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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Molecular Detection of Extended Spectrum-Beta Lactamase Producing Escherichia coli Isolated from Pregnant Women Infected with Urinary Tract Infection Oday Mitib Hadi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

During pregnancy, the urine becomes low concentration and increase the volume of the bladder as a result of an increase of the plasma volume. These factors combined and leading to stasis of urine and ureterovesical reflux [3].A uropathogenic strain of E. coli (UPEC) was the most predominant cause of infection in the urinary tract system in the world [4; 5]. The main bacterial mechanism of resistance to the β-Lactame antibiotic was the β-Lactamase production [8]. Generally, ESBLs genes were SHV type, TEM type, CTX-M type, and OXA. The SHV type of extended-spectrum beta-lactamases was the more commonly present in clinical isolates than any type of extended-spectrum beta-lactamases [25]. A total of two hundred and seventy nine midstream urine samples were collected randomly from the pregnant women suspected to be infected with urinary tract infection admitted to Al-Sader Medical City, Najaf- Iraq, from Oct. 2017 to Dec. 2018. Cultural and Biochemical properties were studied carefully. Vitec 2 system was used to confirm the identification. Extended spectrum beta lactamase genes (bla TEM, bla SHV, bla CTX-M, and bla OXA) were detected by using polymerase chain reaction technique. The highest percent of infected pregnant women was 42.8% in the age group 20-25 years, most of them (76.5%) in the third trimester of pregnancy. According to the educational level (38.13%) of pregnant women had completed the primary school. The recovery of UPEC was 62.60%. From the analysis samples the percentage of E. coli isolates in pure culture were 10.71% (6/56), 39.29% (22/56) and 50% (28/56), in the first, second and third trimesters, respectively. On the other hand, the recovered percentage of E. coli as a mix growth were occupied different ratios there were 18.75%(3/16), 37.5%(6/16) and 43.75%(7/16) in the first, second and third trimesters, respectively. Also, the results revealed that the commonest gene was CTX-M 90.9% (as a single, double and more than two genes). The majority of the E. coli strains carried two or more ESBL genes, of these isolates, 1/22 (4.55%) had two types of ESBL genes were TEM and CTX-M-positive; tow (2/22: 9.09%) were OXA- and CTX-M-positive. Three of these isolate had three types of ESBL genes 3/22 (13.64%) and only five strain 5/22 (22.72%) carried all 4 gene types. From the previous results we conclude the presence of the ESBL bearing strains of UPEC at high level, and this finding may be affected the pregnant women and her fetus. Keywords: UTI, UPEC, Pregnancy trimesters, ESBL.
Characterization of the Dielectric Barrier Discharge (DBD) Plasma Jet for Staphylococcus Aureus Bacteria Deactivation Mohammed K. Khalaf
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

In this paper, the insulation barrier of the dielectric-barrier discharge (DBD) plasma jet is discharged at atmospheric pressure .Where the degradation efficiency of the DBD plasma jet is evaluated on bacteria of Staphylococcus aureus with different exposure times. The influence of the flow rate and applied voltage of the argon gas used is studied and linked to the temperature and column length of the plasma jet. In addition, the Optical Emission Spectroscopy (OES) is examined to detect plasma parameters such as electron temperature and electron density. OES is also used detect active species within a plasma column such as OI, N2 and OH and other. The percentage of bacteria growth inhibition is increased directly with increased time of exposure from the DBD plasma jet. Keywords: Dielectric barrier discharge, Non-thermal plasma, Bacteria inactivation. Optical Emission Spectroscopy.
