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Jurnal Widya Medika
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23380373     EISSN : 26232723     DOI : https://doi.org/10.33508/jwm
Core Subject : Health,
Medicine & Pharmacology
Jurnal Widya Medika is the official publication media of Widya Mandala Surabaya Catholic University, Faculty of Medicine. Jurnal Widya Medika publishes original research articles, case reports, and literature reviews from scientists of various medical education and research institutions, including select scientific works from medical students. All articles published had undergone plagiarism checks, editorial review by the editorial board, and peer review by experts from their respective fields in order to maintain the high standard of articles published in Jurnal Widya Medika.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
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Search results for , issue "Vol. 8 No. 1 (2022): April" : 8 Documents clear
SARCOPENIA IN THE ELDERLY: PATHOGENESIS, DIAGNOSIS AND TREATMENT Edith Maria Djaputra
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3551

Abstract

‘Sarcopenia’ involves a progressive age-related loss of muscle mass and associated muscle weakness that renders frail elders susceptible to serious injury from sudden falls and fractures and losing their functional independence This disease has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. In the previous definition by the European Working Group on Sarcopenia in Older People (EWGSOP) in 2010, the diagnosis of sarcopenia requires the presence of both low muscle mass and low muscle function. Since the 2010 definition is difficult to be translated to clinical practice, the EWGSOP uses low muscle strength as the primary parameter of sarcopenia in the 2018 definition; sarcopenia is probable when low muscle strength is detected. A sarcopenia diagnosis is confirmed by the presence of low muscle quantity or quality. When low muscle strength, low muscle quantity/quality and low physical performance are all detected, sarcopenia is considered severe. According to the pathophysiological factors involved in the pathogenesis of sarcopenia, different treatment strategies against sarcopenia are resistance exercise training, increase essential amino acids intake, vitamin D supplementation for those with vitamin D deficiency, polyunsaturated fatty acids (PUFAs) supplementation, testosterone supplementation, angiotensin-converting enzyme inhibitor administration.
ROLE OF PROBIOTICS, PREBIOTICS AND SYNBIOTICS IN ATOPIC DERMATITIS Patricia Dian Putri
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3571

Abstract

Atopic dermatitis (AD) is a chronic recurrent skin disease, causing itching, with a characteristic distribution of lesions. Giving a combination of probiotics for 8 weeks to children with atopic dermatitis resulted in relieving symptoms based on Scoring Atopic Dermatitis (SCORAD) index, decrease in IgE serum levels, interleukin (IL)-5, IL-6 and interferon γ compared to placebo group. While prebiotics have potential to promote the growth of various microflora in colon. Change in microflora are given an allergic protective effect by modulating postnatal immune development. Synbiotic approach the capacity synergy between probiotics and prebiotics. Synbiotic therapy is a promising therapy for AD
ANALYSIS FACTORS OF BREAST LESION CASE IN RSUD DR. SOETOMO SURABAYA Wilda Fitria Rachmadina; Willy Sandhika; Widati Fatmaningrum
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3615

Abstract

Introduction: Data from Indonesian Health Ministry stated that there was an increase in the prevalence of breast tumors in 2015 – 2017 by 1.8 per 100 to 21.3 per 100,000 women aged 30-50 years. The most common types of benign breast lesions found in women worldwide are fibrocystic changes of breast and fibroadenoma. Aim: This research aims to analyze the factors of age, age at menarche, parity, use of hormonal drugs, and family history with the incidence of benign breast lesions in RSUD Dr. Soetomo Surabaya. Methods: This research method is observational analytic with a case-control approach, consisting of a case group and a control group of 41 respondents in each group. The statistical test of the study used the Chi-Square Test, Independent t-test, Mann Whitney, and Odds Ratio (OR). Results: The results of statistical tests obtained age factor p(sig)=0.002, hormonal use p(sig) 0.000, family history p(sig) 0.016, age at menarche p(sig) 0,282, and parity p(sig) 0.568. Conclusion: Conclusion there is a relationship between age, use of hormonal drugs, and family history and there is no relationship between age at menarche and parity with the incidence of benign breast lesions in RSUD Dr. Soetomo Surabaya. Family history has an Odds Ratio (OR) of 4.796. Keywords: Breast Lesions, Reproductive Health
THE EFFECTS OF PINUS MASSONIANA (PINE POLLEN) AS ADJUVANT THERAPY ON LEUKOCYTES, T LYMPHOCYTES, C-REACTIVE PROTEIN, AND D-DIMERS IN HOSPITALIZED COVID-19 PATIENTS Prettysun Ang Melow; Handi Suyono; Maria Magdalena Ano Djoka; Agata Christi Palupi; Steven Hermantoputra; Anton Hariadi; Yudita Wulandari; Sri Purwaningsih
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3626

