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Makassar Natural Product Journal
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870895     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Natural Product Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Natural Product Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
 1 
Search results for , issue "Juli 2023" : 7 Documents clear
A ANTI-INFLAMMATORY EFFECT OF MATOA LEAF ETHANOL EXTRACT (Pometia pinnata J.R Forst & G. Forst) IN MALE RATS (Rattus norvegicus) FITRI NUR AWALIYAH FAHMI
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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Abstract

Inflammation is the body's normal response to injury or tissue damage which is characterized by heat (calor), pain (dolor), swelling (tumor) and redness (rubor). Matoa leaves contain flavonoid compounds which have anti-inflammatory properties. The purpose of this study was to determine the effect anti-inflammatory of the ethanol extract of matoa leaves (Pometia Pinnata J.R Forst & G. Forst) in male rats (Rattus norvegicus). This study used 25 rat test animals which were divided into 5 treatment groups, group I negative control in the form of 1% Na CMC suspension, group II positive control in the form of diclofenac sodium suspension, groups III, IV and V were given a suspension of ethanol extract of matoa leaves with concentrations of 200 mg/kgBB, 400 mg/kgBB and 800 mg/kgBB. Measurements were made every 1 hour after administration of a comparison or test extract for 6 hours and then recorded. The results showed that the ethanol extract of matoa leaves had the potential as an anti-inflammatory candidate with the most effective dose in reducing the volume and diameter of edema was a dose of 400 mg/kgBB.
THE TOXICITY OF CANDLENUT LEAF EXTRACT (Aleurites moluccana) USING THE BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Nurhasanah Wirasari 15020190196
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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Abstract

Kemiri (Aleurites moluccana) adalah tanaman yang memiliki berbagai macam manfaat. Salah satu bagian tanamannya adalah daun. Daun kemiri diketahui memiliki sifat analgesik, antivirus danantibakteri yang dapat membantu meningkatkan sistem kekebalan tubuh, sedangkan ekstrak etanoldaunnya memiliki efek hipolipidemik yang dapatmengurangi penyerapan protein di dalam usus.Penelitian ini bertujuan untuk mengetahui toksisitas dari daun kemiri dengan menggunakan metodeBrine Shrimp Lethality Test (BSLT). Penelitian ini diawali dengan melakukan ekstraksi daun kemirimenggunakan pelarut etanol 96% dengan metode maserasi kemudian dilakukan skrining kromatografi lapis tipis yang menunjukkan sampel batang kayu wole woe mengandung senyawa alkaloid, flavonoid, saponin dan triterpenoid. Pengujian toksisitas ekstrak daun kemiri terhadap larva Artemia salina Leach dibagi menjadi 5 kelompok uji yaitu 4 kelompok perlakuan (konsentrasi 5 ppm, 10 ppm, 20 ppm, dan 50 ppm)dan 1 kelompok kontrol atau pembanding (air laut).Masing-masing konsentrasi dibuat dalam 3 vial yang dimasukkan 10 ekor larva Artemia salina Leach. Pengamatan dilakukan dengan melihatkematian larva Artemia salina Leach setelah perlakuan selama 24 jam. Hasil penelitian dapat dilihat melalui analisa probit dengan menghitung nilai LC50. Nilai LC50 dari ekstrak daun kemiri adalah 37,670 µg/mL (sangat toksik).
The Isolation and Identification of Flavonoid Compounds Ethanol Extract from Purple Passion Fruit Peel (Passiflora edulis Sims) Fitrah Azzahrah
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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Abstract

The isolation and identification of flavonoid compounds from the ethanol extract of purple passion fruit peel (Passiflora edulis Sims) has been carried out. The aims of this research was to determine the class of flavonoid compounds from the ethanol extract of purple passion fruit peel (Passiflora edulis Sims). About 300 grams was extracted using maceration method with 96% ethanol produces dry 33.127 grams. Preliminary identification was performed using thin layer chromatography method with eluent n-hexane: acetone (8:2), then sprayed with AlCl3 specific reagent. Isolation was done using vacum liquid chromatography method with eluent n-hexane : acetone (100:0, 90:10, 80:20, 70:30, 60:40,50:50, 40:60, 30:70, 20: 80, 10:90, 0:100). The purity was tested using two-dimensional TLC and multi-eluent TLC methods. This research obtained a pure isolate namely isolate 4. The isolate were then identified using UV-Vis spectroscopy showed absorption at a wavelength of 230 nm and 270 nm. Infrared spectroscopy showed absorbance at wave number 3483.44 cm-1 showed possibility of O-H group, reinforced the wave number 1653.00 cm-1 which indicates the possibility of a C=C group, the wave number 1238.30 cm-1 showed possibility the C-O, the wave number 808.17 cm-1 which indicates the possibility of a C-H group, as well as identification using specific reagents. The above observations showed that the isolate is a compound of the flavonoid group.
The Isolation and Identification of Dengen Leaf Flavonoid Compounds (Dillenia serrata Thunb.) Nurul Aulia Kaffi
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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Abstract

