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INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 87 Documents
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Search results for , issue "Vol. 2 No. 1 (2025): July" : 87 Documents clear
Impact of Different Ovarian Stimulation Protocols on Thyroid Hormone Levels: A Prospective Cohort Study: Dampak dari Protokol Stimulasi Ovarium yang Berbeda terhadap Kadar Hormon Tiroid: Sebuah Studi Kohort Prospektif Al-Azzawi, Buthainah
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Ovarian stimulation is pivotal in assisted reproductive technologies, yet its systemic hormonal effects—particularly on thyroid function—remain underexplored. Specific Background: Estrogen-induced increases in thyroxine-binding globulin and the structural mimicry between hCG and TSH suggest a complex thyroid-ovarian interaction. Knowledge Gap: Prior studies yield conflicting evidence on thyroid hormone alterations during stimulation, with limited attention to regimen-specific effects and longitudinal dynamics in thyroid-naïve women. Aim: This study investigates the temporal impact of distinct ovarian stimulation protocols—Clomid, Pergonal, and their combination—on thyroid hormone levels in euthyroid infertile women. Results: A significant elevation in TSH and reduction in T3/T4 was observed as early as month one in the combination group, month two in the Pergonal group, and month three in the Clomid group (P<0.05). Novelty: This study delineates protocol- and time-dependent thyroid disturbances, offering mechanistic clarity on drug-specific endocrine crosstalk. Implications: Findings support tailored thyroid monitoring during ART and propose a stratified approach based on stimulation regimen and exposure duration to prevent potential subclinical hypothyroidism and optimize fertility outcomes.Highlights: Combination therapy (Clomid + Pergonal) caused the earliest and most significant thyroid disruption-elevated TSH and decreased T3/T4 from Month 1. Thyroid dysfunction varied by stimulation protocol: Clomid-only showed delayed effects (Month 3), while Pergonal-only effects began in Month 2. Clinical recommendation: Thyroid monitoring is crucial during ovarian stimulation, especially with combination regimens. Keywords: Ovarian Stimulation, Clomiphene Citrate, Pergonal, Thyroid hormones, Infertility
Synthesis, Characterization, and Anti-oxidant Evaluation of Novel Coumarin–Pyrazoline Derivatives: Sintesis, Karakterisasi, dan Evaluasi Antioksidan Derivatif Kumarin–Pirazolin Baru Mohan, Ahmed Kadhim; Raheem, Leaqaa Abdulredha; Suwaid, Maan Abdul-Razzaq
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.203

Abstract

General Background: Oxidative stress is a major contributor to the pathogenesis of chronic diseases such as cancer and cardiovascular disorders. Specific Background: Coumarin and pyrazoline derivatives are known for their pharmacological activities, particularly their antioxidant potential. Knowledge Gap: However, limited studies have explored the synthesis and evaluation of coumarin–pyrazoline hybrids as potent free radical scavengers. Aims: This study aimed to synthesize and characterize novel coumarin–pyrazoline derivatives and evaluate their antioxidant activity using the DPPH assay. Results: Six new compounds were synthesized and structurally confirmed by ¹H-NMR, ¹³C-NMR, and mass spectrometry. Compounds 2 and 5 exhibited superior antioxidant activity compared to ascorbic acid, with IC₅₀ values of 18.3 μM and 19.7 μM, respectively, versus 23.9 μM for ascorbic acid. Novelty: The enhanced activity was attributed to specific functional groups: the methoxy group in compound 2 and the dimethylamino group in compound 5. Implications: These findings support the potential of coumarin–pyrazoline hybrids as promising antioxidant agents and lay the groundwork for future therapeutic development targeting oxidative stress-related conditions.Highlight : Coumarin–pyrazoline compounds 2 and 5 showed stronger antioxidant activity than ascorbic acid. Structures were confirmed through ¹H NMR, ¹³C NMR, and mass spectrometry. Antioxidant efficiency is linked to specific functional groups like OCH₃ and N(CH₃)₂ Keywords : Anti-oxidant activity, Coumarin, DPPH assay, Pyrazoline, IC50
Training Programs for Paramedics’ First Aid Competence in Traffic Accidents: Program Pelatihan untuk Kemampuan Pertolongan Pertama Paramedis dalam Kecelakaan Lalu Lintas Sadoon, Hajar Haider
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.204

