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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
The Effect of Intracanal Medicament Using Calcium Hydroxide in Root Canal Infection Toward MMP-9, TIMP-1 and EGF Level in Apical Lesion: a Literature Review Ni Kadek Eka Widiadnyani
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Root canal infection is one of periodontitis spectrum that started by dental caries process. There are many bacteria causing root canal infections, mainly obligate anaerobe bacteria. Root canal infection can form apical lesions resulted from the interaction between bacteria and inflammatory cells. The apical lesion can be causing degradation of the extracellular matrix in the root canal system. Collagen degradation is the main characteristic of the apical lesion, which degradation process mediated by pro-inflammatory cells. One of them is a matrix metalloproteinase (MMP) mainly MMP Type-9 (MMP-9). Besides MMP, tissue inhibitor of MMP (TIMP) and epidermal growth factor (EGF) also play a role as MMP regulators. Root canal treatment with intracanal medicament needed to fix dental tissue destruction. There are many intracanal medicaments available, which is calcium hydroxide mostly used in dental therapy. Calcium hydroxide has an antibacterial effect and can be lowering inflammatory cells number. In apical lesion, immune-inflammatory response happened which inflammatory cells play an important role in extracellular matrix degradation. Studies showed that intracanal medicament using calcium hydroxide proven lowering inflammatory cells levels such as MMP-9, TIMP-1 and EGF. This review will have further discussion about calcium hydroxide mechanism in reducing MMP-9, TIMP, and EGF levels in the apical lesion. Keywords: Root canal infection, Intracanal medicament, MMP-9, TIMP-1, EGF.
Treatment of Childhood and Adolescent Depression with Physical Rehabilitation Olga Taranina
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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One of the effective methods of treating depression in children and adolescents is exercising. The aim of the research is to study the effectiveness of physical activity in the treatment of psychogenic depression in children and adolescents. The sampling contained 90 children and adolescents (age 11-15 years) suffering from psychogenic depression, they were divided into 2 groups: group 1 (control group) – 45 children undergoing psychotherapy for 8 weeks; group 2 (study group) – 45 children who, in addition to psychotherapy, were treated with a complex of physical exercises 1 hour a day 4 times a week for 8 weeks. The main methods of the study were clinical-anamnestic and clinical-psychopathological methods, analysis of medical history and lifestyle data, anthropometry methods, laboratory and instrumental diagnostics, mathematical statistics methods. At the end of the 8th week of treatment, HAM-D score level of depression significantly decreased by 2.27 times (p
Potential Protective Effect of Atriplex halimus Extract toward the Doxorubicin - Induced Apoptotic Gene Expression, Genetic and Hepatic Toxicity in Mice Shenouda M. Girgis
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Objective: The anthracycline doxorubicin (DOX) is widely used in chemotherapy as an anticancer drug due to its efficacy in fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers. However, it can induce injury to non-targeted organs after cancer treatment. Thus, exploration of effective drug targets or active lead compounds against DOX-induced organ damage is necessary. Method: In this study the protective effect of Atriplex halimus (Ah) extract towards DOX-induced genetic and hepatic toxicity and apoptosis in male mice was investigated. Animals were divided into 7 groups (10 animals each): 1- Control group treated with physiological saline. 2- Animals treated with DMSO. 3- Low dose of Ah (0.5 mg/kg bw) extracts. 4-high dose of Ah (5mg/kg bw) extracts. 5- Animals were injected i.p with DOX. 6- DOX + low dose of Ah (0.5 mg/kg bw) extracts for 1 week. 7- DOX + high dose of Ah extracts for 1 month. Results: DOX treatment induced a significant increase in the chromosomal aberrations either in the bone marrow or in the spermatocyte cells, increase the DNA fragmentation, malondialdehyde (MDA) level and the expression of apoptosis-related genes, Bax and caspase 3 genes. However, the treatment with Ah declined these negative effects. Conclusion: The findings demonstrated that Ah extract had protected the mice against the negative effects of DOX-induced genetic, hepatic toxicity and apoptosis and could be used as natural antioxidant product for scavenging the reactive oxygen species and to attenuate DOX-induced genetic and hepatic toxicity. Keywords: Doxorubicin (DOX), Atriplex halimus (Ah), Apoptosis, Gene expression, Genotoxicity, Hepatic, mice.
