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Sandy Christiono
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Odonto dental journal
Published by Universitas Islam Sultan Agung
ISSN : 23545992     EISSN : 24604119     DOI : http://dx.doi.org/10.30659/odj.9.2
Core Subject : Health,
Health Professions Medicine & Pharmacology
ODONTO Dental Journal publishes manuscripts within the fields of Oral Biology, Pediatric Dentistry, Oral Maxillofacial surgery, Periodontic, Prosthodontic, Orthodontic, Operative dentistry, Endodontic, Biomoleculer Dentistry, Dental Public Health, Oral Radiology, Oral Medicine, Dental Forensic, Oral Pathology, Dental Material
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol 12, No 3 (2025): December 2025" : 12 Documents clear
Synthetic Coral Scaffold and Platelet Rich Plasma for Bone Remodelling after Tooth Extraction Mahanani, Erlina Sih; Putri, Ferly Aulia; Rahma, Zalfa Kamila Siti; Salsabila, Rismananda Putri; Ramadhanti, Tamara Istna; Puspita, Sartika
Odonto : Dental Journal Vol 12, No 3 (2025): December 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.3.231-240

Abstract

Background: The human body can self-repair. However, if the damage occurs excessively or reaches a critical defect, it requires material substitution to restore its shape and function. Tissue engineering is developed based on the principle of reconstructing damaged tissues due to critical defects to restore, maintain, and repair damaged tissues or organs by applying three main components: scaffolds, signaling molecules, and cells. This study aims to investigate the ability of synthetic coral scaffold incorporated with Platelet Rich Plasma in bone remodeling after tooth extraction. Method: This study was conducted as in vivo experimental laboratory study with a post-test control group design. The 48 male Rattus norvegicus rats were divided into 4 treatment groups. Firstly, the rats’ teeth were extracted, then, on the tooth extraction area, it was treated with povidone-iodine (control group), curaspon, scaffold only, and scaffold-incorporated Platelet Rich Plasma. Result: The results of the Kruskall-Wallis test showed no significant difference (p > 0.05) between the four treatment groups. articleConclusion: The PRP-incorporated synthetic coral scaffold had the highest score of collagen formation density and significantly accelerated collagen formation in the bone remodeling process compared to other treatment materials.
Challenges in Managing Oral Manifestations of Anticonvulsant-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Fajrin, Fildzah Nurul; Wardhany, Indriasti Indah; Rahmayanti, Febrina; Ikhsan, Muhammad; Pangeran, David
Odonto : Dental Journal Vol 12, No 3 (2025): December 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.3.332-345

Abstract

Background : Antiepileptic drugs were common causative agents for DRESS syndrome, which was a severe, idiosyncratic drug hypersensitivity reaction characterized by a prolonged latency period, fever, rash, and marked eosinophilia. The oral manifestations present a diagnostic challenge due its similarity to other hypersensitivity reactions as well as its comprehensive management. Objective: This case report aims to describe the challenges in comprehensive management of DRESS syndrome severe oral manifestations, highlighting the  challenges from diagnosis to management for patient with complex comorbidities. Case: A 19-year-old female inpatient was referred to Oral Medicine division, Dental and Oro-maxillofacial unit of Universitas Indonesia Hospital  (RSUI) for severe oral sores after treated with phenytoin and lamotrigine for her temporal lobe epilepsy and bipolar affective disorder. Patient shows general weakness and clinical examination revealed multiple intra oral erosions, lips erosions with exfoliation and haemorrhagic crust, generalized maculopapular rash, facial oedema, tender lymphadenopathy, and. Laboratory findings confirmed a severe hyper-eosinophilia (32%) and lymphopenia (13.5%), while liver function was normal. A diagnosis of DRESS syndrome was finally established. Case management were immediate withdrawal of phenytoin and lamotrigine, followed by multidisciplinary care including intra vena and topical corticosteroids. The patient's condition significantly improved after collaborative comprehensive treatment. Conclusion: Definitive diagnosis decisions requires careful consideration on the correlation of clinical findings, medication history, and hallmark laboratory results, especially in patients with complex comorbidities and intraoral clinical features with characteristics similar to other hypersensitivity reactions. Comprehensive collaborative management, including patient’s and other healthcare professionals collaboration, is crucial for successful treatment.

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