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Juvita Herdianty
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Strada Journal of Pharmacy
Published by Universitas Strada Indonesia
ISSN : 27763544     EISSN : 27979180     DOI : https://doi.org/10.30994/sjp
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
The journal includes various fields of pharmaceuticals sciences such as: Pharmacology and Toxicology; Pharmacokinetics; Community and Clinical Pharmacy; Pharmaceutical Chemistry; Pharmaceutical Biology; Pharmaceutics; Pharmaceutical Technology; Biopharmaceutics; Pharmaceutical Microbiology and Biotechnology; Alternative Medicines;
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
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Search results for , issue "Vol. 1 No. 2 (2019): October" : 5 Documents clear
Variations in the concentration of magnesium stearate as a lubricant in the evaluation test results of paracetamol tablet preparations Agnes Widian; Dimas Bagus Cahyo
Strada Journal of Pharmacy Vol. 1 No. 2 (2019): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v1i2.125

Abstract

Tablets are an oral drug preparation that can be formulated with or without additional substances. This preparation has many advantages, one of which is that it is practical to use and can be produced on a large scale. Tablets are produced using 3 methods, namely dry granulation, wet granulation and direct compression. Each manufacturing method must be adapted to the tablet material to be printed. So it is necessary for formulators to know the characteristics of the materials to be used.Tablet production involves excipients or additional substances which have an important role. Excipients are one of the considerations in preformulation studies to determine the right characteristics and quantities to produce tablets that meet the requirements. One of the excipients in tablet formulation is a binder. So far tablet binders are divided into 2 types, namely natural polymer binders and synthetic polymer binders. Additional materials play 2 important roles in making tablets, one of which is the binder. The binder is intended to provide tablet compactness and durability so that the binder guarantees the integration of several powder particles into a granulate (Oktavia, 2011). Granulation is a process of increasing the size of small powder particles that are bound together to become large ones that can flow freely. The purpose of granulation is to make the mass flow freely, compact the mixture of ingredients, create a uniform mixture that does not separate, improve the compressibility characteristics of the active substance, control the speed of release of the active substance from the dosage form, reduce dust and improve the appearance of the tablet (Lachman, 1994). Observation of the results of evaluating the physical quality of the preparation includes organoleptic tests, hardness test, brittleness test, disintegration time test and weight uniformity test. The results of this research based on the friability test, the F1 result was 0.74%, fulfilling the requirements of the tablet friability test, namely, no more than 0.8% loss of the total mass of the FI 3rd edition tablet. 4. The results of the tablet uniformity test show that there is not a single tablet whose weight deviates from column A, namely more than 5% and there is not a single tablet whose weight deviates from column B, namely more than 10% from the average weight in F1. All tablets in FI have a uniform tablet weight with no deviation so that FI complies with the specified range requirements.
Analysis of Patient Satisfaction with Pharmaceutical Services at the Northern Region Primary Health Center of Kediri City in 2019 Hanie Kusuma Wardan
Strada Journal of Pharmacy Vol. 1 No. 2 (2019): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v1i2.126

Abstract

Pharmaceutical services are an integral component of the health care system at primary health center. One of the quality indicators in pharmaceutical services at the Northern Region Primary Health Center of Kediri City is patient satisfaction. This study aims to analyze patient satisfaction with pharmaceutical services at the Northern Region Primary Health Center of Kediri City in 2019. Using a cross-sectional design, the study involved 110 respondents selected through accidental sampling. Data were collected using a standard questionnaire from Regulation of the Minister of Health of the Republic of Indonesia No. 74 of 2016 and analyzed using the Community Satisfaction Index method. The results showed a Community Satisfaction Index value of 3.19 (equivalent to 79.66 after conversion), indicating a satisfaction level of "Satisfied" with a service quality of "B". The service element with the highest score was the friendliness of the pharmacist/ pharmacy technician (3.40), while the availability of written educational materials received the lowest score (2.96). This study concludes that although pharmaceutical services at the Northern Region Primary Health Center of Kediri have reached a good level of satisfaction, there are still some aspects that require improvement, especially in terms of physical facilities and the provision of health information.
Addition of Talcum to the formulation of clindamycin capsule preparations on evaluation test results Ivonder; Savira Sandriansyah
Strada Journal of Pharmacy Vol. 1 No. 2 (2019): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v1i2.127