Erythrocyte Changes in Death after General Over Cooling Revo Z. Alekseev
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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In medicine, the problems of hypothermia and body ‘revitalization’ remain open. Insufficient knowledge of the mechanisms of dying at ultralow temperatures gives grounds to supplement the idea of the cellular-molecular mechanisms of deadly hypothermia. The aim of this study was to assess the morphology of red blood cells during fatal hypothermia at extremely low temperatures (i.e. below -40°C) using atomic force and scanning electron microscopy, high resolution JSM-7800F. The subject of the study was blood smears of people who died from hypothermia and from a gunshot wound. In a man who died of hypothermia at extremely low temperatures (i.e. -42°C), whose smear was taken within 1 day, red blood cells were characterized by minimal changes than when dying from a gunshot wound. The discocytic form of erythrocytes with a flat surface was preserved; however, we found an increase in the depth of the central concavity of red blood cells, which may be associated with an increase in the volume of red blood cells. It was found that even a slight difference in the temperature of the body regions (i.e. ∆ 2.4°C) at the time of blood sampling affects the ratio of different forms of red blood cells after complete thawing. The lower the temperature, the more degenerative forms of red blood cells appear. After complete thawing of the corpse on the 4th day, all red blood cells (100%) had a different degree of dysmorphism, a more flattened surface, an increase in diameter and heterogeneity and roughness of the plasma, indicating signs of hemolysis. Keywords: Red blood cells; Death from hypothermia; Atomic microscopy; Scanning electron microscopy.
Clopidogrel as an Oral Antiaggregant in Ischemic Heart Disease Truong Dinh Cam
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The use of antiaggregant in preventing cardiovascular diseases remains an important therapeutic approach. The research aims to perform a comparative analysis of the effect of acetylsalicylic acid (aspirin) and clopidogrel monotherapy or their combination on platelet aggregation applying the method of impedance aggregometry. The study was carried out in 2018-2019 in Grozny (Russia) and in Ho Chi Minh (Vietnam) based on the past medical histories of 557 patients diagnosed with ischemic heart disease in 3 primary health-care facilities. The acetylsalicylic acid monotherapy in amount 100 mg per day was used for the treatment of 367 patients comprising Group I, another 147 patients (Group II) received clopidogrel in a dosage 75 mg per day, and the rest 43 patients (Group III) took both drugs. The method of impedance aggregation with the estimation of three parameters, such as platelet aggregation time, aggregation amplitude, and the area under the aggregation curve, was applied after the introduction of two inducers, namely, collaagen and ADP. In Group I, the use of collagen as an inducer resulted in prolonged platelet aggregation period and reduction of area under the curve (correlation -0.80 (p ≤0.05)). In Group II, the influence of clopidogrel on both inducers was reported. In the case of ADF-initiated platelet aggregation, a positive correlation between amplitude and area under the aggregation curve of 0.98 (p ≤ 0.01) was recorded. A correlation of 0.77 (p ≤ 0.05) was noted between the platelet aggregation extension and the area under the collagen-induced process curve. The results obtained through this research in the opposite correlation coefficients for Group I and Group II show the mechanisms of acetylsalicylic acid and clopidogrel action. The applied methodology allowed establishing qualitative and quantitative changes occurring in the aggregation of platelets with the addition of ADP and collagen as inducers. Keywords: ADP; Antiaggregant; Acetylsalicylic acid (ASA); Clopidogrel; Collagen; Ischemic heart disease.
Taxonomic Study of the Genus Phlomis L. (Lamiaceae) in Iraq Based on Trichome and Palynological Characters Shaemaa Muhi Hasson
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The current investigationincluded a comparative morphological study of the pollen grains of some Phlomis L species distributed in Iraq, as well as study of the Indumentum for species. The pollen grains and trichomes were examined under light and scanning electron microscope. The results showed that there is a limited variability in the characteristics of the pollen grains of the studied species, where the pollen grains were 3-zonocolpate, prolate-subprolate in the shape and the pattern of sculpture (ornamentation) grain surface was reticulate in all species under study, However, the present study showed variability in the dimensions of the pollen grains within the polar and equatorial view. There was also a contrast in indumentum characteristics, and each of these characteristics had a good taxonomic significance to distinguish between the species under study. The results of the current study were found to be taxonomic support to the morphological evidence. Keywords: Pollen grain, Phlomis, Lamiaceae, Indumentums.
The Effect of Nimodipine towards Calcium Ion (Ca2+) Expression in SH-SY5Y Neuron Cell Culture Exposed By Chronic Hyperglycaemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Diabetic neuropathy is a complication of diabetes mellitus which forms clinical or subclinical that affecting the peripheral nervous system. In diabetes condition, changes in calcium ion signalling contribute to the development of distal symmetrical sensorimotor polyneuropathy (DSN) and pain. Increasing of cytosolic calcium involved in neuron degenerative and cell apoptotic process. This study discusses the effect of nimodipine, an L-type calcium channel blocker, on calcium ions (Ca2+) in SH-SY5Y culture cell line exposed to chronic hyperglycemia. This study, using in vitro research model. Before measuring calcium ions (Ca2+), the study sample was divided into three groups with 6 days of glucose administration; 5 mM noromoglycemia, 25 mM hyperglycemia, and 50 mM hyperglycemia. Each group was given different treatment; without nimodipine, nimodipine 10 nM and nimodipine 100 nM for 30 minutes, then proceed to observe of Ca2+ concentration parameters by fluo-3 dye using confocal laser scanning microscopy (CLSM). The results showed that higher dose of glucose could increase the calcium ion significantly. The administration of nimodipine at 10 nM and 100 nM doses significantly reduced calcium ions in the 25 mM and 50 mM glucose groups. In the 5 mM glucose group with administration of 10 nM and 100 nM nimodipine, Ca2+ has shown increased. The conclusion of this study is the administration of nimodipine could decrease calcium ions in SH-SY5Y cells exposed to chronic hyperglycemia. Keyword: Nimodipine, Calcium Ion (Ca2+), Diabetic Neuropathy.
