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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
Effectiveness of Chamomile Tea toward Sleep Quality Amount Autistic Children Nuh Huda
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Autistic children often experience sleep problems when compared to children in the general population. Difficulty in starting sleep or maintaining sleep occurs in about 10% to 20% of children aged 4-15 years; it can cause other problems such as behaviour disorders, cognitive, and hyperactivity. Consuming chamomile tea before going to sleep is believed to make the body's muscles relax and make the individual sleep faster. This study aims to analyze the effectiveness of chamomile tea on sleep quality in autistic children in Surabaya.  Method: pre-experimental research with one group pre-post-test design. The population of 221 of autistic children with a sample of 66 respondents selected by simple random sampling. The instrument used a questionnaire sheet CSHQ (Children Sleep Habit Questionnaire), the independent variable in this study was the drinking of chamomile tea, the dependent variable was sleep quality, data were analyzed using the Wilcoxon Signed Test (α = 0.05).  Results: after being given chamomile tea once every 2 days for 1 month it was found 54 respondents (81.8%) improved their sleep quality and 12 respondents (18.2%) had a stable sleep quality. Wilcoxon Signed Test results show the effectiveness of chamomile tea on sleep quality for children with autism p=0.0013.  Conclusion: Chamomile tea has an active ingredient apigenin which will bind GABA in the brain to reduce excessive brain activity so that the body becomes calmer and more relaxed. So that chamomile tea can be consumed by children with autism to reduce sleep disorders.Keywords: Autistic children; Chamomile tea; Sleep quality.
Analysis of Sildenafil Citrate in Male Stamina Supplements with Densitometry TLC Method Sugijanto .
Journal of Global Pharma Technology Volume 12 Issue 01
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Introduction: Sildenafil citrate is a chemical drug that is prohibited by Indonesia National Agency of Drug and Food Control to being added in male stamina supplements. Recently, several male health supplements have been found to contain sildenafil citrate. Objection: The purpose of this study was to validate the TLC-densitometry method used in the quantitative analysis of sildenafil citrate. Methods: Validation of the method determined is selectivity, detection limit, quantitation limit, linearity, accuracy, and precision. A good solvent for extracting sildenafil citrate from the matrix sample is methanol. Sildenafil citrate was separated from the matrix component in silica gel F254 using methanol: ethyl acetate (1: 2) as an eluent. The retardation factor of sildenafil citrate is 0.41, the resoluteion factor between sildenafil citrate and the closest matrix compound is 3.0. The response is linear in the range of sildenafil citrate concentrations 500 - 1500 ppm. A good solvent for extracting sildenafil citrate from the matrix sample is methanol. Results: The results showed that the detection limit of sildenafil citrate was 4.96 and the quantization limit was 15.03 ppm. Sildenafil citrate recovery was found 98.46-101.09% with an average of 99.83% and precision results of 0.99%. Conclusion: The Densitometry TLC method can be used for quantitative analysis of sildenafil citrate because the validation parameters have met the requirements.Keywords: Sildenafil Citrate, TLC-Densitometry, Validation method.
Molecular Detection and Prevalence of, Cryptosporidium Parvum, Entamoeba histolytica and Giardia lamblia among Patients with Diarrhea at Al- Rifea city/Thi-Qar Province Akram Radhi Salim
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Diarrhea  is defined as having extra stools than are usual for that individuals or as passage of watery stool for more than three times in 24 hours, caused by various pathogens such as  bacteria, viruses and parasites and protozoa consider as important causes of diarrhea and other gastrointestinal infections in humans they include mostly Cryptosporidium parvum, Entamoeba histolytica and Giardia lambella, this study aimed to determined the prevalence of parasitic agents in stool samples  of diarrheic  patients, this study is carried out in Thi-Qar Province/Al-Refaie district in Al-Refaie general Hospital which included collection of stool samples from diarrheic patients at a period extended from October / 2017-January / 2018, (96) stool samples taken from patients with different ages to both sexes examined by PCR technique. The results showed The percentage of positive samples were 63.5% while 36.5% was negative C. parvum (11.9%), E. histolytica (22.6%) and G. lamblia (65.5%), no significant statistical differences between males, females and between Urban and Rural areas while there was significant statistical differences between age groups (the highest rate in less than 1-10 years and lowest age group was (11-20 years).Keywords: Cryptosporidium parvumm, Entamoeba histolytica and Gardia lamblia, Polymerase chain reaction (PCR), Protozoa.