Abstract

Medicines are all single ingredients or mixtures that are used by all living creatures internally and externally, to prevent, alleviate or cure disease. In general, according to the dosage form, drugs are divided into 3 types, namely liquid preparations, semi-solid preparations and solid preparations. In this practicum we made a solid dosage form, namely capsules (Ansel, 1989). Capsules are solid preparations consisting of medication in a hard or soft shell that can dissolve (Fatmawaty et al, 2012). Hard capsules are usually made from gelatin which consists of the capsule shell, the body and the capsule cap. The two parts of the capsule cover will cover each other when brought together and the cover will cover the body of the capsule (Ansel, 2005). Clindamycin inhibits most gram-positive cocci and most anaerobic bacteria, but cannot inhibit aerobic gram-negative bacteria such as 33 Haemophilus, Mycoplasma and Chlamydia (Ministry of Health, 2011). The mechanism of action of clindamycin is the same as erythromycin. Clindamycin is mainly given to treat infections caused by anaerobic bacteria, such as Bacteriodes fragilis bacteria which often cause abdominal infections caused by trauma (Katzung, 2012). Considering the importance of knowledge about antibiotic drugs such as clindamycin, a good and correct method for formulating solid capsule dosage forms has been developed and what must be taken into account when making them. Based on the test results, F1 3.44 seconds, F2 3.76 seconds, F3 3.24 seconds, the flow speed of these three formulas meets the flow speed requirements, namely flow speed ≥ 10 g/second. The flow speed of the three formulas is in the good category, namely 2-10 g/sec which is said to be very good while it is said to be good. The flow speed is good because Aerosil has a very small and fine particle size. Apart from being an absorbent, aerosols are also able to improve flow properties by reducing friction between particles and by averaging test results from angles of repose F1 45°, F2 43° and F3 53°.
Physical Stability Test of Ethanol Extract Ointment Preparation of Ambon Banana Peel (Musa acuminata cavendish subgroup) Rafelin Putri Herlambang
Strada Journal of Pharmacy Vol. 1 No. 2 (2019): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v1i2.129

Abstract

Medical plants found in nature, one of which is the banana plant. Bananas have many benefits but have not been widely used by the public. contains tannins, saponins and flavonoids found in banana hump reported to contain vitamin C, vitamin A, protein and fat which work in the process of wound healing. Ointments are the most suitable preparation for the treatment of burns because they function as carriers of medicinal substances for use on the skin, as lubricants and skin protectors so as to prevent contact of the injured skin surface with external stimuli. Ointment is a semi-solid preparation that is easily applied and used as an external medicine. This study aims to look at the physical stability of the formulation of sakep preparation of ethanol extract of ambon banana peel at concentrations of 10%, 15%, 20%. Evaluation of physical properties includes organoleptic tests, homogeneity, pH, spreadability and adhesion. The test results showed that the best formulation was formulation 3, namely the kapok banana peel extract ointment with a concentration of 20% which met the requirements for pH testing, spreadability test and adhesion ability.
Antibacterial Activity Test of Ethanol Extract of Spoon Leaves (Plantago major. L)Against Salmonella typhi Refaldi Shaputra
Strada Journal of Pharmacy Vol. 1 No. 2 (2019): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v1i2.130

Abstract

Typhoid is a bacterial infection disease of Salmonella typhi. Conventionally, typhoid treatment is carried out with antibiotics. The irrationality of antibiotics against S. typhi is reported to trigger bacterial resistance, thus requiring an alternative antibacterial agent against typhoid. The diversity of Indonesian medicinal plants is still promising as a potential source of antibacterial agent, including sendok leaf. This study was aimed to determine antibacterial activity of ethanol extract of kacapiring leaves and its fractions against S. typhi. Subsequent fractionation was carried out using liquid-liquid partition method to obtain n-hexane, ethyl acetate, and etanol-water fractions. Antibacterial test was carried out using disk diffusion method to determine the diameter of inhibitory zone at concentrations of 20%, 25%, 30%, and 40%. The best antibacterial activity was revealed by residue fraction of 30% and 40% with inhibition zone diameter of 8,5 ± 0.051 mm and 8,7 ± 0.081 mm, respectively. Sendok have moderate antibacterial activity against S.typhi.

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