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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 4 Documents
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Search results for , issue "Volume 12 Issue 04 (2020) April 2020" : 4 Documents clear
Antidepressant Activity of Selective Bioactive Compounds-Diosgenin and Silymarin in an Experimental Animal Model Sathya. B
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The present study was aimed to investigate the combined effect of bioactive compounds, Diosgenin and Silymarin in an animal model of depression. Wistar albino rats of either sex were randomly divided into five groups and treated for 7 days. Groups I and II were served as a control and a standard and groups III, IV and V were treated with Diosgenin (100 mg/kg, p.o.), Silymarin (100 mg/kg, p.o.) and combination of Diosgenin (50 mg/kg, p.o.) + Silymarin (50 mg/kg, p.o.), respectively. Imipramine (25 mg/kg, p.o.) was used as a standard for all antidepressant models and the activity was screened by using Forced swim test and Tail suspension test. The results suggested that Diosgenin and Silymarin, independently, at a dose of 100 mg/kg, shown anti-depressant like effect with P value less than 0.05 and 0.01, respectively. The compounds when given in combination at a dose of 50 mg/kg, each, shown potentiating antidepressant like activity as compared to their individual effect. It can be concluded that Diosgenin has got a synergistic effect on antidepressant action when given in combination with Silymarin.Keywords: Bioactive compounds, Depression, Diosgenin, Silymarin, Imipramine, Forced swim test, Tail suspension test.
Interleukin (IL) 18 and Its Relation with Diabetes Mellitus and Chronic Periodontitis Kavitha J
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
Publisher : Journal of Global Pharma Technology

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Abstract

 IL-18 is a member of the IL-1 family of cytokines. IL-18 demonstrates a unique function by binding to a specific receptor expressed on various types of cells. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Metabolic abnormalities in carbohydrates, lipids, and proteins result from the importance of insulin as an anabolic hormone. Chronic periodontitis, also known as adult periodontitis, is an infectious inflammatory disease caused by the bacteria of the dental plaque, resulting in the progressive destruction of the tissues that support the teeth, i.e. the gingival, the periodontal ligament, cementum, and the alveolar bone. Chronic periodontitis can also play a role as a metabolic stress or for diabetes control. In this review article, we will focus on the unique features of Interleukin (IL) 18 and its relation with diabetes mellitus and chronic periodontitis.
Molecular Modeling and Prediction of Pharmacokinetics of Some Substituted Benzothiazoles That Block Steroidal Sulphatase Inhibitors for the Treatment of Breast Cancer Srimathi R
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective:Breast cancer is the second leading cause of cancer deaths in women worldwide. Around 60 to 80% of breast cancers are hormone dependent (HDBC). Aromatase and steroidal sulfatase (STS) are targets that increase the concentration of estrogens in circulation, thereby causing breast cancer. At the molecular level, 87% of expression of Steroidal sulfatase is observed and therefore STS is targeted. A series of fifteen substituted 2-phenyl 1,3- benzothiazoles were designed to be an inhibitor of STS, the enzyme responsible for conversion of Estrone sulfate (E1) to Estradiol (E2). Estradiol is the active steroid hormone found in circulation that leads to carcinogensis and results in breast cancer.Materials & Methods:Fifteen substituted 2-phenyl 1,3- benzothiazoles were sketched using Chemsketch (ACD LABS) and 2D structures were saved . The 2D structures were converted to 3D structures with Openbabel and energy minimized using Avogadro. The crystal structure of Human estrone sulfate 1P49 was downloaded from protein data bank (RCSB PDB) and prepared using Protein preparation wizard of Autodock 4.2. The grid box was set at 60*60*60 Å and x=72.242 and y=-1.284, z=28.246 centered on C β atom and docked.Results & Discussion:The docked complex was explored for possible interactions to substituted benzthiazole. Herein, we report the interactions of amino acid residue Arg98, Thr99, His290, Lys368, Thr 91as the best possible interactions that plays a role in inhibiting the binding of Ca2+to the active site. Compound 7C and 8C are reported with better binding affinities.Conclusion:Results obtained from insilico evaluation would provide insights in interaction of benzothiazole with STS explaining its favorable interactions.
The Implementation of No-Smoking Area Policy to Improve Community Health and its Relationship to the Country’s Pharmaceutical Policy: A Study in Semarang City in Indonesia Kusworo .
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Cigarettes smoking in Indonesia is rampant despite of its harmful effects on human health and the environment, which calls for government intervention. This study examines the implementation of the No-Smoking Area Policy in increasing the degree of public health in Semarang city by focusing on the inhibiting factors of the policy, and the efforts taken by government to overcome obstacles in its implementation. The study used qualitative research with action research method. Data collection techniques were semi-structured interviews, observations, and documentation study. The data analysis technique used was the triangulation method. Findings indicate that the No-Smoking Area policy has been implemented in Semarang city but it is still in the socialization stage. There are several obstacles in its implementation that still need proper handling by the Semarang City local government, especially its health office, notably the program’s implementation, compliance and responsiveness, and resources involved, including its relatedness to the pharmaceutical policy implementation. The efforts made by the city government to overcome the obstacles in the implementation of the policies include providing guidance to the entire staff of Semarang City Health Center, socialization of the policy to the community through community health units, making No-Smoking signs, stickers, leaflets, and banners, and performing activities during the celebration of the world’s no-tobacco day. Keywords: Tobacco, Smoking and No-Smoking Area, Policy Implementation, Pharmaceuticals and Narcotics, Public health.

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