates were monitored on a weekly basis for the year 2017. Al-Zafaraniya region (residential area) in Baghdad city was selected as a monitoring point for measuring dust fallout rates and to evaluate the potential environmental impact of South-East Baghdad Electrical Power Generation Station (located about 3.2km to the north-west of the sampling point) and Al-Dora Refinery (located about 5.5km to the west of the sampling point) on ambient air quality. Results: Data revealed that the average amounts of dust fallout rates during this period were highly variable, ranged from 352.7kg/km2/month in January 2017 to 4348.8kg/km2/month in June 2017. Compared to permissible limits established in the literature, the annual total dust deposition rate observed in the monitoring point (23820.3kg/km2/year) was considered acceptable. The atmospheric concentrations of selected heavy metals including vanadium, chromium, manganese, copper, nickel, iron, cadmium, lead and zinc were measured using Flammable Atomic Absorption Spectrophotometer. The analysis results showed that cadmium had lowest concentrations among other investigated heavy metals with concentrations ranged from 0.22 to 2.61µg/m3, while zinc showed highest atmospheric concentrations (range from 132 to 410µg/m3). It was found that the mean atmospheric concentrations of lead, chromium, cadmium, copper and nickel were 6.15, 5.1, 1.2, 1.8 and 5.3μg/m³, respectively, exceeded the permissible limits. In contrast, zinc, manganese and vanadium in ambient air had acceptable mean concentrations (285.5, 2.5 and 10μg/m³, respectively) as compared to the corresponding permissible limits. Correlation coefficients between heavy metals concentrations were estimated to investigate potential relationships between atmospheric contaminants and to foretell the possible sources of heavy metals in air. The results showed strong positive correlation coefficients (>0%) between (Fe-Zn), (Fe-V), (Fe-Cd), (Cd-V), (Cu-V) and (Cu-Cd), indicating that these heavy metals have a high probability of being emitted from the same source of pollution.    Keywords: Dust fallout, Heavy metals, Permissible limits, Correlation coefficient, Baghdad city.
Evaluation of Drug Pre¬scription Pattern among Iraqi Dentists in Babylon City Mohammed Abdul-Hassan Jabarah Al-Zobaidy
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Background: Drugs that are commonly prescribed by dentists include analagesics and antibiotics. However, the frequency of antibiotics prescription by dentists, whether for treatment or prvention of bacterial infections, is relatively lower than that by physicians. Also, the pregressive development of bacterial resistance to antibiotics called for seeking best-evidence on antibiotics ptrescription by practicing dentists to prevent the emergence of life-threatening antibiotic-resistant bacterial strains. Methods: Descriptive cross-sectional questionnaire-based study conducted in Babylon City, Iraq from August 2017 to January 2018. Data expressed as absolute numbers and proportions and presented using descriptive statistics. Results: In Babylon City, practicing dentists preferred amoxicillin as the first choice antibiotic for patients not allergic to penicillin; otherwise, macrolides and cephalosporins are recommended alternatives. In addition, mefenamic acid and ibuprofen were the preffered analgesics for pain relief. Also, participants often utilize clinical and scientific justifications for prescription of drugs in question. Conclusions: Dentists need to apply best-evidence concerning treatment of dental infections. And to actively participate in continuing professional development activities regarding antibiotics prescription. Keywords: Dentists, Antibiotics, Analgesics, Prescription for dental conditions, Pharmacology.
DNA- Drug Binding and Uric Acid Concentrations Relationship in Renal Failure Mohsin O. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Kidney diseases are recognised as a significant health problem affecting approximately 188 million peoples in low- and middle-income countries. In this study, investigation of the relationship between DNA and UA concentrations and the interaction of DNA and drug in renal failure patients was studied. DNA was extracted from serum and whole blood by two methods, kit and manual to find the best way, by comparison, the results. Nanodrop and electrical migration technique were used to measure the obtained concentration of DNA. The interaction between DNA and drug (Allopurinol) in the presence of UA was done by using ultraviolet and infrared spectroscopies. The study included 80 healthy and 80 patients samples with chronic renal impairment with ages rang (20-80) of both genders. The result showed a significant increase in the concentration of UA, urea and creatinine in renal failure patients compared to control a significant reduction in DNA concentration in patients with high UA concentration, the DNA extracted by manual method was higher compared to the results of the kit. The type of interference between DNA and Allopurinol is intercalative binding.Keywords: Kidney disease, Allopurinol, DNA, Uric acid and renal failure.
