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Agus Prima
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The Journal of Society Medicine (JSOCMED)
Published by PT. CoinReads Media Prima
ISSN : -     EISSN : 29645565     DOI : https://doi.org/10.47353/jsocmed.v2i1
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
The Journal of Society Medicine (JSOCMED) | ISSN (e): 2964-5565 is a leading voice in the Indonesia and internationally for medicine and healthcare. Published continuously, JSOCMED features scholarly comment and clinical research. JSOCMED is editorially independent from and its The Editor-in-Chief (EIC) is Prof. dr. Aznan Lelo, PhD, SpFK. JSOCMED offers many attractive features for authors, including free online access to all research articles, online publication ahead of print, and online responses to articles published as Quick Comments. In addition, as befitting a publication of the Journal of Society Medicine, JSOCMED implements best practice in scientific publishing with an open peer review process, declarations of competing interests and funding, full requirements for patient consent and ethical review, and statements of guarantorship, contributorship, and provenance.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 252 Documents
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Integrated Wound Bed Preparation and Glycemic Optimization in a Large Plantar Diabetic Foot Ulcer: A Case Report from a Secondary Care Hospital in Indonesia Jeri Yuliansyah
Journal of Society Medicine Vol. 5 No. 9 (2026): September
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v5i9.319

Abstract

Introduction: Diabetic foot ulcers (DFU) are among the most serious complications of type 2 diabetes mellitus (T2DM), affecting up to one-third of individuals with diabetes during their lifetime and preceding most non-traumatic lower-limb amputations. In resource-limited settings, delayed presentation and persistent hyperglycemia frequently compromise wound healing. Case Description: A 60-year-old male entrepreneur with a five-year history of poorly controlled T2DM presented with a progressively enlarging plantar heel ulcer and a random blood glucose level of 372 mg/dL. After referral from primary care, he underwent surgical debridement for infection control at Royal Prima Marelan Hospital. Because healing stalled under persistent hyperglycemia, a structured protocol was instituted comprising weekly outpatient review, serial autolytic and mechanical debridement, cleansing with a mild antiseptic, a hydrocolloid silicone gel dressing under moist wound healing principles, periwound skin-barrier protection, high-protein nutritional counselling, and glycemic optimization with metformin and glibenclamide. Over approximately two months, the wound bed converted from slough-dominated to predominantly healthy granulation tissue with visible contraction, in parallel with improved glycemic control. Split-thickness skin grafting was offered to close the residual defect but was declined by the patient. Conclusion: This case illustrates that even without advanced modalities, integrating wound bed preparation, moisture balance, and sustained glycemic control within a coordinated outpatient pathway can achieve meaningful healing of a large plantar DFU. Early referral, patient adherence, and multidisciplinary follow-up are decisive factors for limb preservation.
Serum Transforming Growth Factor-β, Matrix Metalloproteinase-7, and Acoustic Radiation Force Impulse Elastography for Staging Liver Fibrosis in Children with Biliary Atresia: A Cross-Sectional Study Ari Rahman Iskandar; Tri Hening Rahayatri; Fatima Safira Alatas; Radiana Dhewayani Antarianto
Journal of Society Medicine Vol. 5 No. 9 (2026): September
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v5i9.320

Abstract

Introduction: Biliary atresia (BA) is the leading cause of pediatric cholestatic liver disease and liver transplantation, and its prognosis is driven by hepatic fibrosis. Liver biopsy remains the reference standard for fibrosis staging but is invasive, underscoring the need for noninvasive alternatives. This study evaluated the association between serum levels of transforming growth factor-β (TGF-β) and matrix metalloproteinase-7 (MMP-7) and acoustic radiation force impulse (ARFI) elastography with the histological fibrosis stage in children with BA. Methods: This cross-sectional study enrolled children with suspected BA-related cholestasis at a national tertiary referral hospital in Jakarta, Indonesia, between January and June 2023. Serum TGF-β and MMP-7 levels were measured using enzyme-linked immunosorbent assay, and liver stiffness was assessed using ARFI elastography. Fibrosis was staged using liver biopsy and the Laennec scoring system, and dichotomized as F2–F3 or F4. Results: Fifteen patients (10 girls; median age, 5 months) were analyzed; six had F2–F3 and nine had F4 fibrosis. Median TGF-β was marginally higher in F4 than in F2–F3 (1.081 vs. 1.057 ng/mL; p = 0.77), and MMP-7 did not differ between the groups (p = 0.41). ARFI staging agreed with histology in 13 of 15 patients (86.7%; κ = 0.72; p = 0.011), yielding 88.9% sensitivity and 83.3% specificity for F4. Conclusion: In this cohort, serum TGF-β and MMP-7 did not discriminate between advanced and intermediate fibrosis, whereas ARFI elastography showed agreement with histology. ARFI, a promising minimally invasive tool for fibrosis staging in BA, warrants validation in prospective cohorts.

Page 26 of 26 | Total Record : 252

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