The isolation and identification of flavonoid compounds of dengen leaves (Dillenia serrata Thunb.) has been carried out. The aim of this research was to determine the group of flavonoid compounds from the Dengen Leaves extract (Dillenia serrata Thunb.). A sample of 500 grams was macerated with ethanol solvent to produce 53.369 grams of dry extract with a yield value of 10.673%. The extract was spotted on the TLC plate and then eluted with n-hexane : acetone (7:3), then sprayed with citroborate. The ethanol extract was then isolated using KCV method with the eluent ratio nhexane : acetone (10:0, 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2: 8, 1:9, 0:10) then tested by thin layer chromatography. The fractionation results were isolated by TLC using n-hexane: acetone (7:3) followed by testing the purity of the isolate using multi-eluent TLC and two-dimensional TLC to see the purity of the compound/isolate. Isolates were identified by interpretation of UV-Vis spectrophotometer data obtained maximum wavelengths of 223 nm and 286 nm and by interpretation of FTIR data it was found that there was an absorption band at wave number 3456.44 indicating O-H groups, at absorption of 1653.00 indicating C=O (ketones), at absorption 1093.64 showed a C-O group, and at absorption 802.39 showed a C-H group and obtained color screening data, TLC screening, and UV-Vis and FTIR spectrophotometric identification as a feature of the presence of flavonoid compounds.
Penetapan Kadar Flavonoid Total Buah Dengen (Dillenia serrata) Menggunakan Metode Spektrofotometri UV-Vis ARMELIA RHAIHANA BACHTIAR
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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Abstract

Dengen fruit juice (Dillernia serrata) is a type of medicinal plant that is used as an anti-inflammatory, antioxidant, antimicrobial, antitumor, anti-ulcer, immunoprevention, cancer chemoprevention, medicine for thrush, vomiting blood, fever, and wound medicine because it contains polyphenolic compounds, such as tannins. and flavonoids. This study aims to interpret the total flavonoid content of dengen fruit (Dillenia serrata) using the UV-VIS spectrophotometry method. This type of research is laboratory experimental using a spectrophotometer method based on the determination of extract levels and quarcetin standards. The stages of this research began with sample preparation, qualitative testing of flavonoid compounds, and ended with the determination of total flavonoid content of the sample and quarcetin standard. This study obtained the results that the positive dengen fruit extract contained flavonoids based on the results of identification using wilstater reagents, this sample also tested positive for flavonoids based on the TLC test using AlCl3 reagents and citroborate with an Rf value of 0.636, and on the quantitative test results using extract UV-VIS spectrophotometry Dengen fruit has a percentage of flavonoids of 19.355%.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL KULIT DAN BIJI BUAH SEMANGKA (Citrullus lanatus) MENGGUNAKAN METODE DPPH (1,1 diphenyl-2- picryhidrazyl) ALFILA ALFILA
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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ALFILA. Antioxidant Activity Test of Ethanol Extract of Watermelon (Citrullus lanatus) Peel and Seeds Using the DPPH (1,1 diphenyl-2-picryhidrazyl) Method (Supervised by Andi Amaliah Dahlia and Mamat Pratama).Watermelon is a member of the Cucurbitaceae family which is a type of pumpkin. Empirically it can be used as a traditional medicine for body conditioning, urine laxative, gastric and intestinal lubricant and anti-inflammatory drug. The purpose of this study was to determine the antioxidant activity of the ethanol extract of watermelon rind and seeds and to determine the value of the antioxidant activity of the ethanol extract of watermelon rind and seeds using the DPPH (1,1 diphenyl-2-picryhidrazyl) method. Samples were extracted by maceration method using 96% ethanol solvent. Quantitative tests were carried out on each extract using the UV-Vis spectrophotometry method. The absorbance was measured at a maximum wavelength of 516 nm using quercetin as a reference solution. The percent yield value of watermelon rind is 16.087% and watermelon seeds is 10.215%. The results of the IC50 value of the quercetin comparator are strong antioxidants because they have an IC50 value <50, namely 15,899 µg/mL, while watermelon rind is a strong antioxidant because it has an IC50 value between 50-100 µg/mL, namely 50,003 µg/, and watermelon rind includes strong antioxidant because it has an IC50 value between 50-100 µg/mL, namely 79.321 µg/mL.
Article Review The Potential Of Secang Wood (Caesalpinia sappan L.) as Antihypertensive Putri Nurfadilah Sunusi
Makassar Natural Product Journal (MNPJ) Juli 2023
Publisher : PHARMACY UMI JOURNAL SYSTEM

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Abstract

Hipertensi merupakan suatu kondisi tekanan darah meningkat dimana tekanan darah sistolik lebih dari 140 mmgH dan tekanan darah diastolik lebih dari 90mmgH. Apabila tidak ditangan dapat menimbulkan berbagai komplikasi penyakit seperti penyakit jantung, gagal ginjal, stroke, bahkan kematian. Terapi secara farmakologi dengan menggunakan obat antihipertensi memiliki efek samping yang lebih serius dan jika pengobatannya tidak sesuai akan menimbulakn penyakit lainnya. Sekitar 75-80% populasi dunia telah banyak menggunakan obat herbal untuk menjaga kesehatannya karena obat herbal reatif lebih sedikit memiliki efek samping. Tujuan dari review artikel ini adalah unuk mengetahui potensi kayu secang sebaga antihipertensi. Senyawa metabolit yang terkandung dalam kayu secang adalah polifenol seperti flavonoid dan tanin yang berfungsi sebagai antioksidan. Kayu secang termasuk dalam antioksidan yang sangat kuat dengan nilai IC50 yaitu 0,047 ug/ml. Antioksidan sangat berperan penting dalam menagkal radikal bebas sehingga tidak terjadi kerusakan sel.

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