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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Association between Hypothyroidism and Herpes Simplex Virus with Interleukin-23 Sahar H. Al-Hindawi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Hashimoto’s thyroiditis and Hypothyroidism play a distinct role in the suppression and reactivation of herpes viruses. Herpes simplex virus infections have been assumed as one of the factors that may trigger autoimmune thyroid diseases; however, IL-23 has an important role in the pathogenesis of several inflammatory and autoimmune conditions. Objective: This study aimed to investigate the association between thyroid hormones in hypothyroid state and the Herpes simplex virus status in such patients; besides detecting the role of IL-23 in these cases. Materials and Methods: The present study included 65 Iraqi female hypothyroid patients with age ranged between 26-54 years and 25 healthy controls with age ranged between 25-50 years. Serum samples were collected from the study groups. Levels of thyroid hormones (TSH, T4, and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. The detection of herpes simplex virus IgG and IL-23 levels in the serum samples were determined by an enzyme linked immunosorbent assay (ELISA) kits. Results: The current study results revealed that serum IL-23 and HSV levels are increased significantly (P<0.001) in the hypothyroid patients group as compared with control. There was a significant positive correlation between TSH and (IL-23, HSV); also between IL-23 and HSV (P<0.01). Moreover, there was a significant negative correlations (P<0.01) between IL-23 with (T4, T3) and between HSV with (T4, T3).  Conclusion: The present study pointed to the association between thyroid hormones deficiency in Hashimoto thyroiditis cases and IL-23 levels through disruption of the patient’s immune system; and with Herpes simplex viruse-1by their role in the replication.Keywords: Hashimoto Thyroiditis, Hypothyroidism, Herpes Simplex Virus, IL-23.
Effectiveness of Gac Aril Extract to Stickiness, Retrogradation and Staling of Glutinous Rice Cake Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Gac fruit (Momordica cochinchinensis Spreng) is a popular fruit in rural area of Vietnam. Its aril contain high amount of β-carotene, lycopene, α-tocopherol and fatty acid. Its bright red color attracts consumers besides phytochemical constituents. It is very important to utilize these valuable constituents in Gac aril for multiple food processing applications. Glutinous rice cake is a kind of folk cake, very rustic, was present very early in the cuisine of Vietnam, also the specialty cakes of the local countryside, quite familiar and impressed in the hearts of people, products with aromatic fatty flavor, tasty, sweet flowing with delicate. Nowadays consumers require glutinous rice cake with superior appearance, texture, taste and flavor while stabilizing its nutritional value. Therefore in this present research, we examined the supplementation of Gac aril extract in different concentrations (2.0, 3.0, 4.0, 5.0%, 6.0%) to the physico-chemical, sensory and shelf-life of the glutinous rice cake. Our results showed that 5.0% Gac aril extract was adequate to supplement into glutinous rice cake making to extend its shelf-life for 5 days. Consumers have more chance to enjoy glutinous rice cake in good appearance and high functional properties.Keywords: Gac aril extract, Glutinous rice cake, Supplementation, Physico-chemical, sensory, Shelf-life.
Synthesis and Preliminary Antibacterial Effects of New 1, 3, 4-Oxadiazoles Zeid Hassan Abood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

4-aminobenzoyl hydrazide [I] was reacted with carbon disulfide in the existence of potassium hydroxide in ethyl alcohol to give 5-(4-aminophenyl)-2-thiol-1,3,4-oxadiazole [II]. The initiator aldehyde [III] was prepared via coupling reaction of 2-hydroxybenzaldehyde with the corresponding diazonium salt of compound [II]. Aldehyde [III] was condensed with some anilines including (3-bromoaniline, 4-aminophenol, 3-aminophenol, 2-aminophenol, 4-methoxyaniline, 2, 4-dimethylaniline and 4-acetamidoaniline) utilizing microwave irradiation technique in ethyl alcohol to yield seven imines [IV] a-g. Treatment of imines [IV]a-g with phthalic anhydride in microwave oven gave seven 1,3-benzoxazepine-4,7-diones derivatives of 1,3,4-oxadiazole [V]a-g. The antibacterial activities for the desired compounds were investigated on bacteria, Staphylococcus aurous and Escherichia coli. The results showed that the synthesized 1, 3, 4-oxadiazoles (compounds [V]a, [V]b, [V]c, [V]d and [V]e expressed better activity to gentamycin athwart positive bacteria. On the other hand, the 1,3-oxazepine-4,7-diones [V]a, [V]b, [V]c, [V]d, [V]f and [V]g exhibited greater effect against negative bacteria in comparison with that of the control drug (Gentamycin).Keywords: 1, 3, 4-Oxadiazoles, Benzoxazepines, Imines, Cycloaddition, Antibacterial action.
