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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 11 Documents
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Search results for , issue "Volume 9 Issue 11" : 11 Documents clear
FORMULATION AND EVALUATION OF BUSPIRONE ORAL DISINTEGRATING TABLETS USING BANANA POWDER ahmed ABDUL sami
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

The present study aims to formulate and evaluate oral disintegrating tablet of buspirone. A drug that is used for the treatment of anxiety management was prepared by direct compression method using natural disintegrates. Eight formulations (F1-F8) of oral disintegrating tablets of buspirone were prepared by using natural disintegrates. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption, wetting time, and disintegration time and in-vitro dissolution study. Based on the results of FT-IR and DSC studies, majority of the excipients were found to be compatible with buspirone which were used for the preparation of buspirone oral disintegrating tablets. Among all the formulations F3 (containing 15mg of natural disintegrate banana powder) was considered to be the best formulation, which releases up to 98% drug in 8 minutes. From this study, we can conclude that, a formulated tablet of buspirone containing banana powder is better and effective to meet the patient compliance.
Prevention of Thrombotic Complications during Hysterectomy among Women with Uterine Fibroids M. Makarenko
Journal of Global Pharma Technology Volume 9 Issue 11
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The aim of our study was to determine the state of hemostasis in women with benign tumors of the uterus during and after surgery. Thrombotic complication is one of the most dangerous problems in surgical, obstetrical and gynecological practice. In operative gynecology one of the most dangerous manifestations is thromboembolism, which can be met from 0, 5 to 6, 4% cases. We examined 153 women with the uterine fibroids. Main group consisted of 38 patients who were operated with the usage of the autologous plasma and control group consisted of 115 patients who were operated without the usage of the autologous plasma. We studied a condition of the system of a hemostasis of women of the main and control groups at all stages of supervision. The study found that women with uterine fibroids are at high risk of thrombotic complications during surgery and in the postoperative period. We came to the conclusion that using autoplasma in gynecological practice is economically beneficial and help to reduce the use of donor blood and its components during the surgical treatment of gynecological patients.Keywords: Uterine fibroids, Autologous plasma, Hemostasis system, Thrombotic complication.
Regulatory Effect of Endothelial Dysfunction and Microcirculation Pathology in Pregnant Women Diagnosed with Diabetes Mellitus Tatiana Avramenko
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

The steady incidence of pregnant women diagnosed with diabetes mellitus in the world stimulates the development of research in this direction and deserve special attention. This article presents new methods in usage factors of endothelial dysfunction in development complications of pregnancy with diabetes mellitus. Aim of this research was to study role of endothelial factors in development of obstetrical and perinatal pathology in pregnant women diagnosed with diabetes mellitus. This paper presents the results of the study of 120 pregnant women diagnosed with diabetes mellitus. They were grouped according to the pregnancy complications (pre-eclampsia) and fetal disorders (moderate and severe asphyxia). The researchers defined blood content of prostaglandins Е2 and F2а, prostacyclin, thromboxane, endotheline-1, nitrogen oxide and L-arginine. It was established that the decreased concentration of prostaglandins, nitrogen oxide and L-arginine combined with considerable increase of the thromboxane and endothelin in the recent pregnancy period is an unfavorable prognostic factor for the subsequent pregnancy development course and pregnancy outcome. The decreased concentration of prostaglandins, NO and L-arginine combined with considerable increase of thromboxane and endothelin content in early pregnancy period is an unfavorable prognostic factor of the pregnancy development and outcome. The administration of therapy aimed at correction of the endothelial dysfunction is path genetically grounded, and its timely administration will provide for the decrease of incidence of pregnancy disorders and obstetrical pathologies in diabetic pregnant women.Keywords: Pregnancy, Diabetes Mellitus, Endothelial Dysfunction, Obstetrical Pathology, Microcirculation, Diabetic Fetopathy.
