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All Journal Bali Dermatology and Venereology Journal Jurnal Widya Medika
Putri, Patricia Dian
Faculty Of Medicine Widya Mandala Catholic University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy Putri, Patricia Dian; Rusyati, Luh Made Mas; Adiguna, Made Swastika
Bali Dermatology and Venereology Journal Vol 3, No 1 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i1.34

Abstract

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy Patricia Dian Putri; Luh Made Mas Rusyati; Made Swastika Adiguna
Bali Dermatology and Venereology Journal Vol. 3 No. 1 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i1.34

Abstract

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
ROLE OF PROBIOTICS, PREBIOTICS AND SYNBIOTICS IN ATOPIC DERMATITIS Patricia Dian Putri
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3571

Abstract

Atopic dermatitis (AD) is a chronic recurrent skin disease, causing itching, with a characteristic distribution of lesions. Giving a combination of probiotics for 8 weeks to children with atopic dermatitis resulted in relieving symptoms based on Scoring Atopic Dermatitis (SCORAD) index, decrease in IgE serum levels, interleukin (IL)-5, IL-6 and interferon γ compared to placebo group. While prebiotics have potential to promote the growth of various microflora in colon. Change in microflora are given an allergic protective effect by modulating postnatal immune development. Synbiotic approach the capacity synergy between probiotics and prebiotics. Synbiotic therapy is a promising therapy for AD
THROUGH A MICROSCOPIC LENS: SKIN MICROBIOME AS THE CONFEDERATE IN ATOPIC DERMATITIS Catharina Clarissa Ursia; Patricia Dian Putri
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4265

Abstract

Reciprocity between skin microbiome and the host underlies the occurrence, exacerbation, and severity of atopic dermatitis (AD). However, the role of skin microbiome in the pathogenesis of AD is yet to be depicted. This review highlights the host–microbiome interactions which relies on barrier status, microbiome composition, and microbe–microbe interactions. A microbiome shift, with abundance of S. aureus and lower microbial diversity, compromises the skin barrier function. It goes to show that epidermal barrier defect depletes the protective commensal skin bacteria and demonstrate how dysbiosis of the skin microbiome can lead to AD.
Co-Authors Catharina Clarissa Ursia Luh Made Mas Rusyati Made Swastika Adiguna Ursia, Catharina Clarissa