Abstract

Introduction: SARS-CoV-2 infection has caused the Corona Virus Disease-19 (COVID-19) pandemic until present day. Pine pollen has been known and used as a medicine and has benefits for immunity. Aim: To determine the effects of Pinus massoniana (pine pollen) as an adjuvant on leukocytes count, T lymphocytes (CD4, CD8) count, plasma C-reactive protein level, plasma D-dimer level in hospitalized COVID-19 patients with moderate-severe clinical manifestation. Materials and Method: We used a double blind pretest-posttest control group design, with 2 groups, namely control (placebo) and treatment. The subjects were selected by simple random sampling, male and female patients aged 20-60 years. Peripheral blood samples were taken before and after treatment. Patients were given pine pollen or placebo 3 x 4 capsules (3 g / day) for 7 days. Data were analyzed by SPSS 23.0 t-test with significant value of p < 0.05. Results: The patients of treatment group were 16 people (13 male, 3 female), average age 46,25 years and control 13 people (10 male, 3 female), average age 47,92 years. The leukocytes count increased not significantly in the treatment group (p=0.499; 8.03%) while control increased significantly (p=0.027; 36.42%). The leukocytes count of control was 4,5 times greater than treatment group. The CD4 count increased significantly in the treatment group (p=0.004; 73.44%) and control (p=0.048; 28.97%), and the it was 2,5 times greater than control. The CD8 count increased significantly in the treatment group (p=0.005; 72.90%) and control (p=0.033; 34.66%), and it was 2,1 times greater than control. CRP levels were significantly reduced in the treatment group (p=0.001; 71.61%) and control (p=0.001; 78.13%). D-dimer levels decreased significantly in the treatment group (p=0.048), while the control increased but not significantly (p=0.200). The D-dimer level in the treatment group decreased by 37.93%, while the control increased by 43.70%. Conclusion: Further research is still needed to explore the effect of pine pollen on cellular immunity which in this case is T lymphocytes, especially CD4 and CD8, and hemostasis (coagulation) especially D-dimer. Pine pollen is beneficial for immune modulation in COVID-19 patients.
THE EFFECT OF CINNAMALDEHYDE MEMBRANE APPLICATION ON THE NUMBER OF MACROPHAGES ON THE INFLAMMATION PROCESS OF LABIAL ULCUS OF WISTAR RATS Chrisdina Puspita Sari; Nunuk Purwanti; Ika Dewi Ana
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3712

Abstract

Introduction: Macrophage is the inflammatory cell that dominates the chronic inflammation. Macrophage plays an important role in phagocytic process and secretion of chemical mediators in the early stage of inflammation. Cinnamaldehyde is the major constituent of cinnamon plant has an anti-inflammatory effect. Cinnamaldehyde can be delivered by membrane-shaped hydrogel polymer made from gelatin to maximize its anti-inflammatory effect. Aim: The objective of this study was to investigate the effect of cinnamaldehyde membrane on the macrophage numbers on the labial ulcer of Wistar rats. Methods: Thirty Wistar Rats were divided into 5 groups, 4 groups as treatment and 1 group as a control. An injury of the labial mucosa of Wistar Rat was made by the application of acetic acid glacial on the labial mucosal surface. The cinnamaldehyde membrane 1%, 4%, K-diclofenac membrane, and DMSO membrane were applied on the wound of the treatment groups, while the DMSO was applied on the control group at one day after injury. Three rats from each group were sacrificed on the 3rd and 6th day. The ulcerative mucosal tissues were collected and processed for histological preparation with Hematoksilin Eosin (HE) staining. The numbers of macrophage was counted in 6 fields using trinocular microscope. The data were analyzed using Two-way Analysis of Variance (Two-way Anova). Result: The result of Two-way Anova showed that there were significance differences between the treatment and control groups, so were the interaction of the treatment and the day. Conclusion: The application of cinnamaldehyde membrane has an effect on the numbers of macrophage on the labial ulcer of Wistar Rats.
RELATIONSHIP OF EPICARDIAL ADIPOSE TISSUE THICKNESS AND NEUTROPHIL TO LYMPHOCYTE RATIO WITH CORONARY LESION SEVERITY IN STABLE CORONARY HEART DISEASE Darwin Indra; Lucia Panda; Edmond Jim; Dewi U. Djafar; Victor G. X. Rooroh; Monique P. F. Rotty
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3825

