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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
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Search results for , issue "Volume 13 Issue 02 (2021) Feb. 2021" : 3 Documents clear
Probiotics - A Review Kamala Kumari
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
Publisher : Journal of Global Pharma Technology

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Abstract

Probiotic bacteria are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. While this beneficial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefits by modulating immune functions. Scientists continue to work on elucidation of the mechanisms of the most common probiotic strains. The results that might arise from could be extremely important because the use of probiotics to maintain health must be considered promising, although much remains to be elucidated. The universal use of some strains seems less reasonable from an ecological point of view than selection of strains from their natural habitat were they are adapted to the ecological niche. It is important to understand that all probiotic strains are unique and different and their properties and characteristics should be well defined.
In Vitro Dissolution Enhancement of Curcumin by Melt Dispersion and Solvent Casting Technique Aided by Molecular Modelling Approach Anindya Jana; Subrata Kumar Biswal; Rudra Narayan Sahoo; Partha Niyogi; Subrata Mallick; Rajaram Mohapatra
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
Publisher : Journal of Global Pharma Technology

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Abstract

Purpose: The oral bioavailability of curcumin is low due to its lipophilic nature. The drug also tends to degrade in alkaline pH. This inherent character of curcumin limits its stability and oral bioavailability. Use of polymeric carriers to alter the physicochemical nature of the drug is one of the favoured techniques of drug formulation. Aim of this study was to improve the in-vitro dissolution and solubility of curcumin by using hydrophilic carriers such as polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) of different grades and to check the effect of the different excipients used in the formulation of curcumin by solid dispersion technique. Methods: Solid dispersions of curcumin have been prepared by the solvent evaporation and melting method by using carriers in suitable ratios. In this experiment, ethanol was used as an organic solvent for solvent evaporation. The presence of different release rate modifiers such as croscacamellose sodium, kollidon CL and sodium and lauryl sulphate (SLS) in the SD formulation were also studied. In-silico approach has been applied to quantify the curcumin and carrier interaction. Results: The solubility of the solid dispersion prepared by the solvent evaporation and the melting method was found to be 13.5 and 78.9 fold to that of the pure curcumin respectively. Physical characterization by FTIR and DSC studies advocated that the physical state of crystalline drug has been modified in solid dispersions due to its dispersion in the polymer matrix. Conclusion: Dissolution studies revealed that all the formulations were having better drug release profile compared to the physical mixture. The lowering of binding energy in in-silico ducking study indicated towards possible molecular drug carrier interaction. Keywords: Curcumin, Solubility, Dissolution, Solid dispersion.
Effect of Oct3 Genetic Polymorphism on the Response of Metformin in Type 2 Diabetes Mellitus: Narrative Review Swathi Swaroopa Borra; Bhavya Chebrolu; Poojitha T; Sujin Bright F J; Sadagoban GK; Arun Kanniyappan Parthasarathy
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
Publisher : Journal of Global Pharma Technology

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Abstract

Context: Metformin, the first line therapy of Type 2 Diabetes Mellitus is known to be transported by OCT3 (Organic Cation Transporter 3). Polymorphisms in this gene may lead to interindividual differences in the response to metformin. Objective: This study aims to compile and summarise the effect of OCT3 polymorphism on effect of metformin. Methods: PubMed/MEDLINE, ResearchGate, Google Scholar, Cochrane Library and Scopus were used for literature review. Cmax (Maximum concentration), Tmax (Time to reach maximum concentration), AUC (Area under the curve) and Kel (Elimination rate constant) were used to assess pharmacokinetics and HbA1c (Hemoglobin A1c), blood glucose levels for pharmacodynamics. Results: Data extraction showed that 19 OCT3 polymorphisms were analyzed in various ethnic communities with the plurality of Asians. The results of these genotype alleles were found to be favorable (9), negative (3) and have no impact (7) on the response of metformin. A positive effect on metformin response was expressed as higher Cmax (Maximum concentration), AUC (Area under the curve), lower Kel (Elimination rate constant) or reduced HbA1c (Hemoglobin A1c), FBG (Fasting blood glucose). Conclusion: Influence of OCT3 polymorphisms on metformin responses were unique to the population. This recommends new research requirement on association between OCT3 polymorphism and Metformin.

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