Multibasillary Leprae Lepromatous Leprosy Type Relaps with Erythema Nodosum Leprosum Reaction: Establishing the Diagnosis Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 01
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Introduction: Leprosy or Morbus Hansen is a disease caused by infection with Mycobacterium Leprae with manifestations in the skin and peripheral nerves that can cause neuropathy or disability. The case of relapse in leprosy is a condition in which patients who have successfully completed the MDT (multi drug therapy) program with complete and appropriate but there are new symptoms of the disease either during the monitoring period or after. ENL reactions can occur at any time, namely before, during and after MDT therapy. Case: A woman aged 43 years comes to Dermatovenereology clinic with complaints of red bumps accompanied by pain in the face and extremities. On physical examination fromt the facial, superior and inferior limbs appear multiple erythematous nodules with partial hyper pigmented, multiple, indistinct boundaries. Investigation in the form of an AFB test indicates the presence of IB + 3 and IM 0% which previously earned IB +1 IM 2.09%. Histopathological examination revealed an ENL reaction with a red acid-resistant bacillus. The patient is diagnosed with leprosy MB type LL RFT1, 5 years relapsed with ENL Discussion: Relapse or recurrence in leprosy can occur due to a variety of factors, one of which is due to the presence of persistent leprosy bacilli, Becx-Bleumink criteria can be used as a reference for diagnosing relapse that includes clinical features, BTA examination and histopathological features.Keywords: Erythema nodosum leprosum, Leprosy, Relapse.
Venotonics and Anticoagulants-undisclosed Potential of Drug Treatment of Chronic Venous Insufficiency Olga Pashanova
Journal of Global Pharma Technology Volume 12 Issue 01
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This work aims to conduct a comparative analysis of anticoagulant and venotonic therapy for different groups of patients with a diagnosis of acute venous venous thrombosis of the lower extremities. The tasks included the development of anticoagulants and venotonics combinations and dosages for treatment of a) alleviate an existing disease in a patient; b) disease prevention. Rivaroxaban showed the results of a higher recanalization level of the lower extremities veins in patients compared with warfarin. The maximum recanalization indicators of lower extremities veins, the blood flow velocity in them, and the severity of clinical symptoms were obtained for a group of patients taking a combination of rivaroxaban and diosmin.Keywords: Acute venous insufficiency; Venotonics; Anticoagulants; Vein recanalization; Warfarin; Rivaroxaban; Diosmin.
Antibacterial Activity of Synthesized Graphene Oxide Modified Nickel Phthalocyanine Saad Abbas Jasim
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The antimicrobial properties of Graphene Oxide Modified Nickle Phthalocyanine were evaluated against Staphylococcus aureus, Gram-positive bacterium and sydomonus, Gram-negative one.. Bacteriological tests were performed in Muller Hinton solid agar plates with different concentrations of graphene oxide particles. The inhibition zones as a function of added graphene oxide where studied ,the results show that as the concentration of graphene oxide increased the inhibition zone increased also against both types of bacteria. Whene the ratio of added graphene oxide was (15%) maximum inhibitionzone hase been calculated.Keywords: Graphene oxide; Nickle Phthalocyanine; Antimicrobial.
Topical Applications of Caulerpa spp. Extract Preventing Skin Aging through Improving Skin Moisture, Pigmentation and Decrease Laxity Anak Agung Gde Putra Wiraguna
Journal of Global Pharma Technology Volume 12 Issue 01
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Background: Caulerpa spp. extract contains neoxanthin, free astaxanthin, antheraxanthin, canthaxanthin, astaxanthin monoester, fucoxanthin, astaxanthin diester, and beta carotene, vitamins A, C, and E, minerals, amino acids and polyphenols which are photocemoprotective as to protect skin from damage caused by exposure to UV-B rays. This study aims to determine the effectiveness of topical 0.2% Caulerpa spp. extract in preventing premature skin aging in research subjects assessed by the parameters of skin moisture, pigmentation, and laxity of the skin. Method: This study was purely experimental research, using the randomized double-blind pretest-posttest control group design. A total of 40 research subjects participated in this study and were divided into two groups, namely the treatment group of 20 subjects, who were given interventions in the form of topical 0.2% Caulerpa spp. extract gel on the face, and the control group of 20 subjects who were given intervention in the form of application topical base cream on the face. All groups performed a pretest with a simple A-one scanner to assess skin aging with moisture, pigmentation, and laxity parameters on the skin. The two study groups were then treated for one month and post-tested. The research data was then collected for statistical analysis of using independent t-test and paired sample t-test. Results: Differences in skin assessments were analysed before and after therapy. Differences in assessment before therapy obtained p<0.05 on laxity and pore variables. Differences in assessment after treatment were found to be p<0.05 also in laxity and pores. Test differences in skin assessment in the two groups with Mann-Whitney using the difference in values after and before therapy obtained p<0.05 in pigmentation, laxity, humidity, pores, sebum U zone, and sebum T zone. Conclusion: Topical administration of topical Caulerpa spp. gel on the face has a photo protective effect by reducing pigmentation and laxity and increasing skin moisture.Keywords: Caulerpa spp., Skin aging, Pigmentation, Laxity.