Gallic Acid, a Promising Chemopreventive Agent, Antagonizes Breast Cancer: Molecular Mechanisms of Action from Cell Culture Studies Hanaa H Ahmed
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective The present consideration converged on trailing the underlying molecular mechanism of gallic acid in striking the distinctly invasive breast cancer cell line; MDA-MB-231 in vitro. Methods The cytotoxic influence of gallic acid and 5-fluorouracil (5-FU) on MDA-MB-231 cells was stipulated by MTT assay. The expression levels of apoptosis, proliferation, progression, invasion and metastases-related genes were identified by RT-PCR. Results Our data specified that gallic acid and 5-FU displayed modest growth suppression with IC50 values of 251 and 367.171 µM contra MDA-MB-231 cells respectively after 48 h. Otherwise, treatment of MDA-MB-231 cells with gallic acid inspired significant downregulation in the expression level of survivin, STAT3, IL-6, VEGF, Slug, Snail, MMP7 and Notch-4 genes. Whereas, 5-FU instigated significant downregulation in the expression level survivin, STAT3, IL-6 and VEGF genes correlated with significant upregulation in the expression level of Snail and Notch-4 genes. Likewise, 5-FU provoked insignificant upregulation in the expression level of Slug and downregulation in the expression level MMP7 genes. Conclusion The attained data throw light on the distinct mechanism by which gallic acid could engage breast cancer. Gallic acid manifested chemopreventive potentiality against breast cancer aggressiveness through rectifying several dysregulated molecules implicated in cancer cell survival, proliferation, progression, angiogenesis, chemoresistance and metastasis.
In Vitro Evaluation and Post-thawing Activation of Najdi, Arabi (Najdi × arabi) Rams Spermatozoa Using Amino Acids and Pentoixfilline Added to Tris Extender Bushra F. Hassan
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This study was done on pooled semen ejaculates of three groups of rams, Arabi, Najdi and their crosses collected by artificial vagina, semen was evaluated before dilution and after thawing from freezing for one month. Dilution of ram’s semen was done by Tris extender as a standard diluents and its semen parameters was evaluated compared with parameter of extenders after addition of glycine and cysteine amino acids. Then all spermatozoa of all diluents were in vitro activated using CO2 incubator for one hour after addition of pentoxiphilline. Also a new seminal diluents was used which is 5% of beet pulp juice of pH 7. Results revealed that dilution with extender having amino acids have significantly better results than Tris standard extender. Also in vitro activation after addition of pentoxifilline gave same results. It is obvious that glycin extender had the better results followed by cysteine extender then Tris standered extender and lastly the extender of beet pulp juice. Keywords: Extender, Rams spermatozoa, Amino acid, Beet pulp.
Psychogenic Depression Depending on Gender and Age Differentiation Alena Gura
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The aim of the study is to analyze the factors that can be predictors of the development and progression of psychogenic depressions, as well as establish age and gender characteristics of their clinical options. The study included 140 people (70 females and 70 males) aged 30-70. Patients were divided into 2 groups: group 1 - 70 people diagnosed with psychogenic depression, aged 30 to 50, Group 2 - 70 people diagnosed with psychogenic depression, aged 50-70. In males of the younger age group, anxious (in 10 (28.7%) men) and dysphoric (in 13 (37.1%) men) variants of psychogenic depression were typical. In females, adynamic (in 14 (40%) females) and dysthymic (in 12 (34.2%) females) predominated. In patients of a older age, the gender differentiation of clinical variants of depression disappears, however, in this age group, both among males and females, the proportion of people with the hypochondriacal variant of psychogenic depression significantly increased by 2.6 times (OR = 3.32, 95% CI [1.36- 8, 14]). Thus, we established the presence of significant gender and age differences in the clinical course of psychogenic depressions and the frequency of factors that create the basis for the occurrence of depressive disorders, which should be taken into account when conducting appropriate complex therapy of the disease. Keywords: Gender characteristics of psychogenic depression, Clinical variants of psychogenic depression, Age-related features of psychogenic depression, Trigger factors of psychogenic depression.
Nanoparticles Suspensions as Optical Power Limiting Synthsization and Characterization Gofran Hadi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

In this study, the investigation of the nonlinear and optical properties of nanoparticles (AgNPs) in distilled water with gold nanoparticles (AuNps) was investigated. The non-linear absorption coefficient of nanotubes was measured by Z-scan. Nanonuclear AuNps with AgNPs under exposure to nano-laser pulses at 532 nm as well as 405 nm and 650 nm. The results showed that nonlinear diffusion can increase the performance of the optical marker. A theoretical analysis is proposed Investigate non-linear behavior observed from AgNPs with AuNPs. Shows that the dispersion of non-linear light occurs at high intensity because of the inverse refractive mismatch between silver nanoparticles with gold and water. TheZ- scan experimental data were provided with the proposed theoretical model, allowing the extraction of nonlinear absorption coefficients and linear and nonlinear propagation coefficients for AgNP suspension with AuNPs.