Abstract

Introduction: Stable angina pectoris (SAP) is the one of the leading causes of death in men and women from every major ethnic group. Several studies have shown that the neutrophil to lymphocyte ratio (NLR) is a systemic inflammatory marker associated with cardiovascular events. EAT has been considered to have an important role in cardiovascular physiology and pathogenesis. This study aimed to investigate the relationship of EAT thickness and NLR with coronary lesion severity in patients with stable coronary heart disease. Methods: This study was a cross-sectional study conducted at Department of Cardiology and Vascular of Kandou General Hospital, Manado, North Sulawesi, Indonesia, from May to August 2019. The population were patients with SAP who underwent coronary angiography procedures. The relationship between the EAT and NLR and the SYNTAX score were evaluated on a bivariate and multivariate level. Results: A significant linear relationship between EAT thickness and SYNTAX score was found (Pearson r = 0.32; p = 0.014). In addition, after controlling for sex and NLR, the correlation between EAT thickness and SYNTAX score increased to almost 0.7 points for each millimeter increase in EAT (95% CI 3.45 - 10.25; p
CITOMEGALOVIRUS (CMV) ENCEPHALITIS: A CASE REPORT Meryana, Meryana
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3826

Abstract

Encephalitis results from an inflammatory process in the brain which can be caused by infection, post infection or non-infection processes. The most common etiology is infection, especially by virus. Encephalitis is usually followed by diffuse and or focal neuropsychology dysfunctions of brain and meninges (meningoencephalitis). Symptoms of encephalitis are photophobia, headache or neck stiffness, focal neurological deficits, seizure, decrease of consciousness, behavior disorders, and aphasia. However, some patients may not show predominant neruological deficits or even asymptomatic. Inaccuracy to diagnose the etiology promptly can cause morbidity and mortality due to this disease. The author reports one case of citomegalovirus (CMV) encephalitis with mild symptoms. In this case, a 36-year old man with symptoms of mild fever and mild headache was consulted by an internist to neurologist, because internal examinations couldn’t find the etiology of the patient’s symptoms. The results of laboratory examinations of NS-1, Dengue IgM and IgG Dengue, Salmonella IgM and IgD, hepatitis screening tests, and chest X-ray examination showed normal results. Brain MRI with contrast then was performed with normal result. Cerebrospinal fluid (CSF) analysis showed pleiocytosis, predominantly mononuclear cells. Diagnosis of CMV encephalitis was established by examination of CMV PCR (Polymerase Chain Reaction) of CSF that was positive. The patient was then treated with antiviral agent Gansiklovir 5 mg/kg every 12 hours for 14 days. On the third day of therapy, the patients had been free of symptoms. The patient was discharged form the hospital in good condition.
ACUTE DISSEMINATED ENCEPHALOMYELITIS FOLLOWING A DIPHTHERIA-PERTUSSIS-TETANUS VACCINATION: A CASE REPORT Stephanie Angela Prijanto; Tikto Wahyono; Pipit Soesilowati
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3827

Abstract

Introduction: Acute disseminated encephalomyelitis (ADEM) is a rare, acute progressive autoimmune disease that occurs in the brain and spinal cord, in response to infection or immunization. Myelin autoantigens could share similar antigenic determinants with a pathogen and cross-react with a human’s antibody, causing demyelination of the nerve sheath. Identifying ADEM is essential to treat the patient and reduce any sequelae. Case description: An 11-year-old male was brought to the ER with one day of weakness of the face and the left side of the body. Along with that, the patient vomited, complained of headache and fever. One day prior, the patient received a Diphtheria-Pertussis-Tetanus Vaccination at his elementary school. A head computer tomography (CT) scan with contrast was done and showed multiple hypodense lesions in the bilateral internal capsule, bilateral lateral periventricular, subcortex of the right frontal lobe, and right cerebellum, with suspicion of ADEM. Discussion: There were many clinical signs of patients with ADEM, depending on the lesion. Brain and cerebellar lesions can cause irritability, confusion, coma, incoordination, and gait problems. Spine lesions can cause numbness and paralysis of the limbs. Lesions in the cranial nerve can cause dysarthria, blurry vision, double vision, and facial weakness. Conclusion: The prognosis for ADEM is good and often has improvement within a month. However, some patients need to undergo supportive therapy as appropriate. Further follow-up needs to be done to evaluate the disease progression, as ADEM may be manifesting as Multiphasic ADEM or any other demyelinating disease.

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