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Ayyub Harly Nurung
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Editor's Address: 3rd Floor Laboratory Faculty of Pharmacy, 2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia
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Journal Microbiology Science
Published by Universitas Muslim Indonesia
ISSN : 2808392X     EISSN : 28083911     DOI : https://doi.org/10.56711/jms
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
Journal Microbiology Sciences (J. Mic. Sciences) receives writing in the form of research results, scientific studies and brief descriptions relating to Microbiology, such as Molecular and Microbial Epidemiology Clinical Microbiology Medical Microbiology Pharmaceutical Biotechnology and others related to Microbiology Sciencee
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 15 Documents
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Search results for , issue "Vol 4, No 2 (2024)" : 15 Documents clear
Production of Antibiotics from Endophyte Fungi Isolates of Bidara Plants (Ziziphus mauritina L.) Isolates Codes IFAZ-6, IFBZ-6, IFDZ-8 With Variations in Carbon Sources Fitriana, Fitriana; Nurung, Ayyub Harly; Adnan, Afdina Putri
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1149

Abstract

Research has been carried out on antibiotic production from endophytic fungal isolates coded IFAZ-6, IFBZ-6, and IFDZ-8 from bidara plants (Ziziphus mauritina L.) with variations in carbon sources. This research aims to determine antibiotic production with variations in carbon sources. The first stage was the purification of each selected endophytic fungal isolate. The endophytic fungal isolate was inoculated into the fermentation medium using a variety of carbon sources, namely glucose, fructose, and galactose for 21 days. The antibiotic activity was carried out using the agar diffusion method against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli bacteria. The results obtained showed that the glucose carbon source was better in producing antibiotic compounds than the galactose carbon source in endophytic fungal isolates coded IFAZ-6, the glucose carbon source was better in producing antibiotic compounds than the fructose and galactose sources in endophytic fungal isolates coded IFBZ-6, and the fructose carbon source is better at producing antibiotic compounds than the galactose source in endophytic fungal isolates coded IFDZ-8.
Exploring The Antibacterial Potential of Aqueous and Ethanol Extracts from Bawang Dayak (Eleutherine palmifolia (L.) Merr) Against Skin Infectious Bacteria Through KLT-Bioautography Rusli, Rusli; Nuryanti, Siska; Putria, Yashifa Anandita
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1131

Abstract

Dayak onion plants (Eleutherine palmifolia (L.) Merr) have chemical compounds that have potential as antibacterials such as alkaloids, glycosides, flavonoids, phenolics, steroids and tannins. This study aims to determine the antibacterial activity of water extracts and ethanol extracts of dayak onion bulbs (Eleutherine palmifolia (L.) Merr). This research was conducted with the stages of sample extraction, screening of test bacteria, bioautogram profile testing and antibacterial activity by KLT-Bioautography method. Screening test results at a concentration of 1% against test bacteria Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis were able to inhibit the growth of test bacteria. Then continued with KLT-Bioautography testing using n-hexan: ethyl acetate (2: 1) eluent. The KLT-Bioautography test results showed that there was 1 active spot with an Rf value of 0.63 in the water extract and an Rf value of 0.60 in the ethanol extract against Pseudomonas aeruginosa, Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis bacteria. Based on the research, water extract and ethanol extract of dayak onion bulb (Eleutherine palmifolia (L.) Merr) have potential as antibacterial.Keywords: Antibacterial, KLT-Bioautography, Dayak Onion Bulbs
Antibacterial Activity of Endophytic Fungi Isolated from Parang Romang (Boehmeria virgata (G.Forst) Guill) Leaves Against Gastrointestinal Pathogens Rusli, Rusli; Nurung, Ayyub Harly; Sandyna, Muh. Ivan
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1081

Abstract

Parang romang (Boehmeria virgata (G.Forst) Guill) is a plant traditionally used for treating various digestive tract infections. However, obtaining bioactive compounds directly from the plant requires significant biomass. Therefore, endophytic fungi, sourced from specific plant parts, are explored for their ability to produce similar bioactive compounds. The research examined the potential antibacterial activity of endophytic fungi isolated from parang romang leaves against common gastrointestinal pathogens. The methods used in was, characterization of endophytic fungal isolates, and antagonistic activity was evaluated using the agar diffusion method. The results showed that the endophytic fungal strains, namely isolates IFBV 6, IFBV 7, and IFBV 10 could inhibit the bacteria Escherichia coli, Salmonella typhi, Shigella dysenteriae, and Vibrio cholera. With an average zone of inhibition for each strains isolate against Esherichia coli respectively 11.53 mm, 10.49 mm, and 14.85 mm; Salmonella typhi 14.47 mm, 8.66 mm, and 15.51 mm; Shigella dysenteriae 22.28 mm, 13.76 mm, and 15.33 mm; and Vibrio cholera 16.91mm, 11.94mm, 15.16mm. In conclusion, isolated endophytic fungal strains hold promise as potential as antibacterialn agents.
Synergistic Antibacterial Effects of Areca Nut Seed (Areca catechu L.) and Binahong leaf (Anredera cordifolia (Ten.) Steenis) Extracts Against Propionibacterium acnes Nuryanti, Siska; Nurung, Ayyub Harly; Saputra, Muh. Satrio Surya; Musfatir, Harvanita; Umaiyah, Ummi Putri
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1150

