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Ahmed Abdillah
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Journal of Advances in Medicine and Pharmaceutical Sciences
Published by Lamintang Education & Training Centre
ISSN : 2964268X     EISSN : 29634253     DOI : https://doi.org/10.36079/lamintang.jamaps-xxxx.xxx
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health
Journal of Advances in Medicine and Pharmaceutical Sciences (JAMAPS) scope are including but not limited to: ☛ Drug ☛ Chemistry ☛ Herbal Medicine ☛ Pharmaceutical Science ☛ General and Internal Medicine ☛ Pathology and Forensic Medicine ☛ Pharmacology, Toxicology and Pharmaceutics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 4 No 2: November 2025" : 5 Documents clear
Bioactive Methoxyflavones from Kaempferia parviflora Induce Apoptosis in Breast Cancer Cell Line Watcharin, Supawadee; Prathep, Namuangruk; Karnchanatat, Sorawit; Tanomtong, Rittidech; Mahayothee, Jittima; Srisuwan, Piriyapongsa
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.884

Abstract

Kaempferia parviflora is commonly known as Black Ginger. It is a traditional Thai herbal plant rich in methoxyflavones and other bioactive compounds with promising anticancer properties. Breast cancer remains a leading cause of mortality worldwide, and current therapies face challenges such as toxicity and drug resistance. This study aims to evaluate the cytotoxic effects of ethanol extract of Kaempferia parviflora on human breast cancer cell lines (MCF-7 and MDA-MB-231) and to identify the main bioactive compounds responsible for its anticancer activity. Rhizomes were collected from Central Thailand, extracted using 70% ethanol via maceration, and concentrated with rotary evaporation. Breast cancer cells were cultured and treated with varying extract concentrations for 24 to 72 hours. Cytotoxicity was assessed using the MTT assay, and active compounds were quantified via HPLC. Results show a dose-dependent decrease in cell viability, with IC50 values ranging from 60 to 85 μg/mL. Apoptosis induction was confirmed by fluorescence microscopy and increased caspase-3 activity (up to 4.1-fold). HPLC analysis revealed significant concentrations of 5,7-dimethoxyflavone and 3,5,7-trimethoxyflavone, suggesting their role in ROS-mediated apoptosis. Future research should focus on detailed molecular mechanisms, in vivo toxicity and efficacy, and clinical translation. This study supports Kaempferia parviflora as a potential natural adjuvant in breast cancer therapy.
Antimicrobial Resistance in Escherichia coli and Staphylococcus aureus After the COVID-19 Pandemic Bacabac, Edgardo Joseph; Gomez, Rubenito; Festin, Pompe Cruz; Abesamis, Florencio; Huttley, Andrew
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.921

Abstract

Antimicrobial resistance (AMR) has emerged as one of the most pressing post-pandemic health threats, particularly in low- and middle-income countries such as the Philippines. During the COVID-19 pandemic, widespread empirical use of antibiotics accelerated selective pressure on bacterial pathogens, potentially intensifying resistance trends. This study aims to analyze changes in the resistance patterns of Escherichia coli and Staphylococcus aureus to first-line antibiotics before (2018–2019) and after (2022–2023) the pandemic, and to evaluate the implementation of Antibiotic Stewardship Programs (ASP) in government hospitals. A retrospective observational design was applied using WHONET microbiological data from three public hospitals across Luzon, Visayas, and Mindanao, combined with semi-structured interviews involving infectious disease physicians and clinical pharmacists. Statistical and thematic analyses revealed a significant increase in resistance: E. coli resistance to ciprofloxacin rose from 32% to 48%, and MRSA prevalence increased from 15% to 27%. Hospitals with active ASPs reported smaller resistance increases (Δ = +8%) compared to those without consistent stewardship activities (Δ = +18%). These findings highlight the critical role of structured ASPs, robust microbiology infrastructure, and real-time data integration in mitigating AMR escalation. Strengthening ASP implementation, expanding diagnostic capacity, and integrating surveillance systems into national health information frameworks are essential policy priorities. Future research should explore genomic approaches and digital ASP models to enhance precision in antibiotic governance and resistance control in the post-pandemic era.
Exploratory Clinical Study on Controlled álak Microdosing for Post-Detoxification Recovery Roland Mario; Bermudez, Festin; Fresthel, Mary; Agoncillo, Dominic Calingasan; Santos, Jamora; Espaldon, Ann Monica
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.922