Abstract

General Background: Road traffic accidents are a major cause of global mortality and disability. Specific Background: Limited prehospital care and inadequate paramedic skills worsen trauma outcomes, particularly in Iraq and similar regions. Knowledge Gap: Evidence on the effectiveness of structured training programs for paramedics in first aid procedures is fragmented. Aim: This review critically appraises studies from 2014–2024 evaluating training programs to enhance paramedics’ competencies in managing road traffic injuries. Results: From 17,000 records, 7 high-quality studies were included, covering cardiopulmonary resuscitation, bleeding control, aeromedical evacuation, tactical combat casualty care, and trauma management. Most programs showed significant improvements in knowledge and skills, with simulation-based and video-assisted training being most effective. Novelty: This is the first synthesis focused on paramedics’ first aid training for road accidents in Iraq and comparable settings. Implications: Ongoing, evidence-based training programs are essential to reduce preventable deaths and improve emergency response capacity.Highlight : Highlights the impact of training programs on improving paramedics’ first aid skills. Emphasizes the role of continued education in reducing mortality and disabilities. Identifies effective teaching methods like simulation and video-assisted learning. Keywords : First Aid, Pre-hospital Care, Training Programs, Road Traffic Accidents, Paramedics' Competencies
A Cross-Sectional Study on the Use of Analgesic Medications among Pregnant Women Attending Primary Health Care Centers in Basra City – Iraq Jasim, Utoor Talib; Fatma Ali; Amira Nasser
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.226

Abstract

Analgesics are widely used to relieve pain during pregnancy; however, their safety remains a concern due to potential maternal and fetal risks. In Basra, Iraq, pregnant women frequently use analgesics such as paracetamol and NSAIDs, yet limited data exist regarding their prevalence, types, and associated factors in this population. Despite global studies on medication safety, there is insufficient evidence on the patterns of analgesic use among Iraqi pregnant women and their knowledge regarding associated risks. This study aimed to determine the prevalence, types, and influencing factors of analgesic use among pregnant women attending Maternal and Child Health units, and to assess the association between analgesic use and demographic characteristics. A cross-sectional study of 200 pregnant women revealed that 60% reported using analgesics during pregnancy. Paracetamol was the most frequently used (46%), primarily for symptoms of the common cold (27%). While 41% of women believed analgesics were safe, 32% perceived potential risks, and 23% demonstrated limited awareness. The majority obtained information from drug leaflets (45%). No significant associations were found between analgesic use and demographic variables (p > 0.05). This study provides the first structured evaluation of analgesic use among pregnant women in Basra, highlighting gaps in knowledge and perceptions of drug safety. The findings underscore the need for targeted educational programs and strengthened counseling by healthcare providers to promote safe and rational analgesic use during pregnancy. Highlights: 60% of pregnant women reported using analgesics during pregnancy. Paracetamol was the most frequently used analgesic, mainly for common cold symptoms. Knowledge about safe use of analgesics during pregnancy was generally poor, with drug leaflets being the main information source.
The Efficacy of Cephalosporin Antibiotics Against Urinary Tract Infection (UTI)-Causing Bacteria Saleh, Ali Y.A.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.229

Abstract

Urinary tract infections (UTIs) represent one of the most common bacterial infections worldwide, with over 150 million cases annually, causing significant health and economic burdens. Cephalosporins, a class of β-lactam antibiotics, are widely prescribed for UTIs due to their broad-spectrum activity and low toxicity; however, increasing resistance limits their effectiveness. Despite their extensive use, little is known about the prevalence of resistance mechanisms such as biofilm formation and β-lactamase production in UTI pathogens against different generations of cephalosporins in Baghdad. This study aimed to evaluate the efficacy of 14 cephalosporin antibiotics against UTI-causing bacteria, with particular focus on resistance rates, biofilm formation, and β-lactamase enzyme production. From 140 bacterial isolates, Escherichia coli was the predominant pathogen (82.14%), with infections occurring more frequently in females (84.95%). Resistance to cephalosporins was high (68.5%), particularly against second-generation cefuroxime (97.8%), whereas cefepime, a fourth-generation antibiotic, showed the highest sensitivity (30%). Biofilm production was detected in 62.2% of isolates, while β-lactamase production was observed in 63.5%, both contributing to multidrug resistance. This research provides the first comprehensive evaluation of cephalosporin efficacy against UTI pathogens in Baghdad, combining antimicrobial susceptibility testing with virulence factor analysis. The findings highlight the urgent need for continuous surveillance of antibiotic resistance, rational prescription practices, and consideration of advanced-generation cephalosporins or alternative therapies to manage UTIs effectively. Highlights: Escherichia coli accounted for 82.14% of UTI cases, with infections significantly higher in females (84.95%) than males. Bacterial isolates showed a high resistance rate of 68.5% to cephalosporin antibiotics, with the highest resistance to cefuroxime (97.8%). Virulence factors were prominent, with 62.2% of isolates forming biofilms and 63.5% producing β-lactamase enzymes.
Assessment of Tooth Movement and Bleeding on Probing: Clinical Indicators of Periodontal Disease Progression Haleem, Riyam; Noor Musa; Hind Hadi
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.240