Synthesis of Some New Pyrazoline Compounds Derived from α-β Unsaturated Compounds and Study their biological and Biochemical Effect Wissam M. R. Al-Joboury
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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In this work Compounds Chalcones (w1-8) have been prepared from the reaction of acetophenone derivatives with appropriable aromatic aldehyde in presence of Noah (10%). The reaction of thiosemicarbazide with chalcones (w1-8) yielded compounds (W9-16) 5- (Aryl) -3- (4-sub. Phenyl) 4-5-dihro -1H-Pyrazole -1- Carbathiamide). All the new compounds have been characterized by using spectral (IR, H1-NMR, TLC) data. And physical methods. The antibacterial activity have been tested in vitro by the disk diffusion assay method against two kinds of bacteria gram positive and gram negative .The minimum inhibitory concentration [MIC] have been determined with the reference of standard drugs the results showed that the pyrazoline derivatives are better than growth of both types of bacteria (gram- positive and germ–negative compared to drug .The effect of hydrogen peroxide (0.1%) H2O2 drinking water through the mouth for about (15) days on white male rats shows significant increase (P˂0.01) at the level glucose and cholesterol and Triglyceride in the serum comparison with the control group, where as it shows a significant decrease(P˂0.01) in the level of ,glutathione, glutathione Peroxidase (GSH-Px), Superoxide dismutase (SOD), in serum. Whereas the prepared (W11) compound was injected, results show after (5) days of treatment that the organic compound of (7.14) mg/kg of body weight through the mouth for white male rats exposed to oxidation, with an associated significant decrease (P
Antioxidant Activity, Formulation, and Evaluation of Roselle Seed Oil Extract Nanoemulsions Arpa Petchsomrit
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Roselle Hibiscus is a medicinal plant used in folk medicine. The parts of the flower, calyx, and bracts, are regularly used but the seed of roselle has not been used and studied for antioxidant activities. The objective of the present work was to determine the antioxidant activity of roselle seed oil extract extracted using dichloromethane maceration. The extraction then was formulated as nanoemulsions and evaluated for its physicochemical properties and stability. The oil obtained from Roselle Hibiscus seed demonstrated good antioxidant activity, according to the DPPH assays. Roselle seed oil extract nanoemulsions were developed using non-ionic surfactants and water by ultrasonic emulsification method and evaluated to achieve optimum stability. Nanoemulsions formulated using Tween 60 and Tween 80 had a relatively small droplet size ranging from 20-30 nm. After a seven-day stability test at the room temperature and a 6-cycle heating-cooling study, phase separation or creaming did not occur to the nanoemulsions formulated by Tween 60 and Tween 80. The ratio of roselle seed oil extract and Tween 60 that yielded the best physical properties for the nanoemulsions was 1% and 5%, respectively. The results indicated that nanoemulsions had nanoscale droplet size and were stable under the normal and stress storage condition.
The Comparative Analysis of Asthma Treatment in Pediatric Patients of Russia and China Yue Li
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The correctly prescribed treatment regimen plays a key role in a successful control of asthma symptoms. Therefore, the monitoring studies aimed to facilitate rational medicine use for asthma treatment are relevant. The analysis of drug prescription patterns for asthma in pediatric outpatient care of Russia and China, as well as evaluation of the prescribed therapy conformity with the modern international standards on asthma treatment. This is a retrospective pharmacoepidemiological study on medical histories of asthma patients under the age of 18. The study involved 720 children’s medical records (327 Russian and 393 Chinese) and prescribed medications for asthma within the period of 2018. The short-acting beta-2-agonists in Russia and China were typically prescribed as quick-relief drugs for treating asthma attacks in pediatric patients (in 78.6% and 83.7% of cases, respectively (p> 0.05)). Inhaled corticosteroids (in 65.1% of cases) and leukotriene receptor antagonists (in 18.6% of children) were most frequently prescribed for a long-term control of asthma symptoms in China. In Russia, the rate of commonly prescribed long-term relievers ranged as follows: inhaled corticosteroids -54.1%, cromones-19.6%, inhaled corticosteroids in combination with long-acting beta-2-agonists -15.4%. The drug prescribing patterns for bronchial asthma management in pediatric patients of Russia and China conformed to the modern treatment standards. Still, some differences in asthma therapy (relatively short anti-inflammatory therapy courses, unreasonably prescribed cromons in Russia) were found, which required deeper pharmacoepidemiological monitoring in that field. Keywords: Commonly prescribed asthma medications in pediatric patients, Mistakes in pediatric asthma management, Asthma medication prescribing in China and Russia.

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