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Journal of Biological Science and Education
Published by USN Scientific Journal
ISSN : 27236838     EISSN : 27210804     DOI : http://dx.doi.org/10.31327/jbse.v4i1.1746
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Education
The journal receives research, review, report manuscripts on biology, environment, and education. The paper focus on biology study, curriculum, instruction, and assessment on biology, as well as biology teacher training and education, which are highly invited to be submitted in this journal.
Arjuna Subject : Umum - Umum
Articles 12 Documents
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Search results for , issue "Vol 3, No 1 (2021): June" : 12 Documents clear
Lentiviral shRNA Construction in Gene Therapy for Knock Down CYPIA1, and YWHAZ gene in Lung Cancer Anjayati, Henik
Journal of Biological Science and Education Vol 3, No 1 (2021): June
Publisher : Universitas Sembilanbelas November Kolaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31327/jbse.v3i1.1436

Abstract

Lung cancer is a disease that is in the top 10 causes of death globally. It is caused by CYP1A1 and YWHAZ genes expressed in the lungs. One of the solutions offered for lung cancer sufferers is gene therapy. Gene therapy for lung cancer is focused on the knock-down of expressed CYP1A1 and YWHAZ genes. It can be using shRNA transfected into lung cells by lentivirus. The lentivirus envelope is modified using glycoprotein filovirus, one of which is ebolavirus. Lentivirus pseudotyping can recognize certain cells. Especially, Ebolavirus can recognize lung cells. The lentiviral gene is designed to carry the gene of interest (shRNA) but no the infectious gene. The shRNA gene transfused into lung cancer cells will recognize and complement the specific target mRNA sites of the CYP1A1 and YWHAZ genes. After that, shRNA will cut the mRNA which should be expressed into a cancer protein. Unexpressed mRNA into protein causes cancer cell growth inhibited. Thus, this gene therapy solution is expected to be able to reduce the rate of death caused by lung cancer. Keywords: Lung cancer, CYP1A1 and YWHAZ genes, gene therapy, lentiviral, shRNA
Science Learning Performance and Retention of Biology Concepts Among Secondary Students Adebisi, Rufus Olanrewaju; Adeyemi, Motunrayo I; Umbugadu, Mary Ashelo
Journal of Biological Science and Education Vol 3, No 1 (2021): June
Publisher : Universitas Sembilanbelas November Kolaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31327/jbse.v3i1.1442

Abstract

This study investigated into effects of science learning materials on performance and retention of biology concepts among senior secondary school two students in Afijio local government area of Oyo State. The study was Quasi-experimental involving pretest, posttest equivalent group design. In this design, 40 students were randomly selected from SS2, pretested to ascertain their group equivalence, and then divided into two groups (experimental and control) using the lottery method of sampling techniques. The experimental group was taught biology concepts with science learning materials,while the control group was taught the same concepts without science learning materialsfor three weeks. The two groups were pretested and post-tested for performance and retention, respectively. The data collected were analyzed using a simple percentage method, mean, and standard deviation. Based on the data generated and results obtained from the experiment, the findings revealed that the use of science learning materialsin the leaching of Biology concepts significantly improves the academic performances, enhances the retention ability of students involved in the study. The study also revealed that students exposed to the use of science learning materialsin the teaching of biology concepts generally had better academic performances and retention ability than students who were not exposed to the use of science learning materialsin the experiment. The study recommended, among others, that the Ministry of Education should provide science learning materials for effective teaching and learning of Biology concepts in Oyo State Senior Secondary Schools. Keywoard: Science Learning Performance, Retention, Biology Concepts

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