The Relationships of Cytomegalovirus’s Infection among Pregnant Women with Some Variables Saadya Hadi Humade
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

Back ground: CMV is Human Herpesvirus 5 (HHV-5). Belong to the ''Betaherpesvirinae'' subfamily of ''Herpesviridae'', which also includes Roseola virus. It leads to an initial CMV infection, with a few symptoms. The virus remains latent in the body, reactivating when the body’s immune system is weakened. CMV causes an estimated 400 deaths each year and permanent disabilities in about 8,000 children, according to statistics by the U.S. Centers for Disease Control and Prevention. A pregnant woman can pass CMV to her child and the results gave birth has severe cerebral palsy, hearing and vision loss. Treating a pregnant woman for CMV will lessen or prevent long term disabilities of the fetus in utero.  Objective: To find out the relationship between demographic variable and reproductive variable with the predisposing factors of the disease. Methodology: descriptive study done at Bable maternity hospital conducted, a purposive sample of (56) women how have Cytomegalovirus, from the period    1/4/2017 to 30/4/2017. Results: the study revealed that the high percentage for women who affected with CMV with in age group (16-25) years (41.1%). (33.9%) graduated from the primary school related reproductive variable,(94.28%) they have number (1-4) graveda, (92.8%) they have(92.8%)they have (1-4) para and (76.78%) they have(1-3) abortion.(78.6%) they aborted at 11-20 weeks gestation. Also (30.4%) they have fetal anomalies and (50%)at they didn’t taking medication during pregnancy. The study revealed that a highly significant correlation between age and education, occupation, residence, gravida, para and abortion, highly significant correlation between Gestational age and fetal anomalies and immune disease and highly significant correlation between fetal anomalies& immune disease. Conclusion: the study was concluded that the study sample don’t aware about CMV and its complication. Recommendation: Sequential ultrasound examinations should be performed every 2 to 4 weeks to detect sonographic abnormalities, to determine the prediction of the fetus and serologic testing for CMV for women who develop influenza-like illness during pregnancy.Keywords: Cytomegalovirus, fetal anomalies, abortion.
Bioactive Compounds From Marrubium vulgare L. based on in vitro antioxidant Activity Shamil Ismail Neamah; Ismail Ahmed Sarhan; Oqba NAFIA Al-Shay
Journal of Global Pharma Technology Volume 9 Issue 11
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Marrubium vulgare L. (Lamiaceae) used in the world a viable source of medically important. Six compounds included: flavonoids, triterpenoids, and phenolic acid, they were isolated from the leaf extract by methanolic solvent and were determined as luteolin-7-O-β-glucopyranoside (1), apigenin-7-O-β-glucopyranoside (2), oleanolic acid (3), β-sitosterol (4) luteolin-7-O-rutinoside (5), and rosmarinic acid (6). In the MTT assay, compounds 1-6 at 250 µg/mL concentration gave an absorbance value of 0.524, 0.455, 0.187, 0.088, 0.0362, and 0.241, respectively. The significant LPO inhibitory of the purifications afforded compounds 1, 2, and 5 by 66, 84, and 89 at 100 µg/mL concentration, respectively. 
COMPARISON OF THREE DIFFERENT CONFIGURATION POSTERIOR INSTRUMENTATION OF SYNBONE® BONE MODEL OF ADOLESCENT IDIOPTAHIC SCOLIOSIS LENKE 1: IN VITRO TEST OF BIOMECHANICAL S. Dohar Tobing; Hendar Nugrahaedi Priambodo
Journal of Global Pharma Technology Volume 9 Issue 11
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Introduction. Biomechanical construction test of posterior instrumentation for scoliosis correction is needed to evaluate reliability and instrumentation performance. Latest biomechanical testing have validated bone model as a suitable substitute. Low pedicle screw density can correct without significant complication. This study compared biomechanics of three posterior instrumentations: Bilateral Pedicle Screw (BPS), pedicle screw on proximal end, apex, distal end concave side (PAD), and PAD with sublaminar wire the concave side (PAD+SW).Method. Three groups of vertebral model of Scoliosis Lenke I Synbone® is equipped with configurations of 15 samples posterior instrumentations divided into three groups of BPS, PAD, PAD+SW. Each of the static test is given axial force gradually from 50N, 100N, 150N, and 200N using Tensilon® AMD RTF-1310 from Japan, with dial indicator Mitutoyo, Japan. Total displacement were measured for each groups. Stiffness were also analyzed using load-displacement ratio.Results. BPS as the current gold standard showed minimal displacement, followed by BPS, PAD and PAD+SAW for 50N (p<0.001), 100N (p<0.001), and 200N (p<0.001) force, and was not significant for 150N (p=0.086). There was also significant difference between the stiffness of BPS, PAD and PAD+SW for 50N (p=0.002), 100N (p<0.001), 150N (p<0.001) and 200N (p<0.001)Conclusion. For biomechanical testing with static test, type of posterior instrumentations showed significance relationship with displacement and stiffness. BPS groups were more rigid compared to PAD+SW and PAD. Low density of pedicle screw resulted in the decrease of stiffness and posterior instrumentation sublaminar wire addition significantly added the strength.Keywords: Posterior instrumentation, adolescent idiopathic scoliosis, Lenke I, In Vitro
DECOMPRESSION BY THINNING-OUT A BEAK-TYPE OSSIFICATION OF THORACIC POSTERIOR LONGITUDINAL LIGAMENT, A CASE REPORT S. Dohar A.L. Tobing; Ade Martinus
Journal of Global Pharma Technology Volume 9 Issue 11
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Introduction: Ossification of posterior longitudinal ligament (OPLL) is commonly caused dysfunction of the spinal cord. The conservative therapy has been proved to be ineffective and surgical treatment is often needed. Accessing the anterior border of OPLL for anterior decompression while ensuring safe decompression of spinal cord are technical challenges for the treatment. The objectives of this case report is to introduce a surgical technique of decompression and decided whether it is an effective surgical technique to treat a beak type thoracic OPLL, especially in T9-10.Methods: We reported a male, 38 years old, who were admitted to Cipto Mangunkusumo hospital in 2016 and was diagnosed as paraparesis due to OPLL at the level of   T9-10.Results and Discussion: Surgical decompression was performed from a posterior approach. The left facet, pedicle of T9, and  the distal part of T9 vertebral body were removed using highspeed burr until the interval of calcified area was reached distally. Thinning of the calcified area was done until paper thin and expansion of the dura and spinal cord can be observed. The decompression procedure was followed by stabilization of T7-11 using pedicle screws and rods. No worsening of the neurological symptoms was observed post operatively. The patient could stand and assisted walk in day 3 post operation.Conclusion:. This surgical procedure has been shown to be an effective therapy and achieves satisfactory clinical outcomes for patients.Keywords: thoracic ossification of posterior longitudinal ligament, beak type thoracic OPLL, Surgical Treatment, decompression with posterior approach. 