Assessment the Aurora a Kinas Overexpression among Colorectal Adenocarcinoma in Iraqi Patients Ali A. Majeed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In the worldwide the colorectal carcinoma is  represented the most common gastrointestinal malignancy The cancer represent one of major causes of death after cardiovascular diseases in Iraq. Aurora Kinase a (AURKA) is a member of the serine/threonine kinas family as well refers as (STK15) or (BTAK) regulates the function of centrosome, spindles, kinetochores in mitotic and chromosomal instability. AURKA overexpression is observed in various cancers including colon cancer and depended on our knowledge there is no in our country about the expression of AURKA colorectal carcinoma patients. This study included fifty five blocks embedded in paraffin was 31 (56.36%) males and 24 (43.63%) females which were obtained from colorectal adenocarcinoma patients and all samples composed of 25 (45.45%), 20 (36.36%) had moderate differentiated and (18.19%) had poorly differentiated colorectal carcinoma. The ages of patients had ranged from 20 to 80 years, with a mean of (7.44±50.6  SE).In this study, Iraqi patients showed that the protein overexpression of AURKA by immunohistochemical technique was significantly difference among these grades (p=0.0001,r=552) with high expression in well-moderate than poor differentiated while the AURKA protein overexpression was non- significant difference among different stage tumor sizes (P value =0.1746, r=0.254) as well as, the results showed there were no significant differences between AURKA protein overexpression with the gender, age and lymph-vascular and perinural invasions (P value =0.613,r=0.078), (P value 0.812, r=0.356), (p=0.711,r=0.192) respectively. Conclusion: The AURKA biomarker may be used as prognostic factor of tumor initiation in Iraqi patients with colorectal adenocarcinoma.  Keywords: Iraqi patients, Colorectal Adenocarcinoma, AURKA.
A Thermodynamic Study of Adsorption 2-(4-Antipyriyl azo) Orcinol [APAO] on Zincoxide as Adsorbent Nuha Abdul-Saheb Ridha
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

We can remove Organic materials contaminated from their solutions in several methods, for examples the Adsorption. In this research was studies adsorption APAO which dissolved in 2.5% ethanol/water by the Zinc Oxide as adsorbent. The adsorption isotherms it was found similar to L4-shape according to Gilles classification. Also it studied the influence of adsorbent weight and adsorption time on removal% of APAO; it was 0.35gm best weight and 35 min. best time. The impact of changing the function of the acidic PH on removal% of APAO was found as follows (PH=4> PH=10> PH=7). The thermodynamic values were calculated (∆H, ∆G, ∆S) depending on changing temperature with concentration were (+24.74002KJ/mol, +9.4256KJ/mol, +51.390J/mol.K).
α-Glucosidase Inhibitory Activity of Ethanol Extract Obtained from Dillenia suffruticosa and Pycnarrhena cauliflora Dzul Fadly
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The objective of the study was to find out the inhibitory of α-glucosidase activity and the antioxidant properties of an ethanol extract derived from leaves and stems of Dillenia suffruticosa and Pycnarrhena cauliflora. Dried powder of them was macerated with 96% ethanol solvents. α- Glucosidase inhibitory property was significantly demonstrated by the leaves and stems of D. suffruticosa. Antioxidant activity was found high in D. suffruticosa leaves and stems. The results indicate that D. suffruticosa stem may potential being antioxidant and antidiabetic compounds.Keywords: Dillenia suffruticosa, Pycnarrhena cauliflora, diabetes mellitus, α-glucosidase, ethanol extract.
