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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : https://doi.org/10.33508/jfst
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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year in March and October, containing research articles, review and short communication in the pharmacy science field, including medicinal chemistry, analytical chemistry, biological pharmacy, pharmaceutical sciences, and clinical pharmacy researches; the practice of pharmacy in industry, clinic and community, such as pharmacies, distributors and pharmacy education.
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Articles 7 Documents
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Search results for , issue "Vol. 11 No. 2 (2024): October" : 7 Documents clear
Aktivitas Antibakteri Gel Hand SanitizerMinyak Biji Pala (MyristicafragransHoutt) Terhadap Bakteri Gram Positif dan Gram Negatif Agustin, Rachmawati Dwi; Taihuttu, Yuniasih Mulyani Jubeliene
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.4285

Abstract

One of the media for spreading the bacteria the fastest in hand, so an antibacterial substance is needed. Hand sanitizers, which are more effective in killing bacteria, by quickly processing hands with airflow. However, most of the hand sanitizers' content is alcohol, which can repeatedly irritate the skin, so natural ingredients are needed to make hand sanitizers. Nutmeg is a tropical plant that is commonly found in Indonesia. Nutmeg contains active compounds as antibacterial agents. Research on the antibacterial activity test of the hand sanitizer gel formulation of nutmeg oil has been carried out. This study aimed to determine the antibacterial activity in the optimum formulation of the nutmeg oil hand sanitizer gel. Antibacterial activity test using the disc diffusion method showed that the nutmeg oil hand sanitizer gel had antibacterial activity against several pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, Propionibacterium acne, and Pseudomonas aeruginosa, which were optimum concentration in nutmeg oil by 15% (F1), obtained the inhibition power of 1.42 mm; 1.35 mm; 0.56 mm; and 1.67 mm, respectively.
Uji Mutu Fisik dan Analisis Nilai Sun Protection Factor (SPF) Krim Tabir Surya Ekstrak Daun Kelor (Moringa oleifera L.) Damayanti, Windy Aulia; Cahyani, Erlien Dwi; Nurcahyani, Diah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5007

Abstract

Solar radiation can cause negative effects on human skin such as skin pigmentation, skin cancer, sunburn and aging, so protection is needed, one of which is sunscreen use. Moringa leaves (Moringa oleifera L.) contain flavonoid, secondary metabolite which is effective as photoprotectors because of their ability to absorb UV light and can be formulated into cream preparations. The aim of this research was to evaluate the physical quality and SPF value of 3 Moringa leaf extract cream formulas. The results of the physical quality evaluation for homogeneity, pH and organoleptics have met the requirements. Spreadibility test shows that formula I has a spreading power per load of between 5-6.23cm. The viscosity test showed that all formulas had good average viscosity results, namely formula I 23111 cPs, formula II 22670 cPs, and formula III 20170 cPs. The largest SPF test result was formula III which contained 5% extract which had a value of 4.8653 with medium SPF potential.
Perbedaan Kombinasi Konsentrasi Bahan Pengikat Pati Garut (Maranta Arundinaceae. L) Dan Pati Talas (Colocasia Esculanta L. Scoot) Terhadap Karakteristik Fisik Sediaan Tablet Hisap Ekstrak Jahe Merah (Zingiber Officinale Var. Rubrum) Devi, Sisca; Baiti, Hilma Nur
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5290

Abstract

Red ginger contains gingerol which is used as a throat lozenge. One of the dosage forms used in developing the use of red ginger is lozenges. Making lozenges requires additional ingredients in the form of a binder which can be obtained from starch. Arrowroot starch and taro starch contain amylose and amylopectin which have the ability to adhere. The combination of the use of arrowroot starch and taro starch binders has an impact on the characteristics of the lozenges produced. This research aims to determine the differences in the combination of using concentrations of binding agents, namely arrowroot starch and taro starch, on the physical characteristics of red ginger extract lozenges.This research is an experimental study with the independent variable being the combination of concentrations of arrowroot starch and taro starch (100:0); (50:50); (0:100). Testing of the physical characteristics of red ginger extract lozenges included organoleptic and tablet dimensions, weight uniformity, tablet hardness and friability and disintegration time. Analysis of normally distributed and homogeneous data using One-Way Anova at a confidence level of 95% followed by Post Hoc testing. The Kruskal-Wallis test is used for data that is not normally and homogeneously distributed followed by the Mann Whitney test.The test results showed that the combination of concentrations of arrowroot starch and taro starch binders had an effect on the physical characteristics, namely tablet hardness and brittleness and tablet disintegration time (p<0.05).
Review Artikel: Keragaman Actinomycetes Laut Indonesia Sebagai Sumber Senyawa Antibiotik Baru Pasmawati
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5468

