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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 32 Documents
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Search results for , issue "Vol 8 No 4 (2023)" : 32 Documents clear
ANALGESIC POWER OF THE INSOLUBLE FRACTION N-HEXANE OF MELINJO LEAVES (Gnetum gnemon L.) IN SWISS MICE (Mus musculus) Deni Firmansyah; Renny Amelia; Sulistiorini Indriaty; Didi Rohadi; Muhammad Yani Zamzam; Rizqia Shafa Fauziah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1087

Abstract

Melinjo (Gnetum gnemon L.) has various secondary metabolites including alkaloids, flavonoids, saponins, and tannins. In its function as an analgesic, flavonoids work to inhibit the cyclooxygenase enzyme which can reduce prostaglandin production and reduce pain. This study aims to determine the analgesic power of the n-hexane insoluble fraction of melinjo leaves (Gnetum gnemon L.) as an effective analgesic tested on male white mice (Mus musculus) and to determine the most effective dose as an analgesic. This research was experimental using test animals of 25 male white mice (Mus musculus) divided into 5 groups each consisting of 5 mice. The negative control group (CMC-Na) was 0.5%, the positive control group Mefenamic acid dose of 65 mg/KgBW, insoluble fraction hexane group (ifh) dose of 50 mg/KgBW, 100 mg/KgBW, 200 mg/KgBW. The chemical stimulus was given a dose of 400 mg/KgBW of acetic acid. The parameter measured was the number of wriggles in male white mice (Mus musculus) every 10 minutes for 60 minutes. The results of the study showed a significant difference between the negative control (CMC-Na 0.5%) and various doses of insoluble fraction hexane group, while the positive control (mefenamic acid 65 mg/KgBW) had no difference with ifh doses of 100 mg/kgBB and 200 mg/KgBW. The percentage of analgesic power of ifh at doses of 50 mg/KgBW, 100 mg/KgBW and 200 mg/KgBW was 26.64%, 57.5%, and 58.56% and the percentage of analgesic power of mefenamic acid was 69.67% ...
IDENTIFICATION OF MEDICINAL COMPOUND IN URIC ACID JAMU BY THIN LAYER CHROMATOGRAPHY METHOD Muhammad Yani Zamzam; Iin Indawati; Nina Karlina; Elsa Tiakomala; Windah Widia Ningrum; Aulia Nurkahfi; Andriana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1120

Abstract

Jamu is one of the traditional medicines derived from natural ingredients distributing in Indonesia. In accordance with Permenkes No. 007 of 2012, Medicinal Compound (MC) are prohibited from being added to jamu products. Previous research has found that some of the products in public contain MC. The aim of this study is to determine the presence or absence of allopurinol, piroxicam, and dexamethasone in uric acid jamu.  This research used 5 (five) samples of uric acid jamu, both those with and without distribution permits from The Indonesian Food and Drug Authority, randomly selected in Kedawung District, Cirebon Regency, West java, Indonesia. The identification method used in this study is Thin Layer Chromatography (TLC) with the stationary phase being silica gel GF 254. For the identification of allopurinol, the mobile phase is n-butanol: ammonium hydroxide: ethanol; for piroxicam identification, it is ethyl acetate-methanol-ammonia (6:3:1); and for dexamethasone identification, it is chloroform: acetone (1:4). Spot detection is done using ultraviolet (UV) light at 254 nm. The applied solutions are the test solution (A), the test solution with added allopurinol, piroxicam, or dexamethasone (B), and the reference standard solution (C). The research results from the 5 (five) samples of uric acid jamu identified one positive samples containing allopurinol, and all positive samples contained piroxicam and dexamethasone. Keywords: Jamu,  thin-layer chromatography, allopurinol, piroxicam, dexamethasone

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