Starch/Gum Arabic Blends for Controlled Drug Delivery and Cancer Therapy: Synthesis and Characterization Ismaeel Moslam Alwaan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Cancer is one of the most mortal diseases in the world .This work was planned to prepare a new chemical cross linking starch/gum Arabic hydrogel system in the presence of potassium persulfate(K2S2O8)as initiator, to describe the characteristic of the new material , and to investigate its potential utilizations in controlled drug delivery and cancer therapy. Crosslinked starch /gum Arabic hydrogel will be manufacture with changeable levels of starch and gum Arabic then were loaded with hydroxyurea. The structure of the native starch and starch/gum Arabic blends was characterized by FTIR, SEM. The starch and starch/gum Arabic blends were analyzed for in vitro drug release studies by using UV-vis spectroscopy. The swelling test, MTT assay were also investigated. The drug release and swelling test was monitored at pH 4 and pH7.4. The experimental results proved that the production of starch/gum Arabic blends was reduced the swell ability which lead to slow release of hydroxyurea,  and the rate of hydroxyurea release was significantly higher at pH 7.4 than pH4, at constant incubation time. The swelling ratio and drug release of the blends was decreased with increasing gum Arabic levels. In vitro cytotoxicity study show the killing of 14∼"> 63% colorectal cancer cells at 500µg/ml of hydroxyurea concentration while the 14∼"> 49% destruction of cells require for the starch/gum Arabic/hydroxyurea blends at the same concentration and  after 24hr of incubation. The sustained released of hydroxyurea-loaded starch/gum Arabic blend shows much better anticancer efficacy thereby, revealing a novels vehicle for the treatments of cancer.Keywords: Starch, Gum Arabic, Hydroxyurea, Controlled release drugs.
Natural Outbreaks of Infectious Bursal Disease in Brahma and Aseel Chicken in Iraq Qayssar Ali Kraidi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The infectious bursal disease (IBD) represents one of the most severe poultry diseases and is responsible for marked economic losses in poultry populations in Iraq. Backyard chicken with different breeds have been recently raised successfully in a rural area for hobby and household consumption, however, the status of the disease in free-ranging backyard chickens in Iraq is not documented, for this reason, the objective of the present study was to determine the disease in free-range poultry naturally infected with IBDV currently circulating in Iraq. A tentative diagnosis of IBD was conducted based on clinical findings, gross lesions besides the histopathology and lesion scoring analysis and was confirmed by identification of IBDV antigen in AGPT. Typical IBD clinical signs and lesions were observed in all types of birds with a high mortality rate (30% & 25%) reported in Aseel and Brahma breeds, respectively. Histopathological lesion scores analysis for IBDV characterized by a high lesion score of (+5) observed in the studied birds of all breeds. Based on the results of high mortality rate and high histopathological lesion scores we can suggest the occurrence of the disease in backyard chicken in Iraq associated with pathogenic field IBD virus. The present study provides first background document on the current status of IBD in free-range poultry in Iraq.Keywords: Aseel, Brahma, IBD, Iraq. 
Equilibrium and Thermodynamic Study of Malachite Green & Phenol Red Dyes Adsorption from Aqueous Solution by Use Algae Biomass Ahmed Mohammed Abbas
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Recently the focus has been on using the surfaces of the adsorbent economically cheaper and technologically more efficient technology in treatment environmental pollution problems the biomass of Algae was applied for the adsorption of Malachite Green (MG) and Phenol Red (PhR) dyes from aqueous solution. The prepared adsorbent was characterized by FT-IR and SEM Technique .The adsorption of (MG) and (PhR) dyes onto algae biomass from aqueous phase were taken as a function of the absorbed weight, dye concentration, temperature and contact time. . The equilibrium data of (MG and PhR) adsorption onto biomass of Algae was analyzed by different isotherms models and it follows Langmuir adsorption isotherm model for the (MG) dye while (PhR) dye it follows the Freundlich isotherm. The evaluation of thermodynamics functions such as the Gibbs free energy negative for (MG) dye adsorption, positive for (PhR) dye adsorption and positive enthalpy values indicated respectively the different spontaneous and endothermic behavior of the reaction and the chemisorption of the sorption process.Keyword: Biomass, Algae, Adsorption, Malachite Green, Phenol Red.
Invention and Description of p-CuO /n-Si (200 oC) Heterojunction for Photodiode Applications Ahmed N. Abd
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

P-CuO /n-Si was prepared and studied with respect to Drop casting method  at  200°C temperature, it was concluded that energy band gap of CuO films is (1.6)eV calculated from optical properties. AFM reveal that the generated CuO Films have ball-shape with perfect homogeneity, the measurements of the XRD revealed that the CuO were of cubic crystal structure, the responsively photo detector after deposited CuO showed an increase in response.Keywords: CuO, Structure properties, AFM, Optical properties, Solar cell.

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