Abstract

Infeksi mikroba patogen merupakan penyebab penyakit paling umum dalam dunia medis. Hasil studi menunjukkan bahwa adanya infeksi bakteri merupakan salah satu hambatan dalam proses penyembuhan yang sering ditemukan dalam perawatan pasien dengan Luka Kaki Diabetes. Salah satu upaya pencegahan pada penyakit infeksi yang disebabkan oleh mikroba patogen adalah menggunakan antimikrobial seperti antibiotik. Review artikel ini dilakukan dengan melakukan kajian literatur ilmiah melalui pencarian literatur menggunakan database Google Scholar, PudMed, dan Science Direct dengan kata kunci “marine”, “Actinomycetes”, “Actinobacteria”, “Antimicrobial”, “Indonesia”. Penelitian ini dilakukan untuk mendapatkan informasi mengenai keragaman dan strain Actinomycetes laut Indonesia yang menghasilkan senyawa metabolit sekunder sebagai antimikroba. Data menunjukkan bahwa terdapat keragaman Actinomycetes laut Indonesia yang tersebar hampir diseluruh wilayah Indonesia. Sampel yang diisolasi diperoleh dari berbagai sampel seperti sedimen, tanah rhizosfer mangrove, lumpur, juga ditemukan berasosiasi dengan rumput laut, lamun, alga merah, timun laut, invertebrata, dan spons. Actinomycetes laut Indonesia yang ditemukan didominasi oleh genus Streptomyces, Micromonospora, Nocardiopsis, dan Micrococcus. Actinomycetes laut lainnya yaitu tergolong ke dalam genus Pseudonocardia, Dermacoccus, Nocardiopsis, Verrucosispora, Kytococcus, Corynebacterium, Brachybacterium, Pseudonocardia, Virgibacillus, Labrenzia, dan Halomonas. Actinomycetes laut tersebut dilaporkan menghasilkan senyawa metabolit sekunder yang memiliki aktivitas antimikroba sehingga sangat berpotensi sebagai sumber senyawa antibiotik baru.
Literature Review: Bioactivity and Drug Formulation of Tapak Dara (Catharanthus roseus) Fadhli, Haiyul; Fadillah, Ma’isyatul; Hazimah, Hazimah; Fitriah, Dina
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5696

Abstract

Tapak dara (Catharanthus roseus), also known as Madagascar periwinkle or Vinca, is a tropical plant native to Madagascar and has been widely distributed throughout the world, including in Indonesia. This review article looks at bioactivities and drug formulations using different parts of the Catharanthus roseus plant. Literature sources and data were collected through Google Scholar and Google Books on the topic of formulations and pharmacological activities of Catharanthus roseus, published from 2014 to 2024. This review describes various studies showing the potential of Catharanthus roseus plants in various bioactivities such as antioxidants, anticancer, analgesic, antihyperglycemic, antibacterial, wound healing, anti-inflammatory, hepatoprotective, antihyperlipidemic, and antidiabetic properties. Besides bioactivity aspects, this review also covers formulations involving Catharanthus roseus, including the development of various products such as extracts, ointments, creams, gels, emulgels, and nano emulsions for medical purposes. In conclusion, this article provides an in-depth insight into the bioactivity of the Catharanthus roseus plant and its potential in drug formulations.  
Hubungan Pengetahuan Dan Persepsi Masyarakat Terhadap Minat Beli Sediaan Sirup Di Apotek Terkait Isu Cemaran Etilen Glikol Dan Dietilen Glikol Ramdani, Debby Valenia Azzahra
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5813