Abstract

Periodontal disease is a chronic inflammatory condition that leads to the destruction of the supporting structures of the teeth. Two of its key clinical features are bleeding on probing (BOP) and tooth mobility, often reflective of underlying tissue breakdown. The aims of this study were to investigate the correlation between bleeding on probing and pathological tooth movement in patients with varying stages of periodontal disease, and to assess their diagnostic and prognostic significance. This cross-sectional study included 120 adult patients who underwent comprehensive periodontal examination. Parameters assessed included BOP, and tooth mobility. Statistical analysis was conducted to evaluate associations between BOP and pathological tooth movement. BOP was detected in 78.5% of patients, with a higher prevalence in the posterior sextants. Tooth mobility (Grade 2 or higher) was observed in 31.6% of the sample, predominantly in the maxillary and mandibular anterior teeth. A statistically significant correlation was found between BOP and pathological tooth movement (p < 0.01), with generalized BOP increasing the likelihood of tooth mobility by nearly fourfold (OR = 3.8). The presence of BOP is significantly associated with pathological tooth mobility, underlining its importance as a predictive marker in periodontal assessment. Early identification and intervention at sites with BOP may help prevent progressive tooth loss. Highlights: Iraqi Cardaria daraba L. contains alkaloids, flavonoids, tannins, terpenoids, and saponins with notable antioxidant activity (IC₅₀ = 2.96 mg/ml). HPLC analysis revealed high levels of vitamin C (42.8 mg/ml) and vitamin A (49.8 mg/ml) in the plant extract. AAS and FESEM-EDS analyses confirmed the presence of essential elements such as Fe, Zn, Ca, Mg, Se, and Sr, supporting its medicinal potential.
Periodontal Implications of Orthodontic Treatment: Assessment of The Balance between Tooth Movement and Surrounding Tissue Haleem, Riyam; Noor Musa; Ghufran M. Hayder; Hasanain sabeeh
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.242

Abstract

Orthodontic treatment also aims to maintain ideal periodontal health. Gingival/periodontal conditions and orthodontic interventions have a complicated relationship because orthodontic forces invariably affect periodontal structures. The aims of this study were to investigate the plaque, and gingival index, before and during orthodontic treatment. In order to fully evaluate the periodontal health of orthodontic patients, a study spanning six months was carried out of 100 adult permanent dentition subjects were included in the sample. Participants were recruited from a specialized orthodontic clinic, and OPI, and OGI were assessed at multiple time points: baseline, 3 months, and 6 months post-treatment initiation. The study found that there were significant increasing in orthodontic plaque index, and orthodontic gingival index before orthodontic appliance insertion and over 6 months of post treatment. This study highlights the significant impact of orthodontic appliances on both gingival health and plaque accumulation. The increase in the Orthodontic Gingival Index and Orthodontic Plaque Index during treatment emphasizes the need for effective oral hygiene strategies for patients undergoing orthodontic therapy. Future research should focus on developing innovative methods to help orthodontic patients improve their oral hygiene practices and prevent gingival inflammation and plaque accumulation. Highlights: Orthodontic treatment led to significant increases in gingival inflammation and plaque accumulation over six months. Both Orthodontic Gingival Index (OGI) and Orthodontic Plaque Index (OPI) showed steady rises from baseline to 6 months. Findings emphasize the need for strict oral hygiene strategies during orthodontic therapy to prevent periodontal complications.

Page 9 of 9 | Total Record : 87

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