Abstract

Areca nut (Areca catechu L.) seeds has antibacterial properties due to their alkaloid, flavonoid, tannin, saponin, and polyphenol compounds. Binahong leaves (Anredera cordifolia (Ten.) Steenis) contain flavonoids, polyphenols, saponins, and alkaloids that also act as antibacterial agents. This study aimed to assess the antibacterial activity and synergistic effects of combining extracts from areca nut and binahong leaves against Propionibacterium acnes. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of P. acnes were evaluated for the ethanol extracts of areca nut and binahong leaves. The MIC and MBC values 400 ppm and 1.600 for extract ethanol single areca nut and 50.000 ppm and 100.000 ppm for binahong leaves. The MIC and MBC values for the combination 400/12.500 ppm and 1.600/781,25 ppm for areca nut and 50,000/800 ppm and 100,000/100 ppm for binahong leaves, respectively. The synergy between the two extracts was determined using the Fractional Inhibitory Concentration Index (FICI). The FICI value of 1. P. acnes indicates an indifferent effect (1 < FICI ≤ 4).
Antibacterial Activity of Miana Leaf Ethanol Extract (Coleus scutellarioides (L) Against Some Pathogenic Bacteria Using The TLC Method - Bioautography Fitriana, Fitriana; Harmunanto, Kartika Hatari; Zulkarnain, Iskandar
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1137

Abstract

Miana (Coleus scutellarioides (L.). is one of the plants that grows in areas with rather moist or slightly watery soil conditions, this plant is often consumed by people in Indonesia and is believed to be a medicinal plant. Empirically, miana leaves are used as antibiotics because they are known to have antibacterial activity. The purpose of this study was to determine the bioautogram profile of miana leaf ethanol extract against several pathogenic bacteria using the TLC-Bioautography method. As for the results of this study, ethanol extract of miana leaves (Coleus scutellarioides (L.)) has the potential as antibacterial against bacteria Staphylococcus aureus, Escherichia, Pseudomonas aeurigosa, and Streptococcus mutans, where for Staphylococcus aureus bacteria there are 2 active spots with Rf values of 0, 98, 0.32 and Streptococcus mutans bacteria there are 3 active spots with Rf values of 0.98, 0.76, and 0.69 respectively. As for Escherichia bacteria, there is 1 active spot with an Rf value of 0.81 and Pseudomonas aeurigosa bacteria there are 3 active spots, namely 0.87, 0.49, and 0.29, respectively.
Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Water and Ethanol Extractsof Eleutherine palmifolia (L.) Merr. Against Staphylococcus aureus and Psedomonas aureginosa Rusli, Rusli; Nurung, Ayyub Harly; Erwing, Erwing
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1086

Abstract

Dayak onion bulbs (Eleutherine palmifolia (L.) Merr.) are indigenous herbal plants found in Indonesia, rich in phytochemical compounds such as alkaloids, glycosides, flavonoids, phenolics, steroids, and tannins. This study investigates the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of water and ethanol extracts of Dayak onion bulbs against the bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The water extract of Dayak onion bulbs was obtained by boiling using water, while the ethanol extract was obtained by maceration using 96% ethanol solvent. MIC and KBM were determined using the agar diffusion method. The results showed that water extract exhibited an MIC of 0.4% and MBC of 1.6% against both Staphylococcus aureus and Pseudomonas aeruginosa. Meanwhile, the ethanol extract demonstrated an MIC of 0.4% against Staphylococcus aureus and Pseudomonas aeruginosa bacteria with an MBC of 0.8% against Staphylococcus aureus bacteria and 1.6% against Pseudomonas aeruginosa bacteria. These findings suggest the potential of Dayak onion bulb extracts as antimicrobial agents against these pathogenic bacteria.
Antibacterial Activity in Ethanol Extract of Kersen Flowers (Muntingia calabura L.) Against Bacteria Causing Gastrointestinal Tract Infections Using the Agar Diffusion Method Maryam, St.; Fitriana, Fitriana; Annisa, Nurfiqah
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1157