The Study Influence of Cigarette Smoke by Using Laboratory Animals in Behavioral Test «Open Field» Mustafa S Rauan
Journal of Global Pharma Technology Volume 9 Issue 11
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Objective: All organs and systems of organs suffer from smoking without exception. On average, a smoker lives 10 years less than a non-smoker. In addition, given the harmfulness of second-hand smoke, there is no clear boundary between the smoker and the non-smoker. In this article we have examined the harm of polycyclic aromatic hydrocarbons as one of the harmful constituents of cigarette smoke. Methods: Depending on the drug and their concentration laboratory animals were divided into three groups. Number of laboratory animals in each group was 10.  For first group was given only water. In second group during 4 weeks we used the passive smoking method. In third group during 4 weeks we used the passive smoking method. During the experiment for the testing animal behavior was used "Open field" method. Results: In conclusion, on the behavioral indicators compared with the second and third group in the control group acts sniffing, stand with support, stand there is a significant prevalence of these indicators. Conclusion: Especially there is a sharp change in performance compared to the third group. This is due to a high state of anxiety in laboratory animals the second and third groups compared with the control group. On this we can talk about the positive impact on the overall recovery of the organisms by the action of the drug Ecdyphyt. Keywords: Polycyclic aromatic hydrocarbons (PAHs), "Open field" method, Behavior of laboratory animals, The drug Ecdyphyt.                                                        
Comparison of The Role of VEGF-B, C and D in Angiogenesis and Peripheral Nerve Sprouting After Nerve Repair Post Neurotmesis Injury Ria Margiana
Journal of Global Pharma Technology Volume 9 Issue 11
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Introduction: Vascular endothelial growth factors B, C and D play various roles in angiogenesis and nerve cell sprouting.  The purpose of this study was to explore the individual roles of these growth factors in angiogenesis and peripheral nerve sprouting after nerve repair. Method: A systematic literature review of various databases was conducted for relevant data on the role of VEGF-B, C and D in angiogenesis and peripheral nerve sprouting after nerve repair (neurotmesis). The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines Results: Fifty-four studies that met the inclusion criteria were analysed systematically, and grouped into three categories of vascular endothelial growth factors (VEGF-B, VEGF-C, and VEGF-D). The findings highlight the diverse functions of VEGF-B, VEGF-C, and VEGF-D in angiogenesis as well as peripheral nerve sprouting through the VEGF-B/ VEGFR-1, VEGF-C/ VEGFR-3, and VEGF-D/ VEGFR-3 pathways. Conclusion: VEGF-B, VEGF-C, and VEGF-D each play a unique role in angiogenesis and peripheral nerve sprouting. VEGF-B plays a major role in controlling nerve sprouting and VEGF-C influences this process, while VEGF-D is not implicated in the regulation of primary sprouts Keywords - VEGF-B, VEGF-C, VEGF-D, angiogenesis, peripheral nerve sprouting
Tissue culture technician and in vitro screening of rice (Oryza sativa L) callus for salt tolerance Arshad Alhasnawi
Journal of Global Pharma Technology Volume 9 Issue 11
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World wide, the most important cereal crop is rice (Oryza sativa L.) However, its production goes through from salty environments in several areas since it is one of the salt perceptive crops. NaCl mainly contributes salinity that is one of the significant abiotic stress aspects and, the leading cause of crop failure in the world. Tissue and cell culture methods have been applied to gain salt tolerant plants through using in vitro culture methods. In the present paper, the vitro screening of plant germplasm for salt tolerance, as a successful employment of this technique in rice is raised. The current review, focus on plant tissue culture as a method applied for in vitro to protocol for callus induction and screening of salt tolerance and revival of rice in the laboratory.

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