Abstract

Post-detoxification phases of methamphetamine dependence are often characterized by neurophysiological instability, including tremors, insomnia, and anxiety, due to suppressed GABAergic activity and hyperdopaminergic rebound. Traditional Filipino distilled spirit, álak or lambanog, contains trace levels of ethanol and minor fusel alcohols which may exert mild GABA-A receptor agonism when microdosed under medical supervision. This exploratory clinical study investigates the potential of controlled álak microdosing as an adjunct for stabilizing central nervous system function in post-detoxified methamphetamine patients. Twelve post-detoxification patients (n=12) from rehabilitation centers in Quezon and Batangas were administered álak microdoses (≤10% ethanol, 5–10 ml/day) for 14 days under medical supervision. Physiological and psychological parameters including sleep quality, tremor frequency, and anxiety, were measured using the Clinical Opiate Withdrawal Scale (COWS) adapted for stimulant recovery and the Beck Anxiety Inventory (BAI). Data were analyzed descriptively and statistically using paired t-tests. Eight out of twelve participants (66.7%) demonstrated marked improvement in sleep continuity (p<0.05), tremor reduction (p<0.05), and decreased anxiety scores (mean reduction 23.4%, p<0.05). No signs of ethanol intoxication, craving substitution, or hepatic distress were observed. Mild headache was reported in one participant but resolved spontaneously. Controlled álak microdosing exhibits promising GABAergic modulatory effects that may facilitate neurophysiological stabilization in methamphetamine recovery. While preliminary, these findings support further biochemical validation and integration of ethnopharmacological knowledge into harm-reduction frameworks.
Neuroprotective Effects of Rosmarinus officinalis and Its Pharmacological Potential Against Neurodegenerative Diseases Chen, Fu-Yuan; Yunquan, Wei; Lau, Qu Jian; Xiang-Li, Wang
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.926

Abstract

This study investigates the neuroprotective effects of Rosmarinus officinalis (rosemary) in a rodent model of neurodegeneration, focusing on its potential to enhance motor coordination, cognitive function, and reduce oxidative stress and inflammation. The research employs behavioral tests (rotarod, open field, Morris water maze), biochemical analysis (MDA, NO, SOD, CAT), and histological examination to assess the effects of rosemary extract. The results show that rosemary-treated rats exhibit significant improvements in motor coordination and cognitive performance, as well as reduced oxidative stress and inflammation, compared to the vehicle-treated group. Biochemical analysis reveals a marked reduction in MDA and NO levels and an increase in antioxidant enzyme activity (SOD and CAT) in the rosemary-treated rats. Histological examination confirms the preservation of neuronal integrity and a reduction in amyloid-beta plaques and tau tangles, indicating the potential of rosemary to mitigate neurodegenerative pathology. These findings suggest that rosemary extract may provide a natural therapeutic approach for neuroprotection and cognitive enhancement, particularly in conditions like Alzheimer's and Parkinson’s disease. However, further research, including long-term studies and human clinical trials, is necessary to fully explore the efficacy and mechanisms of rosemary in treating neurodegenerative disorders.
Stability and Controlled Release of Amoxicillin Trihydrate in Novel Biopolymer Matrices Namuangruk, Malinee; Sriariyanun, Loilome; Prathep, Supawadee
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 4 No 2: November 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0402.928

Abstract

Amoxicillin trihydrate is a widely prescribed β-lactam antibiotic, suffers from chemical instability that limits its therapeutic efficacy and shelf life. This study investigates the formulation of controlled-release systems using locally sourced biopolymers in England, specifically alginate, chitosan, and pectin, to enhance drug stability and optimize release profiles. Microspheres were prepared via ionic gelation with varying polymer-to-drug ratios and characterized for particle morphology, thermal properties, crystallinity, and drug–polymer compatibility using SEM, DSC, XRD, and FTIR. Accelerated stability studies were conducted at 40°C and 75% relative humidity for 90 days, while in vitro release was assessed in simulated gastrointestinal fluids at pH 1.2 and 6.8. The results indicated that alginate–chitosan matrices provided superior encapsulation efficiency (>85%), structural integrity, and prolonged stability, reducing the degradation rate by up to fourfold compared to unencapsulated drug. Pectin-based formulations, although biodegradable, exhibited higher moisture sensitivity and faster initial drug release. In vitro release studies demonstrated a biphasic release pattern in alginate–chitosan systems, characterized by an initial burst followed by sustained release, predominantly governed by diffusion and polymer relaxation mechanisms. These findings highlight the potential of natural biopolymer matrices for improving the physicochemical stability and controlled release of amoxicillin, providing a sustainable alternative to conventional synthetic excipients. The study underscores the dual benefits of enhanced therapeutic performance and environmental sustainability, aligning with contemporary UK pharmaceutical priorities. Future work should explore in vivo pharmacokinetics and clinical translation to validate the therapeutic advantages of these formulations.

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