Abstract

Obat adalah bahan yang dimanfaatkan untuk mengobati penyakit, mengidentifikasi penyakit, mengurangi rasa nyeri serta sakit, dan menyembuhkan berbagai organ tubuh. Jumlah kandungan Etilen Glikol (EG) dan Dietilen Glikol dalam sirup obat yang melampaui kadar yang diperbolehkan telah mengkontaminasi sirup obat yang beredar di Indonesia dan meningkatkan risiko gagal ginjal yang akut dikalangan anak-anak. Dengan pendekatan deskriptif secara kuantitatif, penelitian ini memiliki tujuan untuk menganalisis minat beli masyarakat terhadap sediaan sirup berdasarkan tingkat pengetahuan dan persepsi masyarakat. Dalam penelitian ini, IBM SPSS versi 25 digunakan untuk menganalisis data yang sudah ada dengan sampel purposif sebanyak 60 sampel. Analisis regresi berganda dilakukan terhadap data. Hasil penelitian menunjukkan bahwa Nilai thitung pengetahuan = 2,087 dan persepsi = 2,301 dengan nilai ttabel 2,002 sedangkan nilai Fhitung 5,846 dengan nilai Ftabel 3,16. Dengan demikian, penelitian menunjukkan hasil bahwa pengetahuan dan persepsi masyarakat terhadap masalah kontaminasi etilen glikol dan dietilen glikol secara parsial dan simultan mempengaruhi minat beli sediaan sirup obat di Apotek. Medicines are substances that are used to treat diseases, identify diseases, reduce pain and illness, and heal various organs of the body. The amount of Ethylene Glycol (EG) and Diethylene Glycol content of medicinal syrups that exceeding the allowed levels has contaminated the medicinal syrups circulating in Indonesia and increased the risk of acute kidney failure among children. With a quantitative and descriptive approach, this study aims to analyse public buying interest in syrup preparations based on the level of public knowledge and perception. In this study, IBM SPSS version 25 was used to analyse existing data with a purposive sample of 60 samples. The analysis of multiplication regressions was applied to this data. The study results show that tcount value of knowledge = 2.087 and perception = 2.301 with ttable value of 2.002 while Fcount value is 5.846 with Ftable value of 3.16. The study showed that people's knowledge and perceptions about ethylene glycol and diethylene glycol contamination problems partially and simultaneously affect the interest in buying medicinal syrup preparations at the pharmacy.
Analisa BKO Prednison, Paracetamol, Deksametason, Meloksikam dan Piroksikam dalam Sediaan Obat Tradisional Diana; Setiawan, Henry Kurnia; Ramadhani, Rizky Pratama; Nayotama, Brian; Bimantara, Shandy Aditya
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5839

Abstract

AbstrakPenambahan bahan kimia obat ke dalam sediaan obat tradisional masih sering ditemukan. Praktek ini dilarang oleh undang-undang di Indonesia dan dapat menimbulkan efek berbahaya bagi penggunanya. Unsur kesengajaan yang melatarbelakangi hal tersebut, membuat aspek pengawasan sediaan dan penindakan menjadi faktor yang krusial dalam penanganannya. Analisa keberadaan BKO dalam sediaan obat tradisional membutuhkan metode yang handal serta mampu mendeteksi keberadaan beragam BKO yang mungkin ditambahkan ke dalam sediaan. Dalam penelitian ini keberadaan BKO Prednison, Paracetamol, Deksametason, Meloksikam dan Piroksikam dideteksi menggunakan kromatografi lapis tipis-densitometri. Eluasi dilakukan menggunakan kloroform:metanol (9:1) pada fase diam silika yang diamati di λ 240 nm dan 246 nm. Lempeng kemudian dianalisa menggunakan TLC-scanner (densitometri) untuk mendapatkan luas area dibawah puncak untuk masing-masing analit. Metode ini mampu mendeteksi keberadaan BKO dengan konsentrasi 6,5 ppm (Prednison), 3,0 ppm (Paracetamol), 1,8 ppm (Deksametason), 6,0 ppm (Meloksikam), 8,0 ppm (Piroksikam) dalam larutan uji. Metode tervalidasi untuk menganalisa 5 pengotor kimia yang umum dijumpai pada sediaan obat tradisional. Analisis dapat dilakukan secara simultan menggunakan metode sederhana, sehingga sesuai untuk melakukan skrining pengotor yang terdapat dalam obat tradisional. AbstractMisuse of drugs (BKO) in traditional medicinal preparation is still often found. This practice is prohibited by Indonesia’s law and can harm users. Malfeasance behind this problem makes law enforcement and control a crucial factor in handling it. Analysis of BKO requires a reliable method that detects the presence of various BKOs that may be added to the preparation. In this study, Prednisone, Paracetamol, Dexamethasone, Meloxicam, and Piroxicam were detected using thin-layer chromatography–densitometry. Elution was carried out using chloroform:methanol (9:1) on silica stationary phase observed at 240 nm and 246 nm. Plates then analyzed using tlc-scanner (densitometry) to acquire area under curve of each analyte. The method is capable of detecting the presence of BKO with concentration of 6,5 ppm (Prednisone), 3,0 ppm (Paracetamol), 1,8 ppm (Dexamethasone), 5,9 ppm (Meloxicam), 8,0 ppm (Piroxicam) in test solution. The proposed validated method is capable to analyze 5 common chemical impurities often found in traditional drug preparation. Analysis can be done simultaneously using simple method hence it is suitable to used as a tool to screen impurities in traditional medicine.

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