Prevalence of Pediculosis Capitis and its Risk Factors in Elementary School Students I Made Sudarmaja
Journal of Global Pharma Technology Volume 12 Issue 01
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Background: Pediculosis capitis or head-lice infestation is a health problem, especially in children in developing countries. Transmission of pediculosis capitis is also fast, causing a high-incidence in an area. This study was conducted to determine the prevalence of pediculosis capitis and the relationship between risk factors for its infestation. Methods: This is a descriptive study with a cross-sectional design. The data was collected from elementary school students in Tenganan village, Bali, Indonesia in September 2018. The sampling technique was a voluntary sampling method with a sample of 141 elementary school students. Data analysis was carried out with the SPSS with univariate and bivariate analysis. Results: The prevalence of pediculosis capitis in elementary school children in Tenganan Village is 69.5%. Factors related to pediculosis capitis infestation are sex (PR=2.235, p <0.001), long-hair (PR=2.015, p <0,001), shared hair-accessories (PR=1.450, p=0.004), and lived with people infected with head lice (PR=1.692, p <0.001). Conclusion: The prevalence of pediculosis capitis in elementary school children in Tenganan Village is 69.5% with gender as the most influential risk factor for infestation.Keywords:  Pediculosis capitis, Prevalence, Risk factors.
Response of the Green Alga Chlorococcum humicola Developed in Chu-13 Culture Medium to Different Concentrations of CO2 Ibrahim M.A Alsal
Journal of Global Pharma Technology Volume 12 Issue 01
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Microalgae response is one of the criteria that is adopted in estimating the efficacy of any species or genus in tolerance or the fixation and withdrawal of the influential concentrations of CO2 either in its natural or supplied or combined forms with other gases. For the purpose of the application, the current study was chosen Chlorococcum humicola alga belonging to the green algae to follow the effect of different concentrations of CO2 supplier were (25, 50, 75, 100%) volume/volume, of culture volume in curves, growth rates, times of multiplication, biomass and some fatty acids. The experiment and development of alga in the Chu-13 culture medium was carried out under controlled environmental conditions of temperature and density of light and pH, as they were in the order of (25 ±2, 3000 lux, 7.6) and with a lighting system of 16:8 hour light to darkness. The alga cells was incurred into mentioned concentrations for one time by injection of the algal culture by CO2 using a device (gas-flow-meter) for three repeaters of each concentration. The results were recorded at time of Zero and daily for 18 days. The results showed that the growth curve based on the absorbency values at the wavelength 650 nm recorded from the fourth day a higher value than the standard sample of all the concentrations. The highest values of 0.71 with the concentration (50%).As for the time of multiplication, the study found that a slight differences between the standard sample and all concentrations and recorded the highest value (1.84) in the control sample for the 18th day. The dry biomass at harvest in the end of the experiment, the values were recorded (370, 360, 410, 340) mg dry weight/L at the concentrations (25, 50, 75, 100%) volume/volume respectively, while the control recorded 310 mg/dry weight/ L. The HPLC technique that has been applied to diagnose some fatty acids has also indicated the presence of acids: (Arachidic C20:4, LinoleicC18: 2(Omega6), Oleic C18:1(Omega 9), Plamitolic C16:1, Palmetic C16:0, Myristic C14:0). The highest value (403.93) % was recorded for the palmetic acid with a 100% concentration of CO2 supplier and a lower value of (82.38) % for arachidic acid with a 25% concentration of CO2 compared with the standard sample.  The conclusion of the study that the treatment with CO2 although it has not given growth rates and times is remarkably multiplied but on the other side it gave an increase in the biomass ranged of (19.35, 16.13, 32.25, 9.67%) for CO2 concentrations (25, 50, 75, 100%) volume/volume respectively. As well as identified fatty acids stimulated the increase of total percentage after harvest on day 18th of the treatment with values:  (32.443, 47.820, 53.443, 121.211, 144.409, 262.636) for each (Palmetic, Pamiotolic, Myristic  Oleic, Linoleic, Arachidic) respectively.Keywords: Microalgae, CO2, Biofixation, Capturing of CO2, Chlorococcum humicola alga.
46, XX Infertile Male: A Case Report and Review in Infertility Gito Restiansyah Wasian
Journal of Global Pharma Technology Volume 12 Issue 01
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Introduction: 46, XX Testicular Disorder of Sex Development (46, XX Testicular DSD) is a genetic disorder that can cause male infertility. The clinical feature of this disorder varies, ranging from ambiguous genitalia to normal male genitalia characteristics. This disorder is rarely diagnosed early and is often only found during fertility tests. The objective of this work was to determine the characteristics and managements of patient with 46, XX testicular DSD. Methods: Case report and literature review. Results: A 30-year-old came with complaints of wanting to have children after a 7-year marriage. From physical examination, it was shown normal male external genitalia with small testicular volume. Sperm analysis showed azoospermia. From hormonal examination, hypogonadotropin hypogonadism is obtained. Cytogenetics gives an overview of 46, XX male with positive SRY gene. Conclusion: Patient characteristics vary depending on the mutation that occurs. Furthermore, 46, XX testicular DSD with can be found during holistic infertility examination, such as semen and hormonal analysis and karyotyping and SRY gene detection. A multidisciplinary approach should be performed too in the management, particularly for assisted reproductive technology with sperm donor or adoption.Keywords: 46, XX male, Testicular DSD, Male infertility, SRY gene.

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