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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 11 Documents
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Search results for , issue "JPS Volume 7 Nomor 2 (2024)" : 11 Documents clear
Uji aktivitas antibakteri fraksi n-heksana dan etil asetat daun bandotan (Ageratum conyzoides L.) terhadap bakteri Staphylococcus epidermidis Rafliza , Rista; Nasution , Haris Munandar; Dalimunthe , Gabena Indrayani; Mambang , D.Elysa Putri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.500

Abstract

Bandotan (Ageratum conyzoides L) is a wild plant that is easy to find in Indonesia, known to have medicinal properties and has antibacterial properties. The purpose of this study was to determine the antibacterial activity of the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum Conyzoides L) against Staphylococcus epidermidis bacteria.This research was conducted using an experimental method including sample collection, macroscopic examination, microscopic examination, simplicia manufacture, characteristic examination, phytochemical screening, preparation of ethanol extract, then fractionation, then testing of antibacterial activity against Staphylococcus epidermidis bacteria using the agar diffusion method. Data obtained from the diameter of inhibition were statistically analyzed using the Anova test, then followed by the Kruskal-Wallis test and the Ducan test. The results of macroscopic examination, with dark color, egg-shaped, two pointed, obtuse leaf base, serrated leaf margins, hairy veins on the upper and lower surfaces, slightly hairy young leaves, white hair color and pinnate veins. The results of microscopic examination, xylem, covering hair, mesophyll and anomocytic type of stomata. The simplicia characteristic results obtained water content of 7.3%, water-soluble essence content of 32.72%, 42.5% ethanol-soluble extract content, total ash content of 3 .3% and acid insoluble ash content of 1.8%. Phytochemical screening of simplicia powders and extracts showed the presence of alkaloids, glycosides, flavonoids, tannins, saponins and steroids. The results of the antibacterial activity test of the n-hexan fraction on Staphylococcus Epidermidis bacteria at concentrations of 10%, 30%, 50% and 70% were included in the resistant category. Meanwhile, the ethyl acetate fraction at a concentration of 10%, 30% and 50% is in the resistant category, at a concentration of 70% it is in the intermediate category. So it can be concluded that the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum conyziodes L) have activity against Staphylococcus epidermidis bacteria.. 

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