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Jurnal Natural Scientiae
Published by Universitas Lambung Mangkurat
ISSN : -     EISSN : 28099796     DOI : DOI: https://doi.org/10.20527/jns.v2i1
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Energy Immunology & microbiology Materials Science & Nanotechnology Physics
Jurnal Natural Scientiae (JNS), ISSN:2809-9796 (online) adalah sebuah jurnal blind peer review yang didedikasikan untuk publikasi hasil penelitian yang berkualitas dalam bidang IPA namun tak terbatas secara implisit. Semua publikasi di jurnal Natural Scientiae bersifat akses terbuka yang memungkinkan artikel tersedia secara bebas online tanpa berlangganan apapun. Jurnal Natural Scientiae dikelola secara profesional dan diterbitkan oleh FMIPA ULM dalam membantu mahasiswa, akademisi, peneliti dan praktisi untuk menyebarkan hasil penelitiannya. Jurnal Natural Scientiae merupakan media publikasi yang sangat peduli terhadap perkembangan dan inovasi-inovasi pada bidang IPA terutama bidang biologi, kimia dan fisika Indonesia. Focus and Scope: Biosistematika tumbuhan Biosistematikan Hewan Genetika Molekuler Mikrobiologi Ekologi Fisika Instrumentasi Fisika Material Geofisika Kimia Analitik Kimia Organik Kimia Anorganik Biokimia Kimia Fisik Kimia Lingkungan Kimia Komputasi Biomaterial
Arjuna Subject : Umum - Umum
Articles 5 Documents
 1 
Search results for , issue "Vol 2, No 1 (2022): Mei 2022" : 5 Documents clear
Pemodelan Calponin Ikan Gabus (Channa striata) dengan Phyre2 dan Interaksi dengan Protein Lain Mirza Maulana Ahmad; Noer Komari
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.4790

Abstract

Knowledge of the three-dimensional structure of proteins is very important to understand their character and function at the molecular level. Determination of protein structure in the laboratory is expensive and relatively difficult because it requires sophisticated instruments and takes a long time. As an alternative, an in silico approach can be used to predict the three-dimensional structure of proteins, namely the fold recognition method. The purpose of this study was to create a three-dimensional structure model of snakehead fish (Channa striata) calponin protein using the Phyre2 web server. The target protein sequence was obtained from UniProt KB with code K9LH64. The results of the study showed that the template for building the model was the c1wynA code. The results of the model (MP) evaluation obtained a coverage value was 45%, a confidence value was 100%, and an identity value was 69%. Validation of the model (MP) using the PROCHECK program showed the model was in the most favoured residue plot of 82.4%. This model deserves to be used as a model for calponin protein of snakehead fish, because the disallowed area was below 15%. The results of the analysis of interactions with other proteins using STRING-DB obtained the interaction model (MP) with Actin assembly-inducing protein (ACTA2) was 0.791; and Tropomyosin (TPM1) was 0.786. The results of molecular docking using PatchDock obtained the value of Atomic Contact Energy (ACE) for the calponin protein model (MP)-ACTA2 was 372.76 kJ/mol; Calponin model protein (MP)-TPM1 was 406.93 kJ/mol. The interactions that occured in the calponin model (MP)-ACTA2 were hydrogen bonds at residues Gly-41, Glu-60, Arg-64, Arg-66, Pro-67, Gly-68, Lys-71 and hydrophobic bonds at Arg-64, Lys- 71, Lys-72, Ile-73, Va-138. The interactions model of calponin model (MP)-TPM1 were hydrogen bonding at residues Ser-13, Lys-71, Ala-95, Tyr-96, Ser-136, Arg-137, Arg-150 and hydrophobic bonds at residues Leu-12, Ala-14, Lys-71, Ala-95, Val-138, Arg-150, Phe-152. Keywords: fold recognition, Phyre2 , 3D structure protein, calponin, protein-protein interaction
Analisis Hubungan Antar Parameter Kualitas Crude Palm Oil di PT. Laguna Mandiri Rantau Factory Tri Ayu Novelena; Noer Komari
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.4864

Abstract

Analysis of the relationship between the quality parameters of crude palm oil (CPO) at PT. Laguna Mandiri Rantau Factory using a simple linear regression method and multiple linear regression has been carried out. This study was to determine the free fatty acid content, water content, and gross content of CPO and to compare the sample with company standards and SNI. The relationship between parameters was modeled with a simple linear regression mathematical model, Y = a + bx and multiple linear regression, Y = a + b1X1 + c2x2… + bnXn. The results showed that the average free fatty acid was 4.02%, the water content was 0.18%, and the impurities content was 0.018%. The fatty acid content has not met the company standard, while the water content and impurities have met the company and SNI. The relationship of water content (X) to free fatty acids (Y) in the equation Y = 3.328 + 3.804x. The relationship of free fatty acids (X) to water content (Y) in the equation Y = - 0.808 + 0.246x. The relationship between impurities (X) and free fatty acids (Y) in the equation Y = 3.569 + 25.399x. The relationship of free fatty acids (X) to the level of impurities (Y) in the equation Y = -0.124 + 0.035x. The relationship between dirt content (X) and water content (Y) in the equation Y = 0.070 + 6.315x. The relationship between water content (X) and dirt content (Y) in the equation Y = - 0.007 + 0.135x. The relationship of water content (X1) and dirt content (X2) to free fatty acids (Y) in the equation Y = 3.391 + 2.542 X1 + 9.344 X2. The relationship of impurities (X1) and free fatty acids (X2) to water content (Y) in the equation Y = - 0.737 + 0.572 X1 + 0.226X2. The relationship of free fatty acids (X1) and water content (X2) to the level of impurities (Y) in the equation Y = - 0.107 + 0.030X1 + 0.021X2.
PENGARUH PEMBERIAN PUPUK NPK TERHADAP PERUBAHAN INTENSITAS WARNA RELATIF AIR YANG DILEWATKAN PADA TANAH GAMBUT SECARA IN VITRO Azidi Irwan; Rahmat Yunus
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.5020