Post Reconstitution Stability of Co-Amoxiclav Injection for Multiple Usages in Developing Countries Mazlina M Said
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

OBJECTIVE: Co-amoxiclav injections are stored after reconstitution by healthcare givers for multiple usage contrary to manufacturer’s instructions in pediatric patients to reduce the cost of treatment in developing countries. The purpose of this study is to determine the percentage content of amoxicillin and clavulanic acid in co-amoxiclav injections at the point of administering of second dose after reconstitution.METHODS: Samples were reconstituted according to manufacturers’ instructions and stored in a refrigerator (2-5°C) and at tropical temperature (30°C and 75% RH). The samples were assayed immediately and then 8 hours after reconstitution. The assay was carried out using HPLC according to the USP monograph for amoxicillin-clavulanic acid suspension and the percentage content during the administration of the second dose was calculated in reference to a freshly prepared samples.RESULTS: The percentage content of amoxicillin and clavulanic acid in refrigerated samples was <70% and <35% of the freshly prepared samples respectively, While at simulated tropical room temperature, it was <45% and <15% of the freshly prepared samples respectively.CONCLUSION: The study showed that storage of reconstituted co-amoxiclav injection will lead to administering of lower dose at the point of admistration of the second dose; this will lead to treatment and antibiotic resistance.
Evaluation the protective impact of Cape gooseberry (Physalis peruviana L.) extract against benzo(a)pyrene induced DNA damage and gene expression change in male rats Lamiaa M. Salem
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Natural bioactive compounds have been increasingly investigated against carcinogenic agents to prevent tumour progression. Thus, several active ingredients exist in different herbs and medicinal plants exhibited preventive impact against benzo(a)pyrene (BaP) induced carcinogenesis. In the present study, the efficacy of Cape gooseberry fruit (CGF) extract was investigated against BaP induced genetic toxicity in Swiss albino male rats. Male rats (n=90) were allocated in several groups exposed to BaP and/or several doses of CGF extract (100, 150 and 200 mg/kg b.w.). Assessment of DNA damage, generation of DNA adducts and expression alteration of stress (Hsp70a, CYP450) and antioxidant (GST) related genes were conducted. The results showed that treatment of BaP-exposed rats with different doses of CGF extract was able to prevent the genetic toxicity in the forms of DNA damage and DNA adducts as well as gene expression alteration induced by BaP. The results suggested that CGF extract-BaP interaction may reflect the extract efficacy against genotoxicity induced by chemotherapeutic drugs that are metabolized by antioxidant enzymes.
Spectral and Linear Optical Characterization of Organic Laser Dyes Mixture Solution Noor K. Abdulmutalib
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Spectral and linear optical properties for mixture of compounds Aurintricarboxylic Acid after polymerization (H1) and  Aurintricarboxylic Acid after closer ring (H2), were determined at different concentrations (3* 10-4, 6*10-4 and 9*10-4 ) M in Dimethyl sulfoxide (DMSO) solvent at room temperature. The intensity of absorption range is towards longer wavelengths (red shift); organic laser dyes have a spectrum within range (240-600) nm. Results demonstrate that mixture of laser dyes are effective optical materials when contrasted with single laser dyes. It can be utilized as resonator in cavity lasers.Keywords: Linear and nonlinear properties, Mixture dyes, Optical limiting, And organic laser dyes.
The Investigation of the Stability of the Granules Based on Arginine and Tincture of Ginseng Katerina Romas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The article presents the stability studies of the granules based on arginine and tincture of ginseng with neuroprotective (nootropic) action for the treatment of various disorders of the functional activity of the brain. For determining stability and shelf life of the developed medicine, several series of granules were stored at a temperature 15-25 °C in a dark, light protected place. Based on the research, it can be concluded that within 24 months from the date of manufacture, granules remain stable in all respects that have been studied.

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