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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2 Documents
 1 
Search results for , issue "Volume 12 Issue 08 (2020) Aug. 2020" : 2 Documents clear
Optimization and Validation of the Simultaneous Determination of Vildagliptin and Metformin, in Bulk and Formulation by A Reverse Phase HPLC Method Using D-Optimal Experimental Design K Balamurugan; Kirtimaya Mishra
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti-diabetic drugs Vildagliptin (VLD) and Metformin (MET).The optimization of the HPLC methodology included several variables, of which the impacts of each was studied. After a sequence of preliminary-screening experiments, the composition of the mobile phase and the pH of the added buffer solution were set as the examined variables, while the capacity factor (K1) of first peak i.e Metformin (MET), resolution (Rs) between Vildagliptin (VLD) and Metformin (MET), Separation (S) for both the drugs and the retention time (Rt2) of the second peak i.e Vildagliptin (VLD) were chosen as the dependent variables. Using the D-optimal design, the ideal chromatographic conditions for the separation were identified. The technique proved to show good harmony between the experimental data and predictive values throughout the studied parameter range. The optimum assay conditions were carried out with a Onyx C18 Monolithic column (100mm× i.d., 5µm) connected with an Onyx C18 guard cartridge (4mm×3mm i.d., 5µm) and a mixture of methanol (MeOH)/acetonitrile (ACN)/potassium dihydrogen orthophosphate (KH2PO4) (pH 4, 0.003 mol L−1) (31.362:10:58.638, v/v/v/v) as the mobile phase at a flow rate of 0.4 mL min−1 and detection wavelength of 220nm. The run time was under 8 min, which is a lot shorter than the prior optimized methods. The improved analytical method was validated as per FDA guidelines.
Drug Use Evaluation in the Pediatrics Admitted with Severe Respiratory Tract Infections Vineela Chadalavada; Triveni P; Hameeda Begum Md; Pujitha S
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of the present study is to evaluate drug prescribing patterns in children admitted with respiratory tract infections into pediatric ward. This is a prospective cross-sectional study conducted for a period of one year at a tertiary hospital located in a city of Andhra Pradesh, South India. The study was done by using prescribing indicators from the World health organization (WHO) manual for the conduction of drug use evaluation studies. The prevalence of respiratory tract infections, particularly lower respiratory tract infection is high among children less than 5 years. 54.39% of drugs are prescribed with brand names, of which the majority of drugs are administered through parenteral route (58.26%). Antibiotics (34.7%) are highly prescribed in all the cases followed by other category drugs. A significant difference was found in the evaluation of prescribed daily dose and standard dose. The profile of drug use in the present study was similar to previous Indian studies. Most of the prescribing encounters are parental forms and band names that need exploration of the present treatment trends. The present baseline data can serve for the development of national Pediatric prescribing guidelines in the future.

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