Molecular Docking of Benzoylurea Derivatives as Potential Anti-Breast Cancer Agent and Its Admet Profiles Siswandono Siswandono
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Objective: At present therapy for breast cancer leads to target cell therapy. One of the compounds that can be developed as anti-breast cancer agents is benzoylurea. Benzoylurea has the same pharmacophore group with hydroxyurea as urea derivatives which have anticancer activity. This study aims to predict the anticancer activity and ADMET profile of seven benzoylurea-derived compounds as candidates cytotoxic agent for breast cancer. Method: Biological activity of benzoylurea derivatives is predicted through molecular modeling (in silico) using the Autodock program, ADME profiles and toxicity can be predicted using the pkCSM program and the Protox II online tool. In silico test was carried out by docking between benzoylurea derivatives and HER2 receptor targets, PDB ID. 3PP0. Result: All benzoylurea-derived compounds studied were compliant with Lipinski's 5 legal requirements. The 4-tertier butylbenzoylurea compound shows a  better ADME profile and its toxicity is predicted to have mutagenic properties but not hepatotoxic properties. The smallest docking score of seven benzoylurea derivatives is 4-tertier butylbenzoylurea, therefore the compound has the best cytotoxic activity. Conclusion: the 4-tertier butylbenzoylurea compound is chosen as the compound to be synthesized and further developed.Keywords : molecular docking; benzoylurea; anti-breast cancer; ADMET profiles
Study the Effect of the Seed Grape vitis vinifera Plant Extract on Some Pathogenic Bacteria and Fungi Sumayah Sami Hashim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Aqueous extract of grape seed was prepared for the purpose of studying its effect in inhibiting the growth of some pathogenic bacterial and fungal isolates. Candida albicans, Escherichia coli, Staphylococcus aurus, Klebsiella pneumoniae, and Proteus mirobillis. The effect of extract concentrations was studied and the effect varied with the concentration on these isolates. The effect of the same extract on C.albicans was studied. The result was also show the higher concentration of the extract appeared the greater inhibitory effect on C. albicans. The effect of some antibacterial and antifungal agents was also studied. The inhibitory effect varied according to the species of bacteria.at the other hand nystatin showed higher inhibitory effect with inhibition zone 8, 9, 10mm. Keywords: Fungi, Pathogenic Bacteria, Seed Grape vitis vinifera, Plant Extract.
A survey of quality of life among elderly population in Yogyakarta: A questionnaire-based study Dani Hanif Koncoro; Susi Ari Kristina
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Indonesia, as one of the world's developing countries, faced a demographic transition. Indonesian people's life expectancy has risen over time. It imposed the escalating elderly population in Indonesia. Quality of Life ( QoL) was an important assessment to be measured in the elderly as many comorbidities involved. This research aimed at determining QoL among the elderly population and QoL-related factors. A questionnaire-based survey was conducted among 210 elderly participants attending Yogyakarta's Elderly Community Services (Poslansia). QoL was evaluated using WHOQOL-BREF. Socio-demographic variables were analyzed using a questionnaire. Data was analyzed using SPSS version 22. QoL score differences among elderly characteristics were analyzed using Mann Whitney test. QoL score among respondents showed dimensions of social relationships had the lowest score among domains (QoL score 46.78 ± 10.72). Participants with spouses had better QoL scores than widowed participants (p 0.032). Participants who had better QoL scores than smoker participants (p
Association of Heat Shock Proteins (HSP70), Reactive Oxygen Species and Inflammatory Mediators in Male Infertility Nuha Yaarub Al-Harbi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Heat shock protein 70 (HSP70) is considered as a gene which affects semen quality traits. The present study attempted to investigate the relationship between the HSP70 expression level and physiological status in Normozoospermia and an Asthenozoospermi. The current study was planned to investigate the relationship between the HSP70 gene polymorphism and infertility in infertile males with normal sperm parameters. A complete of sixty patients and thirty control subjects were collected between February to May 2019. The genotyping of the HSPA1L gene was performed using polymerase chain reaction (PCR) in addition to restriction fragment length polymorphism (RFLP). We tend to determine vital variations within the genotype frequencies of HSPA1L asthenozoospermia patients and controls. Our results showed highly significant differences between asthenozoospermia patients and control groups in levels TNF, IL-6, and ROS, (p

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