Abstract

The increasing prevalence of antibiotic resistance necessitates the exploration of alternative treatments such as medicinal plants. This study evaluates the antibacterial potential of Kersen flowers (Muntingia calabura L.) against pathogens causing gastrointestinal infections. Aimed at determining the antibacterial effectiveness of ethanol extracts from Kersen flowers, the research tests the activity against Escherichia coli, Salmonella typhi, Vibrio cholerae, and Shigella dysenteriae. Employing the agar diffusion method, various concentrations of the extract (0.05% to 10%) were analyzed. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were also assessed to identify the lowest effective concentrations. The ethanol extract demonstrated significant antibacterial activity; notably, the largest inhibition zone measured 30.74 mm at a concentration of 10%. Effective MICs were as low as 0.1% for all tested bacteria, while MBCs ranged from 0.1% to 0.4%. These results suggest that ethanol extracts of Kersen flowers exhibit potent antibacterial properties against major gastrointestinal pathogens, supporting further exploration of these extracts as a natural antibacterial treatment and offering a potential alternative to conventional antibiotics.
Antibacterial Activity of N-Hexan and Ethyl Acetate Fractions of Gaharu (Aquilaria Malaccensis) Leaves against Bacteria that Cause Infection Yahya, Fifi Adelia; Herwin, Herwin; Fitriana, Fitriana
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1139

Abstract

Gaharu (Aquilaria malaccensis) leaves contain alkaloids, terpenoids, flavonoids, saponins, and tannins that can help cure infections. This study aims to determine the antibacterial activity of n-hexane and ethyl acetate fractions of Gaharu leaves against skin infection bacteria such as Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis by Bioautography-TLC. Gaharu leaves symplisia was extracted using the maceration method using ethanol 96% solvent and fractionation with solid-liquid method to obtain n-hexane and ethyl acetate fractions. The result of the screening antibacterial activity of n-hexane and ethyl acetate fractions of Gaharu leaves with concentrations of 0,5% active to 4 bacteria test. The results of antibacterial activity n-hexane and acetaet ethyl fraction by Bioautography-TLC using n-hexane:ethyl acetate (1:4) eluent showed Rf 0.67 and Rf 0,16 value in the n-hexane fraction and an Rf 0.78 value in the ethyl acetate fraction active to 4 bacteria test.  The identification results of the chemical compound of the n-hexane fraction contain flavonoids and tannins (AlCl3 and FeCl3 reagents.), the ethyl acetate fraction contains flavonoids ( AlCl3 reagents).
Antibacterial Properties in Fermentate Extracts of Endophytic Fungus Derived from Marine Algae Caulerpa lentillifera Against Gastrointestinal Pathogenic Bacteria Paliwengi, Andi Sinrang
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1118

Abstract

Endophytic fungi, residing symbiotically within living plant tissues, are a promising source of novel bioactive compounds. These fungi are known to produce secondary metabolites with a wide range of biological activities, including antibacterial properties. This study explored the antibacterial potential of fermented extracts from endophytic fungi isolated from the marine alga Caulerpa lentillifera, a food source consumed by coastal communities and traditionally used for medicinal purposes. Thin-layer chromatography (TLC) bioautography was employed to identify extracts with activity against common gastrointestinal pathogenic bacteria, such as Escherichia coli, Shigella dysenteriae, and Salmonella typhi. Two endophytic fungal isolates displayed promising antibacterial activity against these pathogens. TLC analysis tentatively identified the presence of flavonoids and alkaloids, potentially responsible for the observed effects. This research sheds light on the pharmacological potential of endophytic fungi and their applications in combating bacterial infections.
Antibacterial Activity Test Of Ethanol Extract Of Matoa Leaves (Pometia pinnata) Against Bacteria That Cause Digestive Tract Infections Kamilah, Eva
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1160

Abstract

Matoa Leaves (Pometia Pinnata) Are One Of The Plants That Are Effective As An Antibacterial. This Study Aims To Determine The Antibacterial Activity Of Ethanol Extract Of Matoa (Pometia Pinnata) Leaves Against Several Bacteria That Cause Digestive Tract Infections. This Research Method Was Carried Out Experimentally To Test The Antibacterial Activity Of Matoa (Pometia Pinnata) Leaves Using An Antibacterial Screening Test, MIC Test And KBM Test With Varying Concentrations Of 0.05%, 0.1%, 0.2%, 0.4%, 0.8%, 1.6%, 3.2%, And 6.4%. As Well As Antibacterial Activity Tests With Varying Concentrations Of 1.6%, 3.2% And 6.4%. The Results Obtained In The Screening Test With A Concentration Of 0.1% Showed No Growth In All The Test Bacteria Used, For The MIC Values, Namely Eschericia Coli 0.2%, Salmonella Typhi 0.8%, And Vibrio Cholerae 0.4%, For The KBM Values Eschericia Coli 0.4%, Salmonella Typhi 1.6%, And Vibrio Cholerae 0.8%. As Well As The Results Of Antibacterial Activity Testing, The Largest Inhibitory Zone Diameter Was Obtained For Escherichia Coli Bacteria At A Concentration Of 4.8%, Namely (18.26mm), For Salmonella Typhi Bacteria At A Concentration Of 4.8%, Namely (15.36mm), And For Vibrio Cholerae Bacteria At A Concentration Of 4.8 % Which Is (15.74mm). The Ethanol Extract Of Matoa (Pometia Pinnata) Leaves Has Antibacterial Activity

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