Abstract

Telah dilakukan penelitian tentang pengaruh pemberian pupuk NPK terhadap perubahan intensitas warna relatif air yang dilewatkan pada tanah gambut secara in vitro. Penelitian dilakukan dengan cara melewatkan air pada tanah gambut yang telah dicampurkan dengan pupuk NPK dengan variasi konsentrasi 0; 1; 5; 10, dan 20% (b/b) dengan berat total 100 gram dalam sebuah kolom, kecepatan aliran air sebesar 1 mL/menit. Air yang keluar dari kolom ditampung setiap interval 8 jam selama 7 hari pengamatan dan diambil datanya berupa nilai pH dan absorbans. Nilai pH larutan pupuk NPK murni dalam air dengan konsentrasi 10, 20, 30, 40, dan 50% juga diamati sebagai pembanding, diperoleh pH larutan yang kontinyu menurun, yaitu berturut-turut 5,122; 4,821; 4,622; 4,566; dan 4,492. Pada air sampel sebaliknya ditunjukkan naiknya konsentrasi pupuk NPK pada tanah menyebabkan rerata pH air sampel yang dihasilkan cenderung mengalami peningkatan, yaitu berturut-turut 5.47; 5.40; 5,86; 5,71, dan 5,83. Larutan kemudian diukur nilai absorbansinya menggunakan spektrofotometer UV-Vis pada  344 nm. Hasilnya menunjukkan perubahan intensitas relatif warna air tertinggi terjadi pada konsentrasi 10% (b/b) pada interval waktu 24 jam, yaitu sebesar 359%. Hasil spektra FTIR pada endapan sampel menunjukkan lima buah puncak dominan untuk gugus fungsi –OH, –NH, –COOH, –C=N, dan O–CH3.Kata kunci: tanah gambut, pupuk NPK, intensitas warna air.
Kajian Molecular Docking Senyawa Karwinaphthol B dari Tanaman Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Inhibitor Enzim Glukokinase Puji Astuty; Noer Komari
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.5412

Abstract

Karwinaphthol B is a compound of the naphthoquinone group. Karwinaphthol B is a chemical compound found in Bawang Dayak. Karwinaphthol B is one of the compounds considered to have antidiabetic effects. Diabetes Mellitus is a chronic disease that occurs when the body cannot produce enough insulin or cannot use insulin (insulin resistance) which causes blood glucose levels to rise (hyperglycaemia) under normal conditions. This study aims to see the potential of karwinaphthol B as a glucokinase inhibitor with parameters such as ∆G value and interaction of amino acid residues with molecular docking and pharmacophore studies using filter Lipinski, pkCSM, and SwissADME. The results of molecular docking showed that karwinaphthol B compound had potential as antidiabetic based on the ∆G value of -8.39 kcal/mole. Karwinaphthol B compound has an LD50 value of 2.168 mole/kg which is included in the non-toxic category; does not have hepatotoxicity, skin sensitization, and has a good bioavailability value. The interaction of Karwinaphthol B compounds with glucokinase enzymes at amino acid residues VAL62, ARG63, SER64,THR65, PRO66,  GLU67, GLY68, SER69, GLN98, MET210 , ILE211, TYR214, TYR215, CYS220, GLU221, MET235,  CYS252, LEU451, VAL452, and VAL455.
Kajian Molecular Docking Senyawa Quercetin dari Buah Terong Pokak (Solanum torwum Swartz) sebagai Antiinflamasi pada Protein Tumor Necrosis Factor-α (TNF-α) Lusi Thenios; Noer Komari
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.4462

Abstract

Quercetin is a polyphenolic flavonoid with potential chemopreventive activity. Quercetin is a chemical compound found in Solanum torvum Sw fruit. Quercetin is one of the compounds that are considered to have anti-inflammatory effects. Inflammation is a localized protective response elicited by tissue damage caused by physical trauma, damaging chemicals, or microbiology. Tumor Necrosis Factor-α (TNF-α) is a proinflammatory cytokine that functions in mediating the innate immune response. Irregular production of cytokines can lead to various immunopathological conditions, including auto-inflammatory, autoimmune, and cancer-causing diseases. This study aims to determine the potential of quercetin compounds derived from turkey berry (Solanum torvum Sw.) which have the potential as anti-inflammatory drugs with parameters such as ∆G, the interaction of residues on TNF-α protein (PDB ID: 6X85) with molecular docking, and pharmacophore studies using Lipinski, pkCSM, and SwissADME filters. The molecular docking simulation results showed that the quercetin compound had a ∆G value of -8.55 kcal/mol and had amino acid residue interactions in the form of ILE155; TYR59; GLY121; TYR119; GLN61; TYR151; VAL123; LEU157; ILE58; GLY122; SER60; LEU120; LEU157. Quercetin has the potential as an anti-inflammatory drug on TNF- α protein with an LD50 value of 2.471; bioavailability value of 0.55; does not have hepatotoxicity and skin sensitization properties and has passed the Lipinski test.

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